Clinical trials: Hypertriglyceridemia
Dyslipidaemias, Dyslipidaemia
GW501516 In Subjects Who Have Low Level Of High-Density Lipoprotein Cholesterol
The purpose of this clinical research study is to compare up to 3 doses of an investigational drug GW501516 to placebo (an inactive pill that looks like GW501516) to see if it is safe, well tolerated and effective in improving…
- Trial name
- NCT00158899
- Testing
- GW501516 oral tablets
- Where
- 64 sites in Belgium, Denmark and 9 more
- Volunteers
- 424 people
- Sponsor
- GlaxoSmithKline
Hypertriglyceridemia, Dyslipidemia
Efficacy Study of Diazoxide Choline to Treat Hypertriglyceridemia
Once a day oral administration with DCCR helps lower triglycerides
- Trial name
- NCT01211847
- Testing
- Diazoxide Choline Controlled-Release Tablet
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Essentialis, Inc.
Hypertriglyceridemia
Effect of Candida Rugosa Lipase on Serum Triglyceride Lowering
The primary objective of this study was to evaluate the safety and tolerability of 3 doses of fungal lipase in the treatment of adults with mildly elevated serum triglycerides.
- Trial name
- NCT05295134
- Testing
- Candida cylindracea lipase (225,000 FIP lipase units per day), Candida cylindracea lipase (450,000 FIP lipase units per day), Candida cylindracea lipase (675,000 FIP lipase units per day)
- Where
- Ireland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- BIO-CAT, Inc.
Hyperlipidemias
Effect of Lapaquistat Acetate Combined With Fenofibrate on Blood Cholesterol Levels
The purpose of this study is to compare changes in cholesterol levels in patients with elevated blood cholesterol with administration of lapaquistat acetate, once daily (QD), and fenofibrate.
- Trial name
- NCT00813527
- Testing
- Lapaquistat acetate and fenofibrate, Fenofibrate
- Where
- 36 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- Takeda
Hypertriglyceridemia, Nonalcoholic Fatty Liver Disease
Phase 2a Study of Safety, Tolerability, and Efficacy of TLC-2716 in Subjects With Hypertriglyceridemia and NAFLD
This is a Phase 2a, randomized, double-blind, placebo-controlled study evaluating the safety, tolerability, and efficacy of 2 dose levels of TLC-2716 in subjects with hypertriglyceridemia and nonalcoholic fatty liver disease as…
- Trial name
- NCT06564584
- Testing
- TLC-2716 Dose 1, TLC-2716 Dose 2
- Where
- 4 sites in Mexico
- Volunteers
- 30 people
- Sponsor
- OrsoBio, Inc
Hypertriglyceridemia
Regulation of Sterol Homeostasis
The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.
- Trial name
- NCT00018720
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Metabolic Disorders, Abdominal Obesity
Exploring Physical Exercise for the Regulation and Control of Metabolic Disorders in College Students.
This clinical trial objective is to evaluate the effect of an aerobic physical exercise program on reducing triglycerides, blood pressure, abdominal obesity, altered glucose levels, and the increase in HDL in college-level…
- Conditions
- Metabolic Disorders, Abdominal Obesity, Blood Pressure Disorders, Hypertriglyceridemia
- Trial name
- (EPE_RCTMCS) (NCT06555159)
- Testing
- Physical exercise prescription: Continuous aerobic training (jogging, swimming, static cycling), Control group: Continuous aerobic physical exercise
- Where
- Mexico
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Metabolic Syndrome, Inflammation
Impacts of Aronia on Inflammation and the Gut Microbiome
The overall goal of this project is to determine the inflammation lowering impact of anthocyanin-rich Aronia berries. Inflammation is an underlying mechanism driving the development of several diseases.
- Conditions
- Metabolic Syndrome, Inflammation, Hypertriglyceridemia, Obesity
- Trial name
- NCT04128839
- Testing
- Aronia berry juice
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Montana State University
Type 2 Diabetes Mellitus, Hypertension
Vitamin D and Omega-3 Inhibit Metabolic Syndrome
The study will test the hypothesis that supplementing the diet of subjects with Metabolic Syndrome with 2000 IU vitamin D and 1.8 g omega-3 fatty acids (EPA + DHA) per day, will facilitate weight loss, improve body composition…
- Conditions
- Type 2 Diabetes Mellitus, Hypertension, Hyperlipidemia, Obesity
- Trial name
- NCT01326442
- Testing
- low glycemic diet, vitamin D omega-3
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Guelph
Hypertriglyceridaemia
Understanding Liver Fat Metabolism: Studies to Understand the Role of Dietary Sugars on Liver Fat Metabolism
High levels of fatty substances in the blood increase the risk of developing coronary heart disease and having a heart attack. The investigators know a lot about one of these fatty substances, cholesterol.
- Trial name
- NCT02478541
- Testing
- Sugar study
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
HIV Infections, AIDS
Omega-3 Fatty Acids for High Triglycerides in HIV-infected Patients
The purpose of this study is to evaluate the efficacy and safety of omega-3-fatty acids in HIV-infected patients with hypertriglyceridemia.
- Conditions
- HIV Infections, AIDS, Dyslipidemia, Hypertriglyceridemia
- Trial name
- NCT00346697
- Testing
- Omega-3 fatty acid administration
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Brown, Todd, M.D., Ph.D.
Dyslipidemia, Hypercholesterolemia
Pilot Study To Assess CAT-2003 in Patients With Hyperlipidemia
The purpose of this study is to determine the safety and efficacy of different doses of CAT-2003 in patients with hyperlipidemia when CAT-2003 is taken for 4 weeks.
- Conditions
- Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- PATHWAYS I (NCT01912560)
- Testing
- CAT-2003, Statin
- Where
- 14 sites in United States, Canada
- Volunteers
- 99 people
- Sponsor
- Catabasis Pharmaceuticals
Obesity, Hypertriglyceridemia
Effects of Omega-3 Fatty Acids on Markers of Inflammation
The major purpose of this study is to examine the effect of two sources of dietary omega-3 fatty acids, each given at two doses, on potential health benefits related to cardiovascular disease prevention.
- Conditions
- Obesity, Hypertriglyceridemia, Insulin Resistance, Hypertension
- Trial name
- NCT01129050
- Testing
- Fish Oil, Flaxseed Oil
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cardiovascular Diseases
Study of the Effectiveness and Safety of Niaspan ® in the Treatment of Lipid Abnormalities in Latin America
Post-Marketing Observational study of Niaspan® tablet in accordance with each country regulations. This study will be conducted in a prospective, single-arm, multi-center format.
- Trial name
- NCT01200160
- Testing
- Niacin
- Where
- 22 sites in Colombia, Mexico and 1 more
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Abbott
Insulin Resistance, Cardiovascular Diseases
Acipimox to Improve Hyperlipidemia and Insulin Sensitivity Associated With HIV
The purpose of this study is to test whether chronic administration of the drug acipimox will improve hyperlipidemia and insulin sensitivity among HIV infected patients experiencing highly active antiretroviral therapy (HAART)…
- Conditions
- Insulin Resistance, Cardiovascular Diseases, Heart Diseases, HIV Infections
- Trial name
- NCT00246402
- Testing
- Acipimox
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Heart Diseases
Pharmacogenetics of Hypertriglyceridemia in Hispanics
To study the effect of genes on lipid-lowering drug treatment in hypertriglyceridemia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertriglyceridemia
- Trial name
- NCT00086437
- Volunteers
- 274 people
- Sponsor
- University of California, Los Angeles
Cardiovascular Diseases
A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin
AMR101 (icosapent ethyl [ethyl-EPA]) is a highly purified ethyl ester of eicosapentaenoic acid (EPA) developed by Amarin Pharma Inc.
- Trial name
- REDUCE-IT (NCT01492361)
- Testing
- AMR101, Statin therapy
- Where
- 410 sites in United States, Australia and 9 more
- Volunteers
- 8,179 people
- Sponsor
- Amarin Pharma Inc.
Hyperlipidemia, Low-density-lipoprotein-type
Combined Effects of Bioactive Compounds in Lipid Profile
The aim of this study is to demonstrate whether, along with dietary recommendations, Armolipid Plus ® can improve the profile of patients with elevated plasma LDL-C acting as a change of lifestyle therapy (TLC) according to the…
- Conditions
- Hyperlipidemia, Low-density-lipoprotein-type, Elevated Triglycerides
- Trial name
- ARM-PLUS-LDL (NCT01562080)
- Testing
- Armolipid Plus
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- Rottapharm Spain
Severe Hypertriglyceridemia
Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (SHTG).
- Trial name
- SHASTA-3 (NCT06347003)
- Testing
- Plozasiran Injection
- Where
- 196 sites in United States, Argentina and 15 more
- Volunteers
- 446 people
- Sponsor
- Arrowhead Pharmaceuticals
Hypertriglyceridemia
An Efficacy and Safety Study of Omega-3-acid Ethyl Ester in Chinese Subjects With Hypertriglyceridemia.
The primary objective was to investigate the effect of 12-week treatment of Omacor on fasting serum triglycerides (TG) in Chinese subjects with hypertriglyceridemia (HTG).
- Trial name
- NCT04756180
- Volunteers
- 248 people
- Sponsor
- Abbott