Clinical trials: Hypoglycemic Syndrome
Diabetes Mellitus, Type 2, Hyperglycemia Stress
Remote Glucose Monitoring in Hospital Settings
Use of real-time continuous glucose monitoring (RT-CGM) systems in inpatient settings especially during the COVID-19 pandemic, may allow hospital staff to remotely monitor glucose while reducing viral exposure and preserving use…
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia Stress, Hypoglycemia
- Trial name
- REMOTE-CGM (NCT04797208)
- Testing
- Real-Time CGM, Capillary blood glucose testing with masked CGM
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Sterility, Placenta; Implantation
A Lifestyle Intervention to Improve in Vitro Fertilization Results
Embryo adhesion and placentation depend on tissue plasminogen activator (tPA)-mediated activation of brain-derived neurotrophic factor, vascular endothelial growth factor and other growth factors, formation of hemidesmosomes, and…
- Conditions
- Sterility, Placenta; Implantation, Risk Reduction Behavior, Lifestyle
- Trial name
- W+D (NCT02648555)
- Testing
- Daily walking, Dietary recommendations
- Where
- Brazil
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Diabetes Mellitus, Type 1, Hypoglycemia
Diabetes Islet Preservation Immune Treatment
To assess whether there is a difference in endogenous insulin secretion, measured as stimulated C-peptide secretion (area under the curve during a 4-hour mixed meal tolerance test), at the 1 year visit, for study subjects…
- Conditions
- Diabetes Mellitus, Type 1, Hypoglycemia, Autoimmune Diseases, Diabetes Mellitus
- Trial name
- DIPIT (NCT02586831)
- Testing
- Anti-Thymocyte Globulin (ATG), Interleukin 2, Exenatide
- Sponsor
- Camillo Ricordi and Jay Skyler
Obstetric Labor, Pregnancy in Diabetics
Intrapartum Glucose and Insulin Compared to Glucose Alone in Diabetic Women
This study aims to examine the effect of intrapartum treatment of diabetic women with combined glucose and constant insulin infusion compared to glucose alone on the incidence of neonatal hypoglycemia.
- Trial name
- NCT03273881
- Testing
- glucose solution and Insulin, glucose solution only
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Neonatal Hypoglycemia
Continuous Glucose Monitoring in At-Risk Newborns
Hypoglycemia (low blood glucose) is a very common problem in newborns, and has been associated with poor neurodevelopment, cognition, and school performance.
- Trial name
- NCT04386005
- Testing
- Continuous Glucose Monitoring Device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Milton S. Hershey Medical Center
Type1diabetes
A Cognitive Behavioral Intervention to Reduce Fear of Hypoglycemia in Young Adults With Type 1 Diabetes
This study is being conducted to determine the feasibility of a cognitive behavioral therapy intervention to reduce fear of hypoglycemia and improve glucose levels in young adults with type 1 diabetes.
- Trial name
- FREE (NCT03165786)
- Testing
- FREE
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Illinois Chicago
Insulin Hypoglycemia, Glucose Test Site Bleeding
Blood Glucose Management in Intensive Care Units
The investigators propose to conduct a study of practices to describe the methods of managing glycemic control in hospitalized patients in critical care.
- Conditions
- Insulin Hypoglycemia, Glucose Test Site Bleeding, Hyperglycemia
- Trial name
- GINGER (NCT05775770)
- Testing
- Insulin
- Where
- France
- Volunteers
- 525 people
- Sponsor
- French Society for Intensive Care
Type 2 Diabetes, Stroke
The Effect of GLP-1 on Glucose Uptake in the Brain and Heart in Healthy Men During Hypoglycemia
Type 2 diabetes mellitus, T2D is a disease characterized by an immense growing prevalence world wide with an increased risk of myocardial infarction and stroke.
- Conditions
- Type 2 Diabetes, Stroke, Myocardial Infarction
- Trial name
- NCT00418288
- Testing
- glucagon-like-peptide-1
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diabetes Mellitus Type I, Hypoglycemia
Intracellular Counter-regulatory Mechanisms Following Low Blood Glucose
Diabetes mellitus type I (DMI) is characterized by lack of endogenous insulin and these patients are 100% dependent on insulin substitution to survive.
- Trial name
- NCT01919788
- Testing
- Insulin (Insuman Rapid), Glucose, Saline
- Where
- Denmark
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
Elevations of plasma cortisol, a stress hormone, during prior episodes of low blood sugar (hypoglycemia) appear to be responsible for the deficient responses during subsequent hypoglycemia.
- Trial name
- NCT00607646
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Type 1 Diabetes
Insulin Analogues and Severe Hypoglycaemia
Severe hypoglycaemia is hampering the lives of many diabetic patients. The effect on the occurrence of severe hypoglycaemia during two different insulin regimens are to be investigated.
- Trial name
- NCT00346996
- Testing
- insulin levemir / aspart, human insulin /insulin isophane
- Where
- Denmark
- Volunteers
- 179 people
- Sponsor
- Lise Tarnow
Blood Glucose, Low, Hypoglycemia
EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE AND ECG MORPHOLOGY OF EUGLYCEMICS:A CLINICAL STUDY
EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE LEVEL OF EUGLYCEMICS:A PRE-CLINICAL AND CLINICAL STUDY. Our aim and objectives are to: 1.
- Trial name
- CT (NCT04692623)
- Testing
- Moxifloxacin 400mg, Gemifloxacin 320 MG
- Where
- Pakistan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Shaheed Benazir Bhutto University Sheringal Dir Upper
Hypoglycemia, Type 1 Diabetes
A Study to Inv. Safety, Efficacy & PD of Dasiglucagon as Hypoglycemia Rescue Therapy in Children <6 Years With T1D
This research study will investigate whether dasiglucagon as a rescue therapy for participants under 6 years of age works and is safe to use.
- Trial name
- NCT05378672
- Testing
- Dasiglucagon
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Zealand Pharma
Type 1 Diabetes Mellitis
Neurocognitive Impact of Hypoglycemia in Type 1 Diabetes
125 children with Type 1 Diabetes mellitis (T1DM) between 4 and 16 were recruited and 62 healthy siblings also enrolled in the study.
- Trial name
- HYPO (NCT00916838)
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 15 Weeks in Adolescents and Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02846857
- Testing
- 15-week intervention with sensor-augmented pump, 15-week intervention with single-hormone closed-loop, 15-week intervention with dual-hormone closed-loop
- Sponsor
- Institut de Recherches Cliniques de Montreal
Hypoglycemia
Pharmacokinetics and Pharmacodynamics of BIOD-961 vs. Marketed Glucagons
BIOD-961 is a dry powder formulation of glucagon intended for use in a device that mixes (reconstitutes) the powder with liquid to make it easier for users to treat patients with severe hypoglycemia.
- Trial name
- NCT02403648
- Testing
- BIOD-961, Lilly Glucagon, Novo Glucagon
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Biodel
Type 1 Diabetes, Diabetes Mellitus, Type 1
Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes
The goal of this clinical trial is to test whether the combination of two safe immune therapies called abatacept and nasal insulin can preserve pancreas function in recently-diagnosed type 1 diabetes.
- Trial name
- IAA (NCT05742243)
- Testing
- Abatacept (CTLA4-Ig) and nasal insulin (Humulin R®)
- Where
- 6 sites in Australia
- Volunteers
- 68 people
- Sponsor
- Melbourne Health
Type 1 Diabetes Mellitus
Effect of Closed Loop Glucose Control on Exercise-Associated Hypoglycemia
The purpose of the study is to compare the glycemic control during and following aerobic exercise using either an open or closed-loop insulin delivery system.
- Trial name
- ePID-03 (NCT00831389)
- Testing
- Closed Loop
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes Mellitus, Hypoglycemia
The HypoVoice Study
The HypoVoice study aims at identifying potential vocal biomarkers associated with hypoglycemia to pave the way towards a voice-based hypoglycemia detection approach.
- Trial name
- HypoVoice (NCT05569876)
- Testing
- Controlled hypoglycemic state
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus, Hypoglycemia
Study of a Primary Care Hypoglycemia Prevention Program
This is a single site, pre-post pilot study. The objective is to evaluate the acceptability and feasibility of a primary care hypoglycemia prevention program for patients taking hypoglycemia-causing medications.
- Trial name
- NCT06353217
- Testing
- Patient Group (Hypoglycemia Prevention Program), Primary Care Physician Group, Clinic Staff Group
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University