Clinical trials: Hyponatremia
Hyponatremia
Factors Associated With Hyponatremia Induced by High-dose Cyclophosphamide
Prospoctive cohort of high-dose cyclophosphamide exposed patients. With active estandardize screening of hyponatremia development in the follow up period.
- Trial name
- NCT02399358
- Where
- Argentina
- Volunteers
- 200 people
- Sponsor
- Diego Hernan Giunta, MD
The Patients Suffered With Sellar Diseases, The Fluid and Electrolyte Imbalance Happened After Surgery
Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy
The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions.
- Trial name
- NCT01406041
- Testing
- Chemical and physical detection
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Southern Medical University, China
SIAD - Syndrome of Inappropriate Antidiuresis, Hyponatremia
Water Load Test Value for Hyponatremia
Acute water load test has been using to diagnose renal ability to excrete water for decades. Latest recommendations for the diagnosis of hyponatremia do not recommend performing such a test.
- Trial name
- WATERLINE (NCT04256499)
- Testing
- Acute water load test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- European Georges Pompidou Hospital
Acute Hyponatremia
Bipolar Versus Monopolar Resection of Benign Prostate Hyperplasia
Aim of this prospective clinical study was to compare two different surgical techniques and used solutions on serum electrolytes, bleeding and Transurethral Resection of Prostate (TURP) syndrome undergoing TURP.
- Trial name
- NCT02681471
- Testing
- 5% Mannitol, 0,9% Sodium chloride, monopolar resectoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University
Carcinoma
Impact of Peri-Operative Hyponatremia on Postoperative Outcomes in Major HPB Surgeries for Cancers
The present study is being designed to study the impact and predictive nature of perioperative hyponatremia on post operative outcomes in patients undergoing Major HPB surgeries for cancers.
- Trial name
- NCT06475911
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hyponatremia
International, Multicenter, Study of One-year, Open-label, Titrated Oral Tolvaptan Tablet Administration in Patients With Chronic Hyponatremia
This study will assess the safety of long-term tolvaptan use in patients previously enrolled in shorter-term Phase 3 studies and gather information on the natural history of hyponatremia in the context of tolvaptan therapy and…
- Trial name
- NCT02449044
- Testing
- Tolvaptan
- Volunteers
- 111 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Hyponatremia, Hypernatremia
Frequency and Origin of Dysnatremias in the Emergency Department
Hypo- and hypernatremia are the most frequent electrolyte disorders found in hospitalized patients. The increasing use of diuretics and other medications influencing the water and sodium homeostasis potentially lead to a rise in…
- Trial name
- NCT01326429
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Non-hypervolemic Hyponatremia
Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial
To assess quantitatively the evolution over time of electrolyte-free water clearance and electrolyte mass balance in patients with non-hypervolemic hypotonic hyponatremia
- Trial name
- EvenT (NCT05692726)
- Testing
- Patients
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Hyponatremia, Inappropriate ADH Syndrome
Urea for Chronic Hyponatremia
This study is examining how a dietary supplement called urea can be used to treat low blood sodium level. Low blood sodium level is a common problem and some studies show that many patients with low blood sodium level suffer from…
- Trial name
- NCT04588207
- Testing
- Urea
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Helbert Rondon Berrios, MD, MS
Syndrome of Inappropriate Antidiuretic Hormone Secretion
A Multicenter Trial to Investigate the Efficacy and Safety of Tolvaptan in Patients With Hyponatremia in SIADH
The objective of this study is to investigate the efficacy and safety of tolvaptan based on the change in serum sodium concentration following administration of tolvaptan oral tablets at 7.5 to 60 mg/day for up to 30 days in…
- Trial name
- NCT03048747
- Testing
- Tolvaptan Oral Tablet
- Where
- 6 sites in Japan
- Volunteers
- 16 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Hyponatremia
Postoperative Hyponatremia - Are There Gender Differences?
The proposed study will focus on anesthesia and anesthesia-induced hypotension as a possible cause for postoperative fluid retention and hyponatremia, and investigate gender differences in this response.
- Trial name
- NCT00636857
- Testing
- Fluid administration, Perioperative fluid management based on Lean Body Mass
- Where
- 5 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Hyponatremia
Variation in Natremia Using Two Different Maintenance Intravenous Fluids in Postsurgical Hospitalized Children
The primary objective of this study is to compare the blood sodium level after 12 hours following the initiation of therapy with either 0.3% NaCl/dextrose 5% or 0.45% NaCl/dextrose 5%, in postsurgical hospitalized children…
- Trial name
- surgical-Na (NCT01251770)
- Testing
- 0.45% NaCl/dextrose 5%, 0.3% NaCl/dextrose 5%
- Where
- Argentina
- Volunteers
- 78 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Brain Injury, Hyponatremia
Pharmacokinetics and Clinical Response of Tolvaptan in Neurocritical Care Patients
To assess the pharmacokinetic profile of tolvaptan in critically ill acute brain injury patients and to secondarily evaluate the clinical response and safety of tolvaptan in acute brain injured patients
- Trial name
- NCT02215148
- Testing
- Tolvaptan
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of North Carolina, Chapel Hill
Hyponatremia
Effects of Oral Salt Supplementation on Physical Performance During a Half-ironman
Background: Ultradistance athletes frequently consume salt supplements during competitions to compensate the loss of electrolytes by sweating.
- Trial name
- SALTED (NCT02103491)
- Testing
- Salt administration
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Camilo Jose Cela University
SIADH, Non-SIADH Hyponatremia
Post-Authorisation Safety Study of Samsca (Tolvaptan) Used in Routine Medical Practice
A Drug Utilisation Survey is performed to monitor and document the drug utilisation patterns of Samsca in routine medical practice.
- Conditions
- SIADH, Non-SIADH Hyponatremia, Non-Hyponatremia
- Trial name
- NCT01228682
- Testing
- Tolvaptan
- Where
- 47 sites in Denmark, Germany and 5 more
- Volunteers
- 200 people
- Sponsor
- Otsuka Frankfurt Research Institute GmbH
Hyponatremia, Ascites
Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites
The purpose of the study is to investigate the efficacy and safety for the management of hyponatremia and ascites in patients with liver cirrhosis.
- Trial name
- TONIC (NCT01716611)
- Testing
- Tolvaptan
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Konkuk University Medical Center
Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:
Subarachnoid hemorrhage (SAH) occurs after rupture of cerebral aneurysms. Treatment of SAH focuses on avoiding medical complications including cerebral vasospasm, which may result in limited circulation to the brain.
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Hyponatremia
- Trial name
- HS3 (NCT02432157)
- Testing
- HTS 3%, Standard fluid management
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Hyponatremia, Subarachnoid Hemorrhage
Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage
Hyponatremia is defined as a plasma sodium concentration below 135 mmol / L. This is a common occurrence (20-50%) during subarachnoid hemorrhage (SAH). Its appearance is often associated with vasospasm.
- Conditions
- Hyponatremia, Subarachnoid Hemorrhage, SIADH
- Trial name
- NAT-URE (NCT04552873)
- Testing
- Urea
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Grenoble
Hyponatremia
Hyponatremia in the Elderly: Benefit From a Change in Drug Therapy?
Mild hyponatremia is the commonest electrolyte imbalance in the older population. Recently, association between hyponatremia and bone fractures in the ambulatory elderly has been shown.
- Trial name
- NATRIPHAR (NCT01212211)
- Testing
- change in drug therapy
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Caen
Hyponatremia
Establishment of an Algorithm for a Clinical Classfication of Hypoosmolar Hyponatremia
The prospective clinical diagnosis of hyponatremia is often very difficult- but requirement for an appropriate and riskless treatment of hyponatremia.
- Trial name
- CONA (NCT00541944)
- Where
- Germany
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg