Clinical trials: Hypoglycemic Syndrome
Fasting
Blood Glucose Levels in Children During Anesthesia
This cross-sectional study aims to investigate blood glucose levels in children during general anesthesia and explore the incidence of hypoglycemia after anesthesia induction in relation to preoperative fasting.
- Trial name
- NCT06915493
- Testing
- General Anesthesia
- Where
- Iceland
- Volunteers
- 350 people
- Sponsor
- Landspitali University Hospital
Intestinal Failure, Hypoglycemia
CGM-Assisted Management of PN
The purpose of this study is to learn more about changes in glucose levels in hospitalized infants with intestinal failure receiving parenteral nutrition or PN (nutrients delivered intravenously), as they transition from…
- Conditions
- Intestinal Failure, Hypoglycemia, Hyperglycemia
- Trial name
- CAMP (NCT05902104)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes, Hypoglycemia
Delayed Mycophenolate Mofetil in Single-Donor Islet Allotransplantation in Type 1 Diabetes
The objective of this study is to assess the safety and efficacy of islet allotransplantation for the reestablishment of stable glycemic control in patients with type 1 diabetes, using anti-thymocyte globulin induction…
- Trial name
- NCT00285233
- Testing
- Allogeneic islets of Langerhans transplant
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 1 Diabetes, Hypoglycemia
Slow Digestible Carbohydrates and Exercise in Adolescents With Type 1 Diabetes
In this within-subject cross-over study, the investigators hypothesize that corn-starch based supplements taken prior to exercise will decrease the risk of delayed hypoglycemia in adolescents with T1D, improve performance during…
- Trial name
- NCT05540132
- Testing
- maltodextrin, super starch
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Hypoglycemia, Diabetes Mellitus, Type 2
Investigating Novel Predictions of Hypoglycemia Occurrence in Real-world Models
Hypoglycemia is the most common diabetes-related adverse event. However, it is often under-reported to healthcare providers by patients and simultaneously, not often asked about by healthcare providers.
- Conditions
- Hypoglycemia, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- iNPHORM (NCT04219514)
- Where
- United States
- Volunteers
- 1,206 people
- Sponsor
- Stewart Harris
Diabetes, Diabetes Mellitus, Type 1
Comparison of Insulin Detemir and NPH With Respect to Lowering the Blood Sugar and Symptoms Experienced by Type 1 Diabetics During Hypoglycaemia
This trial is conducted in UK. The aim of this clinical trial is to investigate lowering the blood sugar and symptoms experienced during hypoglycaemia
- Trial name
- NCT00760448
- Testing
- insulin detemir, insulin NPH
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Collection of Breath and Sweat to Identify Indicators of Hypoglycemia
Subjects with type 1 diabetes will be observed in the diabetes research center clinic following a meal and an insulin injection.
- Trial name
- NCT03600116
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Intensive Care
Efficacy and Safety of Three Insulin Protocols in Medical Intensive Care Unit Patients
To evaluate the efficacy and safety of three insulin algorithms in medical ICU patients (MICU).
- Trial name
- NCT00410852
- Testing
- Computer-assisted IV insulin infusion protocol (algorithm A), Leuven Strict glycemic control protocol (Algorithm B), Conventional Intermittent Insulin Protocol (Algorithm C)
- Where
- 5 sites in Brazil
- Volunteers
- 168 people
- Sponsor
- Hospital Israelita Albert Einstein
Type 1 Diabetes Mellitus, Exercise
Impact of Physical Activity on Blood Glucose Stability and Energy Stores in Individuals With Type 1 Diabetes
Whereas physical activity clearly results in improvements in glycemic control in type 2 diabetes, in individuals with type 1 diabetes (T1DM) the impact of exercise on blood sugar control is more complex.
- Conditions
- Type 1 Diabetes Mellitus, Exercise, Hypoglycemia, Carbohydrate Metabolism
- Trial name
- CARBEX1 (NCT02068638)
- Testing
- IHE first, CONT second, CONT first, IHE second, GLU first, GLU-FRU second
- Where
- Switzerland
- Volunteers
- 27 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypoxic Ischemic Encephalopathy of Newborn, Hyperglycemia
Continuous Glucose Monitoring in HIE
The aim of the study is to examine whether the use of continuous glucose monitoring (CGM) to guide the clinical management of glycaemic control will result into an increased time in the target glucose concentration.
- Conditions
- Hypoxic Ischemic Encephalopathy of Newborn, Hyperglycemia, Hypoglycemia
- Trial name
- NCT06563687
- Testing
- Dexcom ONE+
- Where
- 3 sites in Italy
- Volunteers
- 70 people
- Sponsor
- University of Campania Luigi Vanvitelli
Type 1 Diabetes Mellitus, Nocturnal Hypoglycemia
Insulin Degludec and Symptomatic Nocturnal Hypoglycaemia
The purpose of this study is to determine whether insulin degludec compared to insulin glargine can reduce the risk of symptomatic nocturnal hypoglycaemia in subjects with the greatest potential benefit from optimised insulin…
- Conditions
- Type 1 Diabetes Mellitus, Nocturnal Hypoglycemia, Recurrent Severe Hypoglycaemia
- Trial name
- HypoDeg (NCT02192450)
- Testing
- Insulin aspart/glargine, Insulin aspart/degludec
- Where
- Denmark
- Volunteers
- 149 people
- Sponsor
- Nordsjaellands Hospital
Diabetes Mellitus, Type 2, Hyperglycemia Stress
Remote Glucose Monitoring in Hospital Settings
Use of real-time continuous glucose monitoring (RT-CGM) systems in inpatient settings especially during the COVID-19 pandemic, may allow hospital staff to remotely monitor glucose while reducing viral exposure and preserving use…
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia Stress, Hypoglycemia
- Trial name
- REMOTE-CGM (NCT04797208)
- Testing
- Real-Time CGM, Capillary blood glucose testing with masked CGM
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Diabetes Mellitus
A Study to Determine the Absorption of Peroral Insulin in Dextran Matrix (ORA3)
A pharmacokinetic study on the absorption of perorally delivered insulin in dextran matrix after single dose administration.
- Trial name
- ORA3 (NCT01114750)
- Where
- Sweden
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Bows Pharmaceuticals AG
Diabetes Mellitus, Type 2
Lantus Versus Levemir Treat-To-Target
Primary objective: To demonstrate the non-inferiority of insulin glargine in comparison to insulin detemir in term of percentage of patients who reach the target of HbA1c < 7% at the end of the treatment period and do not…
- Trial name
- L2T3 (NCT00405418)
- Testing
- Insulin glargine, Insulin Detemir
- Where
- 20 sites in Australia, Brazil and 18 more
- Volunteers
- 973 people
- Sponsor
- Sanofi
Obstetric Labor, Pregnancy in Diabetics
Intrapartum Glucose and Insulin Compared to Glucose Alone in Diabetic Women
This study aims to examine the effect of intrapartum treatment of diabetic women with combined glucose and constant insulin infusion compared to glucose alone on the incidence of neonatal hypoglycemia.
- Trial name
- NCT03273881
- Testing
- glucose solution and Insulin, glucose solution only
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
to Identify Which Titration Regimen of Basal Insulin (Being Daily Titration vs 3 Daily Titration) is Better in Reducing hba1c and Have Lesser Hypoglycemia
Difference of Basal Insulin Titration Method in Reducing HbA1c Among Type 2 Diabetes Mellitus (T2DM) Patients.
Introduction Diabetes mellitus is a worrying global non-communicable disease where it is affecting 18.3% of Malaysian adults. Poorly managed diabetes leads to an array of serious complications, namely heart attack, kidney failure…
- Trial name
- NCT05331469
- Testing
- NPH basal insulin titration
- Where
- Malaysia
- Volunteers
- 70 people
- Sponsor
- University of Malaya
Hyperinsulinemic Hypoglycemia, Postprandial Hypoglycemia
Treatment of Post-bariatric Hypoglycaemia
This is an investigator-initiated, proof-of-concept, randomised, double-blind, placebo-controlled, single-centre phase II study aiming to evaluate the efficacy, safety and tolerability of self-administered subcutaneous 120 µg…
- Trial name
- SHERRY (NCT04836273)
- Testing
- Dasiglucagon, HyoPen
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Filip Krag Knop
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
mRNA Based-Covid-19 Vaccine Effects on Blood Glucose Levels
To determine if patients with a history of Diabetes Mellitus Type I or II developed a change in blood glucose levels as reported on Continuous glucose monitoring devices (CGMS) within the first week following administration of…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Hyperglycemia, Vaccine Adverse Reaction
- Trial name
- NCT04923386
- Testing
- None (not interventional)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Levenson, David I., M.D.
Diabetes Mellitus
Pilot Study of Clinician-supported Patient Self-management of Hospital Insulin Therapy
This study will examine the feasibility of implementing a clinician-supported patient self-managed inpatient insulin intervention.
- Trial name
- NCT02144441
- Testing
- glargine and aspart
- Where
- United States
- Sponsor
- University of Pennsylvania
Cirrhosis
Study of the Impact of HYPOglycaemia on Sarcopenia in CIRrhosis
Fasting blood glucose is maintained by hepatic production of glucose from glycogenolysis or gluconeogenesis. In cirrhosis, glycogen storage capacity is reduced, with a consequent increase in gluconeogenesis to maintain blood…
- Trial name
- HYPOCIR (NCT06948656)
- Testing
- fitting a blood glucose sensor, food collection, tests and questionnaires
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Dijon