Clinical trials: Hypogonadism, Male
Hypogonadism, Benign Prostatic Hyperplasia
TRADE-Testosterone Replacement and Dutasteride Effectiveness
The purpose of this research study is to determine whether the combination of the male hormone testosterone [T] in gel form and the oral drug dutasteride [D], used to shrink large prostate glands can safely reduce the size of the…
- Trial name
- TRADE (NCT00194675)
- Testing
- Dutasteride, Testosterone gel
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Steroidogenesis, Klinefelter Syndrome
Human Chorionic Gonadotropin Stimulation Effects on Steroidogenesis in Men With Klinefelter Syndrome
The study design included six visits. During the first visit (visit 0), the subjects underwent physical examination(height, weight, body mass index (BMI), arm span, and upper segment measurement) and testicular ultrasound (US)…
- Conditions
- Steroidogenesis, Klinefelter Syndrome, Human Chorionic Gonadotropin (hCG) Stimulation
- Trial name
- NCT02788136
- Testing
- human chorionic gonadotropin
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Azienda USL Modena
Hypogonadism, Male
Vogelxo(R) ABPM Study in Hypogandal Men
A Phase 4 ABPM study in Hypogonadal Men
- Trial name
- NCT04558567
- Testing
- Vogelxo
- Where
- 7 sites in United States
- Volunteers
- 122 people
- Sponsor
- Upsher-Smith Laboratories
Delayed Puberty, Male Hypogonadism
Testosterone Undecanoate Replacement Therapy in Boys With Pubertal Delay or Confirmed Hypogonadism
The absence of clinical signs of pubertal maturation, i.e. pubertal delay, is a relatively frequent reason for consultation in boys.
- Trial name
- NCT05541172
- Testing
- Testosterone Undecanoate
- Where
- Argentina
- Volunteers
- 27 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Hypogonadism, Hypogonadotropic
Hypogonadotropic Hypogonadism in Obese Young Males
Obesity can lead to low testosterone concentrations in young men. This study will study the effects of low testosterone in those men and the result of treating them with clomiphene.
- Trial name
- NCT03245827
- Testing
- Clomiphene
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sandeep Singh Dhindsa, M.D., F.A.C.E
Endocrinology, Disorders of Sexual Development
Retrospective Analysis of the Neonatal Management of Patients with an Antenatal Diagnosis of Genital Development Variation At the Hospital of Lyon
Variations in genital development (VDG) account for 0.5% to 1% of births. Advances in ultrasound techniques, as well as in prenatal diagnosis techniques, particularly in genetics, have led to improvements in the prenatal…
- Conditions
- Endocrinology, Disorders of Sexual Development, Prenatal Diagnosis, Psychology
- Trial name
- PECAN-VDG (NCT06687252)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Hospices Civils de Lyon
Klinefelter Syndrome, Infertility, Male
Unraveling the Klinefelter's Disease Physiopathology
Organoid Model to unravel Klinefelter Syndrome infertility Klinefelter Syndrome (KS) is characterized by the presence of an extra chromosome X in male (47,XXY), it is the most frequent genetic cause of azoospermia in adult men.
- Trial name
- KLINEFELTER (NCT05997706)
- Testing
- Testicular biopsy
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hypogonadism, Male, Metabolic Syndrome
Physical Exercise as a Sustainability Tool in Men With Dysmetabolic Hypogonadism
Aim of this project is to delineate sustainable physical exercise programs and to assess the effects of such programs mainly on endocrine-metabolic and neurovegetative outcomes in a cohort of men with metabolic syndrome-related…
- Conditions
- Hypogonadism, Male, Metabolic Syndrome, Autonomic Imbalance, Life Style, Healthy
- Trial name
- ExLOH (NCT06094036)
- Testing
- Structured and personalized program of physical exercise
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Istituto Auxologico Italiano
Male Hypogonadism
Time to Eugonadal Range, Time to Steady State and Drying Time
This is a multicenter, open-label, single arm trial to evaluate the time to eugonadal testosterone range after initial testosterone gel 2% application, time to steady state after after initiation of testosterone gel 2%, and…
- Trial name
- NCT01228071
- Testing
- testosterone gel 2%
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Hypogonadism, Erectile Dysfunction
Efficacy and Safety Evaluating Fispemifene in the Treatment of Hypogonadal Men With Erectile Dysfunction Unresponsive to PDE5 Inhibitors
The objective of the study is to assess and compare the preliminary efficacy, safety and tolerability of fispemifene 300 mg and placebo given once daily for 8 weeks in the treatment of hypogonadal men with erectile dysfunction…
- Trial name
- NCT00415571
- Testing
- Fispemifene (once daily for 8 weeks)
- Where
- 14 sites in United States
- Volunteers
- 72 people
- Sponsor
- QuatRx Pharmaceuticals Company
Craniopharyngioma, Hypothalamic Obesity
Intranasal Oxytocin in Hypothalamic Obesity
This research study will test if oxytocin, delivered by nasal spray, will promote weight loss in children, adolescents, and adults with Hypothalamic Obesity as compared to a placebo. The study is divided into two parts.
- Trial name
- NCT02849743
- Testing
- Syntocinon
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Shana McCormack, MD
Down Syndrome (Trisomy 21), Edward's Syndrome (Trisomy 18)
Non-Invasive Determination of Fetal Chromosome Abnormalities
The overall significance of this study is to develop a laboratory developed test (LDT) to use a new marker in the maternal blood to better identify pregnancies that have a child with a chromosome abnormality such as Down syndrome…
- Conditions
- Down Syndrome (Trisomy 21), Edward's Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Klinefelter Syndrome (47, XXY)
- Trial name
- NCT00891852
- Where
- 7 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Lenetix Medical Screening Laboratory
Male Hypogonadism
Study to Compare DITEST to Testosterone Undecanoate in Adult Men With Hypogonadism
DITEST is an oral formulation of native testosterone for the treatment of androgen deficiency in men. The study was a Phase 1 clinical study in hypogonadal men, defined according to FDA and Endocrine Society Guidelines, designed…
- Trial name
- NCT02966652
- Testing
- DITEST, Testosterone undecanoate
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Neurocrine UK Limited
Contraception, Hypogonadism
ORAL T-6: Oral Androgens in Man-6
We propose a study to determine the single-dose pharmacokinetics of these two novel formulations of testosterone in normal men with experimentally induced hypogonadism.
- Trial name
- ORAL-T-6 (NCT00663793)
- Testing
- Acyline, Testosterone, Finasteride
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form
A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
This is a sub-study of Study RM-493-040 (NCT05774756). The goal of this sub-study is to learn how well Setmelanotide works to improve weight reduction, hunger, and quality of life in patients 4 years of age and older with…
- Conditions
- Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form, Septo-Optic Dysplasia, Optic Nerve Hypoplasia
- Trial name
- NCT06760546
- Testing
- Setmelanotide
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 39 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Hypogonadism, Male
Anastrazole and Clomiphene to Evaluate Hypogonadal Symptoms and Erectile Function
This study evaluates anastrazole and clomiphene in the improvement in hypogonadal symptoms and erectile function. Each subject will receive Anastrazole 1 mg/day, clomiphene 25 mg/day and placebo in randomized schedule of 8 week…
- Trial name
- CAP (NCT03933618)
- Testing
- Anastrozole 1mg, Clomiphene Citrate 25mg
- Volunteers
- 24 people
- Sponsor
- Albany Medical College
Hypogonadism, Erectile Dysfunction
The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction
The purpose of this study is to evaluate the response of a treatment with testosterone undecanoate and determine the levels of total and free testosterone in hypogonadal patients with erectile dysfunction.
- Trial name
- NCT00421460
- Testing
- Testosterone Undecanoate,1000mg
- Where
- 3 sites in Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Non-obstructive Azoospermia, Hormone Deficiency
Sperm Retrieval Rates in Non-obstructive Azoospermic Men Subjected to Gonadotropin Therapy
Azoospermia is defined as the complete absence of spermatozoa in the ejaculate. Two-thirds of azoospermic patients have non-obstructive azoospermia (NOA); the latter comprises up to 10% of infertile men overall.
- Conditions
- Non-obstructive Azoospermia, Hormone Deficiency, Hypogonadism, Male, Male Infertility
- Trial name
- NCT05110391
- Testing
- Hormonal Therapy Agent
- Where
- Brazil
- Volunteers
- 616 people
- Sponsor
- ANDROFERT - Clinica de Andrologia e Reproducao Humana
Male Hypogonadism, Testosterone Deficiency
Clinical Evaluation of Subcutaneous Testosterone Implants in Men With Symptomatic Hypogonadism
Introduction: Male hypogonadism is a clinical syndrome associated with significant consequences for health and quality of life. In Brazil, approved testosterone replacement therapy options are limited to injectable formulations…
- Conditions
- Male Hypogonadism, Testosterone Deficiency, Testosterone Replacement Therapy, Testosterone
- Trial name
- NCT07500766
- Testing
- Subcutaneous Testosterone Implants
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Hypogonadism
A Study of Fortigel Testosterone Gel 2% in Males With Low Testosterone
Low testosterone is a condition that occurs when the body is unable to produce sufficient quantities of testosterone. The medical name for low testosterone is hypogonadism. Hypogonadism can be caused by many factors.
- Trial name
- NCT00522431
- Testing
- Testosterone
- Volunteers
- 149 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company