Clinical trials: Hypoglycemic Syndrome
Type 1 Diabetes Mellitus With Hypoglycemia
A Trial to Investigate Hyperglycemic and Hypoglycemic Excursions in Subjects With Type 1 Diabetes
This is a single center, double-blind, randomized trial in subjects with type 1 diabetes mellitus applying an adaptive design approach.
- Trial name
- NCT04712266
- Testing
- Glucagon, Insulin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Abvance Therapeutics
Diabetes Mellitus, Type 2
Efficacy/Safety Study of Glimepiride to Type 2 Diabetes Patients Based on Metformin And Basal Insulin Treatment
All the guidelines suggest that metformin as the basis of type 2 diabetes medication, and evidence is sufficient.At the same time the basal insulin injection once a day are more and more widely used in diabetes patients in China.
- Trial name
- NCT02026310
- Testing
- glimepiride, glargine and metformin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qifu Li
Congenital Hyperinsulinaemic Hypoglycaemia, Octreotide Adverse Reaction
Efficacy and Safety Evaluation of Octreotide in the Treatment of Congenital Hyperinsulinemia
To analyze and evaluate the efficacy and safety of octreotide subcutaneous injection in the treatment of diazazine-ineffective congenital hyperinsulinemia (CHI) in children.
- Trial name
- BCH (NCT05171751)
- Testing
- Octreotide Injection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Children's Hospital
Diabetes, Diabetes Mellitus, Type 1
A Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes
This survey is conducted in South America. The aim of this survey is to investigate hypoglycaemia among Insulin-treated patients with diabetes.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT02230631
- Testing
- No treatment given
- Where
- Brazil
- Volunteers
- 704 people
- Sponsor
- Novo Nordisk A/S
Type1diabetes, Fasting Hypoglycemia
Sahoor Meal Regimen for Patients With Type1 Diabetes
To examine effects of two approaches to sahoor meal consumption during Ramadan on blood sugar control and incidence of early day hypoglycemic episodes requring the discontinuation of fasting.
- Trial name
- NCT04864483
- Testing
- Meal timing in relation to time of starting the fast
- Where
- Saudi Arabia
- Volunteers
- 44 people
- Sponsor
- King Abdullah International Medical Research Center
Type 1 Diabetes, Continuous Glucose Monitoring
Effect of Different Plasma Insulin Levels on the Accuracy of Continuous Subcutaneous Glucose Monitoring
Achieving near-normoglycaemia has been established as the main objective for most patients with diabetes. However, it is well known that intensification of treatment is associated with an increase in the frequency of…
- Conditions
- Type 1 Diabetes, Continuous Glucose Monitoring, Hypoglycemia
- Trial name
- NCT01714895
- Testing
- High insulin eu-hypoglycemic clamp, Low insulin eu-hypoglycemic clamp
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
to Identify Which Titration Regimen of Basal Insulin (Being Daily Titration vs 3 Daily Titration) is Better in Reducing hba1c and Have Lesser Hypoglycemia
Difference of Basal Insulin Titration Method in Reducing HbA1c Among Type 2 Diabetes Mellitus (T2DM) Patients.
Introduction Diabetes mellitus is a worrying global non-communicable disease where it is affecting 18.3% of Malaysian adults. Poorly managed diabetes leads to an array of serious complications, namely heart attack, kidney failure…
- Trial name
- NCT05331469
- Testing
- NPH basal insulin titration
- Where
- Malaysia
- Volunteers
- 70 people
- Sponsor
- University of Malaya
Cesarean Section
The Effect of Administering a Small Dose of Glucose During Cesarean Section
The purpose of this study is to investigate the effect of administering a small dose of glucose on the pregnant women and their neonates during cesarean section.
- Trial name
- NCT01706341
- Testing
- administer acetate Ringer's solution, acetate Ringer's solution containing no glucose, acetate Ringer's solution containing 1% glucose
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Nagoya City University
Diabetes Mellitus, Type 2, Hypoglycemia
Multi-Center Study Comparing Efficacy and Safety of Frequently Modified Insulin Therapy
Hygieia Research seeks to conduct a prospective randomized clinical study involving adult subjects with uncontrolled Type-2 diabetes requiring insulin.
- Trial name
- NCT02424500
- Testing
- d-Nav, Blood Glucose Monitoring System
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Hygieia Research LLC
Small Gestational Age (SGA), Hypoglycemia After Gastric Bypass
Glycemic Variability During Pregnancy After Bariatric Surgery
Pregnancies after Metabolic and Bariatric Surgery (MBS) are linked to increased incidence of small-for-gestational-age (SGA) neonates.
- Conditions
- Small Gestational Age (SGA), Hypoglycemia After Gastric Bypass, Glycemic Variability
- Trial name
- NCT07731165
- Testing
- Intermittently Scanned Continuous Glucose Monitoring (isCGM)
- Where
- Portugal
- Volunteers
- 47 people
- Sponsor
- Centro Hospitalar Universitário de Santo António
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Type 2 Diabetes Mellitus, Hypoglycemia
Role of CGMS Usage in Predicting Risk for Hypoglycemia
This is a clinical study to examine rates hypoglycemia (self-report, EHR review, and review of values from a FDA approved continuous glucose monitoring system (CGMS)). Subjects will wear either blinded or unblinded CGMS.
- Trial name
- NCT03481530
- Testing
- Continuing Glucose Monitor System
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Minnesota
Diabetes Mellitus, Type 1
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
This clinical study will evaluate the safety and effectiveness of Gastrin treatment with islet transplantation to help patients with difficult to control type 1 diabetes make insulin again and improve blood sugar control.
- Trial name
- NCT03746769
- Testing
- Allogenic Human Islet Cells, Gastrin 17
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Hypoglycemia
Effects of Pulsatile Intravenous Insulin Delivery on Hypoglycemic Unawareness
Hypoglycemic unawareness is a major problem in the treatment of Diabetes Mellitus. Hypoglycemic unawareness is the inability to recognize or sense early symptoms of low blood sugar.
- Trial name
- NCT01029639
- Testing
- Pulsatile Intravenous Insulin Therapy (Humulin R, Novolog)
- Where
- United States
- Sponsor
- Florida Atlantic University
Type 1 Diabetes, Hypoglycemia
Insulin Management for Exercise in Patients With Type 1 Diabetes
The purpose of this study is to compare the time spent in glucose target range (4.0-10.0 mmol/L) during exercise and in recovery using three different basal insulin management strategies for prolonged aerobic exercise: A) pump…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Physical Activity
- Trial name
- NCT03130101
- Testing
- Change in their basal insulin rate
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- York University
Postbariatric Hypoglycemia
Effect of Mizagliflozin on Postprandial Glucose and Insulin in Post-Bariatric Hypoglycemia Subjects
This clinical study will examine the safety and tolerability, as well as the effects of orally administered mizagliflozin on post prandial glucose and insulin levels in subjects diagnosed with post-bariatric hypoglycemia (PBH).
- Trial name
- NCT05541939
- Testing
- Mizagliflozin
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Vogenx, Inc.
Hyperparathyroidism, Hypercalcemia
Studies of Elevated Parathyroid Activity
Observational Phase: Patients whose parathyroid activity is elevated above normal are referred to as having hyperparathyroidism.
- Conditions
- Hyperparathyroidism, Hypercalcemia, Parathyroid Neoplasm, Multiple Endocrine Neoplasia
- Trial name
- NCT00001277
- Testing
- 68Ga-Dotatate, 18F-DOPA
- Where
- United States
- Volunteers
- 1,553 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes, Diabetes Mellitus, Type 2
A Trial to Investigate the Impact of Nocturnal Hypoglycaemia on Sleep in Subjects With Type 2 Diabetes
This trial is conducted in Europe. The aim of this trial is to investigate the impact of low blood sugar during the night on sleep in subjects with type 2 diabetes.
- Trial name
- NCT01780272
- Testing
- glucose clamp
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Novo Nordisk A/S
Hypoglycemia
Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes
The purpose of this study is to investigate how the brain responds to low blood glucose in non-diabetic individuals. The ultimate goal is to understand the brain substrates of hypoglycemia unawareness, a condition that can occur…
- Trial name
- NCT02866435
- Testing
- Insulin, Glucose, Potassium phosphate
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type1diabetes, Hypoglycemia
Adrenergic System in Islet Transplantation
To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepatic islet transplantation.
- Conditions
- Type1diabetes, Hypoglycemia, Hypoglycemia Unawareness, Islet Cell Transplantation
- Trial name
- NCT03079921
- Testing
- Phentolamine, Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania