Clinical trials: Hypovolemic Shock
Hypovolemic Shock
Hemodynamic Measurements at Different Inclinations of the Head
The purpose of this study is to determine whether hemodynamic measures vary in angles bedside before and after volume challenge.
- Trial name
- HMDIH (NCT02046785)
- Testing
- 0.9% saline solution
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Uberlandia
Surgery, Hypovolemic Shock
Kinetics of the Sublingual Microcirculation During Fluid Bolus
Fluid therapy is one of the cornerstones of the treatment of organ failure. The investigators assume that fluid bolus will increase the delivery of oxygen to the cells and resolve the shock.
- Trial name
- NCT02675725
- Testing
- Measurement of sublingual microcirculation with Cytocam-IDF camera
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Frisius Medisch Centrum
Hemorrhage, Hypovolemic Shock
Efficacy of Prehospital Tourniquet Models for Arterial Occlusion in Upper and Lower Limbs
The goal of this clinical trial is to compare the occlusive capability and mechanical behavior of different commercially available pre-hospital tourniquet models and the results of their application on upper and lower limbs, in…
- Conditions
- Hemorrhage, Hypovolemic Shock, Tourniquets
- Trial name
- TQ-BR (NCT06725602)
- Testing
- TQ - Proximal Application ("high and tight"), TQ - Controlled application (2-3 inches)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hypovolemic Shock
A Study to Assess the Safety and Efficacy of Centhaquine in Hypovolemic Shock Patients
This is a prospective, multi-centric, open-labeled, phase-IV clinical study to evaluate the safety and efficacy of centhaquine citrate (LYFAQUIN™), a first-in-class drug for treating hypovolemic shock, a life-threatening…
- Trial name
- NCT05956418
- Testing
- Centhaquine
- Where
- 17 sites in India
- Volunteers
- 400 people
- Sponsor
- Pharmazz, Inc.
Critical Illness, Sepsis
Peer Support for Post Intensive Care Syndrome Self-Management
A prospective, 2-arm, single-blind, randomized controlled clinical feasibility trial design is planned. Forty CCI survivors will be randomized (1:1) to either the PS-PICS (peer support) intervention or usual care (control) group.
- Conditions
- Critical Illness, Sepsis, Shock, Septic, Shock
- Trial name
- PS-PICS (NCT03788096)
- Testing
- Peer Support with Motivational Interviewing, Usual Care Group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas at Austin
Trauma, Pelvic Fracture
Pelvic Fractures in Polytraumatized Patients With Hemodynamic Instability: Angioembolization vs Preperitoneal Packing
Pelvic fracture is a usual injury in trauma patients. An unstable trauma patient with a pelvic fracture has an elevated risk of death due to pelvic bleeding and the associated injuries.
- Conditions
- Trauma, Pelvic Fracture, Hemodynamic Instability
- Trial name
- NCT04764864
- Testing
- Angioembolization, Preperitoneal Pelvic Packing
- Where
- Spain
- Sponsor
- Nuria Llorach-Perucho
Hypovolemic Shock, Hemorrhage
Efficacy Study of the Non-Pneumatic Anti-Shock Garment (NASG) in Egypt
This study will test the efficacy of the NASG on women suffering from obstetric hemorrhage as compared to hemorrhaging women who do not receive the NASG.
- Trial name
- NCT00305253
- Testing
- Non-pneumatic Anti-shock Garment (NASG)
- Where
- 2 sites in Egypt
- Volunteers
- 990 people
- Sponsor
- University of California, San Francisco
Shock, Hypovolemia
Vasopressin in Traumatic Hemorrhagic Shock Study
The purpose of the present trial is therefore to assess effects of arginine vasopressin vs. saline placebo on hospital admission rate (primary end point), as well as hemodynamic variables, fluid resuscitation requirements and…
- Conditions
- Shock, Hypovolemia, Hemorrhagic Shock
- Trial name
- NCT00379522
- Testing
- Vasopressin
- Where
- 14 sites in Austria, Germany
- Volunteers
- 64 people
- Sponsor
- Volker Wenzel
Hypotension, Hypovolemic Shock
Inferior Vena Cava Assessment in Term Pregnancy Using Ultrasound: a Feasibility Study of Subxiphoid and RUQ Views
This study is to assess the feasibility of 2 different ultrasound views of the inferior vena cava (IVC), a large vein that returns blood to the heart. Ultrasound is safe in pregnancy and, is regularly used to evaluate the fetus.
- Trial name
- NCT02584803
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock
Artificial Intelligence-driven Virtual Standardized Pediatric Patients Trial
Background: China's healthcare system for children faces significant challenges, particularly due to the limited pediatric service capacity of primary healthcare institutions.
- Conditions
- Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock, Hand-foot-and-mouth Disease, Acute Appendicitis
- Trial name
- NCT06699433
- Testing
- Virtual standardized patients (VSPs), Case teaching manuals, Case teaching videos
- Where
- 3 sites in China
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- Southern Medical University, China
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
the Study Focuses on the Subgoup of Patients With Decreased Effective Blood Volume eg. Trauma Surgical and Non Surgical Patients
The Impact of the Fluid Resuscitation on the Venous Volume and Flow Characteristics in Hypovolemic Shock
We hypothesis that in various situation when the effective blood volume decreased the venous volume flow characteristics change according to the fluid resuscitation
- Trial name
- NCT02474056
- Where
- Israel
- Sponsor
- HaEmek Medical Center, Israel
Hypovolemic Shock, Trauma
Impact of Early Goal-directed Fluid Therapy in Hypovolemic Patients Undergoing Emergency Surgery
This study compares the safety and efficacy of GDTs using standard pressure-related parameters vs. dynamic hemodynamic indices associated with fluid compartment monitoring, in trauma patients requiring emergency surgery.
- Conditions
- Hypovolemic Shock, Trauma, Emergency, Surgery
- Trial name
- NCT01653977
- Testing
- CONTROL, OPTIMIZED
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Shock
HEAVy HAT-HEAlthy Volunteers Heart to Arm Time. Haemorrhage Simulation Protocol in Healthy Volunteers
In prehospital settings, hypovolemic shock diagnosis is based on Advanced Trauma Life Support (ATLS) shock classification. The most often used clinical signs are heart rate (HR), arterial blood pressure (BP), respiratory rate…
- Trial name
- HEAvyHAT (NCT02177188)
- Testing
- LBNP Lower Bodi Negative Pressure Chamber
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Dengue Fever, Children
New Tools for Predicting Capillary Leak Shock During Dengue Fever
Evaluate the prognostic value of different methods (Osmometry / clinical-biological score) compared to the occurrence of capillary leak shock during dengue fever.
- Conditions
- Dengue Fever, Children, Adults
- Trial name
- PrediDengue (NCT04422782)
- Testing
- For each routine sample, an additional tube will be collected to measure the osmotic pressure in the blood and urine
- Where
- France
- Volunteers
- 342 people
- Sponsor
- Centre Hospitalier de Cayenne
Critical Illness
Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients
Background: Two recent systematic reviews of the literature and meta-analyses have suggested that colloids administration might be deleterious in critically ill patients.
- Trial name
- NCT00318942
- Testing
- Crystalloids, Colloids
- Where
- 67 sites in Belgium, Canada and 3 more
- Volunteers
- 2,857 people
- Sponsor
- University of Versailles
Hypovolemic Shock, Cardiogenic Shock
Digital Ischemia Reduction in Critically Ill Patients
Patients requiring high dose pressors (minimum 2) who are unlikely to be weaned off them over 1 day will be identified. Patients will have the device applied to one hand while expectant medical management will continue to the…
- Conditions
- Hypovolemic Shock, Cardiogenic Shock, Digital Ischemia
- Trial name
- DIR (NCT05661773)
- Testing
- the combined use of vacuum assisted suction and heat exchanger warming
- Sponsor
- Wake Forest University Health Sciences
Shock
High Dose Vitamin C in the Critically Ill Patient
The purpose of this study is to determine the effectiveness of high doses of Vitamin C in critically ill patients.
- Trial name
- VitC (NCT01587963)
- Testing
- Ascorbic Acid, Ringers Lactate or Normal Saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Rutgers, The State University of New Jersey