Clinical trials: Hypotension
Septic Shock, Hypotension
Esmolol to Treat the Hemodynamic Effects of Septic Shock
The main purpose of this study is to determine the effects of controlling the heart rate of patients with septic shock using an intravenous medication called esmolol.
- Conditions
- Septic Shock, Hypotension, Tachycardia
- Trial name
- NCT02369900
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Brain Injuries, Hypotension, Orthostatic
Study of Pulse Pressure During Tilttable and Erigo® in Adult Patients With Acquired Brain Injury
The purpose of this study is to determine if the pulse pressure changes are different whether patients are training in a traditional tilt table as compared to a robotic assisted tilt table, which induces leg movement.
- Conditions
- Brain Injuries, Hypotension, Orthostatic, Syncope
- Trial name
- NCT02700399
- Testing
- Erigo® Hocoma, Traditional tilt table from Rehab-Care
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Aarhus
Intraoperative Hypotension, Hepatectomy
Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure
The goal of this clinical trial is to learn whether remimazolam helps prevent low blood pressure better than propofol during major liver surgery in adults.
- Trial name
- NCT07789275
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
The Ability Of Inferior Vena Caval Distensibility Index With Passive Leg Raising Test To Predict Spinal Anesthesia-induced Hypotension In Elderly Patients Undergoing Infra-umbilical Surgeries. A Prospective Observational Study.
Many previous studies have investigated the ability of various methods such as passive leg raising test , and inferior vena cava collapsibility index in predicting post-spinal hypotension, but none of them have succeeded in…
- Trial name
- NCT05991063
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hypotension
Study to Determine the Pharmacokinetics and Pharmacodynamic Effects of Phenylephrine on BP Via IV
The primary objective of this study is to evaluate the dose effect of Phenylephrine Hydrochloride Injection on the treatment of clinically relevant decreased blood pressure in the pediatric population, ≥12 to 16 year old patients…
- Trial name
- NCT02323399
- Testing
- Phenylephrine
- Where
- 10 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- West-Ward Pharmaceutical
Pregnancy Related, Hypotension, Orthostatic
Evaluation of Changes of Venous Return After Spinal and Epidural Analgesia and Anesthesia by Ultrasound Guided Vena Cava Diameter Measurement
The investigators propose this study to test the hypotheses that inferior vena cava (IVC) diameter can predict hypotension after labor analgesia (epidural, combined spinal-epidural) and neuraxial anesthesia for cesarean section…
- Trial name
- NCT03555799
- Testing
- Inferior vena cava ultrasound
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Augusta University
Neurogenic Orthostatic Hypotension
Sinusoidal Galvanic Vestibular Stimulation for Neurogenic Orthostatic Hypotension / Syncope
Neurogenic orthostatic hypotension occurs in a significant number of people and has no effective treatment. Neurogenic orthostatic hypotension is associated with intermittent episodes of fainting which can be debilitating for the…
- Trial name
- NCT04976101
- Testing
- Sinosuidal Galvanic Vestibular Stimulation
- Where
- United States
- Sponsor
- Hackensack Meridian Health
Septic Shock, Sepsis
VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock Patients
This study is being conducted to evaluate the safety and effectiveness of VBI-S in elevating the blood pressure of septic shock patients with absolute or relative hypovolemia.
- Conditions
- Septic Shock, Sepsis, Hypovolemia
- Trial name
- NCT04257136
- Testing
- VBI-S
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- Vivacelle Bio
Hypotension, Pressure Ulcer
Comparison of Nasal and Forehead Oximetry in Critically Ill Patients at Risk for Decreased Peripheral Perfusion
Continuous pulse oximetry monitoring is the standard of care in critically ill patients in emergency departments, operating rooms and intensive care units.
- Trial name
- NCT02382133
- Testing
- Nasal alar oxygen sensor
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Washington University School of Medicine
Acute Kidney Injury, Dialysis Hypotension
Outpatient Recovery From Acute Kidney Injury Requiring Dialysis
There are currently no therapies to improve the chances of recovering enough kidney function to come off of dialysis after severe acute kidney injury.
- Trial name
- ORKID (NCT05158153)
- Testing
- ORKID Bundled Intervention, Furosemide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, San Francisco
Coronary Artery Bypass Grafting, Hypotension
The PRESSURE CABG Cardiac Surgery Trial
This study will be a pragmatic, prospective, single-centre, unit-based cluster crossover, open-label registry trial. The cardiac surgical intensive care unit (CSICU) will be cluster assigned to alternating MAP targets in 6-month…
- Trial name
- PRESSURECABG (NCT04197700)
- Testing
- Target MAP Management
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of Alberta
Trauma and Emergency Care, Shock,Hemorrhagic
Delayed Fluids in Hemorrhagic Shock Due to Severe Injuries.
This study will provide information on the quality of care in hemorrhagic shock of severe injuries in a limited resource facility of Latin America, the strategies of fluid resuscitation, and outcomes.
- Conditions
- Trauma and Emergency Care, Shock,Hemorrhagic, Intravenous Fluid Therapy
- Trial name
- PERMIT-LATAM (NCT07530653)
- Testing
- Crystalloid below 1000 mL., IV fluids more than 1,000 mL
- Where
- Colombia
- Volunteers
- 716 people
- Sponsor
- Hospital Departamental de Villavicencio
Hypotension During Surgery
Electrical Acupoint Stimulation Reduces Intrathecal Anesthesia Induced Hypotension
The parturients may suffer from hypotension after spinal anesthesia and the incidence could be as high as 70-80% when pharmacological prophylaxis is not used.
- Trial name
- EARTH (NCT05724095)
- Testing
- high frequency acupoint stimulation, low frequency acupoint stimulation, electrodes attached
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhihong LU
Hypotension, Orthostatic, Hypertension
Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension
Neurogenic Orthostatic Hypotension (NOH) is clinically defined as a consistent drop in systolic blood pressure (SBP) ≥30mmHg upon standing from a seated or lying position.
- Conditions
- Hypotension, Orthostatic, Hypertension, Autonomic Nervous System Diseases
- Trial name
- NCT02963181
- Testing
- Yohimbine, Melatonin
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Fatigue Syndrome, Orthostatic Hypotension
Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome
A subset of patients suffering from chronic fatigue syndrome exhibit symptoms of neurally mediated hypotension. While the underlying pathophysiology of chronic fatigue syndrome is not precisely understood, a dysfunction of the…
- Conditions
- Chronic Fatigue Syndrome, Orthostatic Hypotension, Neurally Mediated Hypotension, Neurogenic Orthostatic Hypotension
- Trial name
- CFS201 (NCT00977171)
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Chelsea Therapeutics
Hypotension on Induction
Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery
Primary research hypothesis: Patients who continue their chronic ACEI therapy up to and including the morning of a non-cardiac, non-vascular surgery will experience more intraoperative hypotension than those who transiently hold…
- Trial name
- NCT01669434
- Testing
- ACEI continuation, ACEI omission
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- University of Nebraska
Hypotension
Changes in Cerebral Oxygenation During Deliberate Hypotensive Anesthesia
This is a study using cerebral oximetry to evaluate the safety of traditionally adopted hypotensive anesthesia.
- Trial name
- NCT00207987
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Postoperative Acute Kidney Injury, Intraoperative Hypotension
Impact of Intraoperative Blood Pressure Components on Postoperative AKI: A Phenotype-Stratified Analysis
Postoperative acute kidney injury (AKI) is a serious complication often linked to low blood pressure during surgery. This study aims to better protect patients' kidneys by personalizing how blood pressure is managed during an…
- Trial name
- NCT07156474
- Where
- China
- Volunteers
- 44,504 people
- Sponsor
- Lanyue Zhu
Spinal Anesthetic Toxicity, Inferior Vena Cava Abnormality
Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Study Protocol: Outcome Measurements Primary Outcome The main outcome will be the preoperative performance of the dIVCmax/IVCCI ratio to foresee the incidence of hypotension after spinal anesthesia in a greater extent to that of…
- Conditions
- Spinal Anesthetic Toxicity, Inferior Vena Cava Abnormality, Intraoperative Complications
- Trial name
- NCT03266250
- Testing
- spinal anesthesia
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Hypotension, Spinal Anaesthesia
The Effects of Keeping the Patient in a Sitting Position for One Minute After Spinal Anesthesia
The aim of this study was to examine the effect of keeping the patient in a sitting position for 1 minute after spinal anaesthesia in elective caesarean operations, primarily on the formation of hypotension and secondarily on…
- Trial name
- NCT03834259
- Testing
- sitting position, supine position
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Umraniye Education and Research Hospital