Clinical trials: Hypervolemia
Fluid Overload
Body Composition Monitoring(BCM) for Determination of the Fluid Status in Patients Undergoing General Anesthesia
The purpose of this study is to evaluate a recently developed device, which measures body composition (i.e. the water content of the body) in the perioperative setting.
- Trial name
- BCM (NCT01945541)
- Testing
- Body Composition Monitoring
- Where
- Austria
- Volunteers
- 73 people
- Sponsor
- Medical University of Vienna
Hypervolemia, Hypovolemia
Reliability of Internal Jugular Ultrasound : an Observational Transversal Study Conducted Using Images Registered From Patients (AIJV-I)
The goal of this observational study is to test the inter-rater reliability among a group of ultrasound measurements of internal jugular vein using a group of images, registered in several acoustic views of neck of patients…
- Trial name
- AIJV-I (NCT06591234)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Maggiore Bellaria Hospital, Bologna
Fluid Overload, Organ Edema
"The Effect of Reduced Fluid Load After Cardiac Surgery"
The purpose of this study is to verify that an infusion of hypertonic saline/colloids during cardio-pulmonary-bypass will reduce fluid overload and organ edema for cardiac patients with expected long-CPB-time.
- Conditions
- Fluid Overload, Organ Edema, Organ Function
- Trial name
- NCT01438502
- Testing
- HyperHAES® (hypertonic saline/HES)
- Sponsor
- Haukeland University Hospital
Fluid Overload, Fluid Loss
Evaluating the Fluid Balance of Mechanically Ventilated Patients by Ultrasonography
ratio of the diameter of inferior vena cava to the diameter of the thoracic aorta (IVC / Ao) depends on the daily balance of fluids.
- Trial name
- NCT03204292
- Where
- Poland
- Volunteers
- 57 people
- Sponsor
- Jagiellonian University
Fluid Overload
Using Bioimpedance Analysis to Monitor Fluid Status in Children
This study aims to develop a more comprehensive approach to monitoring fluid status in patients undergoing stem cell transplantation by combining conventional methods with a bioimpedance device.
- Trial name
- NCT07834710
- Testing
- Bioimpedance device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- St. Jude Children's Research Hospital
Acute Decompensated Heart Failure
DORAYA-HF OUS Assessment of the Doraya Catheter for the Treatment of ADHF Patients With Insufficient Response to Diuretics
The study objective is to evaluate the feasibility of the Doraya Catheter and measure clinical performance and safety endpoints, in ADHF patients deemed to have insufficient diuretic response.
- Trial name
- NCT05876078
- Testing
- Doraya catheter
- Where
- 10 sites in Germany, Italy and 3 more
- Volunteers
- 25 people
- Sponsor
- Revamp Medical Ltd.
Shock
Consistency of Fluid Tolerance Evaluation Methods and Their Correlation With Clinical Outcomes in Patients With Shock
This study aims to explore the feasibility and scientific validity of carotid-jugular Doppler in evaluating volume tolerance in shock patients (with the VExUS score as an important reference standard), and to conduct an in-depth…
- Trial name
- NCT07373717
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Southeast University, China
Critical Illness, Sepsis
Physiological Effects of 38°C vs. 22°C Fluid Therapy in Critically Ill Patients
A randomized controlled clinical trial. 24 adult ICU patients will be recruited upon decision to administer fluid bolus of 500ml of crystalloid.
- Conditions
- Critical Illness, Sepsis, Fluid Overload, Hemodynamic Instability
- Trial name
- NCT04576806
- Testing
- Body temperature, Fluid bolus, Room temperature
- Where
- 2 sites in Sweden
- Sponsor
- Karolinska Institutet
Ovarian Cancer, Hemodynamic Instability
Proactive Hemodynamic Management During Cytoreductive Surgery and HIPEC
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a complex surgical procedure carried out through laparotomic approach.
- Conditions
- Ovarian Cancer, Hemodynamic Instability, Fluid Overload
- Trial name
- HEMOPEC (NCT07070973)
- Testing
- Assisted Fluid Management, Goal Directed Fluid Therapy (GDT)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COVID-19
Lung Injury (Pulmonary Edema) in COVID-19: Treatment With Furosemide and Negative Fluid Balance (NEGBAL)
In COVID-19, pulmonary edema has been attributed to "cytokine storm". However, it is known that SARS-CoV-2 promotes angiotensin-converting enzyme 2 deficiency, it increases angiotensin II and this triggers volume overload.
- Trial name
- NCT05304702
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Clinica Colon
Thoracic Diseases, Water-Electrolyte Imbalance
TOnicity of Perioperative Maintenance SoluTions
Prospective randomized double blind phase IV trial studying the efficacy and safety of the tonicity of two different perioperative maintenance solutions: an isotonic solution containing NaCl 0.9 in glucose 5% with an added 40…
- Conditions
- Thoracic Diseases, Water-Electrolyte Imbalance, Fluid Overload, Fluid Retention
- Trial name
- TOPMAST-1 (NCT03080831)
- Testing
- NaCl 0.9% in Glucose 5% + 40mmol/L Potassium, Glucion 5%
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Niels Van Regenmortel
Fluid Overload, POCUS
Concordance and Discordance in the Assessment of Volume Status in Home Dialysis Patients: A Comparison of Modified Medical Research Council Dyspnea Scale, Physical Exam, and Point of Care Ultrasound (POCUS)
Fluid overload (when the body has too much fluid), is one of the reasons why people on home dialysis need to go to the hospital. Fluid overload commonly presents as trouble breathing and leg swelling.
- Conditions
- Fluid Overload, POCUS, Lung Ultrasound, Volume Status
- Trial name
- NCT07178470
- Testing
- point-of-care ultrasound (POCUS), specifically lung ultrasound (LUS), Modified Medical Research Council (mMRC) Dyspnea scale, Physical Exam
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
Heart Failure, Congestive Heart Failure
Alfapump Direct Sodium Removal (DSR) Feasibility Study
First in Human feasibility and sfafety study of the alfapump DSR system in the treatment of Heart failure subects resistant to diuretic therapy.
- Conditions
- Heart Failure, Congestive Heart Failure, Cardiorenal Syndrome, Volume Overload
- Trial name
- RED DESERT (NCT04116034)
- Testing
- alfapump DSR system
- Where
- 2 sites in Belgium, Georgia
- Volunteers
- 8 people
- Sponsor
- Sequana Medical N.V.
Septic Shock
Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock
Many observational studies have highlighted an independent association between fluid overload and clinical outcomes during septic shock.
- Trial name
- GOAL (NCT03461900)
- Testing
- Minifluid challenge, Usual practice
- Where
- 18 sites in France
- Volunteers
- 535 people
- Sponsor
- University Hospital, Brest
Endothelial Dysfunction, Hemolysis
Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II
Acute microcirculatory perfusion disturbances is common in critical illness and associated with increased morbidity and mortality.
- Conditions
- Endothelial Dysfunction, Hemolysis, Fluid Overload
- Trial name
- PRIME part II (NCT05647200)
- Testing
- Treatment: additional albumin during cardiopulmonary bypass, control: additional ringers during cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Amsterdam UMC, location VUmc
Fluid Balance of ICU Patients, Fluid Overload
Impact of Rational Control of Fluid Balance in the Intensive Care Unit
Patients admitted in the Intensive Care Unit (ICU) frequently display and excessive fluid balance over a very short period of time.
- Trial name
- IRIHS-REA (NCT02345681)
- Testing
- Furosemide
- Where
- 3 sites in France
- Volunteers
- 171 people
- Sponsor
- Nantes University Hospital
Fluid Retention, Fluid Loss
The Effect of AMP Human Sodium Bicarbonate Lotion on Hydration
The purpose of this research study is to evaluate the effects of a topical sodium bicarbonate lotion on physiological and psychological responses associated with hydration status and fluid balance in humans during passive heat…
- Conditions
- Fluid Retention, Fluid Loss, Sodium Retention, Cognitive Change
- Trial name
- AMPlify (NCT04598386)
- Testing
- PR Lotion - AMP Human Performance
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Fluid Overload
Application of Bioimpedance Spectroscopy in Taiwan Dialysis Patients
A reasonable and simple algorithm was used to guide the dry weight determination with Body Composition Monitor with the principle of Bioimpedance Spectroscopy (BCM-BIS) and analyze the feasibility of this algorithm and evaluate…
- Trial name
- NCT02325856
- Testing
- Bioimpedance Spectroscopy, Clinical judgement
- Volunteers
- 298 people
- Sponsor
- An Hsin QingShui Clinic
Hypervolemia, Cardiogenic Shock
Capital Offload-Shock
CAPITAL OFFLOAD-SHOCK will aim to answer if early use of renal replacement therapy, like dialysis, in patients with reduced body fluids causing the heart to be unable to pump enough blood through the body reduces in-hospital…
- Conditions
- Hypervolemia, Cardiogenic Shock, Renal Replacement Therapies
- Trial name
- OFFLOAD-SHOCK (NCT07756801)
- Testing
- Immediate renal replacement therapy
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Kidney Injury, Renal Insufficiency, Acute
VExUS-guided Fluid Management in Patients With Acute Kidney Injury in the Intensive Care Unit
A quasi experimental study that aims to verify whether the incorporation of VExUS in patients with AKI in the Intensive Care Unit (ICU) may prompt tailored interventions to increases the number of days free from Renal Replacement…
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Acute, Kidney; Disease, Acute, Critical Illness
- Trial name
- AKIVEX (NCT05240833)
- Testing
- VExUS Score
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- Hospital de Clinicas de Porto Alegre