Clinical trials: Hypoxemic Acute Respiratory Failure
Acute Hypoxemic Respiratory Failure
Predictors of HFNC Failure in Patients With AHRF Using Diaphragm Ultrasound
Ultrasound of the diaphragm is an easily reproducible bedside tool that provides a non-invasive measurement of inspiratory muscle function and respiratory efficiency.
- Trial name
- ULTRAFLOW (NCT06096376)
- Testing
- Diaphragm Ultrasound
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Queen Mary Hospital, Hong Kong
COVID-19, Critical Illness
Impact and Sequelae of High Ventilatory Drive in Critically Ill COVID-19 Patients
Critically ill COVID-19 patients with acute respiratory failure, in the intensive care unit (ICU), often feature high respiratory drive, determining large inspiratory efforts resulting in high pressures and global and regional…
- Conditions
- COVID-19, Critical Illness, Hypoxemic Respiratory Failure, Neurocognitive Dysfunction
- Trial name
- NCT05363332
- Where
- 3 sites in Spain
- Volunteers
- 126 people
- Sponsor
- Corporacion Parc Tauli
Severe Acute Respiratory Syndrome Coronavirus 2, Hypoxemic Respiratory Failure
COVIDNOCHE Trial (HFNO Versus CPAP Helmet) in COVID-19 Pneumonia
The purpose of the COVIDNOCHE trial (HFNO versus CPAP Helmet Evaluation in COVID-19 Pneumonia) is to evaluate the comparative effectiveness of standard care non-invasive respiratory support (helmet CPAP versus HFNO) for acute…
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Hypoxemic Respiratory Failure, Pneumonia, Viral, COVID
- Trial name
- COVIDNOCHE (NCT04381923)
- Testing
- Helmet Continuous Positive Airway Pressure (CPAP), High Flow Nasal Oxygen (HFNO)
- Where
- United States
- Sponsor
- University of Pennsylvania
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
Impact of Arterial CO2 Tension on Management and Outcome in Patients With Acute Hypoxemic Respirator Failure and ARDS
There appears to be considerable variability in the approach physicians use to manage arterial carbon dioxide tensions, in patients in the early phases [first 48 hours] of ARDS (Acute hypoxemic respiratory failure and).
- Trial name
- CO2 LUNG SAFE (NCT03415529)
- Where
- Belgium
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- European Society of Intensive Care Medicine
Respiratory Failure
Physiologic Effects of High Flow Nasal Therapy in Patients With Acute Hypoxemic Respiratory Failure (OPTIFLOW)
The aim of the study is to assess, in patients with acute hypoxemic respiratory failure, the short term physiologic effects of the high flow oxygen nasal therapy (Optiflow), in term of inspiratory muscle effort, gas exchange…
- Trial name
- NCT01056952
- Testing
- O2stand, CPAP, Optiflow
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bordeaux
Respiratory Failure With Hypoxia
Assessment of Tidal Volume During Non Invasive Oxygenation Techniques
High Tidal volume is one of the main mechanisms that lead to lung injuries under mechanical ventilation (ventilator induced lung injury: VILI).
- Trial name
- VOLHYPOX (NCT03445455)
- Testing
- Tidal volume measurement
- Volunteers
- 25 people
- Sponsor
- Henri Mondor University Hospital
Respiratory Failure, ICU
A Wake Prone Positioning in Non-intubated Patients With Acute Hypoxemic Respiratory Failure
Patients admitted to the ICU with severe hypoxemia are at high risk for mortality. Few therapies have been proven to improve patient outcomes or duration of mechanical ventilation e.g.
- Trial name
- NCT05698004
- Testing
- prone positioning
- Volunteers
- 244 people
- Sponsor
- Montaser Gamal Ahmed
Hypoxemic Respiratory Failure, Oxygen Toxicity
Handling Oxygenation Targets in COVID-19
Patients with COVID-19 and hypoxaemic respiratory failure and admitted to the intensive care unit (ICU) are treated with supplementary oxygen as a standard. However, quality of quantity evidence regarding this practise is low.
- Trial name
- HOT-COVID (NCT04425031)
- Testing
- Low oxygenation target, High oxygenation target
- Where
- 10 sites in Denmark, Norway and 1 more
- Volunteers
- 726 people
- Sponsor
- Aalborg University Hospital
Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure
Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
This study targets adult patients treated with high flow nasal cannula (HFNC) at emergency department (ED) of Severance hospital, Yonsei university.
- Conditions
- Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure, Hypercapnic Acute
- Trial name
- NCT06064409
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Covid 19, Hypoxemic Respiratory Failure
Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia
The COVID-19 outbreak is associated with a surge in ICU bed requirement and substantial mortality (estimated between 0.5% and 1%).
- Trial name
- AIRVM-COVID (NCT04357457)
- Testing
- Almitrine
- Where
- France
- Volunteers
- 181 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, SARS-CoV2 Infection
Awake Prone Positioning in Moderate to Severe COVID-19
The purpose of this study is comparing vital signs between standard care and prone position groups. Standard care will consist of routine clinical care, including any advice to lie in prone position as routinely recommended by…
- Conditions
- COVID-19, SARS-CoV2 Infection, COVID-19 Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure
- Trial name
- NCT05083130
- Testing
- a wake prone positioning
- Where
- Vietnam
- Volunteers
- 93 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome
EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure
We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF).
- Trial name
- EPIPHANY (NCT05150483)
- Where
- Greece
- Volunteers
- 350 people
- Sponsor
- Evangelismos Hospital
Acute Respiratory Insufficiency
Prevalence AND Outcome of Acute Hypoxemic Respiratory fAilure in CHILDren (PANDORA-CHILD)
The present study is aimed to establish the epidemiological characteristics and clinical outcomes of mechanically ventilated children with acute hypoxemic respiratory failure (AHRF), defined as PaO2/FiO2 ≤300 mmHg on PEEP≥5 cmH2O…
- Trial name
- PANDORA-child (NCT04791501)
- Testing
- Mechanical ventilation
- Where
- 23 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Yolanda Lopez Fernandez
Mechanical Ventilation
Mechanical Power-Guided Lung Protective Ventilation (VentCoach) in Acute Hypoxemic and/or Hypercapnic Respiratory Failure
The purpose of this research is to evaluate a different way of using the mechanical ventilator device to help better protect the lungs while the patient recovers.
- Trial name
- NCT07294768
- Testing
- VentCoach, Standard of Care
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Acute Hypoxemic Respiratory Failure
Predictors of HFNC Failure in Patients With AHRF Using Echocardiography Parameters
Right ventricular dysfunction (RVD) and right ventricular-pulmonary arterial (RV-PA) uncoupling detected by transthoracic echocardiography (TTE) in acute respiratory distress syndrome (ARDS) are associated with poor survival.
- Trial name
- AHRF-ECHO (NCT06096363)
- Testing
- Transthoracic Echocardiography
- Where
- Hong Kong
- Volunteers
- 28 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Evaluation of Prone Position Effect During NIV and HFNC on Acute Hypoxemic Respiratory Failure
Prone Position in Non-Invasive Ventilation and High-Flow Oxygen Therapy
The aim of this trial is to study the effect of prone position during NIV and HFNC on acute hypoxemic respiratory patients.
- Trial name
- ProPNIVFlow (NCT04306107)
- Testing
- Prone position during non-invasive respiratory support
- Volunteers
- 100 people
- Sponsor
- Hospital General Universitario Morales Meseguer
Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome
A Randomized Study to Investigate the Effect of Intravenous Imatinib on the Amount of Oxygen in the Lungs and Blood of Adults With COVID-19 Needing Mechanical Ventilation and Supportive Care.
The COVID-19 pandemic has led to an increase in the number of patients admitted to intensive care units (ICU) with acute respiratory distress syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome, Covid19, ARDS
- Trial name
- IMPRESS COVID (NCT04953052)
- Testing
- Imatinib Mesylate
- Where
- 8 sites in India
- Sponsor
- Exvastat Ltd.
Prone Positioning, Covid19
Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection
This research aims to understand if prone positioning combined with high-flow nasal cannula (HFNC) or non-invasive positive pressure ventilation (NIPPV) safely reduce the rate of intubation in acute hypoxemic and/or hypercapnic…
- Conditions
- Prone Positioning, Covid19, Hypoxemic Respiratory Failure, ARDS
- Trial name
- NCT04694638
- Testing
- Body position change
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Respiratory Distress Syndrome, Adult
High Flow Nasal Oxygen for Acute Hypoxemic Respiratory Failure in the Emergency Room
The aim of this multicenter, randomized, controlled, open-label trial is to investigate the efficacy of early treatment with HFNO compared with SOT in preventing early deterioration of patients admitted to the ER because of acute…
- Trial name
- GLAMOUR (NCT06489379)
- Testing
- high flow nasal cannula, standard oxygen
- Volunteers
- 234 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Transbronchial Lung Cryobiopsy in Undiagnosed Acute Respiratory Failure
In patients with acute hypoxemic respiratory failure whose diagnosis is not established after initial evaluation, obtaining a histopathological diagnosis may improve the patients' prognosis.
- Trial name
- NCT05754866
- Testing
- Transbronchial lung cryobiopsy, Transbronchial lung biopsy
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital