Clinical trials: Hypotension, Controlled
Post Induction Hypotension
Lower Extremity Elevation to Minimize Hemodynamic Instability During Induction of General Anesthesia
The purpose of this study is to determine if lower extremity elevation (LEE) will reduce the incidence of postinduction hypotension, to compare the utilization of vasoactive medications after induction in patients with LEE and…
- Trial name
- NCT06513169
- Testing
- Group 1: LEE
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Induced Hypotension, Old Age; Debility
Efficacy of Subclavian Vein/Artery Diameter Index in Predicting the Incidence of the Spinal-Induced Hypotension in Geriatric Patients
The hypothesis of the study will be that the subclavian vein/subclavian artery diameter (SCVD/SCAD) index will be a good predictor of spinal-induced hypotension in geriatric patients.
- Trial name
- NCT07286422
- Testing
- Assessment of the SCV & SCA, Assessment of the IVC and aorta
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Tanta University
Hypotension
Spinal Anesthesia Induced Hypotension During Cesarean Section
The purpose of this study is to compare two methods for preventing low blood pressure associated with spinal anesthesia during Cesarean sections.
- Trial name
- NCT00846651
- Testing
- Colloid administration, Crystalloid administration, phenylephrine infusion
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Milton S. Hershey Medical Center
Intraoperative Arterial Hypotension, Infant, Newborn
Determination of the Optimal Dose of Ephedrine in Intraoperative Arterial Hypotension of Newborns and Infants up to 6 Months of Age.
The incidence of arterial hypotension under general anesthesia using sevoflurane is particularly high in newborns and infants up to 6 months of age.
- Trial name
- EPHEDRINE (NCT02384876)
- Testing
- Ephedrine 30mg/10mL injectable solution, single administration, dose : 0.6, 0.8, 1.0, 1.2 and 1.4 mg/kG, Ephedrine 30mg/10mL injectable solution, single administration, dose : 0.1 mg/kG.
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Vascular Diseases
Minimal Inflation Tourniquet Pressure Using Induced Hypotension
Limb occlusion pressure (LOP) and arterial occlusion pressure (AOP) are the terms that mean the lowest tourniquet pressure required to stop the arterial blood flow into the limb distal to the cuff.
- Trial name
- NCT04055779
- Testing
- estimation method for arterial occlusion pressure, the limb occlusion pressure
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Healthy Volunteers
A Trial to Learn if Different Doses of REGN7544 Are Safe in Healthy Adult Participants
The study is researching an experimental drug called REGN7544.The study is focused on healthy adults. The aim of the study is to see how safe and tolerable the study drug is in healthy adults.
- Trial name
- NCT05970718
- Testing
- REGN7544
- Where
- New Zealand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Spinal Anesthetic Toxicity, Hypotension Drug-Induced
Comparison of Two Different Norepinephrine Bolus Doses for Management of Spinal Anesthesia-Induced Maternal Hypotension
In this study the investigators will compare two doses of norepinephrine bolus (6 mcg and 8 mcg) in management of maternal hypotensive episode after spinal block during cesarean delivery.
- Conditions
- Spinal Anesthetic Toxicity, Hypotension Drug-Induced, Cesarean Section Complications
- Trial name
- NCT05502146
- Testing
- Noradrenaline Bitartrate, Bupivacaine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mersin University
Hypotension
Neurohumoral Mechanism of Deferent Frequency Transcutaneous Electrical Acupoint Stimulation(TEAS)
The purpose of this study is to explore the neurohumoral mechanism of deferent frequency TEAS pretreatment.
- Trial name
- NCT02611388
- Testing
- TEAS (transcutaneous electrical acupoint stimulation), fake stimulation
- Volunteers
- 81 people
- Sponsor
- wangqiang
Hypotension, Spinal Anesthesia
Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean Section
Spinal anesthesia is the preferred technique for elective cesarean section, but it frequently causes maternal hypotension due to sympathetic blockade and the Bezold-Jarisch reflex, which can threaten both mother and baby.
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Section
- Trial name
- NCT07886151
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Blood Pressure, Intraoperative Hypotension
Perioperative Personalized Blood Pressure Management
The investigators propose a pilot trial to (1) proof the concept that defining the intraoperative mean arterial pressure (MAP) intervention threshold based on the mean nighttime MAP (assessed using preoperative automated blood…
- Conditions
- Blood Pressure, Intraoperative Hypotension, Postoperative Complications
- Trial name
- NCT04894045
- Testing
- Personalized management
- Where
- 2 sites in Germany
- Volunteers
- 105 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Elective Endovascular Abdominal Aortic Surgery With an Expected Surgical Duration Exceeding 2 Hours, Elective Open Abdominal Aortic Surgery With an Expected Surgical Duration Exceeding 2 Hours
The Hypotension Prediction Index Versus Standard Advanced Haemodynamic Monitoring in Patients Undergoing Major Aortic Surgery
The standard procedure during general anesthesia is to monitor vital functions, including cardiovascular functions such as cardiac electrical activity, using continuous ECG recording, blood pressure measurement with a…
- Trial name
- HYPE-AORTA (NCT07510451)
- Testing
- HPI guided heamodynamic monitoring, Standard Heamodynamic Managament according to APCO Monitoring
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Poznan University of Medical Sciences
IL-2 Induced Hypotension
Evaluation of M40403 for the Prevention of Dose Limiting Toxicities of High Dose IL-2
The clinical use of IL-2 is currently limited by development of dose-dependent hypotension (systolic blood pressure (SBP) < 90 mm Hg).
- Trial name
- NCT00033956
- Testing
- M40403
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- MetaPhore Pharmaceuticals
Infant, Newborn, Diseases, Cardiovascular Insufficiency
Hydrocortisone for Term Hypotension
This trial will evaluate the effects of a 7-day course of hydrocortisone therapy on short-term morbidity, cardiovascular function, long-term neurodevelopment, and mortality in critically ill, term and late preterm infants…
- Trial name
- NCT01954056
- Testing
- Hydrocortisone
- Where
- 18 sites in United States
- Volunteers
- 12 people
- Sponsor
- NICHD Neonatal Research Network
Cardiac Surgery
Individualized Blood Pressure Management in Patients Undergoing Cardiac Surgery
This pilot randomized-controlled study will determine the feasibility of large study comparing individualized versus standard blood pressure (BP) management in patients undergoing cardiac surgery under cardiopulmonary bypass…
- Trial name
- PRECISE (NCT03784690)
- Testing
- Individualized intraoperative BP management, Standard intraoperative BP management
- Where
- Russia
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Symptomatic Neurogenic Orthostatic Hypotension (NOH), Parkinson's Disease
Fipamezole in Neurogenic Orthostatic Hypotension
The purpose of this study is to determine whether Fipamezole is effective in the treatment of orthostatic hypotension and related symptoms in multiple system atrophy and Parkinson's disease.
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension (NOH), Parkinson's Disease, Multiple System Atrophy
- Trial name
- Foehn (NCT00758849)
- Testing
- Fipamezole
- Where
- 4 sites in France, Portugal
- Volunteers
- 24 people
- Sponsor
- Juvantia Pharma Ltd
Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs)
PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery
Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications.
- Conditions
- Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs), Fluid Over-load
- Trial name
- PRO STRESS (NCT07627360)
- Testing
- Norepinephrine
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Suez Canal University
Biliary and Pancreatic Diseases, Endoscopic Retrograde Cholangiopancreatography (ERCP)
A 2×2 Factorial Randomized Controlled Trial for ERCP
To investigate the effects of propofol vs. cyclopropofol and sufentanil vs. esketamine on intraoperative hypoxemia and hypotension in elderly patients undergoing ERCP, as well as the interaction between these two factors.
- Trial name
- NCT07584902
- Testing
- Anesthesia induction using propofol+sufentanil, Anesthesia induction using propofol+esketamine, Anesthesia induction using ciprofol+sufentanil
- Volunteers
- 236 people
- Sponsor
- Gang Chen
Hypotension, Cesarean Section
"Effect of Pre-Spinal Mindfulness-Based Breathing Exercise on Hemodynamic Response in Elective Cesarean Section"
Spinal anesthesia-induced hypotension is one of the most frequent and clinically significant complications of obstetric anesthesia, occurring in up to 50-80% of parturients undergoing elective cesarean section.
- Conditions
- Hypotension, Cesarean Section, Hemodynamic Instability, Anxiety, Anticipatory
- Trial name
- BREATHE-CS (NCT07494955)
- Testing
- Mindfulness-Based Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Aysenur Dostbil
Anesthesia; Adverse Effect, Spinal and Epidural
Prophylaxis Ephedrine or Ondansetron Prevents Hypotension After Spinal Anesthesia for Cesarean Section
Maternal hypotension after spinal anesthesia in parturients undergoing cesarean section is a very common problem leading to several complications to both patients and their babies.
- Trial name
- NCT02194192
- Testing
- Ondansetron, Ephedrine
- Where
- Thailand
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hypotension
Control Mean Arterial Pressure in the Intensive Care Unit
The goal of this randomized controlled trial is to compare two different strategies of postoperative mean arterial pressure (MAP) management (manual versus automated) in patients who underwent a major surgery and admitted in the…
- Trial name
- COMAP-ICU (NCT04639037)
- Testing
- Automated adjustment of vasopressor, Manual adjustment of vasopressor
- Where
- 2 sites in France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris