Clinical trials: Hypertrophy, Left Ventricular
Left Ventricular Non-compaction Cardiomyopathy, Left Ventricular Failure
Value of Cardiac Magnetic Resonance (CMR) Derived Parameters for Diagnosing Left Ventricular Non-compaction Cardiomyopathy
Left ventricular non-compaction (LVNC) is a rare cardiomyopathy characterized by numerous excessively prominent left ventricular (LV) trabeculation and deep intertrabecular recesses communicating with the ventricular cavity and…
- Conditions
- Left Ventricular Non-compaction Cardiomyopathy, Left Ventricular Failure, Left Ventricular Hypertrophy
- Trial name
- NCT01481298
- Where
- Germany
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Hypertension, Arteriosclerosis
The Effects of Lowering Dialysate Sodium in Hypertensive Hemodialysis Patients
Unfavorably high sodium intakes remain prevalent around the world. A negative sodium gradient in hemodialysis treatment results in absolute sodium removal via diffusive transport of sodium from the blood to the dialysate, and it…
- Conditions
- Hypertension, Arteriosclerosis, Left Ventricular Hypertrophy
- Trial name
- NCT01455974
- Testing
- Decreasing dialysate sodium from 138 mmol/L to 136 mmol/L
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Capital Medical University
Hypertension, Left Ventricular Hypertrophy
Evaluation of Regional Myocardial Dynamics at Physical Stress in Essential Hypertension
The study hypothesis is stress-related regional tissue dynamics is related to left ventricular outflow tract blood flow.
- Trial name
- NCT01442116
- Testing
- stress echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Mustafa Kemal University
Hypertension, Left Ventricular Hypertrophy
Effect of Valsartan on Left Ventricular Myocardial Functions in Hypertensive Patients With Left Ventricular Hypertrophy
The study hypothesis: Valsartan as an angiotensin II receptor blocker treatment has beneficial effects on both midwall mechanics and myocardial functions in hypertensive patients with Left ventricular hypertrophy.
- Trial name
- NCT01425411
- Testing
- valsartan
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Mustafa Kemal University
Myocardial Reperfusion Injury, Cardiac Output, Low
Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy
Open-heart surgery causes injury of the heart muscle. Although this is usually mild, temporary and reversible, if it is severe it can endanger life and require additional high cost care.
- Conditions
- Myocardial Reperfusion Injury, Cardiac Output, Low, Hypertrophy, Left Ventricular
- Trial name
- HYPER (NCT00989508)
- Testing
- Perhexiline
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- University Hospital Birmingham
Fabry Disease, Left Ventricular Hypertrophy
Viennese Prevalence Study of Anderson-Fabry Disease
The prevalence of Anderson - Fabry disease in patients with left ventricular hypertrophy is unclear. The investigators will examine urine - α - Galactosidase activity and globotriaosylceramide isoforms in these patients.
- Trial name
- VIEPAF (NCT00871611)
- Where
- Austria
- Volunteers
- 4,000 people
- Sponsor
- Medical University of Vienna
Chronic Kidney Disease, Renal Osteodystrophy
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients
Sclerostin, the product of the SOST gene, located on chromosome 17, locus q11.2 in humans, was originally believed to be a non-classical Bone morphogenetic protein (BMP) antagonist.Sclerostin was recently identified as a…
- Conditions
- Chronic Kidney Disease, Renal Osteodystrophy, Left Ventricular Hypertrophy
- Trial name
- NCT01382966
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- RFM Renal Treatment Services
Hypertension, Left Ventricular Hypertrophy
Aliskiren in Combination With Losartan Compared to Losartan on the Regression of Left Ventricular Hypertrophy in Overweight Patients With Essential Hypertension
To compare the efficacy and safety of aliskiren in combination with losartan compared to losartan on the regression of the increased size of the left ventricle in overweight patients with high blood pressure.
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Overweight
- Trial name
- ALLAY (NCT00219141)
- Testing
- Aliskiren 150/300 mg, Losartan 50/100 mg
- Where
- 9 sites in United States, Argentina and 7 more
- Volunteers
- 460 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension; Hypertrophy, Left Ventricular
Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy
This study will evaluate the safety and efficacy of amlodipine plus valsartan in patients with hypertension and left ventricular hypertrophy
- Trial name
- NCT00446563
- Testing
- Valsartan, Amlodipine, Hydrochlorothiazide
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Novartis
Hypertension, Left Ventricular Hypertrophy
Hypertension in Hemodialysis
How high blood pressure in hemodialysis patients should be diagnosed and treated using medications or without medications is the purpose of this study.
- Trial name
- NCT00067665
- Testing
- Ultrafiltration
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Chronic Renal Failure
EPO-BUL-01 - Study of the Optimization of Anemia Management of EPREX (Epoetin Alfa) in Predialysis Patients With Chronic Renal Failure
The purpose of the study is to evaluate the effectiveness, safety and clinical outcome of Epoetin alfa with dosing regime in accordance with Summary of Product Characteristics in the treatment of anemia in predialysis.
- Trial name
- NCT00338000
- Testing
- Epoetin alfa
- Volunteers
- 292 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Anemia, Kidney Failure
A Safety and Efficacy Study for Epoetin Alfa in Pre-dialysis Subjects.
The purpose of this study is to determine if using Eprex, to maintain hemoglobin within the normal range, will prevent or delay the progression of left ventricular mass growth.
- Conditions
- Anemia, Kidney Failure, Left Ventricular Hypertrophy
- Trial name
- NCT00364260
- Testing
- epoetin alfa
- Volunteers
- 172 people
- Sponsor
- Janssen-Ortho Inc., Canada
Acromegaly, Heart Failure
Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant
The purpose of this study is to evaluate changes in left ventricular mass and cardiac function in patients with active acromegaly before and after treatment with the growth hormone receptor antagonist pegvisomant for one year.
- Conditions
- Acromegaly, Heart Failure, Hypertrophy, Left Ventricular
- Trial name
- NCT00552851
- Testing
- pegvisomant
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- University of Wuerzburg
Renal Artery Stenosis, Left Ventricular Hypertrophy
Stenting of Renal Artery Stenosis in Coronary Artery Disease Study
The Stenting of Renal Artery Stenosis in Coronary Artery Disease (RASCAD) study is a randomized controlled trial designed to evaluate the effect of renal artery stenting+medical therapy versus medical therapy alone on left…
- Trial name
- RASCAD (NCT01173666)
- Testing
- stenting angioplasty plus medical therapy, Medical therapy
- Where
- Italy
- Volunteers
- 168 people
- Sponsor
- Azienda Ospedaliera, Universitaria Policlinico Vittorio Emanuele
Atherosclerosis, Congestive Heart Failure
Dallas Heart Study 2: Return Clinic Visit for the Dallas Heart Study Cohort
The Dallas Heart Study (DHS-1) is a large, multi-ethnic, population-based epidemiological study designed to identify determinants of atherosclerotic heart disease (ASHD) in a representative United States (US) urban environment.
- Conditions
- Atherosclerosis, Congestive Heart Failure, Left Ventricular Hypertrophy, Diabetes Mellitus
- Trial name
- NCT00344903
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hypertrophy, Left Ventricular, Aortic Stenosis
Glutamate and Diastolic Function in Patients Undergoing Aortic Valve Repair
Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and overall hemodynamics were studied in patients undergoing elective aortic valve replacement with severe aortic stenosis and associated left…
- Conditions
- Hypertrophy, Left Ventricular, Aortic Stenosis, Myocardial Ischemia, Cardiopulmonary Bypass
- Trial name
- NCT01144039
- Testing
- LG-group, HG-group
- Where
- Austria
- Volunteers
- 27 people
- Sponsor
- Medical University of Vienna
Children, Chronic Renal Failure
Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients
In children with chronic kidney disease, progression to end-stage renal failure is associated with high patient morbidity and poor quality of life.
- Conditions
- Children, Chronic Renal Failure, Hypertension, Acquired Kidney Disease
- Trial name
- ESCAPE (NCT00221845)
- Testing
- ACE Inhibition, Intensified Blood Pressure Control, Add-on Angiotensin Receptor Blockade
- Where
- 33 sites in Czechia, France and 10 more
- Volunteers
- 400 people
- Sponsor
- Heidelberg University
Chronic Kidney Disease, Pediatric
The Cardiovascular Comorbidity in Children With Chronic Kidney Disease Study
Children and adolescents with chronic kidney disease (CKD) are at high risk for cardiovascular (CV) morbidity and mortality. Recent studies suggest that pediatric patients with even moderately impaired kidney function may be…
- Conditions
- Chronic Kidney Disease, Pediatric, Cardiovascular Disease
- Trial name
- 4C (NCT01046448)
- Where
- 50 sites in Austria, Belgium and 13 more
- Volunteers
- 650 people
- Sponsor
- Heidelberg University
Aortic Regurgitation
Diastolic Dysfunction in Aortic Regurgitation
Follow-up study in patients with severe aortic regurgitation after successful valve replacement. Systolic and diastolic function were assessed and persistent diastolic dysfunction was observed late (7-10 years) after operation.
- Trial name
- NCT00976625
- Testing
- Aortic Valve Replacement
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bern
End-Stage Renal Disease, Hemodialysis
Comparison of Four and Eight Hours Dialysis Sessions in Thrice Weekly Hemodialysis
The investigators hypothesize that an increase in the duration of dialysis session in thrice weekly center hemodialysis may provide better outcome, less morbidity, higher quality of life, lesser requirement of medications, and…
- Trial name
- NCT00413803
- Testing
- 4-hour thrice weekly in center hemodialysis, 8-hour thrice weekly in center hemodialysis
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 410 people
- Sponsor
- Ege University