Clinical trials: Hypoglycemic Syndrome
Type 1 Diabetes
A Study of Nasal Glucagon (LY900018) in Pediatric Participants With Type 1 Diabetes
The main purpose of this study is to evaluate the safety and tolerability of a study drug called nasal glucagon (Baqsimi) in pediatric participants with type 1 diabetes (T1D) aged 1 to less than 4 years.
- Trial name
- RescuiNGkids (NCT04992312)
- Testing
- Glucagon Nasal Powder [Baqsimi]
- Where
- 8 sites in United States
- Volunteers
- 7 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitus
Prevention of Hypoglycaemia With Predictive Insulin Suspend Using Sensor Augmented Insulin Pump in Children
The aim of the study is to prove whether the use of the SmartGuard feature of the MiniMed system significantly reduces hypoglycemic excursions and thus provide proactive protection to the user.
- Trial name
- SportGuard (NCT02179281)
- Testing
- Medtronic MiniMed™ 640G system
- Where
- 2 sites in Israel, Slovenia
- Volunteers
- 100 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Diabetes Mellitus, Type I
Effect of the Fat Content of the Bedtime Snack on Overnight Hypoglycemia
Low blood sugar at night (called nocturnal hypoglycemia), can often happen without symptoms and can last for a long time. Doctors often suggest that patients take a bedtime snack to try to prevent low blood sugar at night from…
- Trial name
- NCT00493935
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Jaeb Center for Health Research
Hypoglycemia, Cerebral Blood Flow
External Carotid Blood Flow in Individuals With Post-Bariatric Hypoglycemia
This is a pilot study (small-scale study) that aims to understand more about how blood flow changes in people who have low blood sugar after bariatric surgery (post-bariatric hypoglycemia) compared to those who have had surgery…
- Trial name
- NCT07082478
- Testing
- in-ear device measuring blood flow
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Diabetes, Hypoglycemia
Vildagliptin and the Glucagon Response to Hypoglycemia in Type 1 Diabetes
The study examines whether DPP-4 inhibition by vildagliptin affects the glucagon counterregulatory response to hypoglycemia in type 1 diabetes.
- Trial name
- NCT01147276
- Testing
- Vildagliptin
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Lund University
Type 1 Diabetes, Hypoglycemia
Treatment With Erythropoietin and Cognition During Hypoglycaemia
The purpose of the trial is to determine if erythropoietin (EPO) can enhance cognitive function during hypoglycaemia in patients with type 1 diabetes. Patients with type 1 diabetes will receive one injection of EPO.
- Trial name
- NCT00615368
- Testing
- Epoetin alfa
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- Hillerod Hospital, Denmark
Pregnancy, Diabetes
Severe Hypoglycemia in Pregnant Women With Type 1 Diabetes
Background: The risk of stillbirth and preterm delivery is three times increased among pregnant women with type 1 diabetes compared with healthy pregnant women.
- Trial name
- NCT00435565
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypoglycemia
GLP1R-imaging in Hypoglycemia
Hyperinsulinemic hypoglycemia (HH) is a rare complication that occurs 1 to 5 years after gastric bypass surgery. The underlying mechanism of this complication is not yet completely understood.
- Trial name
- NCT03182192
- Testing
- 68Ga-NODAGA-exendin-4 PET/CT
- Where
- 2 sites in Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Continuous Glucose Monitoring in Dialysis Patients With Diabetes
The primary objective of this multicenter, randomized controlled trial is to assess whether the intermittent or continuous use of continous glucose monitoring can enhance glycaemic control among dialysis patients with type 1 or…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Continuous Glucose Monitoring, Haemodialysis
- Trial name
- NCT06641765
- Testing
- Continous Glucose Monitoring
- Where
- 5 sites in Denmark
- Volunteers
- 96 people
- Sponsor
- Bo Feldt-Rasmussen
Hypoglycemia
Hypoglycemia and the Gut Microbiome
This study is designed to evaluate individuals who are currently experiencing symptoms of hypoglycemia, in order to discern correlations between microbiome composition and patterns of postprandial glycemia.
- Trial name
- NCT03385707
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Joslin Diabetes Center
Evidence of Liver Transplantation, Hyperglycemia
Study of Glycemic Control on Liver Transplantation Outcomes
Many but not all studies have shown improvement in morbidity and mortality with intensive glycemic management postoperatively. In this study, the investigators propose to determine whether improved glycemic control using…
- Conditions
- Evidence of Liver Transplantation, Hyperglycemia, Rejection
- Trial name
- NCT01211730
- Testing
- Insulin
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Northwestern University
Diabetes Mellitus Type 2
Risk of Nocturnal Hypoglycemia and Arrhythmias With Sitagliptin Versus Glimepiride in Patients With Type 2 Diabetes
This exploratory double blind randomized active controlled study is designed to assess the effects of a treatment with therapeutical dosage of sitagliptin versus therapeutical dosage of glimepiride as add on therapy in patients…
- Trial name
- NCT02373865
- Testing
- Sitagliptin, Glimepiride
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- GWT-TUD GmbH
Hypoglycemic Events, Hyperglycemic Therapy
Developing a Model to Predict Inpatient Hypoglycemic Episodes
This study will create a new model to predict hypoglycemic events in diabetic inpatients on anti-hyperglycemic therapy using retrospective data with the goal of developing a model that will accurately predict hypoglycemic…
- Trial name
- NCT05989256
- Testing
- EndoTool, glucose management team, standard of care glucose management
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Hyperglycemia, Hypoglycemia
GLP 1 for Intraoperative Glycemic Control
This is a medical research study designed to see if an infusion of a naturally occurring hormone, GLP-1, works when used to decrease blood sugar during cardiac surgery.
- Trial name
- GLP (NCT00882492)
- Testing
- GLP 1
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
GDM, Hypoglycemia
DiGESTnewborn Study
We wish to study the effect of a mothers sugar (glucose) control during pregnancy on her baby's sugar control after birth.
- Trial name
- DiGESTnewborn (NCT04192422)
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Postbariatric Hypoglycemia
Study to Evaluate Efficacy and Dose Response of Imapextide (STEADI)
The purpose of this study is to assess the preliminary efficacy of single SC administration of MBX 1416 at different dose levels in patients with PBH
- Trial name
- NCT07029412
- Testing
- MBX 1416 (INN imapextide)
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- MBX Biosciences
Diabetes, Diabetes Mellitus, Type 1
A Survey on Low Blod Sugar Among Insulin-treated Patients With Diabetes
This study is conducted globally. The aim of this study is to describe the proportion of patients with hypoglycaemic episodes and estimate the incidence of various types of hypoglycaemia in the retrospective and prospective…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT02306681
- Testing
- No treatment given
- Where
- 8 sites in Bangladesh, Colombia and 6 more
- Volunteers
- 7,315 people
- Sponsor
- Novo Nordisk A/S
Type I Diabetes
Monitoring of Nocturnal Hypoglycemia Using EarlySense Monitoring Device
This study observes the continuous measurement of breathing patterns, heart rate, restlessness, and tremor in sleep using the EarlySense ES 16 device as a tool in the management of hypoglycemia in pediatric type I diabetes…
- Trial name
- NCT00361608
- Testing
- EarlySense ES 16
- Where
- Israel
- Sponsor
- EarlySense Ltd.
Hypoglycemia
Blood/Interstitial Glucose Measurements and Cognitive Function During Hypoglycemia and Recovery
The purpose of this study is to find out the effects of hypoglycemia on cognition in healthy individuals and how well changes in (interstitial) tissue glucose levels correlate with changes in cognitive function as compared to…
- Trial name
- NCT01283126
- Testing
- euglycemic and hypoglycemic clamp
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Hypoglycaemia
An Exploratory Study of 68Ga-DOTA-SEMA in Preoperative Precise Imaging of Patients with Glucagon-Like Peptide-1 Receptor (GLP1R) Positive Insulinomas
Traditional imaging techniques for insulinomas have a low detection rate. This study aims to evaluate the safety, internal radiation dosimetry, and targeted imaging capability of the novel GLP1R imaging agent, 68Ga-DOTA-SEMA, in…
- Trial name
- NCT06759740
- Testing
- 68Ga-DOTA-SEMA
- Where
- China
- Sponsor
- The Affiliated Hospital Of Southwest Medical University