Clinical trials: Hypoglycemic Syndrome
Type 2 Diabetes
Sitagliptin and Glucagon Counterregulation
To evaluate the effect of DPP-4 inhibition on glucagon counter-regulatory mechanisms at moderate hypoglycemia in metformin-treated subjects with T2DM
- Trial name
- SITACLAMP (NCT02256189)
- Testing
- Sitagliptin
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Lund University
Hypoglycemia
Single Doses of ZP4207 Adm. sc to Hypoglycemic TD1 pt. to Describe the PK and PD of ZP4207 as Comp. to Marketed Glucagon
The trial is a single-centre, randomized, double-blind, parallel trial in Group 1 and cross-over trial in Groups 2-4 with single doses of ZP4207 administered s.c.
- Trial name
- NCT02660008
- Testing
- ZP4207, GlucaGen
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Zealand Pharma
Hypoglycemia, Roux-en-Y Gastric Bypass
The Effect of Physical Activity in Individuals With Post-bariatric Hypoglycemia
The goal of this pilot study is to evaluate the magnitude of changes in glucose and hormone levels in response to structured exercise in the fasting state in individuals with post-bariatric hypoglycemia (PBH).
- Conditions
- Hypoglycemia, Roux-en-Y Gastric Bypass, Post-bariatric Hypoglycemia, Physical Activity
- Trial name
- NCT05560789
- Testing
- Physical activity (cycling on a stationary bicycle ergometer or walking on a treadmill)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes Mellitus
Model Predictive Control (MPC) Artificial Pancreas vs. Sensor Augmented Pump (SAP)/Predictive Low Glucose Suspend (PLGS) With Different Food Choices in the Outpatient Setting
The objective of this randomized crossover clinical trial is to 1) assess the efficacy and safety of an automated insulin delivery (AID) system using a Model Predictive Control (MPC) algorithm versus sensor augmented pump therapy…
- Trial name
- NCT03767790
- Testing
- iAPS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sansum Diabetes Research Institute
HIV Infections, Lipodystrophy
Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities
The purpose of this study is to see whether metformin alone, rosiglitazone alone, or metformin and rosiglitazone together will lower insulin levels in the blood and decrease fat in the abdomen or other parts of the body.
- Conditions
- HIV Infections, Lipodystrophy, Hyperinsulinemia
- Trial name
- NCT00015691
- Testing
- Metformin hydrochloride, Rosiglitazone maleate
- Where
- 34 sites in United States
- Volunteers
- 105 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bariatric Surgery, Hormonal Response
Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid Obesity
Obesity is a major global health problem. Bariatric surgery is the most effective treatment, leading to substantial weight loss and improvement in obesity-related comorbidities.
- Conditions
- Bariatric Surgery, Hormonal Response, Post Bariatric Hypoglycemia
- Trial name
- CU BYPASS-DJB (NCT07747779)
- Testing
- Sleeve gastrectomy with duodenojejunal bypass, Roux-en-Y gastric bypass
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Chulalongkorn University
Type 1 Diabetes Mellitus
Safety and Feasibility Evaluation of the APS APP
This clinical trial is a safety and feasibility study to assess the performance of artificial pancreas (AP) system using the Zone Model Predictive control (Zone-MPC) and Health Monitoring System (HMS) algorithms embedded into the…
- Trial name
- NCT03504046
- Testing
- Artificial Pancreas App
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes, Hypoglycemia
Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes
The objectives of this study are to examine how sex hormones (use of hormonal birth control, menstrual cycle phase) impact glycemic control among women with type 1 diabetes (T1D), and to test adjustments to insulin dosing and…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Hyperglycaemia Due to Type 1 Diabetes Mellitus, Menstruation Disturbances
- Trial name
- MERIT (NCT06297980)
- Testing
- Personalized modifications to treatment to address menstrual cycle effects on glycemia
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
Glimepiride Induced Insulin Secretion Will be Inhibited by Hypoglycemia
This study will look at two FDA approved medications that improve how the pancreas works in patients with Type 2 Diabetes. In order to understand how these medications work in patients with diabetes we must first measure the…
- Trial name
- NCT00608179
- Testing
- Glimepiride, glyburide, glucose clamp
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Type 1 Diabetes, Hypoglycemia Unawareness
Measurement of Glucose Metabolism in Humans Using Magnetic Resonance at 4 Tesla. Substudy: Hypoglycemia Unawareness
The purpose of this study is to determine whether islet transplantation alters brain glucose concentrations in patients with type 1 diabetes, recurrent hypoglycemia, and hypoglycemia unawareness when compared to that measured…
- Trial name
- NCT00793741
- Testing
- somatostatin
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetes Mellitus, Type 1, Insulin Hypoglycemia
Effects of Frequency and Duration of Exercise in People With Type 1 Diabetes A Randomized Crossover Study
According to the Standards of Medical Care in Diabetes by the American Diabetes Association, people with diabetes should aim for 30 minutes of moderate-to-vigorous intensity aerobic exercise at least 5 days a week or a total of…
- Trial name
- NCT04089462
- Testing
- "Five sessions per period" - "Two sessions per period", "Two sessions per period" - "Five sessions per period"
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes
Postprandial meal glucose control with closed-loop systems (CLS) still needs some improvements. In the postprandial period, sensor delay in detecting blood glucose rise after a meal together with delays in insulin absorption…
- Trial name
- NCT02416765
- Testing
- 15-hour intervention, Insulin (Lispro, Aspart or guilisine), Glucagon (Eli Lilly)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes Mellitus
Using Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes
This is a single-site study using wearable sensor technology (CGM and smartwatch) to better explain low blood sugars in patients living with type 1 diabetes.
- Trial name
- Wear WOLF (NCT06727071)
- Testing
- Hyperglycemic clamp
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Diabetes Mellitus, Type 1
A Study of LY900014 (Lyumjev) Versus Insulin Lispro (Humalog) in Participants With Type 1 Diabetes
This study will be conducted in participants with type 1 diabetes mellitus on continuous subcutaneous insulin infusion (CSII) or pump therapy to evaluate the effect of LY900014 (Lyumjev) on blood sugar levels during exercise…
- Trial name
- NCT05262387
- Testing
- Lyumjev with 50% basal rate reduction, Humalog with 50% basal rate reduction, Humalog with 100% basal rate reduction
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 2
Lantus Versus Levemir Treat-To-Target
Primary objective: To demonstrate the non-inferiority of insulin glargine in comparison to insulin detemir in term of percentage of patients who reach the target of HbA1c < 7% at the end of the treatment period and do not…
- Trial name
- L2T3 (NCT00405418)
- Testing
- Insulin glargine, Insulin Detemir
- Where
- 20 sites in Australia, Brazil and 18 more
- Volunteers
- 973 people
- Sponsor
- Sanofi
Diabetic Complication, Covid19 Virus Infection
Suspicion of Hypoglycemic Effect of mRNA Based Covid-19 Vaccines (Polyethylene Glycol) Will Happen , Observational Study on Diabetic Patients at Saudia Arabia
vaccines for covid-19 are gold strategy and great achievement at this century for protection against complications of covid-19 , development of many vaccines with different technology represent a big challenge for this disease so…
- Conditions
- Diabetic Complication, Covid19 Virus Infection, Hypoglycemia, Polyethylene Glycol Adverse Reaction
- Trial name
- NCT05087225
- Testing
- polyethelyene glycol
- Where
- Saudi Arabia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Diabetes Mellitus, Type 1
Liraglutide in Newly Onset Type 1 Diabetes.
The purpose of this study is to investigate the effect and safety of liraglutide 1.8 mg once daily compared to placebo for 52 weeks on change in beta-cell function in patients with newly diagnosed type 1 diabetes as an adjunctive…
- Trial name
- NewLira (NCT01879917)
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 65 people
- Sponsor
- Hvidovre University Hospital
Diabetes Mellitus, Type 2 Treated With Insulin
Risk of Hypoglycemia in the Transition From Inpatient to Outpatient Setting. Comparative Study of Basal-bolus Insulin Versus Basal Insulin Plus GLP-1 Analogue
The association of insulin degludec with liraglutide in the same device (IDegLira) is a potent but at the same time safe drug that reduces the risk of hypoglycemia when compared to a basal or basal-bolus insulin schedule.
- Trial name
- NCT05767255
- Testing
- insulin degludec + liraglutide, Insulin Glargine - Insulin Aspart
- Where
- Colombia
- Volunteers
- 66 people
- Sponsor
- Hospital Universitario San Ignacio
Type 1 Diabetes
Preventing Hypoglycemia During Exercise With Proactive Snacking on Closed Loop
This study is designed to look at how snacking during exercise may help prevent low blood sugars while subjects are on the "closed loop artificial pancreas." This system uses a continuous glucose sensor, an insulin pump, and a…
- Trial name
- NCT02135068
- Testing
- Medtronic MiniMed Closed Loop (CL) System, Snacking
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Hyperinsulinemic Hypoglycemia
Evaluating Exenatide for the Treatment of Postprandial Hyperinsulinemic Hypoglycemia
The purpose of the study is to evaluate the effectiveness of exenatide in adults experiencing episodes of hyperinsulinemic hypoglycemia following Roux-en-Y bariatric surgery.
- Trial name
- NCT02685852
- Testing
- Exenatide, Acarbose
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Minnesota