Clinical trials: Hypoglycemic Syndrome
Type 1 Diabetes
Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla
The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain glucose metabolism in humans.
- Trial name
- Glycogen (NCT00786825)
- Testing
- somatostatin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Congenital Hyperinsulinism
Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of Infancy
The purpose of our study is to evaluate the efficacy and safety of Lanreotide Autogel in children with congenital hyperinsulinism already treated with Octreotide by pump.
- Trial name
- NCT01070758
- Testing
- Lanreotide autogel
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Sheba Medical Center
Type 1 Diabetes Mellitus
Safety, Tolerability and Efficacy of Immunomodulation With AT-1501 in Islet Cell Transplantation
This study will evaluate the safety, tolerability and efficacy of AT-1501 in an immunomodulation regimen in adult patients with T1D undergoing an islet cell transplant.
- Trial name
- NCT04711226
- Testing
- AT-1501
- Where
- Canada
- Sponsor
- Anelixis Therapeutics, LLC
Diabetes Mellitus, Diet, Healthy
FEAR of HYPOGLYCEMIA in PATIENTS WITH DIABETES
Fear of hypoglycemia has a significant impact on both medication and dietary adherence in individuals with diabetes. Through avoidance behaviors, it can disrupt metabolic control, prevent the achievement of glycemic targets, and…
- Conditions
- Diabetes Mellitus, Diet, Healthy, Medication Adherence, Hypoglycemia
- Trial name
- NCT07329985
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Type 1 Diabetes, Diabetes Mellitus, Type 1
Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes
The goal of this clinical trial is to test whether the combination of two safe immune therapies called abatacept and nasal insulin can preserve pancreas function in recently-diagnosed type 1 diabetes.
- Trial name
- IAA (NCT05742243)
- Testing
- Abatacept (CTLA4-Ig) and nasal insulin (Humulin R®)
- Where
- 6 sites in Australia
- Volunteers
- 68 people
- Sponsor
- Melbourne Health
Diabetes Mellitus, Type 1, Cardiovascular Diseases
French National Cohort of People With Type 1 Diabetes
Cardiovascular (CV) diseases are the most frequent type 1 diabetes (T1D) complications. A recent epidemiological study showed that patients with T1D have a two-fold CV mortality risk, even in case of good glycemic control.
- Conditions
- Diabetes Mellitus, Type 1, Cardiovascular Diseases, Hypoglycemia, Patient Participation
- Trial name
- SFDT1 (NCT04657783)
- Where
- France
- Volunteers
- 15,000 people
- Sponsor
- Fondation Francophone pour la Recherche sur le Diabete
Type 1 Diabetes
Behavioural Problems and Cognition in Children With Hypoglycemia Unawareness in Type-1 Diabetes Mellitus
The study is designed to explore if a multi-pronged intervention strategy comprising of Psychological Interventions, Dietary Modifications, Targeted therapy and Counselling on Parental Attitude would bring about favorable changes…
- Trial name
- NCT06488469
- Testing
- Psychological Interventions for children and adolescents
- Where
- India
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Postbariatric Hypoglycemia
Safety and Efficacy of Exendin 9-39 in Patients With Postbariatric Hypoglycemia
This clinical study will evaluate whether taking an investigational drug called exendin 9-39 is safe, well-tolerated, and helps to prevent low blood sugar in people who have had bariatric surgery and later develop a rare…
- Trial name
- PREVENT (NCT03373435)
- Testing
- exendin 9-39
- Where
- 5 sites in United States
- Volunteers
- 18 people
- Sponsor
- Eiger BioPharmaceuticals
Type 2 Diabetes Mellitus, Hypoglycemia
Hypoglycemia Risk Assessment in Elderly and Senile Female Patients With Type 2 Diabetes Mellitus
Hypoglycemia poses a particular danger for elderly patients with type 2 diabetes mellitus (T2DM). According to data, more than 30% of patients aged 60-69 years experience hypoglycemic episodes, and among persons over 85 years…
- Conditions
- Type 2 Diabetes Mellitus, Hypoglycemia, Frailty, Sarcopenia
- Trial name
- HYPOGLYCEMIA16 (NCT07887334)
- Testing
- Comprehensive Geriatric Assessment, Sarcopenia assessment, Laboratory assessment
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Samara State Medical University
Congenital Hyperinsulinism (CHI), Beckwith-Wiedemann Syndrome
18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia
This purpose of this study is to determine the ability of an 18F-fluoro-L-dihydroxyphenylalanine (18F-DOPA) PET (Positron Emission Tomography) scan to detect a focal lesion of hyperinsulinism and determine the location in…
- Conditions
- Congenital Hyperinsulinism (CHI), Beckwith-Wiedemann Syndrome, Insulinoma
- Trial name
- NCT01916148
- Testing
- 18F-DOPA
- Where
- United States
- Sponsor
- Children's Hospital of Philadelphia
Central Line-Associated Bloodstream Infection (CLABSI), Venous Thromboembolism
Patient Safety Learning Laboratory: Making Acute Care More Patient-Centered
The Brigham and Women's Hospital (BWH) Patient Safety Learning Laboratory (PSLL) focuses on developing health information technology (HIT) tools to engage patients, family, and professional care team members in reliable…
- Conditions
- Central Line-Associated Bloodstream Infection (CLABSI), Venous Thromboembolism, Patient Fall, Catheter-Associated Infection
- Trial name
- PSLL (NCT02969343)
- Testing
- Patient Safety health information technology
- Where
- United States
- Volunteers
- 21,000 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetic Complication, Covid19 Virus Infection
Suspicion of Hypoglycemic Effect of mRNA Based Covid-19 Vaccines (Polyethylene Glycol) Will Happen , Observational Study on Diabetic Patients at Saudia Arabia
vaccines for covid-19 are gold strategy and great achievement at this century for protection against complications of covid-19 , development of many vaccines with different technology represent a big challenge for this disease so…
- Conditions
- Diabetic Complication, Covid19 Virus Infection, Hypoglycemia, Polyethylene Glycol Adverse Reaction
- Trial name
- NCT05087225
- Testing
- polyethelyene glycol
- Where
- Saudi Arabia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Hypoglycemia, Type 1 Diabetes Mellitus
Affect of RT-CGMS as Part of Clinical Care in Type 1 Diabetes Mellitus Patients
The incidence of Type 1 Diabetes Mellitus is increasing annually, in all pediatric age groups, especially among infants and toddlers.However, only 30% of diabetic children manage to achieve and maintain glycated hemoglobin A1c…
- Trial name
- NCT01525784
- Where
- 4 sites in Israel
- Volunteers
- 300 people
- Sponsor
- Assaf-Harofeh Medical Center
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
In-hospital Diabetes Management With Flash Glucose Monitoring (isCGM) - the INDIGO Study, Part B
The aim of the study is to investigate the applicability of a Flash glucose monitoring sensor (Freestyle Libre, isCGM) for in-hospital glucose monitoring in patients with diabetes and hypoglycemia (<3,9 mmol/l) during the…
- Conditions
- Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus
- Trial name
- INDIGO (NCT04630925)
- Testing
- isCGM
- Where
- Denmark
- Volunteers
- 1 people
- Sponsor
- University of Aarhus
Diabetes Mellitus, Type 2, Hypoglycemia
Hypoglycaemia in People With Type 2 Diabetes in Primary Care
Despite type 2 diabetes comprising the majority of cases of diabetes, the overall frequency of hypoglycaemia in this group has not been as carefully documented as in type 1 diabetes, particularly in relation to the clinical use…
- Trial name
- NCT02666521
- Where
- United Kingdom
- Volunteers
- 2,327 people
- Sponsor
- University of Leicester
Type1diabetes
The Monitoring Study
To conduct an outpatient study testing two configurations of the bionic pancreas (bi-hormonal and insulin-only) with and without remote monitoring of hypoglycemia in 25 adult (≥ 18 years of age) subjects with type 1 diabetes in a…
- Trial name
- NCT02969863
- Testing
- Bihormonal Bionic Pancreas, Insulin Only Bionic Pancreas, Monitored for Hypoglycemia
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type II, Hypoglycemia
Effects of Mild Hypoglycaemia on Cognitive Function in Type 2 Diabetes
Hypoglycaemia in subjects suffering from type 2 diabetes may have substantial consequences including a significant negative impact on quality of life.
- Conditions
- Diabetes Mellitus, Type II, Hypoglycemia, Cognitive Change
- Trial name
- NCT03014011
- Testing
- Hypoglycaemic clamp, Euglycaemic clamp
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Bispebjerg Hospital
Post Prandial Hypoglycemia
Validation of a Diagnostic Tool for Postprandial Hypoglycaemia in Patients After Roux en Y Gastric Bypass Surgery
Roux-en-Y gastric bypass (RYGB) leads to weight reduction but has also some unwanted side effects. A part of this population will develop postprandial reactive hypoglycemia (PPRH).
- Trial name
- EDS (NCT03406312)
- Testing
- Post Prandial Hypoglycemia test
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Ghent
Cystic Fibrosis, Hypoglycemia
Hypoglycemia and Glucagon Response in CF
The goal of this clinical trial is to investigate the etiopathogenesis of isolated hypoglycemia and hypoglycemia with abnormal glucose tolerance in children with Cystic Fibrosis (CF) and to evaluate the role of glucagon and…
- Conditions
- Cystic Fibrosis, Hypoglycemia, Glucagon Deficiency, Pancreatic Insufficiency
- Trial name
- NCT05700604
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Marmara University
Type 1 Diabetes Mellitus
An Evaluation of Novel Glucose Sensing Technology on Hypoglycaemia in Type 1 Diabetes (IMPACT)
The purpose of this study is to evaluate the impact of the Abbott Sensor Based Glucose Monitoring System on hypoglycaemia compared to Self Monitoring Blood Glucose (SMBG) testing using a randomised controlled study design in…
- Trial name
- IMPACT (NCT02232698)
- Testing
- Sensor Based Glucose Monitoring System, Standard Blood Glucose Monitoring
- Where
- 23 sites in Austria, Germany and 3 more
- Volunteers
- 328 people
- Sponsor
- Abbott Diabetes Care