Clinical trials: Hypogonadism, Hypogonadotropic
Obese Hypogonadotropic Hypogonadism
Safety and Efficacy of BGS649 in Obese, Hypogonadotropic Hypogonadal Men
This study is designed as a 2-part study, with Part 1 being open-label to best determine the appropriate dose levels to use in Part 2, which has a randomized, double-blind, placebo controlled design.
- Trial name
- OHH (NCT01200862)
- Testing
- Investigational new drug company code: BGS649
- Where
- 5 sites in United States, Canada
- Volunteers
- 29 people
- Sponsor
- Mereo BioPharma
Primary Amenorrhea With Hypogonadotropic Hypogonadism
LutrePulse Hypogonadotropic Hypogonadism
To compare the ovulation rate in women with primary amenorrhea with hypogonadotropic hypogonadism following pulsatile gonadotropin-releasing hormone (GnRH) treatment using the OmniPod pump versus placebo
- Trial name
- NCT01976728
- Testing
- Gonadorelin acetate subcutaneous (SC) 10 μg/pulse as a fixed dose, administered via. OmniPod pump, Gonadorelin acetate SC 15 μg/pulse as a fixed dose, administered via. OmniPod pump, Gonadorelin acetate SC 20 μg/pulse as a fixed dose, administered via. OmniPod pump
- Where
- 35 sites in United States, Canada
- Volunteers
- 39 people
- Sponsor
- Ferring Pharmaceuticals
Female Hypogonadism
Perception of Hormonal Replacement Therapy Among Patients Aged 11 to 17 Years
To establish a current knowledge and perception of patients and their parents regarding HRT in order to assess the needs that can promote understanding and adherence to treatment by implementing therapeutic education workshops
- Trial name
- THS (NCT07315932)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Hypogonadotropic Hypogonadism
Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome
To investigate the hormone response of hypothalamic-pituitary-gonad axis and spermatogenesis in male pituitary stalk interruption syndrome patients by pulsatile GnRH therapy.
- Trial name
- NCT02705014
- Testing
- Gonadotropin-releasing Hormone
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
Hypogonadism, Hypogonadotropic, Obesity
Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism
The investigators have preliminary data suggesting that obese patients with hypogonadotropic hypogonadism (HHG) have minimal benefit from testosterone therapy likely because of its conversion to estradiol by the abundant…
- Trial name
- NCT03490513
- Testing
- anastrozole (1 mg/day)
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Baylor College of Medicine
Hypogonadism
Effects on the Brain of Lupron Induced Hypogonadotropic Hypogonadism With and Without Testosterone Replacement
There is evidence that suggests male sex hormones (androgens) play a significant role in brain (central nervous system) functioning.
- Trial name
- NCT00001412
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Kallmann Syndrome, Hypogonadism
Investigating the Regulation of Reproductive Hormones in Adult Men
The purpose of the research study is to learn more about the regulation of reproductive hormones in adult men. We would like to understand what role testosterone and estradiol play in controlling the release of LH (lutenizing…
- Conditions
- Kallmann Syndrome, Hypogonadism, Gonadal Disorder
- Trial name
- NCT00392457
- Testing
- ketoconazole, gonadotropin releasing hormone (GnRH)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Genetic Disorder, Infertility
Inherited Reproductive Disorders
Background: During puberty, children begin to develop into adults. Problems with the hormones released during puberty can affect the reproductive system. Some people have low hormone levels that severely delay or prevent puberty.
- Conditions
- Genetic Disorder, Infertility, Hypogonadism, Amenorrhea
- Trial name
- NCT01500447
- Where
- 2 sites in United States
- Volunteers
- 850 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Secondary Hypogonadism
Normalization of Morning Testosterone Levels in Men With Secondary Hypogonadism
The Purpose of the study is to determine the effects of Androxal on morning testosterone and reproductive status in men with secondary hypogonadism(confirmed morning Testosterone less than 250 ng/dL), compared to changes with…
- Trial name
- NCT01270841
- Testing
- topical testosterone, Androxal
- Where
- 18 sites in United States
- Volunteers
- 83 people
- Sponsor
- Repros Therapeutics Inc.
Hypogonadism
The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism
The study is designed to answer the following questions: 1) What is the effect of testosteron replacement treatment on the endothelial dysfunction. 2/ What is the effect of testosteron replacement on the bone mineral metabolism.
- Trial name
- NCT02111473
- Testing
- Testosterone
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Gulhane School of Medicine
Hypogonadotropic Hypogonadism
Kisspeptin Administration Subcutaneously to Patients With IHH
The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in men and women with idiopathic hypogonadotropic hypogonadism (IHH).
- Trial name
- NCT05896293
- Testing
- kisspeptin 112-121, leuprolide acetate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stephanie B. Seminara, MD
Acquired Hypogonadotropic Hypogonadism, Obesity
A Multi-Center Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Body Composition and Metabolic Parameters With Diet and Exercise in Conjunction With Treatment With 12.5 mg or 25 mg Enclomiphene
The purpose of this study is to compare the effects of 12 months of treatment with enclomiphene 12.5 mg, 25 mg, or placebo capsules on body composition and metabolic parameters in overweight men with acquired hypogonadotropic…
- Trial name
- NCT02651688
- Testing
- Enclomiphene
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Repros Therapeutics Inc.
Hypogonadotropic Hypogonadism
Neuropeptides in Human Reproduction
The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system.
- Trial name
- NCT01952782
- Testing
- Kisspeptin 112-121, Naloxone, GnRH
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Idiopathic Hypogonadotropic Hypogonadism
The Effects of Gonadotropin Replacement Therapy in Patients With Hypogonadism
Effects of hCG replacement therapy on metabolic syndrome parameters in hypogonadotrophic hypogonadism.
- Trial name
- NCT02042638
- Testing
- hCG 1500 IU three times a week, Pregnyl (hCG) ampule 1500 IU/three times a week
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Gulhane School of Medicine
Hypogonadism, Male, Metabolic Syndrome
Physical Exercise as a Sustainability Tool in Men With Dysmetabolic Hypogonadism
Aim of this project is to delineate sustainable physical exercise programs and to assess the effects of such programs mainly on endocrine-metabolic and neurovegetative outcomes in a cohort of men with metabolic syndrome-related…
- Conditions
- Hypogonadism, Male, Metabolic Syndrome, Autonomic Imbalance, Life Style, Healthy
- Trial name
- ExLOH (NCT06094036)
- Testing
- Structured and personalized program of physical exercise
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Istituto Auxologico Italiano
Hypogonadism
Testosterone Therapy in Hypogonadal Men Treated With Opioids
The purpose of this study is to evaluate the efficacy of testosterone replacement therapy in men with low testosterone due to opioid treatment on body composition, the haemostatic system, glucose metabolism, muscle function, pain…
- Trial name
- NCT02433730
- Testing
- Testosterone
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Marianne Andersen
Hypogonadism, Low Testosterone
A One Year Open Label Study for the Treatment of Hypogonadism (Low Testosterone) in Men Who Have Completed ZA-203
The purpose of this study is to determine the continued effects of Androxal on morning testosterone and reproductive status in men with secondary hypogonadism who have completed protocol ZA-203.
- Trial name
- NCT01386567
- Testing
- Androxal (enclomiphene citrate), Testim (topical testosterone)
- Where
- 8 sites in United States
- Volunteers
- 48 people
- Sponsor
- Repros Therapeutics Inc.
Idiopathic Hypogonadotropic Hypogonadism
Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism
Idiopathic hypogonadotropic hypogonadism (IHH) is the most common disorders of sex development (DSD).Therapy for IHH includes hormone replacement therapy, gonadotropin therapy and pulsed infusion of gonadotropin releasing hormone…
- Trial name
- NCT02310074
- Testing
- Pulsatile Gonadotropin Releasing Hormone, Human chorionic gonadotropin, Urinary Follicle-Stimulating Hormone
- Volunteers
- 76 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Secondary Hypogonadism
Evaluation of Pharmacokinetic and Safety Profile of Androxal in Male Subjects With Impaired Renal Function
To determine and compare the pharmacokinetics (PK) of a single dose of 25 mg Androxal in overweight male subjects with various stages of renal impairment and in volunteers with normal renal function.
- Trial name
- NCT01923857
- Testing
- Androxal 25 mg
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Secondary Hypogonadism
The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups
The study is designed to answer the following questions: 1. Is there any difference between the compositions of the HDL cholesterol subpopulations of patients with hypogonadism and the healthy controls. 2.
- Trial name
- NCT01454011
- Testing
- Testosteron 250mg injection, Testosterone 50mg transdermal application
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine