Clinical trials: Hypertrophic Scarring
Hypertrophic Scar
Hypertrophic Scar Prevention by Novel Topical Gel Application
Researchers are trying to find out more about the side effects of topical (applied to the skin) Pentamidine, to determine if it is safe for use in people.
- Trial name
- NCT03403621
- Testing
- Pentamidine Isethionate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Hypertrophic or Keloid Scars
Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars
Hypertrophic or keloid scars develop for about 39% to 68% of patients after surgery. The subjective opinion of the patient regarding the scar will often constitute the standard for judging the success or failure of the procedure.
- Trial name
- NCT01861119
- Testing
- Silicone gel Kelo-cort™;, Onion extract gel Contractubex™
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- CHA University
Hypertrophic Scar
A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Revised Hypertrophic Scars
The purpose of this study is to determine the effectiveness of RXI-109 in reducing the recurrence of hypertrophic scar formation following elective revision of a pre-existing hypertrophic scar.
- Trial name
- NCT02246465
- Testing
- RXI-109
- Where
- 6 sites in United States, Honduras
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RXi Pharmaceuticals, Corp.
Hypertrophic Scars
Electromotive Drug Administration of Magnesium Sulphate on Hypertrophic Scar
In this study 80 patients will be randomly assigned into two equal groups (40 patients for each group): 1. Group A: Experimental: Magnesium Sulphate Iontophoresis for Postburn Hypertrophic Scar The study group includes 40…
- Trial name
- NCT06649188
- Testing
- Magnesium Sulphate Iontophoresis, traditional physical therapy program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Wrinkle, Acne Scars - Mixed Atrophic and Hypertrophic
AV-23-001 AVAVA MIRIA Pilot Study
This non-significant risk study is intended to demonstrate the use of the MIRIA Skin Treatment System can show improvement in dermatologic conditions currently indicated for treatment with a laser (such as, but not limited to…
- Conditions
- Wrinkle, Acne Scars - Mixed Atrophic and Hypertrophic, Pigmented Lesions, Skin Laxity
- Trial name
- NCT06557434
- Testing
- MIRIA
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- AVAVA, Inc.
Hypertrophic Scars
Gene Expression During Surgical Scar Remodeling by Fractional Photothermolysis
This project aims to understand the molecular biology underlying the improvement of surgical scars treated by ablative fractional photothermolysis (FP).
- Trial name
- NCT01858038
- Testing
- Fraxel Repair - Fractional Laser treatment
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Burns
Pilot Study of the Ablative Fractional CO2 Laser in Hypertrophic Scars in Adult Burn Patients
This is a randomized, controlled, within-patient, single-blinded, pilot study that will evaluate the impact of laser treatment on burn HSc relative to self-matched control scars.
- Trial name
- NCT03240718
- Testing
- Laser treatment
- Volunteers
- 12 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Skin Scarring
Early Carbon Dioxide Laser Therapy for Alleviation of Incisional Scar Burden
This is a prospective, randomized pilot study of patients who will undergo either early or late incisional laser therapy after breast reduction surgery to alleviate scar burden at NYU Langone Medical Center.
- Trial name
- NCT03306628
- Testing
- CO2 Laser Administration
- Where
- United States
- Sponsor
- NYU Langone Health
Cicatrix, Hypertrophic
To Study Gene Expression of Postburn Hypertrophic Scar
Aim: To compare the gene expression of postburn hypertrophic scar with normal skin.
- Trial name
- NCT01676168
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Facial Scarring
The Application of Intralesional 5-fluorouracil for the Management of Hypertrophic Facial Scars in the Periocular Region Resulting From Trauma and Surgical Procedures in Individuals Aged Over 18 Years
To determine the effectiveness of intralesional 5-fluorouracil in objectively reversing hypertrophic scars in the periocular region resulting from trauma or cosmetic surgery.
- Trial name
- AI5FMHFSPRFSOE (NCT07397520)
- Testing
- Intralesional administration of 5-fluorouracil
- Where
- Mexico
- Volunteers
- 7 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Scar, Surgical Scar
Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars
The purpose of this study is to evaluate the safety and efficacy of the 532nm potassium titanyl phosphate (KTP) laser in comparison with the 595nm pulsed-dye laser (PDL) for the treatment of fresh surgical scars.
- Conditions
- Scar, Surgical Scar, Cicatrix, Cicatrix, Hypertrophic
- Trial name
- NCT01789346
- Testing
- 532nm KTP, 595nm PDL
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cutera Inc.
Age, Cicatrix, Hypertrophic
Prospective Clinical Trials on Skin Wound Healing in Young and Aged Individuals
Regular wound healing follows a well-ordered sequence of overlapping phases: inflammation, proliferation, maturation and remodelling.
- Conditions
- Age, Cicatrix, Hypertrophic, Fibrosis, Diabetes Mellitus
- Trial name
- RESOLVE (NCT01040104)
- Testing
- Skin sample, Skin biopsy, Blood taking
- Where
- Austria
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Keloid, Hypertrophic Scar
A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars
Keloids are thought to result from derailments in the typical wound healing process following cutaneous injury. Current treatment options for keloids include intralesional corticosteroids, silicone gel sheeting, compression…
- Conditions
- Keloid, Hypertrophic Scar, Cicatrix, Hypertrophic
- Trial name
- NCT00754247
- Testing
- 0.5% hydrocortisone, silicone, vitamin E lotion, Onion extract gel, Cetearyl alcohol lotion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Keloids, Hypertrophic Scars
Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars
Keloids and hypertrophic scars are a common subject of dermatologic consultations. Therapeutic management of such conditions remains challenging because of their high rate of recurrence and lack of curative treatment.
- Trial name
- NCT01078428
- Testing
- Topical silicone gel, Vaseline
- Where
- Thailand
- Volunteers
- 38 people
- Sponsor
- Mahidol University
Hypertrophic Scarring
A Randomized Control Trial for Preventative Scar Management
The study's objective is to compare the global scar outcomes in those treated with silicone only therapy (SOT) versus silicone pressure garment therapy (SPGT) for the prevention of hypertrophic scarring in children with skin…
- Trial name
- NCT01602458
- Testing
- Silicone Only Therapy (SOT), Silicone Pressure Garment Therapy (SPGT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Seton Healthcare Family
Keloid, Cicatrix
Intralesional Cryotherapy With a Argon Gas Based Device for the Treatment of Keloid and Hypertrophic Scars
This prospective evaluation studies the effectiveness of Intralesional (IL) cryotherapy with a argon gas based device in treating keloids and hypertrophic scars in population consisting of all Fitzpatrick skin type patients
- Conditions
- Keloid, Cicatrix, Hypertrophic
- Trial name
- NCT02063243
- Testing
- Intralesional cryotherapy
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- Amsterdam UMC, location VUmc
Post-surgical Scars, Hypertrophic Scars
Surgical Care And Recovery With Laser Evaluation Trial (SCARLET)
The Surgical Care and Recovery with Laser Evaluation Trial (S.C.A.R.L.E.T.) is a prospective, single-center clinical study conducted at AdventHealth Medical Group Plastic and Reconstructive Surgery at Innovation Tower.
- Conditions
- Post-surgical Scars, Hypertrophic Scars, Scar Appearance Dissatisfaction, Aesthetic Surgical Outcomes
- Trial name
- SCARLET (NCT07359352)
- Testing
- ProFractional Laser Therapy and/or Broadband Light (BBL) Treatment
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Cicatrix, Cicatrix, Hypertrophic
FS2 Safety and Tolerability Study in Healthy Volunteers
Background Scarring typically occurs after trauma, burn injury or surgery. Hypertrophic scarring presents as raised, red and itchy lesions which variably respond to various treatment modalities, such as corticosteroids, pressure…
- Conditions
- Cicatrix, Cicatrix, Hypertrophic, Keloid
- Trial name
- NCT02340325
- Testing
- Acute Application of kynurenic acid cream, Chronic application of kynurenic acid cream
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- British Columbia Professional Firefighters' Burn and Wound Healing Laboratory
Cicatrix, Hypertrophic, Rehabilitation
The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar
This study explores the smart scar care pad's potential therapeutic effect in treatment hypertrophic scar while elucidating the adverse effects if there is any.
- Trial name
- NCT03469830
- Testing
- SSCP, SPMS
- Volunteers
- 8 people
- Sponsor
- The Hong Kong Polytechnic University
Hand Injuries, Extracorporeal Shock Wave Therapy
Clinical Utility of ESWT in Restoring Hand Function of Patients With Nerve Injury and Hypertrophic Scars Due to Burns
Joint contractures and nerve injuries are common after hand burns. Extracorporeal shock wave therapy (ESWT) is effective not only for the regeneration of various tissues, including scar tissues, but also for reducing pain and…
- Conditions
- Hand Injuries, Extracorporeal Shock Wave Therapy, Burns
- Trial name
- NCT06438224
- Testing
- Extracorporeal shock wave therapy (ESWT)
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Hangang Sacred Heart Hospital