Clinical trials: Hypoxia, Brain
Brain Injuries, Traumatic Brain Injury
Diet Induced Ketosis for Brain Injury - A Feasibility Study
Each year, approx. 100 patients with severe brain injury is admitted to the Clinic for Neurorehabilitation/TBI Unit, Rigshospitalet.
- Conditions
- Brain Injuries, Traumatic Brain Injury, Subarachnoid Hemorrhage, Stroke
- Trial name
- NCT04308577
- Testing
- Ketogenic diet with added MCT
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Jens Rikardt Andersen
Neonatal Encephalopathy (Neonatal Hypoxic-ischemic Encephalopathy)
Cytokines Associated With Cord Blood Cell Therapy for Neonatal Encephalopathy
This is a observational study to assess the effects of and to explore the mechanisms of autologous umbilical cord blood cell therapy for neonatal encephalopathy by way of measuring serum cytokines.
- Trial name
- NCT02455830
- Testing
- Autologous cord blood cell therapy
- Where
- 6 sites in Japan
- Volunteers
- 18 people
- Sponsor
- Neonatal Encephalopathy Consortium, Japan
Cerebral Hypoxia
Brain Oxygenation-II
The Brain Oxygenation-II study (BOx-II) is a phase-II, multicenter, single-arm clinical trial evaluating interventions based on near-infrared spectroscopy (NIRS) monitoring of cerebral oxygen saturation in extremely premature…
- Trial name
- BOx-II (NCT05171881)
- Testing
- Intervention for cerebral hypoxia
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Valerie Chock, M.D., M.S. Epi
Seizures
Pilot Study of Bumetanide for Newborn Seizures
The main goal of the study is to obtain pharmacokinetic and safety data of bumetanide in newborns with refractory seizures. The overall hypothesis is that bumetanide, added to conventional antiepileptic (antiseizure) medications…
- Trial name
- NCT00830531
- Testing
- Bumetanide
- Where
- 4 sites in United States
- Volunteers
- 43 people
- Sponsor
- Soul, Janet , M.D.
Headache, Migraine
Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow by Hypoxia
In this study the investigators will investigate the following hypothesis that hypoxia induce migraine headache and migraine aura the aura phase is associated with a spreading reduction in cerebral blood flow the migraine…
- Conditions
- Headache, Migraine, Aura
- Trial name
- NCT01896167
- Testing
- Hypoxia
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Brain Hypoxia
Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia
The primary objective of this research is to measure changes in neurochemical concentrations during stimulation of the primary visual cortex, in both conditions of normoxia (normal oxygen availability) and induced mild hypoxia…
- Trial name
- NCT02482571
- Testing
- Mild Hypoxia
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cardiovascular Diseases, Cerebral Anoxia
Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest
To compare the influence of two surgical anesthetic techniques, hypothermia with circulatory arrest or hypothermia with low-flow bypass perfusion, on neurologic functioning in infants undergoing heart surgery.
- Conditions
- Cardiovascular Diseases, Cerebral Anoxia, Cerebrovascular Disorders, Defect, Congenital Heart
- Trial name
- BCAS (NCT00000470)
- Testing
- cardiac surgical procedures, cardiopulmonary bypass
- Volunteers
- 171 people
- Sponsor
- Boston Children's Hospital
Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
Cerebral/Cortical Visual Impairment (CVI) is the leading cause of childhood visual impairment in the United States and other industrialized countries.
- Trial name
- CVI (NCT07275021)
- Testing
- Prospective Clinical and Neurodevelopmental Data Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Urea Cycle Disorder, Organic Acidemia
Systemic Biomarkers of Brain Injury From Hyperammonemia
Ammonia is a waste product of protein and amino acid catabolism and is also a potent neurotoxin. High blood ammonia levels on the brain can manifest as cytotoxic brain edema and vascular compromise leading to intellectual and…
- Conditions
- Urea Cycle Disorder, Organic Acidemia, Maple Syrup Urine Disease, Glutaric Acidemia I
- Trial name
- NCT04602325
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Children's National Research Institute
Hypoxic-ischemic Encephalopathy
Neonatal Erythropoietin in Asphyxiated Term Newborns
The purpose of this study is to determine the safety and pharmacokinetics of moderate to high doses of erythropoietin in newborn infants with birth asphyxia.
- Trial name
- NEAT (NCT00719407)
- Testing
- erythropoietin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Hypoxic Ischaemic Encephalopathy
Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth
This study examines the effect of inhaled xenon gas in the treatment of newborn infants with hypoxic-ischemic encephalopathy (HIE) in combination with cooling, which is the standard treatment for this condition.
- Trial name
- CoolXenon3 (NCT02071394)
- Testing
- Xenon gas, Whole body cooling
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Hypoxic-ischemic Encephalopathy
Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia
The goal of this proposal is to profile the pharmacokinetics of dexmedetomidine in newborns ≥36 weeks post-menstrual age during therapeutic hypothermia for hypoxic-ischemic encephalopathy.
- Trial name
- NCT02529202
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Seattle Children's Hospital
Acute Brain Injury, Traumatic Brain Injury
Implementation of Neuro Lung Protective Ventilation
Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Stroke
- Trial name
- NEUROVENT (NCT03243539)
- Testing
- Lung Protective Ventilation
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Colin Grissom
Brain Injury Traumatic Severe (Diagnosis), Coma
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Phase 1 of the STIMPACT trial is an open label,dose-escalation,safety study of intravenous (IV) methylphenidate (MPH) therapy in patients with disorders of consciousness (DoC) caused by severe brain injuries.
- Conditions
- Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
- Trial name
- STIMPACT (NCT03814356)
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy
Healthy Little Eyes
The purpose of this research study is to gather more information on how eye injury is related to a baby's future development and see if eye function and brain test results can be used, along with current measures, to better…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy, Encephalopathy
- Trial name
- NCT05971446
- Testing
- Visual Evoked Potential (VEP), Electroretinogram (ERG)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Neonatal Hypoxic Ischemic Encephalopathy
Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy
This is a pilot study to test feasibility of collection, preparation and infusion of a baby's own (autologous)umbilical cord blood in the first 14 days after birth if the baby is born with signs of brain injury.
- Trial name
- NCT00593242
- Testing
- infusion of autologous cord blood, Neurodevelopmental outcomes
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Michael Cotten
Hypoxic Brain Injury, Maternal Death
High Flow Nasal Cannula to Prevent Deoxygenation During Induction of General Anesthesia in Cesarean Section
Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) using high flow oxygen therapy for preoxygenation and oxygen supplementation during apnoea has shown promising results
- Trial name
- NCT04438798
- Testing
- F Group, H Group
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Hypoxic Ischemic Encephalopathy
Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia
The purpose of this study is to determine whether the administration of topiramate to newborns with hypoxic-ischemic encephalopathy potentiates the neuroprotective effect of treatment with hypothermia.
- Trial name
- NeoNATI (NCT01241019)
- Testing
- Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- Meyer Children's Hospital IRCCS
Brain Injury, Sequelae
Functional and Anatomical Magnetic Resonance Imaging (MRI) of Chronic Brain Injury and Hyperbaric Oxygen (HBO2) Study Subjects
The purpose of this study is to evaluate Brain MRI (Magnetic Resonance Imaging), and Brain CT (Computed Tomography) Angiogram data in subjects who participate in the "Hyperbaric Oxygen for Chronic Stable Brain Injury" (HYBOBI)…
- Conditions
- Brain Injury, Sequelae, Stroke, Anoxia
- Trial name
- HYBOBI-MRI (NCT01126515)
- Testing
- Magnetic Resonance Imaging, Computed Tomography Angiography
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Intermountain Health Care, Inc.
Autism Spectrum Disorder
Evaluating Bone Marrow Cell Transplant for Treating Cerebral Palsy From Brain Hypoxia
This clinical trial aims to evaluate the effectiveness of autologous bone marrow mononuclear cell transfusion in treating cerebral palsy caused by cerebral hypoxia.
- Trial name
- NCT06629324
- Testing
- Autologous Bone Marrow Mononuclear Cell Transfusion, Rehabilitation
- Where
- 2 sites in Vietnam
- Volunteers
- 58 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology