Clinical trials: Hypoventilation
Obstructive Sleep Apnoea (OSA), Hypoventilation Syndrome
Sleep-disordered Breathing Database
The goal of this study is to collect clinical data on patients who have had a sleep study and are given a diagnosis of a sleep related breathing disorder such as obstructive sleep apnoea.
- Trial name
- NCT07402603
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Chest Wall Disorder, Neuromuscular Disease
AutoVPAP Versus VPAP; Assessment of Sleep and Ventilation
The aim of the study is to compare the effects of a modified form (AutoVPAP) of the VPAP non-invasive ventilator versus standard VPAP ventilation on sleep quality and breathing during sleep in stable patients with nocturnal…
- Trial name
- NCT00252252
- Testing
- VPAP non-invasive ventilator, AutoVPAP non-invasive ventilator
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- ResMed
Euthyroid Sick Syndrome, Obesity Hypoventilation Syndrome (OHS)
Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome
The goal of this observational study is to learn about the frequency and clinical impact of Euthyroid Sick Syndrome (ESS) in patients with Obesity Hypoventilation Syndrome (OHS) who are admitted to the intensive care unit (ICU)…
- Trial name
- NCT06983418
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Mansoura University
Obesity Hypoventilation Syndrome, Obesity
The Effect of Obesity Hypoventilation Syndrome on Exercise Capacity, Peripheral Muscle Strength, and Quality of Life in Obese Individuals
Obesity Hypoventilation Syndrome(OHS) is a disease characterized by daytime hypercapnia and sleep-disordered breathing without other causes of hypoventilation in individuals with a body mass index above 30 kg/m2.
- Conditions
- Obesity Hypoventilation Syndrome, Obesity, Hypoventilation, Respiration Disorders
- Trial name
- NCT06142513
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istanbul University
Healthy Adults, Stress
Breathing Interventions for Relaxation: Dosing Through Extended Exhale
Breathing exercises are categorized as a mind-body practice. One in ten adults in the U.S. use breathing exercises for health purposes.
- Trial name
- NCT02870868
- Testing
- Slow breathing
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Bariatric Surgery Candidate, Obesity, Morbid
Prophylactic Use of Noninvasive Ventilation in the Postoperative Period of Bariatric Surgery
Comorbidities associated with severe obesity determine an important public health problem. Few methods are considered potentially effective for the treatment of severe obesity and the clinical relevance of bariatric surgery is…
- Conditions
- Bariatric Surgery Candidate, Obesity, Morbid, Ventilatory Failure
- Trial name
- NCT04805476
- Testing
- Non invasive mechanical ventilation, GP
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obesity-hypoventilation Syndrome, Resting Energy Expenditure
Resting Energy Expenditure in Patients With OHS Treated With Long-term NIV
This study aims to compare, in subjects with obesity-hypoventilation syndrome (OHS) treated by long-term non-invasive ventilation (NIV), resting energy expenditure (REE) in spontaneous breathing and under NIV.
- Conditions
- Obesity-hypoventilation Syndrome, Resting Energy Expenditure, Long-term Non-invasive Ventilation
- Trial name
- NCT04474587
- Testing
- Indirect calorimetry
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Uncontrolled Partial Epilepsy, Ictal Hypoventilation
Efficacy of Fluoxetine in Reducing Ictal Hypoventilation in Patients With Partial Epilepsy
The purpose of this study is to determine the effects of fluoxetine on breathing mechanisms during seizures. Patients with partial epilepsy commonly have changes in their breathing mechanisms during seizures.
- Trial name
- NCT00986310
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, Davis
Pulmonary Disease, Chronic Obstructive, Amyotrophic Lateral Sclerosis
European Home Mechanical Ventilation Registry
The European Home Mechanical Ventilation Registry (EHMVR) will enable a thorough evaluation of HMV by documenting the characteristics of HMV patients and their treatment.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Muscular Dystrophies
- Trial name
- EHMVR (NCT02315339)
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- ResMed
Obesity Hypoventilation Syndrome, Ketogenic Dieting
Ketogenic Diet for Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) is a condition that occurs in small percentage of obese people that causes high carbon dioxide and low oxygen levels in the blood.
- Conditions
- Obesity Hypoventilation Syndrome, Ketogenic Dieting, Hypercapnic Respiratory Failure
- Trial name
- KETOHS (NCT04108819)
- Testing
- Ketogenic Diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Respiratory Failure, Ventilatory Failure
Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19 Infection
This study uses the AirGo band to monitor changes in tidal ventilation in spontaneously breathing patients with COVID-19 associated respiratory failure.
- Conditions
- Respiratory Failure, Ventilatory Failure, COVID-19, Pneumonia
- Trial name
- NCT04356443
- Testing
- AirGo Respiratory Monitor
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Hypercapnic Respiratory Failure, Sleep Disordered Breathing
Remote Monitoring to Improve Low Adherence in Non-invasive Ventilation
Patients are invited to participate in a trial to test a new way to optimise long-term use of non-invasive ventilation using remote monitoring.
- Conditions
- Hypercapnic Respiratory Failure, Sleep Disordered Breathing, COPD, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- READ-NIV (NCT04884165)
- Testing
- Remote monitoring of home mechanical ventilation (NIV) using SRETT, Home mechanical ventilation (NIV) without remote monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Respiratory Insufficiency, Opioid Overdose
Development of a Tracheal Sound Sensor
An observational study will be conducted in 20 hospitalized surgical patients routinely managed with opioids for anesthesia and post-operative pain control.
- Conditions
- Respiratory Insufficiency, Opioid Overdose, Hypoventilation
- Trial name
- NCT05506267
- Testing
- Trachea Sound Sensor (TSS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Metabolic Syndrome, Obesity Hypoventilation Syndrome
Obesity-hypoventilation in Metabolic Syndrom Patients
The purpose of the study is to determined the prevalence of obesity-hypoventilation syndrome in patients with metabolic syndrom.
- Conditions
- Metabolic Syndrome, Obesity Hypoventilation Syndrome, Capnography
- Trial name
- NCT04839419
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- SOS Oxygene Mediterranee
Respiratory Insufficiency, Obesity Hypoventilation Syndrome
Juno Perth Clinical Trial
This study is to evaluate the efficacy of a new therapy (Automatic Expiratory Positive Airway Pressure with intelligent Volume Assured Pressure Support (AutoEPAP iVAPS)) designed to treat respiratory insufficiency, respiratory…
- Conditions
- Respiratory Insufficiency, Obesity Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Disease
- Trial name
- NCT02317042
- Testing
- Juno
- Where
- 2 sites in Australia
- Volunteers
- 25 people
- Sponsor
- ResMed
Alveolar Hypoventilation
Assessment of Therapeutic Education About Non Invasive Ventilation in Patients With Chronic Respiratory Failure (QoVNI)
The purpose of the study is to assess the therapeutic education of patients with chronic respiratory failure who start to be treated with non invasive ventilation and during the first six months of ventilation.
- Trial name
- QoVNI (NCT03090126)
- Testing
- Therapeutic education
- Where
- France
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Pain
The Role of Opioidergic Systems in Breathing Based Analgesia
The purpose of this psychophysical and pharmacologic study is to determine if slow-breathing induced pain relief is mediated by endogenous opioids in response to intravenous (IV) administration of the opioid antagonist naloxone…
- Trial name
- NCT03419858
- Testing
- Mindfulness Meditation, Slow-Breathing, Naloxone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Ventilatory Failure, Hypoxemic Respiratory Failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal…
- Conditions
- Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
- Trial name
- PREVISION (NCT06716463)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
Obesity Hypoventilation Syndrome
Prevalence of Obesity Hypoventilation Syndrome
Rationale of the "BIO-OHS" study (Prevalence of Obesity Hypoventilation Syndrome): The overall prevalence of Obesity Hypoventilation Syndrome (OHS) has never been directly assessed in the general population.
- Trial name
- BIO-OHS (NCT01903135)
- Testing
- Blood test analysis in the clinical labs, Pneumologist consult to establish the diagnosis of OHS
- Where
- 5 sites in France
- Volunteers
- 1,004 people
- Sponsor
- AGIR à Dom
Hypoventilation
Capnography Monitoring in the Bronchoscopic Sedation
Procedure sedation of flexible bronchoscopy (FB) comforts patients undergoing FB. Hypoventilation during FB is a concern. The investigators investigate the feasibility of monitoring capnography in FB sedation.
- Trial name
- NCT02848118
- Testing
- A nasal-oral cannula of capnography, Observer Assessment of Alertness and Sedation scale
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- Chang Gung Memorial Hospital