Clinical trials: Hypoglycemic Syndrome
Type 1 Diabetes
The Effects of Antecedent Hypoglycemia or Exercise on the Response of the Brain to Subsequent Hypoglycemia
The studies proposed in this application seek to use non-invasive techniques to examine the impact of repeated hypoglycemia on the brain.
- Trial name
- NCT00600730
- Testing
- Hyperinsulinemic euglycemic clamp with fMRi, Hyperinsulinemic hypoglycemic clamp study with fMRi
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Type 1 Diabetes Mellitus
Islet Transplantation in Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00434811
- Testing
- Allogeneic Pancreatic Islet Cells, Antithymocyte Globulin, Sirolimus
- Where
- 8 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type1 Diabetes Mellitus, Hypoglycemia
Correlation Between Exercise and Insulin Dose in a Camp for Pediatric Type 1 Patients
Intense exercise is a major challenge to the management of type 1 diabetes. The management is even more difficult, during a camp, probably due to increased hypoglycemia maybe from increase of intensity of physical activity.
- Conditions
- Type1 Diabetes Mellitus, Hypoglycemia, Exercise
- Trial name
- inCamp (NCT03725657)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Diabete Type 2, Pregnancy in Diabetic
Time Spent In Target Glucose Range in Women With T2D Diabetes in Pregnancy
Prospective cohort study to determine to what extent women with type 2 diabetes are achieving the time in the target range outlined for women with type 1 diabetes (70-140 mg/dl or 3.5-7.8 mmol/l), overall and by trimester, by…
- Trial name
- Timely (NCT06147466)
- Testing
- Dexcom Continuous Glucose Monitoring
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Hypoglycemia
Differing Levels of Hypoglycemia
Hypoglycemia can produce a spectrum of pro-inflammatory and pro-atherothrombotic changes. To date no studies appear to have investigated the effects of differing levels of hypoglycemia on the vasculature and pro-atherothrombotic…
- Trial name
- NCT02445781
- Testing
- Glucose clamp
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 2, Hypoglycemia
Safer Aging With Diabetes Monitoring
Older adults with type 2 diabetes are at higher risk for severe hypoglycemia and its related complications (including hospitalization and death) when taking insulin.
- Trial name
- SAGE (NCT06296485)
- Testing
- SAGE Group Sessions, Usual Care
- Where
- 6 sites in United States
- Volunteers
- 360 people
- Sponsor
- Kaiser Permanente
Sugar; Blood, Low
ENSO 16 - Study in Healthy Subjects
The objective of this study is to evaluate differences in glucose metabolism parameters after oral administration of 30g glucose or 30g ENSO16.
- Trial name
- NCT05457400
- Testing
- ENSO 16, Glucose Powder
- Where
- Austria
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Alpha Republic GmbH
Type 1 Diabetes Mellitis
Neurocognitive Impact of Hypoglycemia in Type 1 Diabetes
125 children with Type 1 Diabetes mellitis (T1DM) between 4 and 16 were recruited and 62 healthy siblings also enrolled in the study.
- Trial name
- HYPO (NCT00916838)
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
COVID 19, Coronavirus
Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19
The coronavirus disease 2019 (COVID-19) is an emerging pandemic in 2020 caused by a novel coronavirus named SARS-CoV2. Diabetes confers a significant additional risk for COVID-19 patients.
- Conditions
- COVID 19, Coronavirus, Diabetes Mellitus, Type 2, Diabetes Mellitus
- Trial name
- NCT04371978
- Testing
- Linagliptin 5 MG
- Where
- 3 sites in Israel
- Volunteers
- 64 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus, Type 1
A Study of LY3532226 in Participants With Type 1 Diabetes Mellitus
The main purpose of this study is to evaluate the response of glucagon to insulin-induced low blood sugar after administration of the study drug LY3532226 in participants with type 1 diabetes mellitus (T1DM).
- Trial name
- NCT05887999
- Testing
- LY3532226
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes, Hypoglycemia
Islet Allotransplantation With Steroid Free Immunosuppression
The restoration of endogenous insulin secretion carries significant hopes for shifting the paradigm of life long exogenous insulin therapy in selected groups of patients with type 1 diabetes(T1D).
- Conditions
- Type 1 Diabetes, Hypoglycemia, Metabolic Diseases
- Trial name
- NCT00446264
- Testing
- islet transplantation, daclizumab - sirolimus - tacrolimus
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
Hypoglycemia, Diabetes Mellitus, Type 1
Comparison Between Hypoglycemic Counter Regulatory Responses in Type 1 Diabetics vs Control Subjects
This study compares the hypoglycemic counter regulatory response in type 1 diabetics and in healthy control subjects with and without antecedent hypoglycemia
- Trial name
- NCT03034226
- Testing
- Glucose clamp technique
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hyperinsulinemic Hypoglycemia
Evaluating Exenatide for the Treatment of Postprandial Hyperinsulinemic Hypoglycemia
The purpose of the study is to evaluate the effectiveness of exenatide in adults experiencing episodes of hyperinsulinemic hypoglycemia following Roux-en-Y bariatric surgery.
- Trial name
- NCT02685852
- Testing
- Exenatide, Acarbose
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Minnesota
Type 1 Diabetes
Efficacy of Small Subcutaneous Glucagon Dose to Treat Hypoglycemia in Adults With Type 1 Diabetes
In the unfortunate case of severe hypoglycaemia, glucagon is the first-line treatment because of its potent and rapid action starting as fast as 5 minutes after subcutaneous or intramuscular injection.
- Trial name
- NCT01828125
- Testing
- Hypoglycaemic hyperinsulinemic clamp, Glucagon
- Where
- Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes, Hypoglycaemia
DPP4inhibitors in Type 1 Diabetes
A small, pilot, randomised, cross over trial that investigates the potential for DPPIVi therapy to reduce insulin requirements in type 1 diabetes was studied.
- Trial name
- NCT01922817
- Testing
- Saxagliptin
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Dundee
Type 1 Diabetes
Preventing Hypoglycemia During Exercise With Proactive Snacking on Closed Loop
This study is designed to look at how snacking during exercise may help prevent low blood sugars while subjects are on the "closed loop artificial pancreas." This system uses a continuous glucose sensor, an insulin pump, and a…
- Trial name
- NCT02135068
- Testing
- Medtronic MiniMed Closed Loop (CL) System, Snacking
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Hypoglycemia, Diabetes Mellitus, Type 1
A Trial to Evaluate the Immunogenicity of Dasiglucagon and GlucaGen in Patients With Type 1 Diabetes Mellitus
The trial's objective is to evaluate the immunogenicity of repeated single doses of dasiglucagon* and GlucaGen following subcutaneous (SC) administration in patients with type 1 diabetes mellitus (T1DM) and further to evaluate…
- Trial name
- NCT03216226
- Testing
- dasiglucagon, GlucaGen
- Where
- 7 sites in United States, Austria and 2 more
- Volunteers
- 112 people
- Sponsor
- Zealand Pharma
Glycogen Storage Disease, Congenital Hyperinsulinism (CHI)
Continuous Glucose Monitoring Alerts, Accuracy, and Patient Outcomes in Adults With Inherited Metabolic Disorders
The goal of this clinical trial is to learn if a continuous glucose monitor (CGM) with predictive alerts works better than a CGM with standard alerts to prevent low blood sugar (hypoglycemia) in adults with inherited metabolic…
- Conditions
- Glycogen Storage Disease, Congenital Hyperinsulinism (CHI), Hypoglycemia
- Trial name
- NCT07614139
- Testing
- Continuous glucose monitor with threshold and predictive alerts (Dexcom G7), Continuous glucose monitor with threshold-only alerts (Dexcom ONE+)
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- University Hospital Padova
Diabetes Mellitus Type 2
Hypoglycemia- and Weight-related Quality of Life in Patients With Diabetes Mellitus Type 2 on Sulfonylurea Derivatives.
1. A prospective, non-interventional study, 125 patients with Diabetes Mellitus Type2 will be enrolled, who, while on metformin, have a sub-optimal glycemic control and who thus will receive additional treatment with a…
- Trial name
- NCT01244646
- Where
- 22 sites in Netherlands
- Volunteers
- 48 people
- Sponsor
- AstraZeneca
Post-bariatric Hypoglycemia
Closed-Loop Glucagon Pump for Treatment of Post-Bariatric Hypoglycemia
To assess the efficacy of a closed loop glucagon system to prevent and treat hypoglycemia occurring in patients with Post-Bariatric Hypoglycemia (PBH) in response to meals and exercise.
- Trial name
- NCT03255629
- Testing
- glucagon, Closed loop glucagon pump
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Joslin Diabetes Center