Clinical trials: Hyponatraemia
CHRONIC HYPONATREMIA
Phase 2a Study for PK/PD of nC-001
CHRONIC EUVOLEMIC HYPONATREMIA
- Trial name
- NCT06798675
- Testing
- nC-001
- Volunteers
- 24 people
- Sponsor
- nephCentric
Exercise-associated Hyponatremia
The Efficacy of Oral Versus Intravenous Hypertonic Saline Administration in Runners With Exercise-Associated Hyponatremia
The purpose of the study is to 1) evaluate incidence and primary cause of exercise-associated Hyponatremia (EAH) in race finishers participating in the Western States 100-mile Endurance Run, 2) determine if the ingestion of oral…
- Trial name
- NCT01110655
- Testing
- Intravenous hypertonic Saline, Oral hypertonic saline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western States Endurance Run Research Foundation
Hyponatremia
A Trial of Tolvaptan in Children and Adolescent Subjects With Euvolemic and Hypervolemic Hyponatremia
The purpose of this trial is to demonstrate that tolvaptan effectively and safely increases and maintains serum sodium concentrations in children and adolescent subjects with euvolemic or hypervolemic hyponatremia.
- Trial name
- NCT02442674
- Testing
- Tolvaptan
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Inappropriate ADH Syndrome, Hyponatremia
Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion
To assess the efficacy of SR121463B in correcting hyponatremia in patients with syndrome of inappropriate antidiuretic secretion (SIADH).To assess the long-term efficacy of SR121463B in maintaining normal levels of serum sodium…
- Trial name
- SIADH (NCT00264927)
- Testing
- SR121463B
- Where
- 11 sites in United States, Belgium and 9 more
- Volunteers
- 77 people
- Sponsor
- Sanofi
Hyponatremia, SIADH
The Clinical and Laboratory Characteristics of Recurrent Drug- Related Hyponatremia
The aim of this study is to identify factors associated with hyponatremia among patients hospitalized in the internal medicine ward. Consequtive patients hospitalized because of hyponatremia will be recruited.
- Trial name
- 0597-10-HMO (NCT01509170)
- Where
- 2 sites in Israel
- Volunteers
- 500 people
- Sponsor
- Hadassah Medical Organization
Hyponatremia
Reexamining Hypotonic Intravenous Fluid Use
The study aim is to isolate a single type of patient (pediatric patient with acute gastrointestinal symptoms) and evaluate the use of hypotonic (0.45 NS) vs.
- Trial name
- NCT02667977
- Testing
- 0.9 Normal Saline, 0.45 Normal Saline
- Where
- United States
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Dehydration in Children, Fluid Therapy
Boluses of Ringer's in Surgical Kids (BRiSK Study)
Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar.
- Trial name
- BRiSK (NCT05285371)
- Testing
- Urinalysis (UA), Complete Metabolic Panel (CMP), Glucose Stick Test (d-Stick)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Hyponatremia, Water-Electrolyte Imbalance
Hyponatremia Volume Status Analysis by Point-of-care Ultrasound
This observational study aims to analyze the time of correction of hyponatremia in patients within an internal medicine ward. The researchers will assess volume status using both clinical evaluation and point-of-care ultrasound.
- Trial name
- Vostaus (NCT06013800)
- Testing
- Measurement of sodium levels
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Veracruzana
Hyponatremia Symptomatic, Osmotic Demyelination Syndrome
International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia
Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l.
- Conditions
- Hyponatremia Symptomatic, Osmotic Demyelination Syndrome, Cerebral Edema
- Trial name
- PRONATREOUS (NCT07576036)
- Testing
- Hypertonic 3% saline
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Rochester General Hospital
Cerebral Hyponatremia, SIADH
Fractional Urate Excretion in Nonedematous Hyponatremia
Hyponatremia, defined as a serum sodium < 135 mmol/l, in patients without edema has undergone significant changes where it is now evident that even mild hyponatremia should be treated because of its association with symptoms…
- Conditions
- Cerebral Hyponatremia, SIADH, Cerebral Salt-wasting Syndrome, Reset Hypothalamic Osmostat
- Trial name
- NCT01425125
- Testing
- Tolvaptan in euvolemic hyponatremia
- Where
- United States
- Sponsor
- NYU Langone Health
Syndrome of Inappropriate ADH (SIADH) Secretion, Hyponatremia
Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion
The study is designed to assess the efficacy of an investigational drug called SR121463B (vasopressin receptor antagonist) in the treatment of low levels of sodium in the blood associated with the Syndrome of Inappropriate…
- Trial name
- NCT00032734
- Testing
- satavaptan (SR121463B)
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 35 people
- Sponsor
- Sanofi
Healthy Volunteers
Adaptation of Thirst to a Single Administration of Tolvaptan (TOLVATHIRST)
Tolvaptan is a new drug that specifically antagonizes the V2-receptor of antidiuretic hormone (ADH) and leads to water diuresis: During acute administration of tolvaptan, the main fear is to induce a too fast increase in plasma…
- Trial name
- TOLVATHIRST (NCT03931369)
- Testing
- Tolvaptan 15 MG
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
SIADH, Non-SIADH Hyponatremia
Post-Authorisation Safety Study of Samsca (Tolvaptan) Used in Routine Medical Practice
A Drug Utilisation Survey is performed to monitor and document the drug utilisation patterns of Samsca in routine medical practice.
- Conditions
- SIADH, Non-SIADH Hyponatremia, Non-Hyponatremia
- Trial name
- NCT01228682
- Testing
- Tolvaptan
- Where
- 47 sites in Denmark, Germany and 5 more
- Volunteers
- 200 people
- Sponsor
- Otsuka Frankfurt Research Institute GmbH
Coronary Artery Disease, Hyponatremia
Hyponatremia and Hypoalbuminemia is Morbimortality Predictors in Coronary Artery Bypass Graft Surgery
Coronary artery disease is a common medical disease in many populations. The pathogenesis of this disease is very complex. Surgery is one of the treatment choices. Assessing the risk factors will improve the surgical outcome.
- Conditions
- Coronary Artery Disease, Hyponatremia, Hypoalbuminemia
- Trial name
- NCT02765061
- Volunteers
- 1,157 people
- Sponsor
- Ankara University
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
An Observational Study to Describe the Adherence to the SEOM Algorithm for the Treatment of Hyponatraemia in Spain
In 2014, the Spanish Sociedad Española de Oncología Médica (SEOM) algorithm for the treatment of hyponatraemia secondary to to syndrome of inappropriate antidiuretic hormone (SIADH) in oncology patients was developed.
- Trial name
- ALGA (NCT02548845)
- Where
- 4 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Otsuka Pharmaceutical Europe Ltd
Thiazide Diuretics Induced Hyponatremia
Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia
The purpose of this study is to detect if there are any differences in the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without…
- Trial name
- NCT01346891
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Italiano de Buenos Aires
Liver Disease, Hyponatremia
Study to Compare Conivaptan in Subjects With Mild & Moderate Liver Impairment Versus Subjects With Normal Liver Function
A study to compare a 48-hour continuous infusion of conivaptan in subjects with mild and moderate liver impairment versus subjects with normal liver function
- Trial name
- NCT00851227
- Testing
- conivaptan hydrochloride
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cumberland Pharmaceuticals
Hyponatremia, Hyponatremic
Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery)
Hyponatremia is defined as sodium below the normal range of 135-145. Symptomatically, it can cause patients to experience a wide range of symptoms including lethargy, headache, nausea, vomiting and in severe cases coma and even…
- Conditions
- Hyponatremia, Hyponatremic, Pituitary Tumor, Pituitary
- Trial name
- DHAPS (NCT03636568)
- Testing
- Fluid Restricted Group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Syndrome of Inappropriate Antidiuretic Hormone Secretion
A Multicenter Trial to Investigate the Efficacy and Safety of Tolvaptan in Patients With Hyponatremia in SIADH
The objective of this study is to investigate the efficacy and safety of tolvaptan based on the change in serum sodium concentration following administration of tolvaptan oral tablets at 7.5 to 60 mg/day for up to 30 days in…
- Trial name
- NCT03048747
- Testing
- Tolvaptan Oral Tablet
- Where
- 6 sites in Japan
- Volunteers
- 16 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Hyponatremia, Subarachnoid Hemorrhage
Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage
Hyponatremia is defined as a plasma sodium concentration below 135 mmol / L. This is a common occurrence (20-50%) during subarachnoid hemorrhage (SAH). Its appearance is often associated with vasospasm.
- Conditions
- Hyponatremia, Subarachnoid Hemorrhage, SIADH
- Trial name
- NAT-URE (NCT04552873)
- Testing
- Urea
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Grenoble