Clinical trials: Hypoxemic Respiratory Failure, active
Acute Respiratory Distress Syndrome (ARDS), Acute Hypoxemic Respiratory Failure
Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure may progress to acute respiratory distress syndrome, a life-threatening condition that often requires mechanical ventilation.
- Trial name
- SVALBARD (NCT07463885)
- Testing
- Spontaneous Ventilation Strategy, Controlled Ventilation Strategy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Acute Hypoxemic Respiratory Failure
Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptoms - a Feasibility Study
Acute hypoxemic respiratory failure (AHRF) happens when the lungs are unable to absorb enough oxygen. The bloodstream is deprived of oxygen which can eventually lead to more severe conditions like multi-organ failure (MOF) and…
- Trial name
- IDENTIFY (NCT07334379)
- Testing
- Tocilizumab (Actemra®), Dexamethasone
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Lorenzo delSorbo
Acute Hypoxemic Respiratory Failure
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen.
- Trial name
- NCT05675345
- Testing
- HFNC only, HFNC + CNEP10, HFNC + CNEP20
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Respiratory Failure, Acute Hypoxemic Respiratory Failure
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen…
- Conditions
- Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia
- Trial name
- NCT06501118
- Testing
- Education, Epic notification alert
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- University of Colorado, Denver
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients
High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding…
- Trial name
- PRO-WEAN HFNC (NCT07452406)
- Testing
- Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Rush University Medical Center
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome
EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure
We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF).
- Trial name
- EPIPHANY (NCT05150483)
- Where
- Greece
- Volunteers
- 350 people
- Sponsor
- Evangelismos Hospital
Blunt Chest Trauma, Respiratory Failure
Combined Lung and Diaphragmatic Ultrasound to Predict Respiratory Failure in Blunt Chest Trauma
Blunt chest trauma is a leading cause of emergency hospital visits and can result in severe breathing complications such as hypoxemic respiratory failure.
- Conditions
- Blunt Chest Trauma, Respiratory Failure, Thoracic Injuries, Hypoxemic Respiratory Failure
- Trial name
- NCT07807566
- Volunteers
- 130 people
- Sponsor
- Assiut University
Acute Hypoxemic Respiratory Failure, Hypoxemia
Evaluation of the FreeO2 System for Oxygen Weaning After Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure (AHRF) is a common condition associated with substantial morbidity, mortality, and healthcare resource utilization.
- Trial name
- EVOLUERA (NCT07794124)
- Testing
- FreeO2 automated oxygen titration system, Standard oxygen weaning
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Hypoxemic Respiratory Failure, Sepsis
EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) remains a major cause of respiratory failure and mortality in critically ill patients.
- Conditions
- Acute Hypoxemic Respiratory Failure, Sepsis, ARDS (Acute Respiratory Distress Syndrome)
- Trial name
- EARLY-SARDS (NCT07281911)
- Testing
- Serial bronchoalveolar lavage and biological-physiological assessment
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN)
Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)
This pilot randomized clinical trial compares dopamine and norepinephrine as first-line vasoactive therapies in term and late preterm neonates with pulmonary hypertension associated with hypoxemic respiratory failure and systemic…
- Conditions
- Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN), Hypoxemic Respiratory Failure
- Trial name
- DONE (NCT07322133)
- Testing
- Dopamine administration, Norepinephrine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Acute Hypoxemic Respiratory Failure
IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure requires endotracheal intubation and invasive mechanical ventilation in approximately 30-40% of cases, due to severe hypoxemia and/or clinical signs of acute respiratory distress.
- Trial name
- IntHyx (NCT07189078)
- Testing
- Restrictive intubation strategy, Liberal intubation strategy
- Where
- 9 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Tracheostomy, Mechanical Ventilation
Trcheal High-flow for Weaning From Mechanical Ventilation
Multicentre randomized trial to determine whether tracheal high-flow nasal oxygen can improve weaning outcome vs. conventional oxygen therapy in critically ill tracheostomized patients who are hypoxemic.
- Conditions
- Tracheostomy, Mechanical Ventilation, Hypoxemic Respiratory Failure
- Trial name
- TRACFLOW (NCT07714564)
- Testing
- Oxygen therapy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Hypoxemic Respiratory Failure
Is Hypoxemia Driving Outcome in Acute Hypoxemic Respiratory Failure? (HOMELAND Study)
Acute hypoxemic respiratory failure (AHRF) is the most common cause of admission in the intensive care units (UCIs) worldwide. The investigators will assess the value of mediation analysis (a statistical method to understand the…
- Trial name
- HOMELAND (NCT07708506)
- Testing
- mediation analysis
- Where
- 18 sites in Spain, United Kingdom
- Volunteers
- 1,241 people
- Sponsor
- Jesus Villar
Hypoxemic Respiratory Failure
Optimisation of High Flow Oxygen Therapy Settings During Hypoxaemic Respiratory Distress Based on Non-contact Measurement of Lung Volumes by Depth Camera
The goal of this clinical trial is to validate the interest of a strategy adjusting the flow rate delivered under high-flow oxygen (HFO) therapy according to the lung volumes measured by a new technique, in intensive care…
- Trial name
- DiStok (NCT06819644)
- Testing
- high flow oxygen therapy rate adjusted of lung volumes measured
- Where
- 8 sites in France
- Volunteers
- 406 people
- Sponsor
- University Hospital, Brest
Acute Hypoxemic Respiratory Failure
Predicting High-Flow Nasal Cannula Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data
The goal of this observational study is to determine whether metabolomic profiles combined with clinical data can predict high-flow nasal cannula (HFNC) failure and help optimize respiratory support in adult patients with acute…
- Trial name
- META-RESPIRE (NCT07607080)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation Complication
Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation
The TEMA study (Targeting prEssure-Muscle-index to avoid ventilatory over-Assistance during pressure support ventilation) is a prospective, interventional crossover trial investigating the relationship between pressure support…
- Trial name
- TEMA (NCT06921655)
- Testing
- Variation of Pressure Support Levels
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Centre for Medical Sciences
Obesity, Respiratory Insufficiency
Inhaled Nitric Oxide in Severe Obesity
The goal of this clinical trial is to learn about the effects of inhaled nitric oxide on oxygenation and lung perfusion in participants with severe obesity who have acute hypoxemic respiratory failure and are on mechanical…
- Conditions
- Obesity, Respiratory Insufficiency, Hypoxemic Respiratory Failure, Nitric Oxide
- Trial name
- NCT06675435
- Testing
- Nitric oxide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Acute Hypoxemic Respiratory Failure, Ventilation, Mechanical
Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure
This observational study will analyze data already collected by the investigators as part of their routine clinical practice from patients with acute respiratory failure (ARF) treated with mechanical ventilation.
- Trial name
- TAC-EIT-20-5 (NCT07175194)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure
Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning Pathway
Treatment of patients with Hypoxemic respiratory failure (HRF) and Acute Respiratory Distress Syndrome (ARDS) is complex. Therapies that have been shown to save the lives of patients with HRF and ARDS are available but they are…
- Conditions
- Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure, ARDS, Human
- Trial name
- NCT04744298
- Testing
- TheraPPP
- Where
- 17 sites in Canada
- Volunteers
- 19,916 people
- Sponsor
- University of Calgary
Acute Hypoxemic Respiratory Failure
Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia
Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia.
- Trial name
- PROSA (NCT06931938)
- Testing
- Awake Prone Positioning
- Where
- Germany
- Volunteers
- 342 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf