Clinical trials: Hyponatremia, open to volunteers
Critical Care, Intensive Care, Fluid Accumulation
CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS
This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the…
- Conditions
- Critical Care, Intensive Care, Fluid Accumulation, Fluid and Electrolyte Imbalance, Critical Illness
- Trial name
- CRUSADERS (NCT07189091)
- Testing
- Glucose 5% for fluid creep, NaCl 0.9% (normal saline) for fluid creep, PlasmaLyte as maintenance fluid
- Where
- 4 sites in Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Antwerp
Hyponatremia
Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia
ICU patients with severe hyponatremia and a high risk of rapid SNa overcorrection.
- Trial name
- DASSOH (NCT06020495)
- Testing
- DDAVP, Standard hyponatremia treatment
- Where
- 15 sites in France
- Volunteers
- 260 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-hypervolemic Hyponatremia
Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial
To assess quantitatively the evolution over time of electrolyte-free water clearance and electrolyte mass balance in patients with non-hypervolemic hypotonic hyponatremia
- Trial name
- EvenT (NCT05692726)
- Testing
- Patients
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Cologne
SIAD - Syndrome of Inappropriate Antidiuresis
Urea for Treatment of Hyponatremia in Patients With SIAD Unresponsive to Fluid Restriction
Hyponatremia due to SIAD is frequently insufficiently corrected by fluid restriction alone, which remains the first-line therapy but is often poorly tolerated. Urea supplementation is recommended as second-line therapy.
- Trial name
- UREA-BIVA (NCT07528365)
- Testing
- urea
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Turin, Italy
Hyponatremia
Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges
Hyponatremia is the most common electrolyte disorder of all and can be observed in more than 30% of all patients in hospitals. Osmotic homeostasis of body fluids is essential for survival of all living creatures.
- Trial name
- RESERVE (NCT06408077)
- Testing
- Water administration, NaCl-Administration
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Cologne
Thiazide Associated Hyponatremia
Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics
This study is looking at two new parameters, aSID and ChU, to see if these can help physicians to distinguish between different causes of low sodium levels (hyponatremia) in Patients taking a medicament against high blood…
- Trial name
- NCT06381934
- Testing
- Standard Care, aSID/ChU Guided Therapy
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- University Hospital, Basel, Switzerland
Subarachnoid Hemorrhage (SAH)
Interest of Impedancemetry in Monitoring Hydration and Hyponatremia During Subarachnoid Hemorrhages
Subarachnoid hemorrhage (SAH) is a rare and serious form of stroke, mainly linked to the rupture of an intracranial aneurysm responsible for bleeding into the meningeal spaces.
- Trial name
- BIASHA (NCT06646484)
- Testing
- Impedancemetry evaluation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
CHRONIC HYPONATREMIA
Phase 2a Study for PK/PD of nC-001
CHRONIC EUVOLEMIC HYPONATREMIA
- Trial name
- NCT06798675
- Testing
- nC-001
- Volunteers
- 24 people
- Sponsor
- nephCentric
Thiazide-induced Hyponatremia (TIH)
Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia
Thiazides and thiazide-like diuretics are one of the five major classes of antihypertensive drugs. This study is to investigate whether urinary PGE2 concentration at baseline (prior to thiazide initiation) is associated with the…
- Trial name
- PROPHECY (NCT05542056)
- Testing
- Data and biosample collection
- Where
- 3 sites in Spain, Switzerland
- Volunteers
- 232 people
- Sponsor
- University Hospital, Basel, Switzerland
Hyponatremia
Saline Infusion Test in Hyponatremia
Observational study of biochemical volume biomarker levels in response to a standardized intravenous isotonic saline infusion in patients with hyponatremia.
- Trial name
- SITH (NCT06498856)
- Testing
- Isotonic saline infusion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Cardiac Surgery, Diuresis
Natriuresis-guided Depletion After Cardiac Surgery
Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical.
- Conditions
- Cardiac Surgery, Diuresis, Congestion, Venous, Sodium Depletion
- Trial name
- EASY-CS (NCT07077772)
- Testing
- Furosemide intravenous titration based on natriuresis, Furosemide intravenous titration based on clinical examination
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hyponatremia, Syndrome of Inappropriate Antidiuresis
Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis
The goal of this study is to assess the impact of protein supplementation on hyponatremia caused by the syndrome of inappropriate antidiuresis during hospitalization.
- Trial name
- TREASUREx (NCT06821802)
- Testing
- Moltein PURE Protein Powder, Fluid restriction
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Basel, Switzerland
Hyponatremia, Pituitary Surgery
Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery
The investigators are conducting this study to investigate new preventive measures for patients with low sodium levels (hyponatremia), which can occur after surgery on the pituitary gland.
- Trial name
- TREASURE-PIT (NCT07273630)
- Testing
- Fluid restriction, Dietary protein supplementation, Standard post-operative care
- Where
- Switzerland
- Volunteers
- 282 people
- Sponsor
- University Hospital, Basel, Switzerland
Post-operative Pain
Investigation of the Effect of Distention Medium Temperature on Image Quality, Hyponatremia Risk, and Post-operative Pain in Operative Hysteroscopy
Minimally invasive applications are seen as the gold standard in today's gynecology practice and are frequently preferred by both patients and physicians.
- Trial name
- NCT05973045
- Testing
- Operative Hysteroscopy 24 Centigrade Degree, Operative Hysteroscopy 37 Centigrade Degree
- Where
- Turkey (Türkiye)
- Volunteers
- 244 people
- Sponsor
- Ege University
Hyponatremia Symptomatic, Osmotic Demyelination Syndrome
International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia
Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l.
- Conditions
- Hyponatremia Symptomatic, Osmotic Demyelination Syndrome, Cerebral Edema
- Trial name
- PRONATREOUS (NCT07576036)
- Testing
- Hypertonic 3% saline
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Rochester General Hospital