Clinical trials: Hypotension During Surgery
Cerebral Oxygenation
The Influence of Anesthetic Technique on Cerebral Oxygenation During Spinal Surgery
Postural changes during anesthesia can lead to decreased cerebral blood flow and oxygenation, especially when moving from a supine to a prone position.
- Trial name
- NCT06325462
- Testing
- sensors of regional cerebral oxygen saturation (O3 regional oximeter, Masimo Corp, Irvine, CA) FDA Reg No. 3011353843
- Where
- Saudi Arabia
- Volunteers
- 54 people
- Sponsor
- Prince Sultan Military Medical City
Ischemic Heart Disease, Cardiac Valve Disease
Passive Leg Raising Test to Predict Hypotension During Induction of Anesthesia in Patients Undergoing Cardiac Surgery
Hypotension frequently occurs during anesthesia induction. Preload decrease by anesthetics was often considered as one of main causes for this hypotension. However, the studies on this topic have been lacking.
- Trial name
- NCT01144546
- Testing
- passive leg raising (45 degree leg elevation for 1-2 min)
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Seoul National University Hospital
Hypotension
Norepinephrine and Phenylephrine, Which Better for Elderly?
this is a prospective, double-blinded and single-center study. this study is based on the Stroke volume variation fluid guided therapy, to compare the effects of norepinephrine and phenylephrine in treating perioperative…
- Trial name
- NCT04067817
- Testing
- norepinephrine, Phenylephrine
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Intraoperative Hypotension
HPI Algorithm for the Prevention of IOH During Spinal Surgery [HPIFPIOH]
The aim of this study is to investigate the hypothesis that the use of the Hypotension Prediction Index algorithm (HPI) can reduce intraoperative hypotension (IOH) in adult patients undergoing spinal surgery in the prone position…
- Trial name
- HPIFPIOH (NCT05341167)
- Testing
- HPI algorithm using Edwards device https://www.edwards.com/gb/devices/decision-software/hpi, Vasoactive Agent
- Where
- 2 sites in Greece
- Volunteers
- 85 people
- Sponsor
- Attikon Hospital
Hypotension During Surgery
The Noninvasive Blood Pressure Measurement Effect on the Hypotension
Around 300 million surgical operations are performed globally, and of these, 40 to 50 million are performed in the USA. The perioperative period is characterized by hemodynamic instability and, most importantly, hypotension.
- Trial name
- NCT05993481
- Testing
- Blood Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Hypotension, Bradycardia
Effects of Ondansetron on Hemodynamic Changes After Spinal Anesthesia in Geriatric Urologic Surgery
Spinal anesthesia is frequently used in urologic surgery in geriatric patients; however, it may cause significant hemodynamic changes such as hypotension and bradycardia.
- Conditions
- Hypotension, Bradycardia, Hypotension During Surgery, Spinal Anesthesia Induced Hemodynamic Change
- Trial name
- NCT07551219
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara City Hospital Bilkent
Hypotension
Safety of Norepinephrine Administered Through Peripheral Venous Catheter
Norepinephrine is a drug that elevates the blood pressure. It is routinely administered through peripheral catheters during surgery.
- Trial name
- NCT03695445
- Testing
- Peripheral administration of Norepinephrine
- Where
- 3 sites in Sweden
- Volunteers
- 1,004 people
- Sponsor
- Christer Svensen
Hypotension During Surgery, Kidney Transplant; Complications
Hypotension Prediction With HPI Algorithm During Decessed-donor Kidney Transplant (HPI2022)
HPI monitoring and the adoption of therapeutic interventions before hypotension occurs should be ensure a shorter time of intra-operative hypotension (MAP < 65 mmHg) during deceased-donor kidney transplant surgery.
- Trial name
- HPI2022 (NCT05394896)
- Testing
- ACUMEN (Edwards Lifesciences, Irvine, USA), Invasive Blood Pressure
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Preeclampsia, Cesarean Birth
Norepinephrine Infusion vs Bolus vs Ephedrine for Blood Pressure Stability During Cesarean Delivery in Women With Preeclampsia
This randomized controlled trial will compare norepinephrine infusion, norepinephrine bolus, and ephedrine bolus for maintaining hemodynamic stability during spinal anesthesia for scheduled cesarean delivery in women with…
- Conditions
- Preeclampsia, Cesarean Birth, Hypotension During Surgery
- Trial name
- NCT07842783
- Testing
- Norepinephrine (0.05 μg/kg/min), Norepinephrine 4mcg, Ephedrine Bolus 6 mg
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Benha University
Tissue Perfusion, Deliberate Hypotension
Effects of Nitroglycerin Versus Labetalol on Tissue Perfusion During Deliberate Hypotension
Deliberate hypotension is used to provide bloodless field during endoscopic sinus surgery; however, hypotension might impair perfusion of vital organs.
- Conditions
- Tissue Perfusion, Deliberate Hypotension, Sinus Endoscopic Surgery
- Trial name
- NCT03809065
- Testing
- Nitroglycerin, Labetalol
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Intraoperative Hypotension
Hypotension Prediction Index for Blood Pressure Management
Design: Single-center randomized comparison of invasive arterial pressure monitoring vs. arterial pressure monitoring combined with Acumen Hypotension Prediction Index (HPI) software guidance on intraoperative hypotension…
- Trial name
- HPI (NCT03610165)
- Testing
- Acumen HPI-enabled EV1000 screen, Control
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- The Cleveland Clinic
Hemodynamic Instability, Blood Pressure, Low
Hemodynamic OptimizaTion in Sitting POsition Surgery Trial
Intraoperative hypotension (MAP <65 mmHg) in patients undergoing general anesthesia is a notable risk factor for the development of post-operative complications including acute kidney injury (AKI), myocardial injury, stroke and…
- Conditions
- Hemodynamic Instability, Blood Pressure, Low, Orthopedic Disorder
- Trial name
- HOTSPOT (NCT05143632)
- Testing
- ClearSight
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypotension Drug-Induced
Is Labetalol More Effective Than Metoprolol for Controlled Hypotensive Anesthesia During Endoscopic Nasal Surgeries?
Background: Mucosal bleeding is the most frequent complication with endoscopic nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, leading to increased complications, operation duration…
- Trial name
- NCT05368376
- Testing
- Labetalol Hydrochloride Oral Tablet, Metoprolol Tartrate Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Shoulder Injuries, Shoulder Osteoarthritis
The Effects of General Anesthesia and Combined Anesthesia in Controlled Hypotension During Arthroscopic Shoulder Surgery
Controlled hypotension is one of the important techniques used for facilitates the clarity of the surgical field during arthroscopic shoulder surgery.
- Trial name
- NCT05451550
- Testing
- Brachial plexus block, General anesthesia, Suprascapular nerve block
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Ningxia Medical University
Remimazolam, Propofol
Comparison in Frequency of Hypotension Between Remimazolam and Propofol in Hip Surgery
The purpose of this study is to compare the incidence of hypotension between remimazolam and propofol for intraoperative sedation in patients undergoing hip surgery with spinal anesthesia.
- Conditions
- Remimazolam, Propofol, Orthopedic Procedures, Sedatives
- Trial name
- NCT05651399
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Asan Medical Center
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania
Hypotension on Induction
CirQPOD Shoulder Study
Intrathoracic pressure regulation (IPR) therapy, delivered by impedance threshold devices (ITDs) or intrathoracic pressure regulators (ITPRs), increases venous return, preload, cardiac output, blood pressure, and cerebral…
- Trial name
- NCT04299776
- Testing
- CirQPOD, Standard airway management
- Where
- United States
- Sponsor
- Zoll Medical Corporation
Hypotension During Surgery
External Validation of Prediction Algorithm Using Non-invasive Monitoring Device for Intraoperative Hypotension
The goal of this prospective observational study is to externally validate the prediction algorithm using non-invasive monitoring device for intraoperative hypotension.
- Trial name
- NCT06897514
- Testing
- Prediction algorithm for intraoperative hypotension
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Hypotension During Surgery
Hypotension Prediction Index for Shoulder Surgery in Beach Chair.
The beach chair position is the most commonly used position during shoulder surgery and offers the surgeon numerous advantages over the lateral decubitus position.
- Trial name
- NCT06120296
- Testing
- Acumen Hypotension prediction Index software
- Where
- Belgium
- Volunteers
- 144 people
- Sponsor
- Geertrui Dewinter
Hypotension, Hypertension
Oliceridine Versus Sufentanil for Blood Pressure Control During Anesthesia Induction in Older Women With Hypertension Undergoing Gynecological Laparoscopic Surgery
Blood pressure can fall during the start of general anesthesia, particularly in older patients with high blood pressure. This study compared two medicines, oliceridine and sufentanil, to assess their effects on low blood pressure…
- Trial name
- NCT07871500
- Testing
- Oliceridine, Sufentanil
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Xingguo Xu