Clinical trials: Hypovolemia
Hypovolemia
Plasma-Lyte 148® versUs Saline Study
The aim of PLUS is to conduct a multi-centre, blinded, randomised, controlled trial (RCT) to determine whether fluid resuscitation and therapy with a "balanced" crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality…
- Trial name
- PLUS (NCT02721654)
- Testing
- Plasma-Lyte 148®, 0.9% sodium chloride
- Where
- 51 sites in Australia, New Zealand
- Volunteers
- 5,037 people
- Sponsor
- The George Institute
Hypovolemia
Fluid Responsiveness Using Forehead Sensor in Children
Forehead sensor can predict the more accurate fluid responsiveness than finger sensor in children
- Trial name
- forehead (NCT03132480)
- Testing
- fluid resuscitation
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Fluid Therapy, Hemodynamics
Predicting Fluid Responsiveness in Mechanically Ventilated Critically Ill Children Using Transthoracic Echocardiography
Initial fluid resuscitation remains the first treatment step for most children experiencing circulatory failure and/or systemic hypotension.
- Conditions
- Fluid Therapy, Hemodynamics, Hypovolemia, Shock
- Trial name
- PREDIPEN (NCT05054452)
- Testing
- Echocardiographic assessment
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypovolemic
Corrected Flow Time in the Carotid Artery as a Predictor of Fluid Responsiveness in Mechanically Ventilated Patients With Low Tidal Volume in the Intensive Care Unit
The purpose of this study is to evaluate predictability of carotid corrected flow time for fluid responsiveness in mechanically ventilated patients with low tidal volume in the intensive care unit.
- Trial name
- NCT04139031
- Testing
- Ultrasonographic measurement of corrected flow time in carotid artery
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Yonsei University
Hypovolemia, Hemodynamic Instability
Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia
To monitor the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.
- Trial name
- LBPN (NCT03592290)
- Testing
- Lower body negative pressure
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Shock, Hypovolemia
RApid Fluid Volume EXpansion in Patients in Shock After the Initial Phase of Resuscitation.
Rapid volume expansion using repeated intravenous fluid boluses is a very common intervention performed in the intensive care unit (ICU) in the early days of resuscitation of patients with shock.
- Trial name
- RAVEXO (NCT02645851)
- Testing
- fluid bolus, PiCCO system (Pulsion, Germany), Vascular pressure transducers (Edwards Life Science, USA)
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Shock, Hypovolemia
IVC Ultrasound Versus Central Venous Pressure for Early Detection of Hypovolemia in Shock Patients
This study aims to compare ultrasound-guided inferior vena cava (IVC) assessment with central venous pressure (CVP) monitoring for the detection of hypovolemia in shock patients in the emergency department.
- Conditions
- Shock, Hypovolemia, Circulatory Failure
- Trial name
- NCT07206732
- Testing
- Ultrasound-Guided Inferior Vena Cava Assessment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Trauma, Hypovolemia
Trauma Heart to Arm Time
In the prehospital setting it would be helpful to assess primary changes in central blood volume or preload (venous return, stroke volume, diastolic ventricular volume) that occur during the stability phase following injury when…
- Conditions
- Trauma, Hypovolemia, Hemorrhage
- Trial name
- THAT (NCT01210417)
- Testing
- Non invasive monitoring
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Shock, Hypovolemia
Bedside Ultrasound Measurement of the Inferior Vena Cava Correlates to Central Venous Pressure
This study proposes to examine the correlation of central venous pressure to measures of the diameter of the inferior vena cava as determined by bedside ultrasonography.
- Conditions
- Shock, Hypovolemia, Hypervolemia
- Trial name
- NCT00596921
- Volunteers
- 100 people
- Sponsor
- Brooke Army Medical Center
Acute Respiratory Distress Syndrome (ARDS), Hypovolemia
Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS)
The need for fluid resuscitation (FR) in ICU patients with acute respiratory distress syndrome (ARDS) is common. Indeed, relative or absolute hypovolemia is a common phenomenon that the intensivist must recognize early and treat…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Hypovolemia, Pulmonary Edema
- Trial name
- IROCA (NCT01763853)
- Testing
- 4% albumin
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Clermont-Ferrand
Shock, Shock, Septic
Early Initiated Vasopressor Therapy in the Emergency Department
The goal of this pragmatic, multi-center, superiority, randomized clinical trial is to compare early treatment with peripheral (through a vein) infused noradrenaline (a natural hormone that increases blood pressure) with fluid…
- Conditions
- Shock, Shock, Septic, Hypotension, Hypotension and Shock
- Trial name
- VASOSHOCK (NCT05931601)
- Testing
- Noradrenaline
- Where
- 8 sites in Denmark, Sweden
- Volunteers
- 320 people
- Sponsor
- Odense University Hospital
Hypovolemia, Cardiac Output, High
Validation of Capnography as a Predictor of Cardiac Output Change as Measured by FloTrac
The aim of this study is to evaluate the correlation of capnography with non-invasive measurement of cardiac output with the FloTrac/EV1000 following a reversible fluid challenge, a passive leg raising maneuver, using…
- Conditions
- Hypovolemia, Cardiac Output, High, Cardiac Output, Low
- Trial name
- NCT01880684
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Montreal Heart Institute
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Hypovolemia
Hemodynamic Changes Induced by Alveolar Recruitment Maneuver With Respect to Volemic State in Colon Surgery
Intraoperative hemodynamic management is important, since even mild variations in circulatory volume can be extremely damaging for patients.
- Trial name
- RecruVol (NCT03468764)
- Testing
- Vigileo monitoring during lung recruitment maneuver
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Shock, Cardiogenic, Shock Hypovolemic
Clinical Validation of Algorithms for Mean Systemic Filling Pressure and Automated Cardiac Output
Prospective combined clinical validation of an algorithmic calculated mean systemic filling pressure (Pms-Nav) with the gold standard for Pms (Pms calculated from venous return curves during inspiratory hold procedures with…
- Conditions
- Shock, Cardiogenic, Shock Hypovolemic, Hypovolemia, Cardiac Failure
- Trial name
- PP3D (NCT04202432)
- Testing
- Mean systemic filling pressure
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Autonomic Nervous System Imbalance, Hypovolemia
Autonomic Challenges From Mild Hypovolemia and Mechanical Ventilation
Heart Rate Variability (HRV) analysis has been studied in the critically ill patients although it is affected by several uncontrolled variables in the clinical conditions.
- Conditions
- Autonomic Nervous System Imbalance, Hypovolemia, Positive-Pressure Respiration
- Trial name
- NCT03244891
- Testing
- Increase of central volume, Ventilation mode
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Perioperative/Postoperative Complications, Hypovolemia
Goal-directed Therapy in High-risk Surgery
There is growing evidence that the risk of postoperative complications can be decreased by optimizing the amount and type of infusion fluids given during surgery, steered by goal-directed therapy based on flow-related hemodynamic…
- Conditions
- Perioperative/Postoperative Complications, Hypovolemia, Hypoxia
- Trial name
- NCT01681238
- Testing
- Protocol group 2, Protocol group 1
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangzhou First People's Hospital
Fluid Overload, Hypovolemia
Non-invasive Cardiac Output Monitor in Young Adults
The investigators would like to study cardiac output, stroke volume, and fluid responsiveness on young adult pediatric patients undergoing anesthesia and surgery with the use of the NICOM, a non-invasive monitor.
- Trial name
- NICOM (NCT02813915)
- Testing
- NICOM
- Volunteers
- 50 people
- Sponsor
- Indiana University
Blood Pressure, Critical Illness
Influence of Mechanical Ventilation Mode on Arterial Pressure Variations- a Pilot Study
Mechanical ventilation has been known to produce changes in the flow of blood through the major blood vessels in the body. These changes may go undetected, but with continuous arterial blood pressure measurements, changes in the…
- Conditions
- Blood Pressure, Critical Illness, Hypovolemia
- Trial name
- NCT03246425
- Testing
- Ventilator mode change, Monitoring of blood pressure variation
- Where
- United States
- Sponsor
- State University of New York - Upstate Medical University
Hypovolemia
Comparison of Two Gelatine Solutions
The aim of volume replacement is to compensate a reduction in the intravascular volume e.g. during surgery and to counteract hypovolemia in order to maintain hemodynamics and vital functions.
- Trial name
- NCT01515397
- Testing
- Gelofusine balanced, Gelofusine 4%
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- B. Braun Melsungen AG