Clinical trials: Hypothermia
Out-Of-Hospital Cardiac Arrest, Accidental Hypothermia
Core Temperature in Patients With OHCA
A prospective observational study aiming to monitor core temperature via an esophageal probe in out of hospital cardiac arrest during transport and until arrival in hospital.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Accidental Hypothermia, Temperature Change, Body
- Trial name
- CT-OCHA (NCT04976712)
- Where
- Italy
- Volunteers
- 256 people
- Sponsor
- Azienda Sanitaria dell'Alto Adige
Hypothermia
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III
The overall hypothesis is that plastic bags used in combination with WHO thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine WHO…
- Trial name
- NCT01604434
- Testing
- Incubator-torso bag, Incubator-no plastic bag
- Where
- Zambia
- Sponsor
- University of Alabama at Birmingham
Out of Hospital Cardiac Arrest
Initiation of Cooling by EMS to Promote Adoption of In-hospital Hypothermia in Cardiac Arrest Survivors
This is a large pragmatic, randomized controlled trial comparing pre-hospital initiation of therapeutic hypothermia by Emergency Medical Services (EMS) providers to conventional post-resuscitation care.
- Trial name
- NCT01528475
- Testing
- Pre-hospital cooling
- Where
- 3 sites in Canada
- Volunteers
- 585 people
- Sponsor
- Sunnybrook Health Sciences Centre
Neonatal Encephalopathy
CoolCap Followup Study-Coordination of Participating Centers
This observational study will assess long-term functional outcome of survivors from neonatal encephalopathy who were previously treated with either head cooling or with conventional care in a randomized clinical trial.
- Trial name
- NCT00581581
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Rochester
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Concomitant Limb Cryocompression and Scalp Cooling to Reduce Paclitaxel-induced Neuropathy and Alopecia
Paclitaxel is a chemotherapy drug that is used to treat breast cancer, one of the most common cancers. It causes two side effects very often - hair-loss and numbness.
- Trial name
- NCT03248193
- Testing
- Concomitant limb cryocompression and scalp cooling
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Coronary Artery Bypass, Cardiopulmonary Bypass
The Effect of Nitroglycerin Infusion Rate on Cerebral Rewarming During Hypothermic Coronary Artery Bypass Grafting
Glyceryl trinitrate is used in coronary artery bypass grafting surgery. This surgery frequently employs hypothermic cardiopulmonary bypass, where the whole body is cooled down to 28-32 °C to arrest the heart, and protect the…
- Trial name
- nitrotherm (NCT03251599)
- Testing
- Glyceryl trinitrate 0.2, Glyceryl trinitrate 0.5
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Recep Tayyip Erdogan University
Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
Cerebral/Cortical Visual Impairment (CVI) is the leading cause of childhood visual impairment in the United States and other industrialized countries.
- Trial name
- CVI (NCT07275021)
- Testing
- Prospective Clinical and Neurodevelopmental Data Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Hypoxic Ischaemic Encephalopathy
Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth
This study examines the effect of inhaled xenon gas in the treatment of newborn infants with hypoxic-ischemic encephalopathy (HIE) in combination with cooling, which is the standard treatment for this condition.
- Trial name
- CoolXenon3 (NCT02071394)
- Testing
- Xenon gas, Whole body cooling
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Hypoxic-ischemic Encephalopathy
Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia
The goal of this proposal is to profile the pharmacokinetics of dexmedetomidine in newborns ≥36 weeks post-menstrual age during therapeutic hypothermia for hypoxic-ischemic encephalopathy.
- Trial name
- NCT02529202
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Seattle Children's Hospital
Hypothermia, Hyperthermia
Temperature Measurement in Surgical and Intensive Care Patients - Comparison of Four Measurement Methods
Comparison of four methods for measuring temperature perioperatively in patients scheduled for laparoscopic surgery and intensive care patients who are hypo-, normo-and hyper terme; Bladder Monitoring, Nasopharyngeal, SpotOn TM…
- Trial name
- Temp (NCT02220101)
- Where
- Norway
- Volunteers
- 95 people
- Sponsor
- Sykehuset i Vestfold HF
Ischemic Stroke, Revascularization
Reperfusion With Hypothermia in Acute Ischemic Stroke
The primary objective of this study is to determine the feasibility and safety of receiving intravascular hypothermia treatment for patients experiencing endovascular treatment after acute ischemic stroke(AIS) due to a large…
- Conditions
- Ischemic Stroke, Revascularization, Endovascular Treatment, Reperfusion Injury
- Trial name
- RESCUE-HYPO (NCT05676957)
- Testing
- Thermogard XP3
- Volunteers
- 30 people
- Sponsor
- Liping Liu
Hypothermia Due to Cold Environment
Thermoregulation During a 25-km Open Water Race
Open water swimming is a swimming discipline which takes place in outdoor water such as open oceans, lakes, and rivers. Elite swimmers are exposed to hypothermia when swimming in cold water, especially in long duration races…
- Trial name
- THERMO25 (NCT04460339)
- Testing
- Swimming participants in the 25-km
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Caen
Out-of-hospital Cardiac Arrest
Prehospital Resuscitation Intra Nasal Cooling Effectiveness Survival Study
Promising result of intra-arrest cooling on neurological intact survival in cardiac arrest patients has recently been published in the PRINCE-study in Circulation 2010.
- Trial name
- PRINCESS (NCT01400373)
- Testing
- Prehospital intra-nasal cooling with RhinoChill
- Where
- 2 sites in Belgium, Sweden
- Volunteers
- 700 people
- Sponsor
- Karolinska Institutet
Organ Preservation, Liver Transplantation
Long-term Outcomes After Hypothermic Oxygenated Machine Perfusion of Donor Livers Using Real-world Data
End-ischemic hypothermic oxygenated machine perfusion (HOPE) of human donor livers mitigates ischemia-reperfusion injury, resulting in a reduction of post-reperfusion syndrome, early allograft dysfunction and biliary…
- Conditions
- Organ Preservation, Liver Transplantation, Hypothermic Machine Perfusion
- Trial name
- HOPE-REAL (NCT05520320)
- Testing
- Hypothermic oxygenated machine perfusion (any device)
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Critical Illness, Cardiac Arrest
Influence of Skeletal Muscle Paralysis on Metabolism in Hypothermic Patients After Cardiac Arrest
The purpose of this study is to evaluate the impact of muscle relaxing drugs on the energy rate during hypothermia after cardiac arrest.
- Trial name
- NCT01683006
- Testing
- Rocuronium
- Where
- Austria
- Volunteers
- 43 people
- Sponsor
- Medical University of Vienna
Cerebrovascular Circulation
Cerebral Perfusion in Hypothermic Circulatory Arrest
Selective antegrade cerebral perfusion (sACP) during aortic arch surgery in hypothermic circulatory arrest (HCA) is an established method for intraoperative neuroprotection.
- Trial name
- NCT03484104
- Testing
- Measurement of tissue oxygenation index (TOI)
- Where
- 2 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Accidental Hypothermia
International Registry of Accidental Hypothermia
Transient mild hypothermia (core body temperature 35-32°C) is common and usually without consequences for the brain or other organs.
- Trial name
- IHR (NCT06200285)
- Testing
- Registry of patients with accidental hypothermia
- Where
- 16 sites in Austria, Denmark and 7 more
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Acute Ischemic Stroke
Intra-arterial Selective Hypothermic Magnesium Sulfate Infusion in Combination With Endovascular Thrombectomy in Acute Ischemic Stroke
The primary objective of this study is to estimate the safety and effectiveness of selective intra-arterial hypothermic magnesium sulfate infusion after endovascular thrombectomy in patients with acute ischemic stroke.
- Trial name
- ICE-MAG (NCT07163299)
- Testing
- Endovascular thrombectomy combination with selective intra-arterial hypothermic magnesium sulfate infusion (350 ml)., Endovascular thrombectomy combination with selective intra-arterial hypothermic magnesium sulfate infusion (500 ml)., Endovascular thrombectomy combination with selective intra-arterial hypothermic magnesium sulfate infusion (650 ml).
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Capital Medical University
Cerebral Hemorrhage, Hypothermia
Targeted Temperature Management After Intracerebral Hemorrhage
Early hematoma growth (HG) after spontaneous intra-cerebral/intra-parenchymal hemorrhage (IPH) is common and associated with neurological deterioration and poor clinical outcome.
- Trial name
- NCT01866384
- Testing
- mild induced hypothermia, Normal Temperature
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Cardiac Arrest
Multicenter Registry Study With Therapeutic Hypothermia After Cardiac Arrest in Japan
Recently, early defibrillation and cardiopulmonary resuscitation (CPR) for sudden onset of cardiac arrest are advancing, however, survival rate is still very low in the world.
- Trial name
- J-PULSE-HYPO (NCT00901134)
- Where
- 14 sites in Japan
- Volunteers
- 452 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan