Clinical trials: Hypoventilation, active
Acute Respiratory Distress Syndrome (ARDS), Pneumonia
Medical Device Clinical Trial Without CE Marking to Evidence Safety and Performance of the INBENTUS VERSATILE Ventilator in Patients Requiring Assisted/Controlled Mechanical Ventilation and Weaning.
Pre-market clinical trial on 81 aldults participants to evidence safety and performance of the non-CE-marked medical device INBENTUS VERSATILE ventilator.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Pneumonia, COPD (Chronic Obstructive Pulmonary Disease), Postoperative Respiratory Distress
- Trial name
- NCT07432191
- Testing
- INBENTUS VERSATILE
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Iconic Solutions By Murcia SL
Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that frequently alters oxygen delivery to the brain.
- Conditions
- Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation, CCHS, CCHS With Hirschsprung Disease
- Trial name
- NCT03568669
- Testing
- NIH Toolbox Cognition Battery
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Multiple Myeloma, Breathing Techniques
Effects of Controlled Breathing Added to Therapeutic Exercise in Multiple Myeloma
A randomized, parallel, double-blind, controlled, multicenter clinical trial with two intervention arms. Two groups of participants will be included, both receiving a therapeutic exercise intervention and an educational session…
- Conditions
- Multiple Myeloma, Breathing Techniques, Breathing Exercises, Exercise Activity
- Trial name
- NCT07312942
- Testing
- Controlled breathing exercise protocol + therapeutic exercise + initial education session, Therapeutic exercise + initial education session
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad Complutense de Madrid
Hypoventilation, Hypoxemia
Postoperative Respiratory and Activity Monitoring
This study plans to learn more about specific breathing and activity recommendations for patients after surgery. Participants will be monitored after abdominal surgery to identify what activities help them breathe better and…
- Conditions
- Hypoventilation, Hypoxemia, Postoperative Pulmonary Complications
- Trial name
- NCT06239831
- Testing
- ExSpiron and ActivPAL Monitors
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Respiratory Failure With Hypercapnia, Therapeutic Bronchofiberoscopy
To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated Respiratory Acidosis (Complete Respiratory Failure).
Background: Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes.
- Trial name
- NCT06970041
- Testing
- Use of NIV during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure, Use of HFNC during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure
- Volunteers
- 315 people
- Sponsor
- Medical University of Silesia
Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary)
Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy
This study will evaluate whether quantitative pupillometry measurements can be used to identify children at risk for postoperative opioid-induced respiratory depression (OIRD) following tonsillectomy.
- Conditions
- Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary), Respiratory Complications Due to Anesthesia
- Trial name
- NCT07573150
- Testing
- Infrared Pupillometry
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- NeurOptics Inc
Bronchial Asthma, Bronchiectasis
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis.
- Conditions
- Bronchial Asthma, Bronchiectasis, ILD, COPD
- Trial name
- NCT07060079
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
End of Life, Respiratory Failure
Feasibility of the Comfort Measures Only Time Out (CMOT)
Nearly 25% of Americans die in intensive care units (ICUs). Most deaths in ICUs are expected and involve the removal of ventilator support, or palliative withdrawal of mechanical ventilation (WMV).
- Conditions
- End of Life, Respiratory Failure, Ventilatory Failure, Coma
- Trial name
- NCT05861323
- Testing
- Comfort Measures Only Time out (CMOT)
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Beth Israel Deaconess Medical Center
Ondine Syndrome (Congenital Central Hypoventilation Syndrome)
Locus Coeruleus and CCHS (Congenital Central Hypoventilation Syndrome)
This study investigates whether cognitive dysfunction in young patients with congenital central hypoventilation syndrome (Ondine Syndrome) is related to the severity of the disease and dysfunction of the locus coeruleus (a…
- Trial name
- ONDINE-LC (NCT07081464)
- Testing
- MRI, EEG, Pupillometry
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Myeloma (MM), Breathing Techniques
Effects of Controlled Breathing on Cardiorespiratory Variables in Multiple Myeloma
A randomized, parallel, double-blind, controlled, clinical trial. Two groups of participants will be included, both receiving a therapeutic exercise intervention and an educational session on the importance of proper breathing…
- Conditions
- Multiple Myeloma (MM), Breathing Techniques, Breathing Exercises, Exercise Activity
- Trial name
- NCT07376733
- Testing
- Controlled breathing exercise protocol + therapeutic exercise + initial education session, Therapeutic exercise + initial education session
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Universidad Complutense de Madrid
Acute Respiratory Distress Syndrome
Effects of End-inspiratory Pause on Ventilation
This study aims to evaluate the effect of reducing tidal volume and respiratory rate together with an end-inspiratory pause setting on ventilatory efficiency and the distribution of inspired gas within the lungs in ARDS patients.
- Trial name
- NCT06692634
- Testing
- mechanical ventilation setting
- Where
- 2 sites in Chile
- Volunteers
- 20 people
- Sponsor
- Clinica las Condes, Chile
Hypoventilation, Hypoxemia
Oxygen Supplementation and Ventilator Hyperinflation in the Endotracheal Suction (OSVHES)
This is a double crossover study where all patients are randomly allocated to one of two treatment sequences associated with endotracheal aspiration.The first treatment (A) uses two suctioning methods for each patient: one…
- Trial name
- OSVHES (NCT02440919)
- Testing
- Hyperoxygenation 100% FiO2, Hyperoxygenation 20% FiO2, Hyperinflation (PEEP- ZEEP) Basal FiO2
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Universidade Federal de Sao Carlos
Fibromyalgia, Fibromyalgia Syndrome
Slow Breathing and Resistance Exercise in Fibromyalgia
This randomized controlled trial investigates whether slow breathing techniques influence heart rate variability, exercise self-efficacy, and resistance exercise performance in women with fibromyalgia.
- Trial name
- Breath-fibro (NCT07404384)
- Testing
- Slow Breathing with Visual Pacer, Slow Breathing without Visual Pacer, Spontaneous Breathing (Active Control)
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- University of Malaga
Respiratory Sinus Arrhythmia, Heart Rate Variability
Smartphone Camera Measurement of Breathing-Related Heart Rate Variability Compared With ECG in Healthy Adults
This study examines how accurately a smartphone can measure the rhythmic rise and fall of heart rate that occurs with breathing (respiratory heart rate variability).
- Conditions
- Respiratory Sinus Arrhythmia, Heart Rate Variability, Healthy Volunteers
- Trial name
- NCT07922161
- Testing
- Smartphone simultaneous facial and fingertip photoplethysmography (research app), Audio-guided paced breathing
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- BELL Therapeutics Inc.
Childhood Obesity, Morbid Obesity
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation.
- Trial name
- NCT02602769
- Testing
- Transcriptome profiling
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Slow Breathing
Assessing the Acute Effects of Virtual Reality Interventions on Stress
A Four-Arm RCT, testing the acute effects of a Virtual Reality (VR)- based slow-paced breathing intervention on subjective and physiological markers of stress.
- Trial name
- VR_Stress_25 (NCT07191288)
- Testing
- VR (VR-Breathing+Mystical), VR (VR-Mystical), Computer (Non-VR-Breathing)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Obstructive Sleep Apnoea (OSA), Hypoventilation Syndrome
Sleep-disordered Breathing Database
The goal of this study is to collect clinical data on patients who have had a sleep study and are given a diagnosis of a sleep related breathing disorder such as obstructive sleep apnoea.
- Trial name
- NCT07402603
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Obstructive Sleep Apnea, Obesity (BMI>30)
Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep Apnea
Obesity-related sleep hypoventilation represents a continuum ranging from isolated nocturnal hypoventilation to obesity hypoventilation syndrome.
- Conditions
- Obstructive Sleep Apnea, Obesity (BMI>30), Obesity Hypoventilation Syndrome (OHS), Sleep Hypoventilation
- Trial name
- HBO-POSA (NCT07809061)
- Testing
- Sleep Inertia Questionnaire (SIQ)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Congenital Central Hypoventilation Syndrome
CCHS Secure Health-hub Advancing Research Efforts (CCHS SHARE)
The purpose of this study is to capture longitudinal natural history data in Congenital Central Hypoventilation Syndrome (CCHS).
- Trial name
- NCT06554275
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS)
The Effect of Mask Design on Ventilation Parameters in COPD and OHS Patients on Long-term Home Non-invasive Ventilation. An Experimental Study.
Chronic obstructive pulmonary disease (COPD) and obesity hypoventilation syndrome (OHS) are respiratory conditions that disrupt normal breathing.
- Trial name
- NCT06972589
- Testing
- Investigational Mask, Conventional mask
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Fisher and Paykel Healthcare