Clinical trials: Hypospadias
Hypospadias, Penoscrotal, Chordee
Transverse Preputial Island Flap Versus Double Faced Preputial Flap for Repair of Penoscrotal Hypospadias With Chordee
The purpose of this study is to compare the outcomes and complications of the transverse preputial island flap (Duckett's procedure) to those of double-faced preputial flap (DFPF) for one-stage repair of penoscrotal hypospadias…
- Trial name
- DuckettvDFPF (NCT04605068)
- Testing
- Transverse preputial island flap (Duckett's technique), Double-faced preputial flap (DFPF)
- Volunteers
- 144 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Hypospadias
Urethrocutaneous Fistula Rate After Double Dartos and Single Dartos Tubularized Incised Plate Urethroplasty
The subjects were divided into two groups. Each group comprised 30 children. Children were randomly allocated in two groups via computer generated tables.
- Trial name
- NCT04699318
- Testing
- Group B, Group A
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Distal Penile Hypospadias
Cosmotic Outcome of Distal Penile Hypospidias Repair Using Stitch by Stitch Glanuloplasty Versus TIP
Hypospadias is generally defined as the combination of three anatomic anomalies of penis, which are an abnormal ventral opening of the urethral orifice, ventral curvature of the penis, and abnormal distribution of the foreskin…
- Trial name
- NCT05742529
- Testing
- TIP, STITCH BY STITCH
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
PRF, Hypospadias
A Multicenter Randomized Controlled Trial Comparing Platelet-Rich Fibrin and Ventral Dartos Flap as Intermediate Layers in Tabularized Incised Plate (TIP) Urethroplasty for Distal Hypospadias With Mild Penile Curvature
Distal hypospadias is the most common form of hypospadias. The Tubularized Incised Plate (TIP) repair is the standard surgical technique for this condition; however, complications such as fistula formation and meatal stenosis…
- Conditions
- PRF, Hypospadias, Distal Hypospadias, Hypospadias Repair
- Trial name
- PRF (NCT07045545)
- Testing
- - Group A: Platelet-rich fibrin membrane prepared intraoperatively and applied over neourethra, Group B: Ventral dartos flap rotated over neourethra
- Where
- Uzbekistan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Children's Medical Center, Uzbekistan
Circumcision, Meatotomy or Distal Coronary Correction of Hypospadia
DPNB vs. Modified DPNB With Ventromedial Infiltration (DPNB According to Dalens' Technique)
Dorsal penile nerve block (DPNB) is a regional nerve block probably most often performed throughout the world. There are several different methods described in the literature.
- Trial name
- NCT01974011
- Testing
- Performing dorsal penile nerve block (DPNB)
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Claudia Spies
Narrow Urethral Plate Hypospadias
Evaluation of Slit-like Adjusted Mathieu Versus Onlay Island Flap for Hypospadias Repair in Pediatrics
Purpose** To compare the Slit-like Adjusted Mathieu (SLAM) technique versus the inner transverse preputial onlay island flap for repair of anterior and mid-penile hypospadias with narrow urethral plate, evaluating complication…
- Trial name
- NCT07592026
- Testing
- Slit-like Adjusted Mathieu, onlay island flap
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Hypospadias, Penoscrotal
Preputial Graft Versus Preputial Flap in Treatment of Proximal Hypospadias With Marked Ventral Curvature (a Comparative Study)
Hypospadias is a male congenital anomaly characterized by the abnormally located urethral meatus being displaced along the ventral side of the penis along a line from the tip of glans penis to the perineum.
- Trial name
- NCT06165120
- Testing
- Bracka's repair using preputial graft, STPIF (Staged Transverse Preputial Island Flap) repair using preputial flap
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Residual Severe Ventral Curvature, Transection of the Urethral Plate
Urethral Plate Flap vs. Tunica Vaginalis Flap for Residual Severe Ventral Curvature in Hypospadias
The correction of ventral curvature in hypospadias follows a stepwise principle. Clinically, in some cases of hypospadias, residual severe ventral curvature (VC ≥ 30°) persists even after thorough skin degloving and transection…
- Conditions
- Residual Severe Ventral Curvature, Transection of the Urethral Plate, Corporoplasty, Pedicled Tunica Vaginalis Flap (TVF)
- Trial name
- NCT07404722
- Testing
- Urethral Plate Flap Corporoplasty, Tunica Vaginalis Flap Corporoplasty
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Hypospadias
Engaging Families to Improve the Care of Patients With Hypospadias
Reconstructive surgery is advocated for most children with hypospadias, a condition in which the pee hold is not in the correct place on the penis, to prevent potentially serious cosmetic and functional problems.
- Trial name
- NCT05056311
- Testing
- Decision Aid Website
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypospadias
Snodgrass Versus Grafted Snodgrass Repair in Narrow Urethral Plate in Distal Penile Hypospadias
We aime to compare between Snodgrass and grafted Snodgrass repair in the outcome in distal penile hypospadias with urethral plate less than 8mm
- Trial name
- NCT06405763
- Testing
- Snodgrass repair, Snodgrass repair with graft
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Perioperative Bleeding During Recurrent Hypospadias Repair
Evaluating the Efficacy and Safety of Tranexamic Acid in Reducing Perioperative Bleeding During Recurrent Hypospadias Repair.
This study aims to fill that gap by evaluating the efficacy and safety of intravenous TXA in children undergoing redo hypospadias surgery, potentially establishing a new standard of care
- Trial name
- NCT07778992
- Testing
- single intravenous (IV) bolus dose of tranexamic acid (TXA) at 15 mg/kg (maximum dose 1000 mg), Control (Normal saline)
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Aswan University Hospital
Hypospadias, Urethrocutaneous Fistula
Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants?
This is a prospective randomized multi-center non-inferiority trial conducted through the Pediatric Regional Anesthesia Network study sites to determine if caudal block increases the incidence of urethrocutaneous fistula…
- Trial name
- NCT02861950
- Testing
- Caudal block with ropivacaine, penile nerve block with bupivacaine
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of Colorado, Denver
Hypospadias
Evaluation of Double Faced Transverse Preputial Onlay Island Flap for Hypospadias Repair in Pediatrics
Evaluation of double faced transverse preputial onlay island flap for hypospadias repair in pediatrics. The preputial onlay island flap technique has been popularized for hypospadias repair as a result of offering a consistent…
- Trial name
- DFOF#TIOF (NCT05144659)
- Testing
- Double faced transverse preputial onlay island flap, Transverse inner preputial onlay island flap
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Postoperative Analgesia
Intravenous Paracetamol in Combination With Caudal Ropivacaine
To investigate whether the addition of intravenous paracetamol with caudal ropivacaine leads to better quality of postoperative recovery in patients undergoing hypospadius repair than caudal ropivacaine alone.
- Trial name
- NCT03781505
- Testing
- Paracetamol +caudal ropivacaine
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Aga Khan University
Hypospadias
Antibiotic Use Following Distal and Mid-shaft Hypospadias Repair
The purpose of this study is to evaluate the efficacy of prophylactic antibiotics following distal or mid-shaft hypospadias repair in influencing the rate of postoperative urinary tract infection and complications.
- Trial name
- NCT02593903
- Testing
- Septra
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Medical College of Wisconsin
Sacral Erector Spinae, Penile And Caudal Block For Pain Relief After Hypospadius Surgery
Sacral Erector Spinae,Penile and Caudal Block for Pain Relief After Hypospadias Surgery
Caudal anaesthesia is recommended for most surgical procedures of the lower part of the body, mainly below the umbilicus, including inguinal hernia repair, urinary and digestive tract surgery and orthopaedic procedures on the…
- Trial name
- NCT05307653
- Testing
- Penile block, Erector spinea plain block, Caudal block
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Tanta University
Postoperative Pain, Hypospadias
Comparison of Sacral ESP Block and Dorsal Penile Nerve Block in Pediatric Hypospadias Surgery
This randomized controlled trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Sacral Erector Spinae Plane (ESP) block versus Dorsal Penile Nerve Block (DPNB) in pediatric patients aged 1-7 years…
- Trial name
- NCT07426731
- Testing
- Sacral ESP Block Group, Dorsal Penile Nerve Block Group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Medipol University
Postoperative Pain
Perfusion Index in Assessment of Postoperative Pain in Children.
The aim of this study will be to examine the validity of perfusion index in predicting pain and evaluation of its severity in the postoperative period.
- Trial name
- NCT06245239
- Testing
- perfusion index
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Assiut University
Hypospadias, Pediatric Urology
Can a Platelet-Rich Plasma Covering Layer Reduce Urethrocutaneous Fistula Rate After Distal Penile Hypospadias Repair Using the STAR Technique: A Randomized Controlled Trial
Methods We conducted a prospective randomized controlled study at the Pediatric Urology Department of Cairo University Specialized Pediatric Hospital between July 2024 and January 2025 .
- Trial name
- NCT07006922
- Testing
- hypospadias repair using the STAR technique with PRP as protective layer, hypospadias repair using the STAR technique
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University
Congenital Urogenital Anomaly
Distribution of Smooth Muscle In Dartos In The Non Conspicuous Penis
Non-conspicuous penis (congenital megaprepuce, occult penis) is a symptomatic malformation that includes phimosis and excessively baggy, urine-filled prepuce with alteration of the appearance of the penis.
- Trial name
- DISMUD (NCT03295175)
- Testing
- Hematoxylin-eosin and smooth muscle actin markers
- Where
- Colombia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital Universitario San Ignacio