Clinical trials: Hypotension, Orthostatic
Parkinson Disease, Multiple System Atrophy, Parkinson Variant
Abdominal Binders to Treat Orthostatic Hypotension in Parkinsonian Syndromes
The purpose of the present clinical trial is to determine whether the use of an elastic abdominal binder is effective in the non-pharmacological management of symptomatic, neurogenic orthostatic hypotension (OH) in individuals…
- Conditions
- Parkinson Disease, Multiple System Atrophy, Parkinson Variant, Orthostatic; Hypotension, Neurogenic
- Trial name
- ABOH-PS (NCT04920552)
- Testing
- Elastic abdominal binder
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Universitätsklinik für Neurologie, Innsbruck
Orthostatic Hypotension
SalT Supplementation in Older Adults With Orthostatic Intolerance Disorders
Background Orthostatic hypotension (OH) is a common cause of falls, and key source of morbidity and mortality due to injury (e.g. hip fracture).
- Trial name
- STOOD (NCT06188663)
- Testing
- Salt supplementation (encapsulated sodium chloride)
- Where
- Ireland
- Volunteers
- 42 people
- Sponsor
- University of Galway
Parkinson Disease, Orthostatic Hypotension
Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension
Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants.
- Trial name
- HYPOPARK (NCT07139756)
- Testing
- Lower body negative pressure
- Where
- Switzerland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Brain Injuries, Hypotension, Orthostatic
Study of Pulse Pressure During Tilttable and Erigo® in Adult Patients With Acquired Brain Injury
The purpose of this study is to determine if the pulse pressure changes are different whether patients are training in a traditional tilt table as compared to a robotic assisted tilt table, which induces leg movement.
- Conditions
- Brain Injuries, Hypotension, Orthostatic, Syncope
- Trial name
- NCT02700399
- Testing
- Erigo® Hocoma, Traditional tilt table from Rehab-Care
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Aarhus
Orthostatic Hypotension
Breathing Device for Orthostatic Hypotension (OH)
The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease blood pressure drops on standing in patients with orthostatic hypotension.
- Trial name
- NCT00962884
- Testing
- Inspiratory Threshold Device (Res-Q-Gard ITD)
- Where
- United States
- Sponsor
- Alfredo Gamboa
Benign Prostatic Hyperplasia
Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial)
After surgery for benign prostatic hyperplasia (BPH) that physically removes the prostatic transition zone (such as TURP or laser enucleation), many men are routinely sent home with a 2- to 4-week prescription of an alpha-blocker…
- Trial name
- CLEAR (NCT07846579)
- Testing
- Tamsulosin hydrochloride 0.2 mg
- Volunteers
- 400 people
- Sponsor
- Shanghai East Hospital
Hypotension, Orthostatic Hypotension
Orthostatic Hypotension Among Veterans
Orthostatic hypotension (OH) is defined as a fall in blood pressure when standing. Several different underlying diseases, conditions, or combinations of medicines may contribute to OH; therefore the cause of the condition varies…
- Trial name
- OH (NCT02123303)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Orthostatic Hypotension
Hemodynamic Effects of Aquatic vs. Land Exercise in Patients With Orthostatic Hypotension
Orthostatic hypotension is a highly prevalent deficit in the aging population especially when coupled with stroke, frailty, diabetes, Parkinson's disease or spinal cord injuries.
- Trial name
- NCT04399486
- Testing
- Physical Therapy
- Where
- United States
- Sponsor
- University of Texas at Austin
Orthostatic Hypotension
Hemodynamic Effects During Land vs Water Exercise for Older Adults With Orthostatic Hypotension
The purpose of the study is to understand how blood pressure, heart rate, and symptoms of low blood pressure (such as dizziness or nausea) are affected by positional changes and exercise when on land or in the water for people…
- Trial name
- NCT05233865
- Testing
- Water exercise, Land exercise
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas at Austin
Hypertension, Pure Autonomic Failure
Local Heat Stress in Autonomic Failure Patients With Supine Hypertension
Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension).
- Conditions
- Hypertension, Pure Autonomic Failure, Multiple System Atrophy, Autonomic Failure
- Trial name
- NCT02417415
- Testing
- Passive heat stress, Control (non-heating)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University
Orthostatic Hypotension, Diabetes
Insulin Therapy and Falls Due to Orthostatic Hypotension
In the proposed study, the investigators examine in older adults with Type 2 diabetes the impact of beginning insulin therapy on the orthostatic drop in blood pressure as well as the response of arterial blood pressure and…
- Conditions
- Orthostatic Hypotension, Diabetes, Syncope
- Trial name
- NCT01914146
- Testing
- Insulin, No Insulin
- Where
- Canada
- Sponsor
- University of British Columbia
Orthostatic Hypotension, Syncope
The Effect of Water Carbonation on Orthostatic Tolerance
The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers.
- Conditions
- Orthostatic Hypotension, Syncope, Vasovagal Syncope
- Trial name
- NCT05621460
- Testing
- 500mL carbonated water, 500mL still water, 50mL still water
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Parkinson's Disease, Multiple System Atrophy
Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy
Patients with Parkinson's Disease or Multiple System Atrophy (MSA), and symptoms of orthostatic hypotension, are eligible for the study.
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Orthostatic Hypotension
- Trial name
- NCT00103597
- Testing
- Fludrocortisone, Domperidone, Conservative Measures for Orthostatic Hypotension
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Royal Brisbane and Women's Hospital
Cardiovascular, Diabetes
Home-Based Walking Study in Older Adults With Type 2 Diabetes
Older persons with diabetes have a harder time maintaining blood pressure when standing up. When blood pressure drops when standing up, fainting may occur.
- Conditions
- Cardiovascular, Diabetes, Orthostatic Hypotension, Type 2 Diabetes
- Trial name
- NCT00824330
- Testing
- Control Phase; Exercise Phase
- Where
- 2 sites in Canada
- Volunteers
- 13 people
- Sponsor
- University of British Columbia
Hemodynamic, Exercise
Sex and Exercise-mode Differences in Post Exercise Blood Pressure and Heart Rate Variability Responses During Workday
The present study compared the acute effects of Sex and exercise mode on subsequent blood pressure (BP) and heart rate variability (HRV) responses during daily work in healthy adults.
- Trial name
- NCT03080636
- Testing
- Aerobic exercise, Resistance exercise, Control session
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Orthostatic Hypotension, Ischemia
Evaluation of the ORTHO-LBNP System
The pilot study aims to evaluate a prototype system that enables military pilots to train under conditions of orthostatic hypotension and ischemic hypoxia.
- Conditions
- Orthostatic Hypotension, Ischemia, Hypoxia
- Trial name
- ORTHO-LBNP (NCT03354234)
- Testing
- Head up tilt (HUT), Lower body negative pressure (LBNP), Head down tilt (HDT)
- Where
- Poland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Military Institute of Aviation Medicine
Young Adults, Hypertension
Examining the Circadian Timing Effects of the Hypotensive Response to Exercise
The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns.
- Conditions
- Young Adults, Hypertension, Post-Exercise Hypotension, Circadian Rhythm
- Trial name
- XTIME (NCT07049783)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Freda Patterson
Hypertension
Active Video Game and Potential to Cause Post-exercise Hypotension
The aim of this study was to determine the energy demand and the potential to promote reduce blood pressure of an active video game (AVG).
- Trial name
- NCT02924012
- Testing
- video game active, sedentary video game, walking
- Volunteers
- 14 people
- Sponsor
- Federal University of Paraíba
Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic
Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.
This study is aimed at patients with multi-system atrophy - parkinsonian type (P-MSA) or Parkinson's disease (PD) receiving dopaminergic drugs and suffering from orthostatic hypotension (OH).
- Conditions
- Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic, Parkinson Disease
- Trial name
- CARBIDOH (NCT06831500)
- Testing
- Administration of Carbidopa/levodopa
- Where
- 2 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Julien Bally
Orthostatic Hypotension
Orthostatic Hypotension in Elderly Nursing Home Residents
In this study the investigators aimed 1. to investigate the prevalence of orthostatic hypotension in elderly nursing home residents. 2.
- Trial name
- NCT01362751
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 290 people
- Sponsor
- Medical Research Foundation, The Netherlands