Clinical trials: Hypoglycemic Syndrome
Type 2 Diabetes Treated With Insulin, Hypoglycemia
Reducing Treatment Risk in Older Adults With Diabetes
This study will evaluate the impact of academic detailing (evidence-based provider education) with or without patient pre-visit preparation (elicitation of values and preferences) on safe insulin de-prescribing among older…
- Conditions
- Type 2 Diabetes Treated With Insulin, Hypoglycemia, Primary Health Care, Polypharmacy
- Trial name
- RETRO-DM (NCT04585191)
- Testing
- Conversation Aid, Attention Control Educational Handout
- Where
- 4 sites in United States
- Volunteers
- 450 people
- Sponsor
- Kaiser Permanente
Type 1 Diabetes, Nocturnal Hypoglycemia
Development and Assessment of Feasibility of Non-invasive Multiple Sensor Hypo-Sense as a Tool for Detection of Hypoglycemia
Hypo Sense is a non- invasive method for detection of hypoglycemia. The Hypo Sense combines an array of non-invasive sensors which monitors the patient's physiological parameters (heart \& respiration rate, perspiration, skin…
- Trial name
- Hypo-Sense (NCT02225379)
- Testing
- Hypo-Sense (non invasive sensor)
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes
Pancreatic Islet Cell Transplantation
The purpose of this study is to assess a novel approach to immunosuppression in allogenic pancreatic islet cell transplant recipients.
- Trial name
- NCT00214786
- Testing
- Islet cell transplantation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Baylor Research Institute
Type 1 Diabetes Mellitus With Hyperglycemia, Type 1 Diabetes Mellitus With Hypoglycaemia
The Expert System VoiceDiab in Children With Diabetes
The purpose of this study to conduct the preliminary investigation on the efficacy and safety in terms of postprandial glucose value and the rates of hypoglycaemia when expert VoiceDiab system supports patient's decision on…
- Trial name
- VoiceDiab (NCT02403427)
- Testing
- VoiceDiab expert system
- Where
- Poland
- Volunteers
- 42 people
- Sponsor
- Instytut Diabetologii Sp. z o.o.
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes and HbA1C<7.5% Under Free Living Conditions
The main objective of this study is to determine whether day and night closed-loop insulin delivery for 4 weeks under free living conditions is superior to usual insulin pump therapy in adults with type 1 diabetes and HbA1C<7.5%.
- Trial name
- NCT02727231
- Testing
- Florence D2A or similar closed loop glucose control system, CSII with CGM
- Where
- 2 sites in Austria, United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Cambridge
Type 1 Diabetes, Hypoglycemia Unawareness
Measurement of Glucose Metabolism in Humans Using Magnetic Resonance at 4 Tesla. Substudy: Hypoglycemia Unawareness
The purpose of this study is to determine whether islet transplantation alters brain glucose concentrations in patients with type 1 diabetes, recurrent hypoglycemia, and hypoglycemia unawareness when compared to that measured…
- Trial name
- NCT00793741
- Testing
- somatostatin
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 2 Diabetes Mellitus
GIP Effects at Insulin Induced Hypoglycemia in Patients With Type 2 Diabetes
Investigation of GIP effects at fasting and hypoglycemia
- Trial name
- GIP-HYPO-T2DM (NCT01414556)
- Testing
- Glucose-dependent Insulinotropic polypeptide, saline
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Mikkel Christensen
Neonatal Hypoglycemia, Neurodevelopmental Disorders
Neurodevelopment of Hypoglycemic Neonates
The investigators propose to prospectively conduct a neurodevelopmental evaluation of SGA and late preterm neonates who underwent risk-based screening for hypoglycemia at newborn nursery during the first 24 hours of life based on…
- Trial name
- NCT04875624
- Testing
- Bayley Scales of Infant and Toddler Development, Fourth Edition (Bayley-4)
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Montefiore Medical Center
Type 1 Diabetes
Exercise Detection Study
The risk of hypoglycemia in individuals with type 1 diabetes increases considerably during exercise. As a result, many patients with type 1 diabetes experience fear of and reluctance to pursue physical activity, in order to avoid…
- Trial name
- NCT02688218
- Testing
- Aerobic Exercise, Resistance Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hypoglycemia, Type 1 Diabetes
EEG-Changes During Insulininduced Hypoglycemia in Type 1 Diabetes
The aim of this study is based on recent pilot studies carried out at Odense University Hospital showing that the acute changes in electroencephalographic (EEG) signals (i.e.
- Trial name
- NCT00810420
- Where
- Denmark
- Sponsor
- UNEEG Medical A/S
Type 1 Diabetes, Hypoglycemia
Investigation Into the Effects Upon Brain Response to Change in Circulating Glucose Levels in Diabetes Mellitus
This study is designed to investigate the effects of diabetes mellitus and its treatment upon the body's responses to low blood glucose (blood sugar) levels.
- Trial name
- NCT00580710
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 1 Diabetes
Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Children With Type 1 Diabetes in a Diabetes Camp
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02189694
- Testing
- Single-hormone closed-loop strategy, Dual-hormone closed-loop strategy, Insulin pump therapy
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Critical Illness, Hyperglycaemia
Intermittent Versus Continuous Glucose Monitoring in Intensive Care Unit
Glucose control is an important part of supportive care for critically ill patients. Achieving optimal glucose control in such situations is challenging due to frequent fluctuations in blood glucose levels.
- Conditions
- Critical Illness, Hyperglycaemia, Hypoglycaemia
- Trial name
- ICONS-ICU (NCT07088549)
- Testing
- Continuous glucose monitoring, Control Arm - standard of care
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Ljubljana
Hypoglycemia
Disorders of Systemic Glucose Balance
We wish to identify people with hypoglycemia (low blood sugar) and ultimately determine why the blood sugar levels are so low. To do so, we will contrast the responses of patients suspected to have hypoglycemia with those of…
- Trial name
- NCT00006508
- Testing
- Controlled hypoglycemia using insulin, formula meal
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Type 2 Diabetes Mellitus, Hypoglycemia
Effects of a Health Intervention on Hypoglycemic Coping : a Pilot Study
From August 2023 to January 2024, 100 patients with type 2 diabetes who met the inclusion and exclusion criteria were selected from the endocrinology department of The purpose of this study was to construct a hypoglycemia coping…
- Conditions
- Type 2 Diabetes Mellitus, Hypoglycemia, Health Education
- Trial name
- NCT06384118
- Testing
- Impact of an IMB theory-based health education intervention on hypoglycemic coping in patients with type 2 diabetes: a pilot study
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yating Liu
Hypoglycemia Hyperglycemia
Pediatric Critical Illness Hyperglycemia and Glycemic Control Registry
The objective in this project is to assemble a consortium of pediatric critical care centers of varying size, acuity, and composition to evaluate our glycemic control protocol on at least 250 children with hyperglycemia in…
- Trial name
- NCT01116674
- Where
- 3 sites in United States
- Volunteers
- 206 people
- Sponsor
- Indiana University
Type 2 Diabetes
Glucose Response, Excursions And Treatment (GREAT) Study
Patients with type 2 diabetes have very variable endogenous insulin secretion. While some patients have relatively preserved endogenous insulin with marked insulin resistance others may develop the very severe insulin deficiency…
- Trial name
- GREAT (NCT02506296)
- Testing
- DPPIV inhibitor -, Continuous glucose monitoring system.
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Hypoglycemia in Newborn Infants
Gel for Early Hypoglycaemia Prevention in Preterm Infants
The GEHPPI study is a multicentre placebo controlled randomized controlled trial that aims to prevent early hypoglycaemia in preterm newborns born at ≤32 week's gestation.
- Trial name
- GEHPPI (NCT04353713)
- Testing
- 40% Dextrose Gel, 2% carboxymethylcellulose gel
- Where
- 5 sites in Czechia, Ireland
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Type 1 Diabetes, Organ Transplantation
Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation
This single center phase 2 clinical trial, is designed for confirming the efficacy and safety of sequential islet allotransplantation with steroid free immunosuppression in patients with previous kidney transplantation.
- Conditions
- Type 1 Diabetes, Organ Transplantation, Immunosuppression
- Trial name
- NCT01123187
- Testing
- islet transplantation
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
Diabetes Mellitus, Type 1
Use of Real-time Continuous Glucose Monitoring System in Patients With Type 1 Diabetes Mellitus
The purpose of this study is to determine whether a real-time continuous glucose monitoring system is able to improve HbA1c in patients suffering from type 1 diabetes compared to conventional finger prick glucose measurements.
- Trial name
- NCT00824148
- Testing
- Guardian REAL-Time Continuous Glucose Monitoring System, Conventional self-monitoring of plasma glucose
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Norwegian University of Science and Technology