Clinical trials: Hypothermia
Anesthesia Induced Hypothermia, Inadvertent Perioperative Hypothermia
Study to Evaluate Safety and Efficacy of Blanket Used to Prevent Anesthesia Induced Hypothermia
The investigation was designed as an Open-Label, Multicenter, Randomised, Controlled Investigation to Evaluate the Efficacy and Safety of the BARRIER® EasyWarm Active Self-Warming Blanket Used for Continuous Active Warming to…
- Trial name
- NCT01900067
- Testing
- BARRIER® EasyWarm Active Self-Warming Blanket
- Volunteers
- 271 people
- Sponsor
- Molnlycke Health Care AB
Ischemic Stroke, Large Vessel Occlusion
Combination of Hypothermia and Thrombectomy in Acute Stroke
The goal of this clinical trial is to test the combination of hypothermia and endovascular treatment in acute stroke patients with large vessel occlusion.
- Conditions
- Ischemic Stroke, Large Vessel Occlusion, Endovascular Treatment
- Trial name
- COTTIS-2 (NCT06301412)
- Testing
- hypothermia
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University of Freiburg
Cardiac Arrest
Cerebral Oxygenation in Cardiac Arrest and Hypothermia
Data indicate that neurological prognostication is difficult after cardiac arrest if mild therapeutic hypothermia is part of the post resuscitation care.
- Trial name
- CoCaHYp (NCT01531426)
- Testing
- near infrared spectroscopy (INVOS®, Covidien)
- Where
- Germany
- Volunteers
- 94 people
- Sponsor
- Charite University, Berlin, Germany
Infant, Newborn, Hypoxia, Brain
Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE)
The Optimizing Cooling trial will compare four whole-body cooling treatments for infants born at 36 weeks gestational age or later with hypoxic-ischemic encephalopathy: (1) cooling for 72 hours to 33.5°C; (2) cooling for 120…
- Conditions
- Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic
- Trial name
- NCT01192776
- Testing
- Whole-body Cooling
- Where
- 19 sites in United States
- Volunteers
- 364 people
- Sponsor
- NICHD Neonatal Research Network
Postoperative Hypothermia, Thermal Comfort
The Effects of Active Warming on Temperature on Core Body and Thermal Comfort
Purpose: This study was conducted to examine the effect of warmed intravenous fluids (WIVF) on the core body temperature and the patients' thermal comforts during the postoperative period in patients undergoing transurethral…
- Conditions
- Postoperative Hypothermia, Thermal Comfort, Body Temperature Changes
- Trial name
- NCT04985617
- Testing
- Warmed Fluids
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Ege University
Perioperative Care, Surgery--Complications
Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
We propose to test the hypothesis that aggressive warming reduces the incidence of major cardiovascular complications, compared to routine care.
- Conditions
- Perioperative Care, Surgery--Complications, Hypothermia; Anesthesia, Myocardial Injury
- Trial name
- PROTECT (NCT03111875)
- Testing
- aggressive warming, routine thermal management
- Where
- 11 sites in United States, China
- Volunteers
- 5,056 people
- Sponsor
- The Cleveland Clinic
Cardiac Arrest
Hypothermia After In-hospital Cardiac Arrest
ILCOR Recommendations "On the basis of the published evidence to date, the Advanced Life Support (ALS) Task Force of the International Liaison Committee on Resuscitation (ILCOR) made the following recommendations in October 2002…
- Trial name
- HACAinhospital (NCT00457431)
- Testing
- Mild therapeutic hypothermia
- Where
- Germany
- Volunteers
- 249 people
- Sponsor
- University Hospital Schleswig-Holstein
Perioperative Hypothermia
Thermal Insulation System in Inadvertent Hypothermia
This study compares the effectiveness of a new layered thermal insulation system (SIT-3c) versus the traditional thermal body protection (warmed forced air system) for patients under total knee arthroplasty, during the…
- Trial name
- SIT-3c (NCT05131568)
- Testing
- Layered thermal insulation system
- Where
- Portugal
- Volunteers
- 124 people
- Sponsor
- Universidade do Porto
Hypoxic-ischemic Encephalopathy, Neonatal Encephalopathy
Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO)
Hypoxic-ischemic encephalopathy (HIE), a condition of reduced blood and oxygen flow to a baby's brain near the time of birth, may cause death or neurologic disability.
- Conditions
- Hypoxic-ischemic Encephalopathy, Neonatal Encephalopathy, Birth Asphyxia
- Trial name
- NEATO (NCT01913340)
- Testing
- Erythropoietin, Normal saline
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Preterm Infant, Hypothermia Neonatal
Kangaroo Mother Care With Plastic Bag (Trials 2A & 2B)
The purpose of this study is to determine whether the combination of Kangaroo Mother Care (KMC) as continuously as possible together with the use of a plastic bag in combination with routine World Health Organization (WHO)…
- Trial name
- NCT03141723
- Testing
- KMC & WHO protocol (0-1 hour), KMC, WHO protocol & bag (0-1 hour), KMC & WHO protocol (1-24 hours)
- Where
- Zambia
- Volunteers
- 423 people
- Sponsor
- University of Alabama at Birmingham
Anesthesia; Hypothermia, Injection Site Irritation
Topical Ice-therapy for Intravitreal Injections
Purpose: To examine the difference in patient's pain experience in the setting of intravitreal anti-VEGF injections with pretreatment of topical ice-therapy compared with no-ice.
- Trial name
- NCT05269823
- Testing
- Ice-therapy, No Ice-therapy
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypothermia, Heart Arrest
Hypothermia and Hemostasis After Cardiac Arrest
This is a sub-study to the Time-differentiated Therapeutic Hypothermia (TTH48, ClinicalTrials.gov Identifier: NCT01689077). TTH48 compares 24 with 48 hours of therapeutic hypothermia at a target temperature of 32-34°C in…
- Conditions
- Hypothermia, Heart Arrest, Hemostasis, Coagulants
- Trial name
- NCT02258360
- Testing
- Therapeutic hypothermia
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- University of Aarhus
Stroke, Ischemic
Safety and Efficacy of Therapeutic Hypothermia in Acute Ischemic Stroke
Therapeutic hypothermia (TH) in stroke has demonstrated robust neuroprotection in animals especially after ischemia-reperfusion injury, but its safety and efficacy remain controversial.
- Trial name
- THIS (NCT05779176)
- Testing
- Therapeutic hypothermia
- Where
- China
- Volunteers
- 252 people
- Sponsor
- RenJi Hospital
Hypothermia
Efficacy of Warming Garment in the Perioperative Period With Integrated Chemical Heat Packs to Maintain Normothermia
Efficacy of Stand-alone, Non-tethered, Self-applying Warming Garment in the Preoperative, Intraoperative and Postoperative Recovery Period; Using an Integrated Chemical Heat Pack Construction, With a View to Maintaining…
- Trial name
- NCT02905708
- Testing
- Air-Activated heating packs, Forced Air Warming Device
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr K Services PC
Hypothermia
Effects of Warmed, Humidified CO2 Insufflation on Body Core Temperature and Cytokine Response
The aim of this study is to assess if the conditioning of the insufflation carbon dioxide (CO2) allows for an additional benefit in terms of prevention of the heat loss, when compared with the usual prevention with a forced warm…
- Trial name
- NCT02586974
- Testing
- Humigard
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Hypothermia, Cerebral Perfusion
Assessment of the Cerebral Perfusion During the Period of Deep Hypothermia at 18°C in Patient Undergoing Pulmonary Endarterectomy Surgery.
Cardiopulmonary bypass (CPB) surgery present risk of acute postoperative neurological complications. These complications are most often postoperative cognitive dysfunction (confusion, cognitive disorders, executive disorders)…
- Conditions
- Hypothermia, Cerebral Perfusion, Transcranial Doppler Ultrasound, Pulmonary Hypertension
- Trial name
- HYPO-TEP (NCT06250374)
- Testing
- Bilateral trans-cranial Doppler ultrasound
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Encephalopathy, Hypoxic Ischemic
Neurodevelopmental Outcome in Newborn With Hypoxic-ischemic Encephalopathy Treated With Therapeutic Hypothermia
The goal of this observational study is to identify early signs of poor neurodevelopmental outcome by performing specific neurological, neurophysiological and neuroimaging assessments in newborns with hypoxic-ischemic…
- Trial name
- NCT05767476
- Testing
- Clinical and instrumental neurological assessment
- Where
- 2 sites in Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Cognitive Dysfunction
Cerebral Oximetry and Neurological Outcomes in Aortic Arch Surgery Patients
The investigators hypothesize that early intervention to optimize regional cerebral oxygenation detected by cerebral oximetry monitoring during deep hypothermic circulatory arrest (DHCA) for patients undergoing aortic surgery…
- Trial name
- NCT01149148
- Testing
- INVOS Somanetics Cerebral Oximeter
- Volunteers
- 25 people
- Sponsor
- University of Michigan
Hypothermia
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV
The overall hypothesis is that plastic bags used in combination with WHO thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine WHO…
- Trial name
- NCT01604447
- Testing
- Hypothermia prevention with plastic bag, Hypothermia prevention without plastic bag
- Where
- Zambia
- Volunteers
- 118 people
- Sponsor
- University of Alabama at Birmingham
Neuromuscular Blockade, Postoperative Pulmonary Atelectasis
Rocuronium vs Cis-atracurium: Do Rocuronium Still 'ROCKS' In Coronary Artery Bypass Grafting
The current trend in most cardiac surgeries was to use rocuronium as it provides faster recovery in train-of-four ratio compared to other aminosteroid non-depolarising neuromuscular blocker.
- Conditions
- Neuromuscular Blockade, Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complication, Coronary Artery Disease
- Trial name
- NCT06102915
- Testing
- Rocuronium Bromide 10 MG/ML, Nimbex 10 MG in 5 ML Injection
- Where
- Malaysia
- Volunteers
- 289 people
- Sponsor
- Institut Jantung Negara