Clinical trials: Hypotension
Arterial Hypotension, Anaesthesia
Effects of Phenylephrine on Cardiac Preload
In patients under general anesthesia, episodes of hypotension are often treated with phenylephrine. The effect of phenylephrine is conventionally attributed to afterload increase.
- Trial name
- NCT02739399
- Testing
- Phenylephrine
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Marfan Syndrome
Clinical Signs and Activity Limitations Associated With Dural Ectasia in Patients With Marfan Disease
Primary outcome is to compare the frequency and clinical features of spinal symptoms between Marfan patients with dural ectasia (cases) and those without (controls). 1. / Frequency of orthostatic headaches 2.
- Trial name
- MARFANLOMB (NCT05123339)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head-Down Tilt Following Spinal Anesthesia
Cephalic Spread of Block With Head Down Tilt in Spinal Anaesthesia - A Randomised Controlled Study
Subarachnoid block has become an established and reliable method of providing anaesthesia for lower abdominal and lower limb surgeries. Several factors determine the spread of local anaesthetic solutions in CSF.
- Trial name
- NCT03491319
- Testing
- Group X - head low tilt, Group Y - head low tilt, Group C - neutral
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nitte University
Intraoperative Hypotension, Hemodynamic Instability
AI-Assisted Blood Pressure Control During Anesthesia
This proof-of-concept randomized controlled trial evaluates a reinforcement learning (RL)-based clinical decision support system for intraoperative hemodynamic management during non-cardiac surgery.
- Trial name
- RL-PRAIS PoC (NCT07123675)
- Testing
- Device: AI Clinical Decision Support System, Procedure: Standard of Care Anesthesia
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Post-Induction Hypotension
Prediction of Post-Induction Hypotension Using Plethysmographic Variability Index During Diagnostic Laryngoscopy
This prospective observational study aims to evaluate whether non-invasive hemodynamic parameters, including the plethysmographic variability index (PVI) and perfusion index (PI), can predict post-induction hypotension in…
- Trial name
- NCT07458893
- Testing
- Plethysmographic Variability Index (PVI) and Perfusion Index (PI) Monitoring
- Volunteers
- 110 people
- Sponsor
- University of Gaziantep
Percutaneous Nephrolithotomy
Effect of Ondansetron on Spinal-induced Hypotension for Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is the surgical standard for treating large or complex renal stones. The stones are removed by passing a small telescope through the side of the patient directly into the kidney, so the stone…
- Trial name
- NCT04891484
- Testing
- Ondansetron group, Saline group
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University
Fetus or Neonate Affected by Maternal Epidural Anesthesia During Labor and Delivery
Pulse Pressure and Post-epidural Fetal Heart Rate Changes
Epidural anesthesia, the most common method of pain control in labor, can contribute to alterations in maternal blood pressure and/or fetal heart rate changes.
- Trial name
- NCT02565485
- Testing
- Lactated Ringer's
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- MetroHealth Medical Center
Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease
A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy
Evaluate the clinical efficacy and safety of droxidopa versus placebo over a 17 week (maximum) treatment period in patients with symptomatic NOH.
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease, Multiple Systems Atrophy, Pure Autonomic Failure
- Trial name
- NCT01927055
- Testing
- Droxidopa
- Where
- 3 sites in United States
- Volunteers
- 61 people
- Sponsor
- Chelsea Therapeutics
Hypotension, Point of Care Ultrasound
Sonography in Hypotension and Cardiac Arrest in the Emergency Department.
This study is designed to determine if there is any relationship between performing an abdominal ultrasound on patients who present with hypotension and their clinical outcomes (as measured by 7, 30 day and discharge mortality).
- Conditions
- Hypotension, Point of Care Ultrasound, Shock
- Trial name
- SHoC-ED (NCT01419106)
- Testing
- Ultrasound (A point of care ultrasound protocol)
- Where
- 6 sites in Canada, South Africa
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Horizon Health Network
Post-induction Hypotension, Eadyn
The Relationship Between Hypotension and Tissue O2 in Invasive Eadyn During Anesthesia Induction in Open Heart Surgery
Our aim is to identify patients who may experience hypotension during anesthesia induction. Intraoperative hemodynamic stability plays an important role in tissue oxygenation.
- Conditions
- Post-induction Hypotension, Eadyn, Cerebral and Kidney Regional Saturation, Open Heart Surgery
- Trial name
- Eadyn (NCT07831252)
- Testing
- mostcare hemodynamic monitor, Masimo NIRS, Hemodynamic Measurements on Standart Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Haseki Training and Research Hospital
Spinal Anesthesia-Induced Hypotension, Cerebral Oxygenation
Effects of Ondansetron Timing During Spinal Anesthesia for Urologic Surgery
This study will evaluate whether the timing of intravenous ondansetron administration affects cerebral oxygenation and hemodynamic stability in older adults undergoing endoscopic urologic surgery under spinal anesthesia.
- Trial name
- NCT07858149
- Testing
- Ondansetron 8 mg, 0.9 % sodium chloride
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Istanbul University
Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
The Ability Of Inferior Vena Caval Distensibility Index With Passive Leg Raising Test To Predict Spinal Anesthesia-induced Hypotension In Elderly Patients Undergoing Infra-umbilical Surgeries. A Prospective Observational Study.
Many previous studies have investigated the ability of various methods such as passive leg raising test , and inferior vena cava collapsibility index in predicting post-spinal hypotension, but none of them have succeeded in…
- Trial name
- NCT05991063
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hypotension During Surgery
Controlled Hypotension in Rhinoplasty and Septoplasty: Incidence of Cognitive Dysfunction and Delirium
Controlled hypotension application is a commonly preferred anesthesia practice during surgical procedures, particularly in regions with rich tissue perfusion, aiming to reduce bleeding, enhance surgical field visibility, and…
- Trial name
- NCT06238973
- Testing
- Group Low, Group Middle
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hitit University
Postinduction Hypotension, Hypotension During Surgery
The Effect of Preoperative Intravenous Fluid Bolus on Post-induction Hypotension in Elective Cystoscopies.
This study aims to determine whether a standardized, weight-based crystalloid fluid bolus administered preoperatively reduces the incidence of postinduction hypotension (PIH) in patients undergoing cystoscopy.
- Trial name
- NCT06985654
- Testing
- Lactated Ringers
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Missouri-Columbia
Hypotension, Orthostatic Hypotension
Orthostatic Hypotension Among Veterans
Orthostatic hypotension (OH) is defined as a fall in blood pressure when standing. Several different underlying diseases, conditions, or combinations of medicines may contribute to OH; therefore the cause of the condition varies…
- Trial name
- OH (NCT02123303)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Intraoperative Complications, Intraoperative Hypotension
The Use of Surgical Pleth Index in Guiding Anesthesia in Gastroenterological Surgery
Surgical Pleth Index (SPI) is an intraoperative monitor aimed into detection of nociception and guidance of intraoperative opioid administration.
- Conditions
- Intraoperative Complications, Intraoperative Hypotension, Intraoperative Hypertension
- Trial name
- NCT04519203
- Testing
- SPI, Standard
- Where
- Finland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Acute Kidney Injury, Hypotension
A Pilot Analysis of the Association Between Anesthesia Induction Dosing and AKI in the Elderly Population
This study proposes to perform a pilot observational study looking at the doses of propofol used for the induction of general anesthesia and its association with the development of hypotension and AKI among elderly patients at…
- Conditions
- Acute Kidney Injury, Hypotension, Anesthesia; Adverse Effect
- Trial name
- NCT03699696
- Testing
- Propofol
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Yale University
Intradialytic Hypotension
Safety and Benefit Study of Droxidopa to Treat Patients With Intradialytic Hypotension
In clinical trials in Japan, droxidopa has been shown to be effective in affecting blood pressure changes upon orthostatic challenge in patients with autonomic dysfunction, as well as reducing the severity and frequency of…
- Trial name
- IDH201 (NCT00657046)
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Chelsea Therapeutics
Arterial Hypotension
Effect of Phenylephrine Versus Norepinephrine on Venous Return
Induction of general anesthesia often induces a decrease in the mean arterial blood pressure (MAP) caused by arterial and venous dilatation.
- Trial name
- NCT03872570
- Testing
- Phenylephrine, Norepinephrine
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Apheresis Related Hypotension
Evaluation of the Aurora Xi New Nomogram Software 2.0
A clinical trial to evaluate the safety and effectiveness of the Aurora Xi Plasmapheresis System with a new plasma collection volume nomogram.
- Trial name
- NCT06122935
- Testing
- Aurora Xi New Nomogram Software 2.0, Aurora Xi Currently Approved Software 1.3
- Where
- 3 sites in United States
- Volunteers
- 6,735 people, healthy volunteers welcome
- Sponsor
- Fenwal, Inc.