Clinical trials: Hypotension; Controlled
Hypotension Drug-Induced
Is Labetalol More Effective Than Metoprolol for Controlled Hypotensive Anesthesia During Endoscopic Nasal Surgeries?
Background: Mucosal bleeding is the most frequent complication with endoscopic nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, leading to increased complications, operation duration…
- Trial name
- NCT05368376
- Testing
- Labetalol Hydrochloride Oral Tablet, Metoprolol Tartrate Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries
Dexmedetomidine Versus Nitroglycerin on Surgical Field Quality and Drug Cost in Functional Endoscopic Sinus Surgeries
Sinus surgery is one of the most prevalent ear, nose, and throat (ENT) surgeries, which is mainly carried out nowadays through functional endoscopic sinus surgery (FESS) and leads to significant improvement in the clinical…
- Conditions
- Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries, Hypotension
- Trial name
- NCT07585201
- Testing
- controlled hypotension using dexmedetomidine, controlled hypotension hypotension using nitroglycerin
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Zagazig University
Magnesium Sulfate, Remifentanil
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus…
- Conditions
- Magnesium Sulfate, Remifentanil, S 100beta, S100 Beta Protein, Human
- Trial name
- NCT07181564
- Testing
- Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University General Hospital of Patras
Anesthesia, Hypotension
Anesthetic Advantages of Dexmedetomidine for Hypotensive Anesthesia
The aim of this study was to evaluate the positive anesthetic properties such as reduce intraoperative analgesic requirement, time to extubation and recovery, and early postoperative pain of dexmedetomidine used as a hypotensive…
- Trial name
- NCT02083055
- Testing
- Dexmedetomidine, Nitroglycerin
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Oxygen Saturation
Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension
Controlled hypotension is a preferred method for reducing surgical bleeding during septoplasty operations however, the level of hypotension and bradycardia should not disrupt cerebral oxygenation.
- Trial name
- NCT02834845
- Testing
- Sevoflurane, Desflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Ufuk University
Hypotension, Anesthesia
Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension
Background: Spinal anesthesia (SA) is preferred over general anesthesia in Cesarean section (CS) due to its better safety profile but SA induced hypotension remains a big challenge for the clinical Anesthetist.
- Trial name
- NCT05348980
- Testing
- Phenylephrine Hydrochloride 4 mg, Phenylephrine Hydrochloride 8 mg
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Preeclampsia, Cesarean Birth
Norepinephrine Infusion vs Bolus vs Ephedrine for Blood Pressure Stability During Cesarean Delivery in Women With Preeclampsia
This randomized controlled trial will compare norepinephrine infusion, norepinephrine bolus, and ephedrine bolus for maintaining hemodynamic stability during spinal anesthesia for scheduled cesarean delivery in women with…
- Conditions
- Preeclampsia, Cesarean Birth, Hypotension During Surgery
- Trial name
- NCT07842783
- Testing
- Norepinephrine (0.05 μg/kg/min), Norepinephrine 4mcg, Ephedrine Bolus 6 mg
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Benha University
Prostate Cancer
Pneumatic Compression and Post-induction Hypotension
The purpose of this study is to evaluate the effect of pneumatic compression on post-induction hypotension in elderly patients undergoing robot assisted laparoscopic prostatectomy.
- Trial name
- NCT05343689
- Testing
- Pneumatic compression
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Orthostatic Hypotension, Parkinson's Disease
A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease
This is a study to evaluate the effects of an investigational drug, Droxidopa, in participants with neurogenic orthostatic hypotension (NOH), associated with Parkinson's disease.
- Trial name
- 306A/306B (NCT01176240)
- Testing
- Droxidopa
- Where
- 60 sites in United States
- Volunteers
- 225 people
- Sponsor
- Chelsea Therapeutics
Hypotension
Echocardiography Based Algorithm for Spinal Anaesthesia
The main aim of the study is to compare the proposed algorithm for preventing and treating spinal hypotension with normal anesthesia management of a spinal anesthesia.
- Trial name
- NCT03106649
- Testing
- Echocardiography, Treatment of spinal hypotension
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hypotension
Reduction in Spinal-induced Hypotension With Ondansetron in Parturients Undergoing Caesarean Section
Subarachnoid block is the preferred method of anaesthesia for caesarean section, but is associated with hypotension and bradycardia, which may be deleterious to both parturient and baby.
- Trial name
- NCT02913768
- Testing
- Ondansetron, Normal saline
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Assiut University
Hypertension, Hypotension
Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure
The purpose of this study is to determine whether continuing or discontinuing furosemide (a diuretic) on the day of elective noncardiac surgery for those who take furosemide on a chronic basis, causes more intraoperative…
- Conditions
- Hypertension, Hypotension, Edema, Congestive Heart Failure
- Trial name
- NCT00115726
- Testing
- furosemide
- Where
- 3 sites in United States, Canada
- Volunteers
- 198 people
- Sponsor
- University of Calgary
the Severity and Duration of Intraoperative Hypotension
Remimazolam in High Risk ERCP Patients
We conducted a randomized trial to investigate whether the administration of Remimazolam in patients undergoing high-risk endoscopic retrograde cholangiopancreatography (ERCP) could significantly reduce the occurrence of…
- Trial name
- NCT06258356
- Testing
- Remimazolam
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Hypotension, Spinal Cord Injury
Prevention of Low Blood Pressure in Persons With Tetraplegia
The aim of this investigation is to determine the blood pressure response to NOS inhibition, with L-NAME, in persons with tetraplegia compared to non-SCI control subjects and to establish if blood pressure can be increased while…
- Trial name
- NCT00237770
- Testing
- N-Nitro L-arginine-methylester (L-NAME), Head-up Tilt maneuver
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Cesarean Section, Hypotension
Prevention of Post-spinal Anesthesia Hypotension in Caesarean Delivery Using Delayed Supine Positioning
Maternal hypotension is a common complication after spinal anaesthesia for caesarean delivery. Prophylaxis against post-spinal hypotension (PSH) during caesarean delivery would prevent serious maternal and fetal complications.
- Conditions
- Cesarean Section, Hypotension, Spinal Anaesthesia
- Trial name
- NCT04777123
- Testing
- sitting position
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Cairo University
Intraoperative Hypotension, Hemodynamic Instability
Hypotension Prediction With HPI Algorithm During Major Gynecologic Oncologic Surgery
Intraoperative hypotension (IOH) is a rather common event during general surgery, with variable incidence that ranges between 5 and 99% based on the definition used.
- Conditions
- Intraoperative Hypotension, Hemodynamic Instability, Gynecologic Cancer
- Trial name
- HPI-GOS (NCT04547491)
- Testing
- HPI - hypotension prediction index, GDT
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cognitive Dysfunction
Dexmedetomidine and Esmolol Early Post Operative Cognitive Dysfunction
Dexmedetomidine is a highly selective α2adrenoceptor agonist recently introduced to anesthesia that produces dose dependent sedation, anxiolysis, and analgesia (involving spinal and supraspinal sites) without respiratory…
- Trial name
- NCT03892512
- Testing
- Esmolol Hydrochloride, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Beni-Suef University
Myocardial Infarction Postoperative, Myocardial Injury
Intraoperative Hypotension and Perioperative Myocardial Injury
Acute myocardial infarction (MI) is a significant complication following non-cardiac surgery. We sought to evaluate incidence of perioperative MI, its preoperative - and intraoperative - risk factors and outcomes after this…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Intraoperative Complications, Intraoperative Hypotension
- Trial name
- NCT03974321
- Where
- Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Labor Pain, Maternal Hypotension
Lower Limb Compression Prevents Hypotension After Epidural in Labor
The goal of this study is to determine whether the use of sequential compression devices (lower limb compression) can reduce the rate of maternal hypotension after epidural, and therefore reduce the incidence of fetal heart…
- Trial name
- NCT04750486
- Testing
- Sequential compression devices
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Spinal Anesthesia-Induced Hypotension, Preeclampsia
Investigation of the Role of Internal Jugular Vein Collapsibility Index in Predicting Spinal Anesthesia-Induced Hypotension in Preeclamptic Parturients
This prospective, single-center observational study aims to evaluate the predictive value of the internal jugular vein collapsibility index (IJVCI) for spinal anesthesia-associated hypotension in preeclamptic parturients…
- Conditions
- Spinal Anesthesia-Induced Hypotension, Preeclampsia, Cesarean Section
- Trial name
- NCT07496788
- Testing
- Internal Jugular Vein Collapsibility Index Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ankara City Hospital Bilkent