Clinical trials: Hypogonadism, Male, open to volunteers
Hypogonadism, Male, Secondary Hypogonadism
AIM-TEST: Microbiome-Targeted Nutrition for Functional Secondary Hypogonadism
AIM-TEST is a randomized, double-blind, placebo-controlled clinical trial evaluating whether an AI-guided, microbiome-targeted nutritional intervention can increase the body's own testosterone production in men aged 30-65 years…
- Trial name
- AIM-TEST (NCT07761546)
- Testing
- Fixed-Formula Microbiome-Targeted Oral Nutritional Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Varol TUNALI
Testosterone Deficiency, Male Hypogonadism
Anthropometric, Functional and Lifestyle Factors Associated With Testosterone Levels in Middle-Aged Men
Decreased testosterone levels in middle-aged men are associated with multiple metabolic, functional and psychosocial consequences.
- Trial name
- TESMEN (NCT07476222)
- Testing
- Observational Assessment
- Where
- Uzbekistan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Andijan State Medical Institute
Hypogonadism, Male, Endocrine Disease
Anticipated Stigma, Illness Identity, and Quality of Life in Male Hypogonadism
This study aims to systematically compare the levels of anticipated illness stigma and illness identity among men diagnosed with hypogonadism to those of men with other chronic endocrine conditions (e.g., diabetes mellitus…
- Conditions
- Hypogonadism, Male, Endocrine Disease, Hypertension
- Trial name
- NCT07752511
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial
Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life.
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Injuries, Spinal Cord, Spinal Cord Contusion
- Trial name
- TRT-SCI (NCT07742553)
- Testing
- testosterone cypionate, finasteride
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Opioid Use, Pain
Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic…
- Conditions
- Opioid Use, Pain, Hypogonadism, Male
- Trial name
- PATH (NCT04798469)
- Testing
- Testosterone Undecanoate 250 MG/ML
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Testicular Cancer, Survivorship
Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
- Conditions
- Testicular Cancer, Survivorship, ASCVD, Coronary Artery Disease
- Trial name
- NCT05611307
- Testing
- Lipid profile, Coronary artery assessment, Hormone levels for hypogonadism
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Prostate Cancer, Hypogonadism, Male
Testosterone Replacement Therapy in Hypogonadal Patients With Prostate Cancer Under Active Surveillance
The purpose of this study is evaluate the safety of testosterone replacement therapy in men with newly diagnosed low-risk prostate cancer and hypogonadism on active surveillance.
- Trial name
- NCT07278362
- Testing
- Testosterone cypionate
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Miami
Erectile Disfunction, Hypogonadal Males
Assessment of Effectiveness of Pelvic Floor Muscle Training With Biofeedback in Male With Hypogonadism and Erectile Dysfunction
The goal of this clinical trial is to learn if Pelvic Floor Muscle Training (PFMT) with biofeedback works to treat Erectile Disorders (ED) in males with Functional Hipogonadism. The main hypothesis is: 1.
- Conditions
- Erectile Disfunction, Hypogonadal Males, Functional Hypogonadism, Pelvic Floor Muscle Exercise
- Trial name
- NCT07687173
- Testing
- Training with handheld biofeedback device, Pelvic Floor Muscle Training (PFMT)
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Poznan University of Physical Education
Hypogonadism, Male, Fatigue Syndrome, Chronic
Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone
The overall goal of this study is to evaluate the effect of a testosterone drug called Depo-Testosterone (or 'testosterone cypionate'), an FDA-approved drug for improving fatigue, sexual function, quality of life, body…
- Trial name
- NCT04049331
- Testing
- Testosterone Undecanoate 750 MG/3 ML Intramuscular Solution [AVEED]
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Frail Elderly Patients, Hypogonadal Males
Effect of Testosterone on Elderly Frail Men With Testosterone Deficiency
The purpose of this study is to increase the functional level of the elderly to thereby reduce fall risk, improve motor skills, and increase psychological well-being, as well as to assess whether the restoration of a normal…
- Conditions
- Frail Elderly Patients, Hypogonadal Males, Testosterone Replacement Therapy, Falls (Accidents) in Old Age
- Trial name
- NCT07512323
- Testing
- Nebido (Testosterone Undecanoate)
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Rune Skovgaard Rasmussen
Hypogonadism, Male, Kidney Disease, Chronic
Testosterone Treatment in Men With Chronic Kidney Disease
This study in being conducted in men who have low testosterone and chronic kidney disease. The investigators will evaluate the effects of an oral testosterone preparation, JATENZO, on testosterone levels and hemoglobin (red blood…
- Trial name
- NCT05249634
- Testing
- Jatenzo Pill
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Louis University
Psychological Experience in Fertility Treatment, Hypogonadism
Male Experiences With Intra Cytoplasmic Sperm Injection (ICSI) and Reduced Sperm Quality
Several international studies indicate that men with reduced semen quality often feel overlooked in the context of fertility treatment.
- Conditions
- Psychological Experience in Fertility Treatment, Hypogonadism, Testosteron Levels, Quality of Life
- Trial name
- NCT07546435
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peter Humaidan
APHRODITE Group
Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructive
The goal of this clinical trial is to determine whether short-term gonadotropin therapy (hCG + FSH) can increase sperm availability for ICSI in men with idiopathic non-obstructive azoospermia (NOA) and hypogonadism.
- Trial name
- GTIHNO (NCT07540611)
- Testing
- No intervention, hCG + FSH therapy
- Where
- 8 sites in India
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
Varicocele, Male Infertility
Intratesticular Artery Resistive Index Changes After Varicocelectomy
This study aims to evaluate how blood flow inside the testicles changes after surgery to correct a varicocele, and whether these changes correlate with improvements in semen quality and testosterone levels.
- Conditions
- Varicocele, Male Infertility, Secondary Hypogonadism
- Trial name
- NCT07517952
- Testing
- Microscopic Sub-inguinal Varicocelectomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Male Hypogonadism, Testosterone Deficiency
Clinical Evaluation of Subcutaneous Testosterone Implants in Men With Symptomatic Hypogonadism
Introduction: Male hypogonadism is a clinical syndrome associated with significant consequences for health and quality of life. In Brazil, approved testosterone replacement therapy options are limited to injectable formulations…
- Conditions
- Male Hypogonadism, Testosterone Deficiency, Testosterone Replacement Therapy, Testosterone
- Trial name
- NCT07500766
- Testing
- Subcutaneous Testosterone Implants
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Hypogonadism, Male
52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism
This is a 52-week open label single arm study + 24-Month long-term safety extension to investigate the effects of XYOSTED, as testosterone replacement therapy, on adolescent males with either primary or secondary hypogonadism.
- Trial name
- NCT06689085
- Testing
- Testosterone enanthate
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Halozyme Therapeutics
Erectile Dysfunction, Hypogonadism, Male
EndoPAT Device for Endothelial Dysfunction in ED
To assess endothelial dysfunction in young men (aged 30-50) with vasculogenic ED identified through penile Doppler ultrasound. To evaluate changes in endothelial function using EndoPAT before and 3-6 months after daily low-dose…
- Conditions
- Erectile Dysfunction, Hypogonadism, Male, Endothelial Dysfunction
- Trial name
- NCT06720597
- Testing
- Daily low-dose PDE5 inhibitor therapy, Testosterone therapy as per clinical guidelines.
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Hypogonadism, Male
Ambulatory Blood Pressure Monitoring (ABPM) Study in Hypogonadal Men
A Phase 4, multi-center, open-label, single-arm 24-hour Ambulatory Blood Pressure Monitoring (ABPM) study of Testosterone Cypionate Injection in Hypogonadal Men to assess change in 24-hour ambulatory blood pressure from Baseline…
- Trial name
- NCT07328542
- Testing
- Testosterone Cypionate Injection 200 mg/mL
- Where
- 6 sites in United States
- Volunteers
- 144 people
- Sponsor
- Azurity Pharmaceuticals
Spinal Cord Injury, Spinal Cord Injuries
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injury
- Trial name
- NCT04460872
- Testing
- Testosterone Enanthate, Locomotor Training
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- North Florida Foundation for Research and Education
Gonadal Dysfunction, Gonadal Failure
Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes
This study investigates the safety and efficacy of stem cell or stem cell-derived exosome therapy for gonadal failure, including testicular failure, hypogonadism, ovarian insufficiency, and premature ovarian failure (POF).
- Conditions
- Gonadal Dysfunction, Gonadal Failure, Azoospermia, Testosterone Deficiency
- Trial name
- FERTILE (NCT06841328)
- Testing
- Stem cells
- Where
- United Arab Emirates
- Volunteers
- 60 people
- Sponsor
- Jumeirah American Clinic