Clinical trials: Hypothermia, Induced
Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy
The Impact of Holding on Stress and Bonding in Mother-Infant Pairs During Therapeutic Hypothermia
This research is being done to try to improve the experience of mothers and babies during therapeutic hypothermia. Currently, mothers are not able to hold their baby during hypothermia treatment.
- Trial name
- NCT03837717
- Testing
- Holding, Saliva collection, No Holding
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- MaineHealth
Hypoxic-ischemic Encephalopathy, Neonatal Encephalopathy
Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO)
Hypoxic-ischemic encephalopathy (HIE), a condition of reduced blood and oxygen flow to a baby's brain near the time of birth, may cause death or neurologic disability.
- Conditions
- Hypoxic-ischemic Encephalopathy, Neonatal Encephalopathy, Birth Asphyxia
- Trial name
- NEATO (NCT01913340)
- Testing
- Erythropoietin, Normal saline
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal
Effect of Targeted Temperature Management on Cerebral Autoregulation in Patients With Neurocritical Diseases
Change and effect of cerebral autoregulation during targeted temperature management in neurocritical patients
- Conditions
- Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal, Sepsis, TBI (Traumatic Brain Injury)
- Trial name
- NCT04728438
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Cardiac Arrest
Induction of Mild Hypothermia in Resuscitated Cardiac Arrest Patients
The primary objectives of this study are to determine the safety and feasibility of inducing mild hypothermia using a non-invasive thermoregulatory device, the Medivance Arctic Sun Temperature Management System, in patients…
- Trial name
- NCT00282373
- Testing
- mild hypothermia
- Where
- 6 sites in United States
- Volunteers
- 64 people
- Sponsor
- Medivance, Inc.
Out-Of-Hospital Cardiac Arrest, Hypothermia
Prehospital Resuscitation Intranasal Cooling Effectiveness Survival Study 2
The aim of this clinical trial is to study the impact of ultra-early transnasal evaporative cooling after cardiac arrest and subsequent hypothermia at hospital, on survival with complete neurologic recovery, compared to currently…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Hypothermia, Ventricular Fibrillation
- Trial name
- PRINCESS2 (NCT06025123)
- Testing
- Early transnasal evaporative cooling with the RhinoChill device
- Where
- 17 sites in Austria, Belgium and 6 more
- Volunteers
- 1,022 people
- Sponsor
- Karolinska Institutet
Subarachnoid Hemorrhage, Aneurysmal
Mild Hypothermia During Intracranial Aneurysm Clipping
The purpose of this study is to determine whether mild hypothermia causes reduction of vasoconstriction in microcirculation after clipping of aneurysms, and affects the blood flow in small diameter arteries at operating site…
- Trial name
- NCT02544256
- Testing
- Mild hypothermia
- Where
- Czechia
- Sponsor
- University Hospital Hradec Kralove
Hypothermia, Induced, Rewarming
Hypothermia as an Adjunctive Therapy to Percutaneous Intervention in Patients With Acute Myocardial Infarction
To evaluate and improve the safety and efficacy of hypothermia as an adjunctive therapy to percutaneous coronary intervention in patients with acute myocardial infarction.
- Conditions
- Hypothermia, Induced, Rewarming, Myocardial Infarction, Percutaneous Cornonary Intervention
- Trial name
- COOL-MI InCor (NCT02664194)
- Testing
- Proteus® Cooling System, Primary Percutaneous Coronary Intervention
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Sao Paulo General Hospital
Knee Osteoarthritis
Effect of Foot Massage on Pain and Analgesic Consumption in Total Knee Prosthesis
This randomized controlled trial aims to examine the effects of foot massage combined with cold application on postoperative pain, patient satisfaction, and analgesic consumption in individuals undergoing Total Knee Arthroplasty…
- Trial name
- NCT07126340
- Testing
- Foot Massage and Cold Application, Cold Application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alev Keskin
Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Heat and Cold Therapy for Chemotherapy-Induced Neuropathy
Cancer patients undergoing chemotherapy experience various side effects depending on the treatment protocol used. Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a dose-limiting and quality-of-life-reducing complication…
- Trial name
- NCT06889129
- Testing
- Experimental- Heat application, Experimental-Cold application
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Hypoxic Ischemic Encephalopathy
California Transport Cooling Trial
Hypoxic ischemic encephalopathy (HIE) remains a major cause of death and severe disability despite advances in neonatal and perinatal medicine. Therapeutic hypothermia is the single most promising intervention for HIE.
- Trial name
- CTCT (NCT01683383)
- Testing
- Device (servo-regulated cooling), Control (standard practice)
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- Stanford University
Hypoxic-Ischemic Encephalopathy Mild, Neonatal Encephalopathy
TIME Study: Therapeutic Hypothermia for Infants With Mild Encephalopathy
The TIME study is a randomized, controlled trial to evaluate impact on early measures of neurodevelopment and the safety profile of therapeutic hypothermia in term neonates with Mild Hypoxic-Ischemic Encephalopathy who are < 6…
- Trial name
- TIME (NCT04176471)
- Testing
- Therapeutic Hypothermia, Normothermia
- Where
- 5 sites in United States
- Volunteers
- 68 people
- Sponsor
- Stanford University
Breast Cancer
Prevention of Paclitaxel Neuropathy With Cryotherapy
The purpose of this study is to determine if cryotherapy can effectively decrease the rate of neuropathy in patients undergoing weekly paclitaxel treatments.
- Trial name
- NCT02230319
- Testing
- Cryotherapy, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Medical Oncology & Hematology Associates of Northern Virginia
Chemotherapy Adjuvant, Breast Cancer
Efficacy and Safety of Dignicap System for Preventing Chemotherapy Induced Alopecia
The efficacy and safety of the Dignicap System to prevent chemotherapy induced alopecia will be evaluated in women with early breast cancer undergoing adjuvant or neoadjuvant chemotherapy regimens.
- Trial name
- NCT01831024
- Testing
- Dignicap System
- Where
- 4 sites in United States
- Volunteers
- 110 people
- Sponsor
- Target Health Inc.
Hypothermia, Aneurysmal Subarachnoid Hemorrhage
Trial of Long-term Therapeutic Hypothermia for Poor-grade Aneurysmal Subarachnoid Hemorrhage
This study is a prospective, multi-centre, randomized,controlled trial to compare the efficacy of long-term mild hypothermia with normothermic intensive management in patients with poor-grade aneurysmal subarachnoid hemorrhage.
- Trial name
- NCT03442608
- Testing
- Zoll 2000 and/or CureWrap 3500 cooling system
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Cardiac Arrest
Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest
The hypothesis is: In patients after an out of hospital cardiac arrest, treated with therapeutic hypothermia (33°C) will be found significantly more microcirculatory abnormalities, compared to the same group of patients treated…
- Trial name
- NCT01850485
- Testing
- microcirculation by SDF and NIRS, in 33 and 36 degrees
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Frisius Medisch Centrum
Septic Shock
The Cooling And Surviving Septic Shock Study (CASS)
Septic shock is in critically ill patients is a condition associated with a high rate of organ failure and hereto attributable mortality ~45-55% Hypothesis: Mild Induced Hypothermia reduces the mortality of critically ill…
- Trial name
- CASS (NCT01455116)
- Testing
- Mild Induced Hypothermia
- Where
- 11 sites in United States, Denmark and 1 more
- Volunteers
- 433 people
- Sponsor
- Danish Procalcitonin Study Group
Cardiac Arrest
Intra-arrest Therapeutic Hypothermia in Prehospital Cardiac Arrest
The aim is to precise the place of therapeutic hypothermia induced before Return of Spontaneous Circulation (ROSC) in pre hospital cardiac arrest.
- Trial name
- HITUPPAC-BIO (NCT00886184)
- Testing
- Hypothermia., No early hypothermia
- Where
- France
- Volunteers
- 244 people
- Sponsor
- University Hospital, Grenoble
Hypoxic-ischemic Encephalopathy (HIE)
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy in Vietnam
This study aims to evaluate the effectiveness of therapeutic hypothermia in neonates diagnosed with hypoxic-ischemic encephalopathy (HIE).
- Trial name
- HIE-TH Vietnam (NCT07555652)
- Testing
- Therapeutic Hypothermia
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- National Children's Hospital, Vietnam
Hypothermia
A Comparison of Inhalation vs. Intravenous Induction
To compart differences on the effect on core temperature between anesthetic induction with intravenous propofol versus inhalation induction with sevoflurane
- Trial name
- INHvsIV (NCT02331108)
- Testing
- Selection of anesthetic induction technique
- Where
- United States
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- Albert Einstein Healthcare Network
Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia
EEG-Based Decision-Support Algorithm for Hypoxic-Ischemic Encephalopathy in Term Newborns
This retrospective, multicenter, observational study evaluates how well a decision-support algorithm can tell apart mild forms of hypoxic-ischemic encephalopathy (HIE) from moderate or severe forms in full-term newborns born…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia, Neonatal Brain Injury
- Trial name
- COOLDECIDE (NCT07764315)
- Volunteers
- 310 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris