Clinical trials: Hypoglycemic Syndrome
Hypoglycemia
Hypoglycemia and the Mineralocorticoid Receptor
The purpose of this study is to look at whether blockade of the mineralocorticoid receptor will result in changes in the cardiovascular and inflammatory response to hypoglycemia.
- Trial name
- HypoMR (NCT01394627)
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetes Type 1
French Version of the Scales of Fear of Hypoglycaemia in Children With Type 1 Diabetes and Their Parents
Type 1 diabetes usually appears brutally in children or young adults. While many factors of poor glycemic balance have been identified in the literature (age, socio-cultural and socio-economic level, family structure, adherence…
- Trial name
- FHS (NCT03529188)
- Where
- 3 sites in France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Brest
Type 2 Diabetes
Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 4
Hypoglycemia (low blood glucose level) occurs frequently in intensively treated patients with diabetes. Although hypoglycemia was thought to occur almost exclusively in T1DM, with the advent of improved metabolic control in T2DM…
- Trial name
- NCT00574340
- Testing
- Hyperinsulinemic Hypoglycemic Clamp
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus
Continuous Glucose Monitoring in the Intensive Care Unit
The aim of the proposed clinical trial is to study the use of the Dexcom G7 continuous glucose monitor (CGM) within the intensive care unit (ICU) environment.
- Trial name
- NCT06190808
- Testing
- Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Type 1 Diabetes Mellitus, Hypoglycemia
MGA031, Sirolimus and Tacrolimus in Islet Transplantation
This clinical trial is designed to extend the observations made in our pilot clinical trial (IND 8971, Study #1) on the safety and efficacy of immunotherapy with the anti-CD3 monoclonal antibody hOKT3γ1 (Ala-Ala), (currently…
- Trial name
- NCT00265473
- Testing
- Allogeneic Islets of Langerhans
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Minnesota
Congenital Hyperinsulinism
Compassionate Use of SOM230 for Hyperinsulinemic/Hypoglycemia
Congenital hyperinsulinism is a rare condition that can cause life-threatening hypoglycemia. Current treatment for congenital hyperinsulinism is often suboptimal, and such individuals may respond to a new somatostatin analog…
- Trial name
- NCT02835131
- Testing
- Pasireotide
- Where
- United States
- Sponsor
- Montefiore Medical Center
Gestational Diabetes Mellitus in Pregnancy, Pregestational Diabetes Mellitus
Intrapartum Glucose Control and Risk of Neonatal Hypoglycemia
The purpose of this study is to assess whether a liberal intrapartum glycemic target range compared to usual care standard control ranges will lead to a decrease in the rate of neonatal hypoglycemia among pregnant patients in…
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Pregestational Diabetes Mellitus, Neonatal Hypoglycemia
- Trial name
- NCT06643351
- Testing
- Standard Intrapartum Glucose Target Range, Liberalized Intrapartum Glucose Target Range
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- University of Pittsburgh
Drug-specific Antibodies, Diabetes Mellitus
Evaluate the Immunogenicity of a Novel Glucagon Formulation
This study provides information on immunogenicity of Nasal Glucagon (AMG504-1) with regards to the potential development of treatment-emergent anti-glucagon antibodies.
- Trial name
- NCT01959334
- Testing
- Nasal Glucagon (NG), Glucagon IM
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Eli Lilly and Company
Hyperglycemia, Hyperglycemia Stress
Diabetes Clinical Decision Support
The purpose of this study is to determine the impact of an electronic medical record clinical decision support tool on rates of dysglycemia in the hospital, and its clinical and economical outcomes.
- Conditions
- Hyperglycemia, Hyperglycemia Stress, Diabetes, PreDiabetes
- Trial name
- NCT05447806
- Testing
- Active Electronic Medical Record Inpatient Diabetes Clinical Decision Support
- Where
- 2 sites in United States
- Volunteers
- 15,732 people
- Sponsor
- Milton S. Hershey Medical Center
Bariatric Surgery
Understanding Hypoglycaemia After Bariatric Surgery
Postprandial hyperinsulinaemic hypoglycaemia is an increasingly recognized adverse side effect of bariatric surgery. Affected individuals experience low glucose levels 1-3 hours after intake of meals, accompanied by symptoms such…
- Trial name
- HYPOBAR1 (NCT03609632)
- Testing
- Dietary Supplement: Glucose
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus, Lipohypertrophy
Lipohypertrophy Monitoring Study
The investigators intend to audit the impact of optimal injection technique education delivered through a multimodal tailored approach augmented with a digital 'tailorable' patient learning platform on clinical parameters and…
- Conditions
- Diabetes Mellitus, Lipohypertrophy, Hypoglycemia
- Trial name
- LiMo (NCT04659330)
- Testing
- Online education (BdandMe) for injection technique, 4mm needles
- Where
- Belgium
- Volunteers
- 171 people
- Sponsor
- University Hospital, Antwerp
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes
Regular physical activity is associated with many health benefits for individuals with type 1 diabetes including improved cardiovascular fitness and vascular health, decreased insulin requirements, improved body composition and…
- Trial name
- NCT02855307
- Testing
- 60-minute exercise, Insulin pump, Dexcom G4 Platinum glucose sensor
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes Mellitus, Type II, Hypoglycemia
Effects of Mild Hypoglycaemia on Cognitive Function in Type 2 Diabetes
Hypoglycaemia in subjects suffering from type 2 diabetes may have substantial consequences including a significant negative impact on quality of life.
- Conditions
- Diabetes Mellitus, Type II, Hypoglycemia, Cognitive Change
- Trial name
- NCT03014011
- Testing
- Hypoglycaemic clamp, Euglycaemic clamp
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Bispebjerg Hospital
Type 1 Diabetes
Clinical Assessment of a Closed-loop System With Glucagon, Exercise and Mixed Meals
The diabetes technology group at Imperial College have developed a bio-inspired artificial pancreas (BiAP) system which uses a control algorithm based on a mathematical model of beta-cell physiology.
- Trial name
- NCT02397265
- Testing
- Bi-hormonal closed loop pump, Standard opened loop pump, Insulin closed loop
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Imperial College London
Type 1 Diabetes, Hypoglycemia
Neuronostatin - a Glucagonotropic Agent in Humans?
With the present study the investigators wish to delineate the effects of neuronostatin-13 (NST) on glucose-dependent glucagon secretion in humans.
- Conditions
- Type 1 Diabetes, Hypoglycemia, Type1diabetes
- Trial name
- NSTCLAMP (NCT06143267)
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Infants of Diabetic Mothers, Placenta
Placental Weight in Infants of Gestational Diabetic Mothers
This prospective cross-sectional study examined the relationship between placental weight and early neonatal outcomes, such as blood glucose levels within the first 24 hours and early neonatal morbidities in infants born to…
- Conditions
- Infants of Diabetic Mothers, Placenta, Hypoglycaemia
- Trial name
- NCT07765784
- Testing
- Blood Glucose Level
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Nocturnal Hypoglycemia, Type 1 Diabetes
Prevalence of Nocturnal Hypoglycemia in Children on a Type 1 Diabetes (TID) Insulin Regimen Using a Continuous Glucose Monitoring System (CGMS)
This study will help determine the frequency and magnitude of nocturnal hypoglycemia (low blood sugar at night during sleep), in children with type 1 diabetes who are on a standard insulin regimen, by using a Continuous Glucose…
- Trial name
- NCT00542334
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Eastern Ontario
Type 1 Diabetes Mellitus With Hypoglycemia
A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
The goal of this clinical trial is to learn about the effect of the study drug (ZT-01) on low blood sugar (hypoglycemia) in adults with type 1 diabetes (T1D) who have been having low blood sugars ("hypos") at night.
- Trial name
- ZONE (NCT05762107)
- Testing
- ZT-01, 7 mg, ZT-01, 15 mg, ZT-01, 22 mg
- Where
- 46 sites in United States, Canada
- Volunteers
- 186 people
- Sponsor
- Zucara Therapeutics Inc.
Hypoglycaemia
Point of Care Ketone Measurement in the Newborn
Low blood sugar levels are common in babies after birth. This may be normal as babies can use other sources of energy. However if a baby does not produce these fuels the brain can be starved of energy and be damaged.
- Trial name
- POCKET (NCT02341313)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Kathryn Beardsall
Hypoglycemia, Hyperglycemia
Exploration of Continuous Glucose Monitoring on the Intensive Care Unit
Both hyperglycemia and hypoglycemia in patients at the intensive care unit (ICU) are strongly associated with increased morbidity and mortality.
- Trial name
- CGM-IC (NCT06645873)
- Testing
- Continuous glucose monitoring (CGM) device
- Where
- 3 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Kim Kamphorst