Clinical trials: Hypoglycemia (Diabetic)
Neonatal Hypoglycemia, Infant, Small for Gestational Age
Effect of Tahneek on Hypoglycemia in Newborn Infants
Tahneek is an Arabic word which means putting something sweet such as dates, in the infant's mouth after the birth. Neonatal hypoglycemia is common in the first few days after birth.
- Conditions
- Neonatal Hypoglycemia, Infant, Small for Gestational Age, Macrosomia, Fetal, Intrauterine Growth Restriction
- Trial name
- THIN (NCT03726697)
- Testing
- Tahneek
- Where
- Saudi Arabia
- Volunteers
- 324 people
- Sponsor
- King Abdullah International Medical Research Center
Impaired Awareness of Hypoglycemia, Interoceptive Awareness
Adapted Mindfulness Training for Diabetic Patients With Impaired Hypoglycemia Awareness
The purpose of this randomized controlled trial is to evaluate the effectiveness of an 8-week interoception-integrated adapted mindfulness training program for patients with type 1 or type 2 diabetes who experience impaired…
- Conditions
- Impaired Awareness of Hypoglycemia, Interoceptive Awareness, Mindfulness-based Intervention
- Trial name
- NCT07586527
- Testing
- Adapted Mindfulness Training, Routine Intervention
- Volunteers
- 100 people
- Sponsor
- Yangzhou University
Diabetes Mellitus, Type 1
The Impact of Different CSII and CGM Systems on Different Clinical Outcome Variables in Children and Adolescents With Type 1 Diabetes. An Observational Study Form the Norwegian Childhood Diabetes Registry (NCDR)
To examine the effect of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) on metabolic control, in a large population-based nationwide observational study under real life conditions.
- Trial name
- NCT04201171
- Testing
- CSII and CGM
- Volunteers
- 2,749 people
- Sponsor
- Helse Fonna
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Diabetes Mellitus, Hypoglycemia
Perioperative Hypoglycemia in Diabetic Patients Undergoing Vitrectomy: a Masked CGM Prospective Observational Study
Patients with diabetes are at increased risk of perioperative glycemic disturbances due to preoperative fasting, the surgical stress response, and the use of insulin or oral hypoglycemic agents.
- Trial name
- NCT07696910
- Testing
- Masked continuous glucose monitoring (FreeStyle Libre 2®)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hypoglycemia (Diabetic)
Comparing Blood Glucose Control Intraoperative Between Insulin Drip vs. Insulin Boluses Will Provide Valuable Information on the Optimal Method for Achieving Blood Glucose Control Intraoperatively.
Cardiac surgery patients often experience elevated blood glucose levels, which can lead to poor surgical outcomes and increased postoperative complications. Therefore, tight blood glucose control during surgery is important.
- Trial name
- RANDOM-IB (NCT07056088)
- Testing
- Insulin Drip Therapy, Insulin boluses
- Volunteers
- 384 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Diabetes, Hypoglycemia
Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Complications in Diabetic Patients
A recent pilot study, GLIMPSE (NCT02690168), was recently completed which demonstrated that the rate of glial acetate metabolism (GAM) is closely associated with susceptibility to fasting-induced hypoglycemia in healthy adults.
- Trial name
- GLEAM (NCT04430660)
- Testing
- 13C-MRS procedure/Acetate infusion, Continuous glucose monitoring
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Pennington Biomedical Research Center
Hypoglycemia
Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers
Thesis Infants of diabetic mothers are at high risk to develop hypoglycemia after birth. After birth, glucose and ketone bodies are the main substrates of brain energy.
- Trial name
- NCT00434772
- Testing
- glucagon
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Type 2 Diabetes Mellitus, Colonoscopy
Abnormal Blood Sugar Tests in Diabetic Patients During Colonoscopy Preparation
Type 2 diabetes is rapidly increasing globally and has been associated with an increased risk of colorectal cancer. Therefore, the numbers of diabetic patients who will undergo colonoscopic screening are expected to grow…
- Trial name
- NCT03109951
- Testing
- Colonoscopy preparation using polyethylene glycol
- Where
- South Korea
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Catholic Kwandong University
Diabetes Mellitus, With Complications
Effects of Pulsatile IV Insulin Delivery on Diabetic Retinopathy in Patients With Types 1 and 2 Diabetes Mellitus
Diabetic Retinopathy is the leading cause of blindness in the world. Previous studies have documented beneficial effects of physiologic administration of pulsatile insulin on a variety of diabetic complications such as…
- Trial name
- NCT00287651
- Testing
- Pulsatile IV Insulin, Effects of Pulsatile IV Insulin on Diabetic Retinopathy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Florida Atlantic University
Diabetes Mellitus
Clinical Effects of Pulsatile Insulin Delivery on Cognitive Function- Phase 1
To determine if restoring normal metabolic function in patients with either Type I or Type II Diabetes can improve overall cognitive function.
- Trial name
- NCT00228865
- Testing
- Pulsatile IV insulin therapy, Effects of Pulsatile IV Insulin on Cognitive functions
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Florida Atlantic University
Type I Diabetes
Evaluation of the Function "Stop Before Hypoglycemia" on External Insulin Pump
This study compares the apparition of hypoglycaemia in type I diabetic patients between 2 phases: the one without the use of SmartGuard® function and the one with the use of SmartGuard® function.
- Trial name
- AAHPI (NCT03653533)
- Testing
- MiniMed™ 640G, Captor CGM Enlite®, SmartGuard®
- Where
- France
- Volunteers
- 8 people
- Sponsor
- ARAIR Assistance
Hypoglycemia
Single Doses of ZP4207 Adm. sc to Hypoglycemic TD1 pt. to Describe the PK and PD of ZP4207 as Comp. to Marketed Glucagon
The trial is a single-centre, randomized, double-blind, parallel trial in Group 1 and cross-over trial in Groups 2-4 with single doses of ZP4207 administered s.c.
- Trial name
- NCT02660008
- Testing
- ZP4207, GlucaGen
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Zealand Pharma
Diabetic Ketoacidosis
Comparison of a Low Dose to a Standard Dose of Insulin in Adult DKA in ICU to Reduce Metabolic Complications
Diabetic ketoacidosis (DKA), a frequent complication of diabetes, is the consequence of a profound insulin deficiency responsible for osmotic polyuria and thus major losses of water, glucose, sodium and potassium as well as a…
- Trial name
- LOSTINDIAB (NCT05443802)
- Testing
- Insulin 0.05 IU/kg/h, Insulin 0.10 IU/kg/h
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Insulin Dependent
Evaluation of Interests of FIT Therapy on Diabetics Children Insulin-dependent
Evaluation of interests of the functional insulin therapy (FIT Therapy) on metabolic control, hypoglycemia prevention and life quality of diabetics children insulin-dependent treated with insulin pump.
- Trial name
- DIABFIT (NCT01443741)
- Testing
- Therapeutic education
- Where
- 6 sites in France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Angers
Diabetes Mellitus, Hypoglycemia (Diabetic)
Continuous Bloodsugar Monitoring System With a Sensor Compared to Fingerstick Bloodsugar Monitoring
This clinical trial aims to compare a continuous glucose monitoring system with traditional fingerstick blood glucose monitoring.
- Conditions
- Diabetes Mellitus, Hypoglycemia (Diabetic), Hypoglycemia Night, Hyperglycemia
- Trial name
- GLUCOSENS (NCT06473480)
- Testing
- Abbott FreeStyle Libre System 2 Plus, Abbott Freestyle Libre Pro
- Where
- 2 sites in Denmark
- Volunteers
- 329 people
- Sponsor
- Odense University Hospital
Infants of Diabetic Mothers, Placenta
Placental Weight in Infants of Gestational Diabetic Mothers
This prospective cross-sectional study examined the relationship between placental weight and early neonatal outcomes, such as blood glucose levels within the first 24 hours and early neonatal morbidities in infants born to…
- Conditions
- Infants of Diabetic Mothers, Placenta, Hypoglycaemia
- Trial name
- NCT07765784
- Testing
- Blood Glucose Level
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Hypoglycemia, Reactive, Hypoglycaemia Night
CGM (Continuous Glucose Monitoring) Use in Diagnosis of Spontaneous and Reactive Hypoglycaemia
Use of CGM to determine diagnosis in possible spontaneous or reactive hypoglycaemia. Use of CGM to aid treatment optimisation in spontaneous or reactive hypoglycaemia
- Conditions
- Hypoglycemia, Reactive, Hypoglycaemia Night, Hypoglycemia Non-Diabetic, Hypoglycemia Unawareness
- Trial name
- NCT04452396
- Testing
- use of continuous glucose monitoring
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Barts & The London NHS Trust
Type 1 Diabetes
Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration?
Previous data from our clinical trial has demonstrated that the combination of dapagliflozin plus pioglitazone cause robust decrease in the plasma glucose concentration without significant increase in plasma ketone concentration…
- Trial name
- NCT06922656
- Testing
- Dapagliflozin (DAPA), Pioglitazone 45 mg
- Where
- 3 sites in Kuwait, Qatar and 1 more
- Volunteers
- 60 people
- Sponsor
- Dasman Diabetes Institute
Type 1 Diabetes, Hypoglycemia
Late Night Snack and Insulin Glargine
Twenty patient with Type 1 diabetes, using insulin glargine as basal insulin, participated in a prospective, controlled crossover trial comparing blood glucose profiles over two 24 h periods with and without a late night snack (a…
- Trial name
- NCT02871180
- Testing
- Late night snack, No late night snack
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Diabeteszentrum Bad Lauterberg im Harz