Clinical trials: Hypogonadism, Male
Hypogonadism, Male, End Stage Renal Disease (ESRD)
TRT as an Adjunctive ERAS Therapy in ESRD Patients Undergoing Kidney Transplantation
This prospective study aims to evaluate the safety and efficacy of testosterone replacement therapy (TRT) as an adjunct to an enhanced recover after surgery (ERAS) protocol in men with end-stage renal disease (ESRD) undergoing…
- Conditions
- Hypogonadism, Male, End Stage Renal Disease (ESRD), Kidney Transplant
- Trial name
- NCT07287800
- Testing
- Testosterone Replacement Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Los Angeles
Klinefelter Syndrome (47, XXY), Sex Chromosome Aneuploidy
Clinical, Biochemical, and Cytogenetic Heterogeneity in Mosaic 46,XX/47,XXY Sex Chromosome Aneuploidy
Mosaic sex chromosome aneuploidy 47,XXY/46,XX is an exceptionally rare variant within the spectrum of Klinefelter syndrome. Available data remain limited, especially regarding adult phenotype and long-term characteristics, and no…
- Conditions
- Klinefelter Syndrome (47, XXY), Sex Chromosome Aneuploidy, Disorders of Sex Development (DSD), Sex Chromosome Disorders
- Trial name
- MOSAI-XX (NCT07885163)
- Where
- France
- Volunteers
- 257 people
- Sponsor
- Université Paris-Saclay
Hypogonadism
Pilot Pharmacokinetic Study of Oral Testosterone Ester Formulations in Hypogonadal Men
Determine the serum pharmacokinetic profile for two oral formulations of T-esters (one TE and one TU) administered once -(QD) and twice-daily (BID) to hypogonadal men.
- Trial name
- NCT02697188
- Testing
- Testosterone undecanoate, Testosterone enanthate
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Clarus Therapeutics, Inc.
Hypogonadism, Male, Infertility, Male
The Effects of Natesto For Treatment Of Hypogonadism
In this prospective study, the investigators plan is to confirm the role of Natesto (intranasal testosterone) to combat hypogonadal symptoms in men trying to recover spermatogenesis following the withdrawal of conventional…
- Conditions
- Hypogonadism, Male, Infertility, Male, Testosterone Deficiency
- Trial name
- NCT04717362
- Testing
- Natesto Nasal Product
- Sponsor
- Baylor College of Medicine
Hypogonadism
Assessment of Long Term Treatment With Testosterone Undecanoate in Males With Hypogonadism
This study will evaluate the preparation of testosterone undecanoate under conditions which resemble real-life situations.
- Trial name
- NCT00220298
- Testing
- Testosterone undecanoate (TU) - NebidoTM
- Where
- 14 sites in Germany
- Volunteers
- 96 people
- Sponsor
- Bayer
Hypogonadotropism
A Dose Ranging Study to Examine TDS-Testosterone 5%
This study is a continuation of previous studies done in healthy volunteers to prove the efficacy of delivering Testosterone, the male hormone, rapidly across intact skin in s series of doses from low to high in men with…
- Trial name
- PARC-T-D (NCT01894308)
- Testing
- Testosterone, Pump Sprayer
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Transdermal Delivery Solutions Corp
Hypogonadism
Testosterone Replacement Therapy Decreases Plasma Paraoxonase 1 Enzyme Activity In Male Patients With Hypogonadism
The purpose of this study is investigating the effect of testosterone treatment on paraoxonase level in male patients with hypogonadotrophic hypogonadism
- Trial name
- NCT01107067
- Testing
- Sustanon
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Gulhane School of Medicine
Isolated Hypogonadotropic Hypogonadism, Kallmann Syndrome
Efficacy and Safety of Long Term Use of hCG or hCG Plus hMG in Males With Isolated Hypogonadotropic Hypogonadism (IHH)
This study will evaluate the efficacy and safety of long term use of hCG alone or hCG plus hMG in the treatment of male patients with isolated hypogonadotropic hypogonadism (IHH).
- Conditions
- Isolated Hypogonadotropic Hypogonadism, Kallmann Syndrome, Infertility
- Trial name
- IHH (NCT03687606)
- Testing
- Human Chorionic Gonadotropin, human menopausal gonadotropin
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Tongji Hospital
Hypogonadism, Metabolic Syndrome
Testosterone Replacement in Metabolic Syndrome and Inflammation
Hypogonadism (HG) frequently complicates the Metabolic Syndrome (MetS), whether testosterone replacement (TRT) is beneficial has not been clearly ascertained.
- Conditions
- Hypogonadism, Metabolic Syndrome, Obesity, Erectile Dysfunction
- Trial name
- TERMSINFAT (NCT01123278)
- Testing
- Testosterone
- Where
- 2 sites in Italy
- Volunteers
- 82 people
- Sponsor
- University of Roma La Sapienza
Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism
Growing up With the Young Endocrine Support System (YESS!)
Transition from paediatric to adult endocrinology is a challenge for adolescents, families and doctors. Up to 25% of young adults with chronic endocrine disorders are lost to follow-up ('drop-out') once the young adult moves out…
- Conditions
- Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism, Growth Hormone Deficiency, Combined Pituitary Hormone Deficiency
- Trial name
- YESS (NCT04252001)
- Testing
- YESS! game, Snake '97, Transition-toolkit
- Where
- 7 sites in Belgium, Netherlands and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)
The investigators are doing this research study to look at the relationship between testosterone (the main sex hormone in men) and insulin (the hormone that controls blood sugar levels) in men with Idiopathic Hypogonadotropic…
- Trial name
- NCT03118479
- Testing
- Anastrozole Pill, Testosterone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Sex Chromosome Abnormality, Klinefelter Syndrome
Endocrine, Metabolic, Cardiovascular and Immunological Aspects of Sex Chromosome Abnormalities in Relation to Genotype
Observational study of 160 patients with sex-chromosome abnormalities and 160 matched controls. Blood, fat, muscle, skin, buccal swaps, urine will be collected and analyzed for DNA, RNA and methylation patterns.
- Conditions
- Sex Chromosome Abnormality, Klinefelter Syndrome, Turner Syndrome, Metabolic Disease
- Trial name
- EMKISCA (NCT05425953)
- Testing
- No intervention other than obtaining biopsies
- Where
- Denmark
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Opiate Dependence, Osteoporosis
Bone Density and Serum Testosterone in Male Methadone Maintained Patients
This is a pilot study designed to answer the question " Do men who are receiving methadone maintenance therapy have lower spinal bone densities compared with age-matched controls who are not receiving methadone therapy?" The…
- Conditions
- Opiate Dependence, Osteoporosis, Erectile Dysfunction, Hypogonadism
- Trial name
- NCT00170339
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hennepin Healthcare Research Institute
Hypogonadism
Gonadal Dysfunction in Male Long-term Survivors of Malignant Lymphoma; Vitality-Obs
This study is an observational cross-sectional study which aims to investigate the relationship between treatment with chemotherapy and the development of low levels of testosterone in the blood in patients cured for aggressive…
- Trial name
- NCT04630275
- Where
- 3 sites in Denmark
- Volunteers
- 172 people
- Sponsor
- Lars Møller Pedersen
Non Obstructive Azoospermia, Hypogonadism
Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism
Hypothesis: Prescribed clomiphene citrate to azoospermic patients with hypoandrogenism could improve the sperm retrieval in either fresh sperm or after surgical sperm extraction.
- Trial name
- NCT02137265
- Testing
- Clomiphene
- Where
- Spain
- Sponsor
- University of Illinois Chicago
Klinefelter Syndrome, Hypergonadotropic Hypogonadism
Androgen for Leydig Cell Proliferation
Patients with infertility often presents alterations at ultrasonographic examination of the testis. These alterations include a much higher incidence of small, multiple, non-palpable hypoechoic micro-nodules that can show…
- Conditions
- Klinefelter Syndrome, Hypergonadotropic Hypogonadism, Hypergonadotropic Azospermia, Hypergonadotropic Cryptozoospermia
- Trial name
- ALCeP (NCT01206270)
- Testing
- Testosterone undecanoate, Castor Oil
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Roma La Sapienza
Male Hypogonadism, Primary Hypogonadism
Pharmacokinetic Study to Determine Time to Steady-state
The purpose of the study is to confirm how long (i.e., how many days) it takes to reach steady-state when testosterone undecanoate is administered twice daily.
- Conditions
- Male Hypogonadism, Primary Hypogonadism, Secondary Hypogonadism
- Trial name
- NCT00911586
- Testing
- Testosterone undecanoate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Clarus Therapeutics, Inc.
Hypogonadism, Male
Calciotropic Effects After HCG Stimulation Test
We have in a pilot study found that serum calcium levels change in response to hCG stimulation test. We observed that serum calcium level measured at baseline and 72 hours after hCG stimulation were different in men with gonadal…
- Trial name
- NCT03254641
- Testing
- human chorionic gonadotropin
- Where
- 2 sites in Denmark
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Martin Blomberg Jensen
Hypogonadism
Safety of Subcutaneous Testosterone Enanthate in Adult Male Hypogonadism
Evaluation of the safety and tolerability of testosterone enanthate (TE) following a single dose via QuickShot® Testosterone (QST) when administered by intended users in a usability study.
- Trial name
- NCT02777242
- Testing
- Testosterone enanthate auto-injector
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Antares Pharma Inc.
Erectile Dysfunction, Hypogonadism, Male
EndoPAT Device for Endothelial Dysfunction in ED
To assess endothelial dysfunction in young men (aged 30-50) with vasculogenic ED identified through penile Doppler ultrasound. To evaluate changes in endothelial function using EndoPAT before and 3-6 months after daily low-dose…
- Conditions
- Erectile Dysfunction, Hypogonadism, Male, Endothelial Dysfunction
- Trial name
- NCT06720597
- Testing
- Daily low-dose PDE5 inhibitor therapy, Testosterone therapy as per clinical guidelines.
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine