Clinical trials: Hypothermia
Hypoxic-Ischemic Encephalopathy, Hepatitis B Vaccination
Hypothermia's Effect on Hepatitis B Vaccination
The purpose of the research is to determine if the Hepatitis B vaccine after birth provides enough protection after cooling for Hypoxic Ischemic Encephalopathy (HIE).
- Conditions
- Hypoxic-Ischemic Encephalopathy, Hepatitis B Vaccination, Hypothermia, Newborn
- Trial name
- NCT05787899
- Testing
- Hypothermia Protocol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Medical University of South Carolina
Cellular Injury and Post-Cryogenic Recovery, Cryogenic Cellular Stress
Evaluation of In-Vitro Cryo Therapeutic Protocols on Human Cell Samples (TWH-CRYO-001)
This laboratory-based study evaluates the effects of controlled cryogenic preservation on human cell samples using Truway Health's in-vitro cryo therapeutic methodology.
- Conditions
- Cellular Injury and Post-Cryogenic Recovery, Cryogenic Cellular Stress, Cold-Induced Cellular Injury, Thermal Injury Response
- Trial name
- CRYO-IVT (NCT07321028)
- Testing
- Standard Laboratory Cryopreservation Procedure, Enhanced Laboratory Cryopreservation Procedure, Normothermic Cell Culture Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Truway Health, Inc.
Shivering, Hypothermia
Effect of Preoperative Intranasal Dexmedetomidine on Incidence of Intraoperative Shivering in Patients Undergoing Cesarean Section Under Spinal Anesthesia
Shivering is a common and distressing complication occurring in 40% to 60% of women undergoing cesarean section under spinal anesthesia.
- Conditions
- Shivering, Hypothermia, Cesarean Section, Spinal Anaesthesia
- Trial name
- NCT07855536
- Testing
- Dexmedetomidine, Meperidine, Normal Saline 0.9%
- Volunteers
- 99 people
- Sponsor
- Assiut University
Cardiac Arrest
Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial
Cardiac arrest is a sudden, unexpected loss of heart function. Therapeutic hypothermia, in which the body's temperature is lowered and maintained several degrees below normal for a period of time, has been used to successfully…
- Trial name
- THAPCA-IH (NCT00880087)
- Testing
- Therapeutic Hypothermia, Therapeutic Normothermia
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 329 people
- Sponsor
- University of Michigan
Hypothermia
Effectiveness of Nefopam for Thermoregulation During Surgery
Nefopam may help blunt thermoregulatory defenses, thus facilitating induction of therapeutic hypothermia
- Trial name
- NCT03122665
- Testing
- Nefopam Low dose, Nefopam High dose
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Hypoxic Ischemic Encephalopathy
Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy
The hypothesis is that premature infants' can have enough cooling applied to cool their brain to decrease CNS injury without cooling their body.
- Trial name
- NCT00620711
- Testing
- Olympic Cool Cap
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University
Asphyxia Neonatorum, Hypoxia
TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia
Hypothesis: Prolonged whole body cooling in term infants with perinatal asphyxial encephalopathy reduces death and severe neurodevelopmental disability.
- Conditions
- Asphyxia Neonatorum, Hypoxia, Encephalopathy, Seizures
- Trial name
- NCT00147030
- Testing
- Whole body mild induced hypothermia
- Where
- United Kingdom
- Volunteers
- 325 people
- Sponsor
- Imperial College London
Hypoxic-Ischemic Encephalopathy Mild, Neonatal Encephalopathy
TIME Study: Therapeutic Hypothermia for Infants With Mild Encephalopathy
The TIME study is a randomized, controlled trial to evaluate impact on early measures of neurodevelopment and the safety profile of therapeutic hypothermia in term neonates with Mild Hypoxic-Ischemic Encephalopathy who are < 6…
- Trial name
- TIME (NCT04176471)
- Testing
- Therapeutic Hypothermia, Normothermia
- Where
- 5 sites in United States
- Volunteers
- 68 people
- Sponsor
- Stanford University
Neonatal Hypothermia
Pilot Clinical Assessment of Low-cost Infant Incubator in Monitoring Temperature and Treating Hypothermia in Infants
A team of researchers at Rice University and Queen Elizabeth Central Hospital (QECH) are working to develop a low-cost infant incubator called "IncuBaby" that consists of two components: a temperature sensor that can continuously…
- Trial name
- NCT03965312
- Testing
- Continuous temperature monitor, Neonatal Incubator, Patient monitor
- Where
- Malawi
- Volunteers
- 150 people
- Sponsor
- William Marsh Rice University
Hypothermia
Multicenter Application of the Intraoperative Hypothermia Risk Prediction Scale and the Distribution of Risk Factor Characteristics in Surgical Patients
Research Plan 1.Data Collection and Quality Control Before the study begins, operating room nursing managers and clinical specialist nurses from 12 participating medical institutions will undergo unified online and offline…
- Trial name
- NCT06836245
- Testing
- Measure the patient's body temperature intraoperatively using instruments
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Orthostatic Hypotension, Hemodynamic Instability
Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery
The purpose of this study is to evaluate the effect of low dose versus high dose steroids vital signs of patients currently on steroids or recently treated with steroids undergoing major colorectal surgery.
- Conditions
- Orthostatic Hypotension, Hemodynamic Instability, Fever, Hypothermia
- Trial name
- NCT01559675
- Testing
- Hydrocortisone High Dose, Hydrocortisone Low Dose
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Cedars-Sinai Medical Center
Anoxic-Ischemic Encephalopathy
Becoming Children With Perinatal Anoxo-Ischemic Encephalopathy Without Indication of Therapeutic Hypothermia
There are 3 levels of severity of anoxo-ischemic encephalopathy (EAI): mild, moderate and severe. Therapeutic hypothermia is beneficial in children with moderate EAI.
- Trial name
- SARNATUN (NCT03744481)
- Testing
- Questionaire
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Hospices Civils de Lyon
Hypothermia, Accidental, Hypothermia Due to Cold Environment
Accidental Hypothermia in Drowning-related OHCA
This study aims to report mortality and neurological outcome 180 days after drowning incident in patients with accidental hypothermia vs normothermia following drowning-related OHCA in Denmark during a six-year period from…
- Conditions
- Hypothermia, Accidental, Hypothermia Due to Cold Environment, Drowning, Out-Of-Hospital Cardiac Arrest
- Trial name
- NCT05908630
- Testing
- Hypothermia
- Where
- Denmark
- Volunteers
- 119 people
- Sponsor
- Prehospital Center, Region Zealand
Hypothermia Due to Cold Environment
Characterization of Corticospinal Excitability During Progressive Skin Cooling
This study characterizes the changes in corticospinal excitability that accompany basic cold stress via skin cooling that result in reduced skin or core temperature and shivering.
- Trial name
- NCT04253730
- Testing
- Cold Stress
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hypothermia; Anesthesia, Hypothermia, Newborn
Perioperative Warming Measures in Cesarean Delivery
The purpose of this study is to evaluate the best method for keeping patients warm during cesarean deliveries and the effect of temperature change on the patient and baby
- Conditions
- Hypothermia; Anesthesia, Hypothermia, Newborn, Hypothermia, Sequela
- Trial name
- NCT05015582
- Testing
- Pre op upper body forced air warming (32˚C), Pre op lower body forced air warming (32˚C), Pre op fluids (45˚C)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center, Houston
Out of Hospital Cardiac Arrest, Stent Thrombosis
Definite Stent Thrombosis in Comatose Out of Hospital Cardiac Arrest Survivors
Reliable data on stent thrombosis (ST) in comatose out of hospital cardiac arrest (OHCA) survivors is lacking. In comatose OHCA survivors suspicion of ST can be made with precise clinical monitoring of the patient with definite…
- Conditions
- Out of Hospital Cardiac Arrest, Stent Thrombosis, Drug Eluting Stent, Therapeutic Hypothermia
- Trial name
- ST OHCA (NCT03312296)
- Where
- Slovenia
- Volunteers
- 151 people
- Sponsor
- University Medical Centre Ljubljana
Traumatic Brain Injury
Hypothermia in Children After Trauma
The primary hypothesis for this application for a multicenter phase III randomized clinical trial (RCT) is that induced moderate hypothermia (HYPO) (32-33 °C) after severe traumatic brain injury (TBI) in children and maintained…
- Trial name
- NCT00222742
- Testing
- induced moderate hypothermia
- Where
- 30 sites in United States, Australia and 4 more
- Volunteers
- 90 people
- Sponsor
- Phoenix Children's Hospital
Perinatal Asphyxia, Hypothermia Treatment
Quantification of Brain and Kidney Perfusion Before, During, and After Hypothermia Treatment in Neonates With Perinatal Asphyxia Using Contrast-enhanced Ultrasound
In this clinical study vascular dynamics in the neonatal brain and kidney will be monitored by CUES and ULM before, during and after hypothermia treatment in neonates with asphyxia.
- Conditions
- Perinatal Asphyxia, Hypothermia Treatment, Gestational Age Min. 36SSW
- Trial name
- NCT06611254
- Testing
- Contrast enhanced ultrasound imaging (CEUS) and post processing with ULM
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Acute Type A Aortic Dissection, Hypothermia
Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection
The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals in China.
- Conditions
- Acute Type A Aortic Dissection, Hypothermia, Total Aortic Arch Replacement, Frozen Elephant Trunk
- Trial name
- AHEAD (NCT07150559)
- Testing
- Arch-Clamping Technique under Mild Hypothermia, Arch-Clamping Technique under Moderate Hypothermia, Total Arch Replacement combined Frozen Elephant Trunk Implantation using Bilateral Antegrade Cerebral Perfusion under Moderate Hypothermic Circulatory Arrest
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Arrest
Hypothermia After In-hospital Cardiac Arrest
ILCOR Recommendations "On the basis of the published evidence to date, the Advanced Life Support (ALS) Task Force of the International Liaison Committee on Resuscitation (ILCOR) made the following recommendations in October 2002…
- Trial name
- HACAinhospital (NCT00457431)
- Testing
- Mild therapeutic hypothermia
- Where
- Germany
- Volunteers
- 249 people
- Sponsor
- University Hospital Schleswig-Holstein