Clinical trials: Hypoglycemic Syndrome
Congenital Hyperinsulinism
Compassionate Use of SOM230 for Hyperinsulinemic/Hypoglycemia
Congenital hyperinsulinism is a rare condition that can cause life-threatening hypoglycemia. Current treatment for congenital hyperinsulinism is often suboptimal, and such individuals may respond to a new somatostatin analog…
- Trial name
- NCT02835131
- Testing
- Pasireotide
- Where
- United States
- Sponsor
- Montefiore Medical Center
Type 1 Diabetes Mellitus
Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose
The main purpose of the study is to investigate the reason for the reduced number of hypoglycaemic attacks in type 1 diabetic patients when, for a period of time, using Insulin Aspart at meals together with NPH insulin mornings…
- Trial name
- NCT00145353
- Testing
- Insulin NovoRapid versus Actrapid
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Odense University Hospital
Diabetes Mellitus, Type 2, Hypoglycemia
A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus
The main purpose of this study is to learn more about how tirzepatide affects the body's response to low blood sugar (hypoglycemia). The study is open to participants with type 2 diabetes.
- Trial name
- NCT04050553
- Testing
- Tirzepatide
- Where
- Austria
- Volunteers
- 42 people
- Sponsor
- Eli Lilly and Company
Diabetes, Diabetes Mellitus, Type 2
A Trial to Investigate the Impact of Nocturnal Hypoglycaemia on Sleep in Subjects With Type 2 Diabetes
This trial is conducted in Europe. The aim of this trial is to investigate the impact of low blood sugar during the night on sleep in subjects with type 2 diabetes.
- Trial name
- NCT01780272
- Testing
- glucose clamp
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Novo Nordisk A/S
Hypoglycaemia
Effect of Hypoglycaemia on Social Cognition and Cardiac Conduction
It is known that hypoglycaemia affects various domains of cognitive function. One aspect of cognitive function is 'social cognition', which is our ability to interpret facial expressions, gestures and speech.
- Trial name
- NCT02347553
- Testing
- This is not an interventional study
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Edinburgh
Hypoglycemia
Safety and Efficacy of a Novel Glucagon Formulation in Type 1 Diabetic Patients Following Insulin-induced Hypoglycemia
In this study, participants with Type 1 diabetes received insulin through an infusion into a vein to reduce their blood glucose, and then received nasal glucagon (NG) or glucagon for injection under the skin, and their blood…
- Trial name
- AMG102 (NCT01556594)
- Testing
- Nasal Glucagon 1 mg, Nasal Glucagon 2 mg, SC Glucagon
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes
Blood Glucose Target Before and During Exercise in Adults With Type 1 Diabetes Using an Artificial Pancreas
Despite major technological advances in type 1 diabetes (artificial pancreas), the management of hypoglycemia remains a major challenge, especially during and after physical activity.
- Trial name
- GUARDIA (NCT05821322)
- Testing
- Physical activity trial intervention
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes, Hypoglycemia
Sitagliptin Versus Sulphonylurea in Type 2 Diabetes During Ramadan
This study will assess if Sitagliptin addition to metformin or glitazone is better than current sulphonylurea based treatments during Ramadan.
- Trial name
- NCT00766441
- Testing
- Sitagliptin, sulphonylurea
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Manchester
Postoperative Dumping Syndrome
Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome
Dumping Syndrome consists of (1) a too rapid gastric emptying, (2) an inappropriate release of GI hormones (as a reaction to the hyperosmolar contents in the duodenum) and (3) an hyperinsulinemic response to a too rapid…
- Trial name
- CSOM230BBE01T (NCT01895296)
- Testing
- Pasireotide
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 2 Diabetes
Effect of GlucoNorm vs Glyburide on Post-Prandial Hyperglycemia in Elderly Subjects With Type 2 Diabetes
The results from the DECODE Study have shown that postprandial (1 - 2 hours after a meal) hyperglycemia (elevated blood sugar) is more common in elderly people with diabetes than younger people with diabetes and is the best…
- Trial name
- NCT00451620
- Testing
- glyburide, GlucoNorm
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Type 2 Diabetes, Stroke
The Effect of GLP-1 on Glucose Uptake in the Brain and Heart in Healthy Men During Hypoglycemia
Type 2 diabetes mellitus, T2D is a disease characterized by an immense growing prevalence world wide with an increased risk of myocardial infarction and stroke.
- Conditions
- Type 2 Diabetes, Stroke, Myocardial Infarction
- Trial name
- NCT00418288
- Testing
- glucagon-like-peptide-1
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypoglycemia
Hypoglycemia and the Mineralocorticoid Receptor
The purpose of this study is to look at whether blockade of the mineralocorticoid receptor will result in changes in the cardiovascular and inflammatory response to hypoglycemia.
- Trial name
- HypoMR (NCT01394627)
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Type 1 Diabetes Mellitus, Hypoglycemia
Allogeneic Islet Cells Transplanted Onto the Omentum
Current islet transplantation into the portal vein of the liver has shown the unique ability of islets to stabilize blood glucose levels and prevent severe hypoglycemia in a selected group of subjects with Type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT02213003
- Testing
- Islet transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rodolfo Alejandro
Type 1 Diabetes, Diabetes Mellitus
Therapeutic Education in Very Young Children With Diabetes Mellitus
DIAB-EDUC tests in a group of young diabetic patients (less than 6 years old) a specific educational tool in order to assess its impact on glycemic control, quality of life, knowledge about the disease and its daily management…
- Trial name
- DIAB-EDUC (NCT01354288)
- Testing
- Educational tool
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypoglycemia, Obesity, Morbid
The Effect of 'Medical Nutrition Therapy' on Post-bariatric Hypoglycemia 2-4 Years After Gastric Bypass Surgery
This is a pilot study to explore the effect of 'medical nutritional therapy' in patients diagnosed with post-bariatric hypoglycemia (PBH), 2-4 years after gastric bypass surgery.
- Trial name
- NCT05011682
- Testing
- Regular diet, 10-point nutrition plan
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- Helse Nord-Trøndelag HF
Diabetes Mellitus With Hypoglycemia
Ubiquitous Healthcare Service With Multifactorial Intervention in Diabetes Care
Recently, we generated a new multidisciplinary ubiquitous healthcare system by upgrading our clinical decision supporting system (CDSS) rule engine, and integrating a physical activity-monitoring device and dietary feedback into…
- Trial name
- NCT02025296
- Testing
- U-healthcare
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Diabetes Mellitus, Type 1
Diabetes Pump With Predictive Low Glucose Suspend Pivotal Trial
A 6-week crossover study will compare PLGS to SAP outcomes in adults and youth > 6 years old with type 1 diabetes (T1D).
- Trial name
- NCT03195140
- Testing
- Predictive Low Glucose Suspend
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Tandem Diabetes Care, Inc.
Type 1 Diabetes
Determining the Appropriate Intensity of Exercise to Prevent Post-exercise Hypoglycemia in Persons Living With T1D
Over 300, 000 youth and young adults across Canada are living with Type 1 Diabetes (T1D) which is considered the most common endocrine condition.
- Trial name
- NCT03583268
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Type 1 Diabetes Mellitus
Effect of Closed Loop Glucose Control on Exercise-Associated Hypoglycemia
The purpose of the study is to compare the glycemic control during and following aerobic exercise using either an open or closed-loop insulin delivery system.
- Trial name
- ePID-03 (NCT00831389)
- Testing
- Closed Loop
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 2 Diabetes, Hypoglycemia
Glycemic Excursions in Type 2 Diabetic Patients With Vildagliptin and Metformin Versus Vildagliptin and Glimepiride
The purpose of this study was to compare the effect of a fixed dose combination of vildagliptin plus metformin versus combination therapy of glimepiride plus metformin in glycemic variability in patients with type 2 diabetes who…
- Trial name
- GLOBE (NCT02007278)
- Testing
- vildagliptin and metformin (combination), glimepiride, Metformin
- Where
- 8 sites in Colombia
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals