Clinical trials: Hypothermia
Covid19, SARS-CoV Infection
COVID-19 in Polish Ice Swimmers.
Ice swimming is an increasingly common phenomenon in Poland. It has been confirmed that it has a beneficial effect on health by increasing the natural non-specific immunity to infections.
- Conditions
- Covid19, SARS-CoV Infection, Resistance, Disease, Hypothermia
- Trial name
- ICE (NCT04817280)
- Testing
- Ice Swimming
- Where
- 3 sites in Poland
- Volunteers
- 2,534 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Subdural Hematoma, Traumatic
To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients
This randomized, prospective trial will study the effect of very early cooling in patients undergoing surgical evacuation of acute subdural hematomas (35°C prior to opening the dura followed by maintenance at 33°C for a minimum…
- Trial name
- HOPES (NCT02064959)
- Testing
- Temperature management Zoll Intravascular Temperature Management device
- Where
- 14 sites in United States, Japan
- Volunteers
- 32 people
- Sponsor
- The University of Texas Health Science Center, Houston
Liver Transplantation
Hypothermic Oxygenated Perfusion for Extended Criteria Donors in Liver Transplantation (HOPExt)
Given the scarce donor supply, an increasing number of so-called marginal or extended criteria donor (ECD) organs have been used for liver transplantation.
- Trial name
- HOPExt (NCT03929523)
- Testing
- End-ischemic Hypothermic Oxygenated Machine Perfusion (HOPE), classic static cold storage
- Where
- 8 sites in France
- Volunteers
- 266 people
- Sponsor
- Hospices Civils de Lyon
Hypothermia
National Epidemiologic Survey on the Incidence of Perioperative Hypothermia
Study Objective: to project the incidence of perioperative hypothermia in patients with elective surgery under general anesthesia in China to determine the risk factors associated with perioperative hypothermia.
- Trial name
- NCT02211703
- Where
- China
- Volunteers
- 2,208 people
- Sponsor
- Jie YI
Newborn Asphyxia, Hypothermia Neonatal
Effectiveness of Simulation-based Training Delivered to Special Newborn Care Providers on Resuscitation Management and Kangaroo Mother Care: Simulation-based Training for Asyphxia in Babies Trial (STAR-Baby Trial)
Summary Background Neonatal mortality remains a major global public health challenge, with about 2.4 million newborn deaths occurring within the first month of life in 2020.
- Trial name
- STAR-Baby (NCT07574944)
- Testing
- Simulation-based training using Neonatalie
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Integrated Development Foundation Nepal
Hypothermia, Reperfusion Injury
A Trial of Intravascular Hypothermia Therapy in Acute Ischemic Stroke Patients
Acute ischemic stroke (AIS) has been one of the major causes of global mortality and morbidity. The superiority of endovascular therapy (EVT) over standard medical therapy in treating AIS due to large vessel occlusion (LVO) in…
- Conditions
- Hypothermia, Reperfusion Injury, Ischemic Stroke, Thrombectomy
- Trial name
- NCT04695236
- Testing
- ZOLL Intravascular Temperature Management system, Quattro catheter, Standard Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- jiaoliqun
Congenital Heart Defects
Cylexin for Reduction of Reperfusion Injury in Infant Heart Surgery
We conducted a multicenter, randomized, placebo-controlled trial of Cylexin, an inhibitor of the attachment of white blood cells to the endothelium.
- Trial name
- NCT00226369
- Testing
- CY-1503
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Boston Children's Hospital
Myocardial Infarction Complicated With Cardiogenic Shock
Adjunctive Mild Hypothermia Therapy to Primary Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction Complicated With Shock: A Feasibility Study
The purpose of this study is evaluate the safety and feasibility of mild therapeutic hypothermia (TH) during and 12 hours after primary percutaneous coronary intervention for acute myocardial infarction complicated with shock
- Trial name
- NCT00846222
- Testing
- Hypothermia
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Assaf-Harofeh Medical Center
Hypoxic Ischemic Encephalopathy
California Transport Cooling Trial
Hypoxic ischemic encephalopathy (HIE) remains a major cause of death and severe disability despite advances in neonatal and perinatal medicine. Therapeutic hypothermia is the single most promising intervention for HIE.
- Trial name
- CTCT (NCT01683383)
- Testing
- Device (servo-regulated cooling), Control (standard practice)
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- Stanford University
Inadvertent Perioperative Hypothermia
Prevention of Hypothermia During Caesarean Section: Continuous Core Temperature Monitoring With Zero-heat-flux
Nowadays, caesarean sections account for about 7% of all surgical procedures worldwide. Over 30% of the patients undergoing a caesarean section experience a fall of the body core temperature under 36°C during the procedure.
- Trial name
- NCT04132154
- Testing
- Convective Forced-Air Active Warming
- Where
- Germany
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- St. Marien-Hospital Düren
Spinal Surgery
The Effect of Perioperative Warm Socks on Maintaining Body Temperature in Patients Undergoing Spinal Surgery
It is important to maintain the body temperature of patients during spine surgery because hypothermia that occurs during surgery can increase the risk of complications and negatively affect the recovery process.
- Trial name
- NCT06592807
- Testing
- Perioperative Warm Socks
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Kocaeli University
Fever, Scoliosis
Immediate Fever During Anaesthesia Recovery After Surgical Procedure With Scoliosis
Fever is a common clinical symptom in patients with postoperative scoliosis. However, there are rare reports of immediately fevers occurring following operative procedures.
- Conditions
- Fever, Scoliosis, Surgical Trauma, Hypothermia
- Trial name
- NCT06405659
- Testing
- correction for pedicle fixation
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Affiliated Hospital of Guangdong Medical University
Cardiopulmonary Bypass, Hypothermia; Anesthesia
Effect of Hypothermia on BIS and PSI Correlation During Cardiopulmonary Bypass
The goal of this observational study is to evaluate whether hypothermia affects the relationship between electroencephalography-derived indices during cardiac surgery in adult patients undergoing cardiopulmonary bypass.
- Conditions
- Cardiopulmonary Bypass, Hypothermia; Anesthesia, Depth of Anesthesia Monitoring
- Trial name
- NCT07508579
- Testing
- Simultaneous BIS and PSI Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Preterm Infant, Low Birth Weight Infant
m-Health System for Tracking Kangaroo Mother Care and Temperature in Southern India
The product innovation is a wearable device that (combined with a smartphone and back-end analytics system) acts as a sensor, processor and actuator, and is therefore designed to identify critical parameters (Kangaroo Mother Care…
- Conditions
- Preterm Infant, Low Birth Weight Infant, Kangaroo Mother Care, Hypothermia, Newborn
- Trial name
- NCT04929977
- Testing
- Wearable device with smart mobile phone
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. John's Research Institute
Out of Hospital Cardiac Arrest
Time-differentiated Therapeutic Hypothermia
The purpose of this study is to determine if 48 hours of mild therapeutic hypothermia following out of hospital cardiac arrest gives a better cerebral outcome compared to 24 hours therapeutic hypothermia.
- Trial name
- TTH48 (NCT01689077)
- Testing
- Therapeutic hypothermia
- Where
- 10 sites in Belgium, Denmark and 4 more
- Volunteers
- 355 people
- Sponsor
- University of Aarhus
Hypothermia, Newborn
Kangaroo Mother Care to Prevent Hypothermia in Term Infants
The overall hypothesis is that better adherence to Kangaroo Mother Care (KMC) in combination with existing WHO thermoregulation care will reduce the incidence of moderate hypothermia (32-36 degrees C) or severe hypothermia (<32.0…
- Trial name
- NCT02189759
- Testing
- Continuous Kangaroo Mother Care to one hour after birth, Standard Kangaroo Mother Care to one hour after birth, Continuous Kangaroo Mother Care to discharge
- Where
- Zambia
- Volunteers
- 375 people
- Sponsor
- University of Alabama at Birmingham
Acute Ischemic Stroke
Hypothermia in Acute Stroke With Thrombolysis Imaging Evaluation of Revascularization
The primary objective of this Phase 2 HASTIER study, as an ancillary study to ICTuS 2, is to compare key imaging measurements for serial changes in recanalization and reperfusion between hypothermia and normothermia treatment…
- Trial name
- HASTIER (NCT01778855)
- Testing
- IV t-PA and normothermia, IV-tPA and hypothermia
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of California, Los Angeles
Septic Shock
The Cooling And Surviving Septic Shock Study (CASS)
Septic shock is in critically ill patients is a condition associated with a high rate of organ failure and hereto attributable mortality ~45-55% Hypothesis: Mild Induced Hypothermia reduces the mortality of critically ill…
- Trial name
- CASS (NCT01455116)
- Testing
- Mild Induced Hypothermia
- Where
- 11 sites in United States, Denmark and 1 more
- Volunteers
- 433 people
- Sponsor
- Danish Procalcitonin Study Group
Out of Hospital Cardiac Arrest, Inflammatory Response
Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response.
The on-going randomized clinical trial TTM2 (Target Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, NCT02908308) investigates if there is a difference in mortality, neurological function or quality…
- Conditions
- Out of Hospital Cardiac Arrest, Inflammatory Response, Ischemia Reperfusion Injury, Hypothermia
- Trial name
- IH3 (NCT03743584)
- Testing
- Targeted temperature management, Standard care, early treatment of fever
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Hypothermia Following Anesthesia
Impact of Forced Air Warming on Perioperative Thermodynamics
The purpose of the study is to assess the temperature changes that take place throughout the body in a real world setting, when a patient is given general anaesthesia.
- Trial name
- NCT03191214
- Testing
- Intraoperative Forced Air Warming
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London