Clinical trials: Hypnotic; Sleep Disorder, open to volunteers
Sleep Disorders
Optimization of Melatonin Administration in Healthy Adults
The goal of this clinical trial is to evaluate whether the timing and dosage of exogenous melatonin can improve sleep onset and maintenance in healthy adults aged 18-45 years (50% female) with no history of sleep disorders.
- Trial name
- MelOpt (NCT07514507)
- Testing
- Mel 2 mg 30 min, Mel 2 mg 3 h, Mel 4 mg 30 min
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Sleep Apnea, Obstructive Sleep Apnea
Continuous Positive Airway Pressure, Arousability and Links to Mechanisms in Obstructive Sleep Apnea
The study design is a randomized, controlled clinical trial to test the hypothesis that arousal threshold (ArTH) will affect how individuals with obstructive sleep apnea (OSA, Apnea-Hypopnea Index (AHI) of 10/hour of higher)…
- Trial name
- CALM-OSA (NCT07332442)
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Yale University
Harmful Use of Hypnotic
Brief Intervention for Sleep Medication Misuse Among Elderly
Randomized controlled trial to evaluate effectiveness of behavioral Brief Intervention administered by General practitioners (GPs) versus business as usual on use of Z-hypnotics by elderly patients in primary care.
- Trial name
- BI-sleep (NCT06032715)
- Testing
- BI (Brief Intervention)
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- University Hospital, Akershus
Insomnia, Hypnotic Dependence
Enhancing Hypnotic Medication Discontinuation in Primary Care
Many individuals with insomnia seek treatment in primary care settings, where they often receive prescription hypnotic medications as their first and sometimes only treatment.
- Trial name
- NCT06435520
- Testing
- Digital Cognitive Behavioral Therapy, Structured Medication Tapering
- Where
- United States
- Volunteers
- 430 people
- Sponsor
- National Jewish Health
Insomnia
Photobiomodulation for Reducing Sedative-Hypnotic Use:Clinical Trial of a Light-Therapy Device
Background: Insomnia is a prevalent and growing public health issue, with one in three adults affected globally and one in five Taiwanese adults reporting significant sleep disturbances.
- Trial name
- NCT07764107
- Testing
- PBM intervention
- Volunteers
- 60 people
- Sponsor
- National Health Research Institutes, Taiwan
Insomnia Chronic, Hypnotics and Sedatives
Physical Activity Interventions for Sleep Improvement and Sedative-Hypnotic Reduction in Middle-Aged and Older Adults: Investigating the Role of Sarcopenia
Background: The prevalence of sedative-hypnotic use among middle-aged and older adults in Taiwan has continued to rise, highlighting the need to better understand the underlying factors contributing to sleep disturbances and…
- Conditions
- Insomnia Chronic, Hypnotics and Sedatives, Physical Activities
- Trial name
- NCT07896603
- Testing
- resistance training, Relaxation training
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Insomnia, Chronic Pain
Lemborexant vs Clonidine vs Sedatives to Treat Insomnia in Chronic Pain Patients
Prospective observational crossover study of 250 adults undergoing chronic pain management. For insomnia treatment, patients alternate their usual prescribed sedative versus Lemborexant or Clonidine; on alternate nights.
- Conditions
- Chronic Insomnia, Chronic Pain, Restless Leg Syndrome (RLS), Substance Abuse
- Trial name
- NCT05618002
- Testing
- Lemborexant
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Salem Anaesthesia Pain Clinic