Clinical trials: Hysterectomy, Vaginal
Postoperative Pelvic Organ Prolapse, Benign Hysterectomy
Vaginal Vault Suspension During Benign Hysterectomy. A Questionnaire and Register-based Study.
Female pelvic organ prolapse (POP) is characterized by lack of vaginal support which enables pelvic organs to bulge into the vaginal walls and sometimes protrude through the genital hiatus.
- Conditions
- Postoperative Pelvic Organ Prolapse, Benign Hysterectomy, Suspension
- Trial name
- NCT02859272
- Volunteers
- 11,000 people
- Sponsor
- Nykøbing Falster County Hospital
Cervical Intraepithelial Neoplasia, Hysterectomy
Longitudinal HPV Pap in CIN and VAIN
This study will construct a longitudinal risk model of VaIN according to the HPVs distribution of cervix and vaginal for those had CIN2+.
- Conditions
- Cervical Intraepithelial Neoplasia, Hysterectomy, Human Papillomavirus, Vaginal Intraepithelial Neoplasia
- Trial name
- LHPCV (NCT05931354)
- Testing
- HPV test and Pap Smear
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- Chang Gung Memorial Hospital
Pelvic Organ Prolapse, Abnormal Uterine Bleeding
Evaluating Artisential Laparoscopic Instruments in Gynecologic Surgery
This study evaluates the efficacy and safety of Artisential laparoscopic instruments in minimally invasive gynecologic surgery.
- Conditions
- Pelvic Organ Prolapse, Abnormal Uterine Bleeding, Mesh Augmentation, Laparoscopic Surgery
- Trial name
- MIGS-ART (NCT06050161)
- Testing
- Articulating laparoscopic instrument, Conventional laparoscopic instrument, Robotic surgical instrument
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kern Medical Center
Pelvic Organ Prolapse, Surgery
Comparison of Two Apical Repair Methods in Women Undergoing Repairs for Prolapse
To date no study has determined prospectively which technique is superior to prevent recurrent Pelvic Organ Prolapse (POP) after vaginal hysterectomy- a major unmet clinical need.
- Conditions
- Pelvic Organ Prolapse, Surgery, Quality of Life, Complication
- Trial name
- NCT03113513
- Testing
- fixation of the vaginal apex
- Where
- Austria
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Endometrial Adenocarcinoma, Stage I Uterine Corpus Cancer
Laparoscopic Surgery or Standard Surgery in Treating Patients With Endometrial Cancer or Cancer of the Uterus
This randomized phase III trial is studying laparoscopic surgery to see how well it works compared to standard surgery in treating patients with endometrial cancer or cancer of the uterus.
- Conditions
- Endometrial Adenocarcinoma, Stage I Uterine Corpus Cancer, Stage I Uterine Sarcoma, Stage II Uterine Corpus Cancer
- Trial name
- NCT00002706
- Testing
- Laparoscopic Surgery, Quality-of-Life Assessment, Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 2,616 people
- Sponsor
- Gynecologic Oncology Group
Closure of Vaginal Cuff at Laparoscopic Hysterectomy
Barbed Suture vs Smooth Suture for Vaginal Cuff Closure
This study compares outcomes among patients having a total laparoscopic hysterectomy. This involves removing the uterus and cervix using a laparoscopic or keyhole technique.
- Trial name
- NCT01262573
- Testing
- Closure of vaginal cuff
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Brigham and Women's Hospital
Post-Op Infection
PROJECT PREVENT: Metronidazole Antibiotic Per Vagina Before Hysterectomy: Is Additional Antibiotic Prophylaxis Beneficial?
Despite use of intravenous antibiotic prophylaxis, pelvic infection including vaginal and urinary complaints and infections are still noted after hysterectomy.
- Trial name
- PREVENT (NCT04478617)
- Testing
- Metronidazole Vaginal
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- New York Medical College
Pelvic Organ Prolapse
The Development of De-novo Stress Urinary Incontinence After Stage II-III Pelvic Organ Prolapse Surgery
Surgery for Stage II-III Pelvic organ prolapse
- Trial name
- NCT03221725
- Testing
- sacrospinous ligament fixation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Hysterectomy, Urinary Retention
Postoperative Urinary Retention and Urinary Track Infection (UTI) After Laparoscopic Assisted Vaginal Hysterectomy (LAVH) for Benign Disease
With the advent of minimally invasive surgery, laparoscopic assisted vaginal hysterectomy (LAVH) is currently advocated as an alternative to abdominal hysterectomy.
- Conditions
- Hysterectomy, Urinary Retention, Urinary Tract Infection
- Trial name
- NCT00564135
- Testing
- on Foley time
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Prolapse of Vaginal Vault After Hysterectomy
Prophylactic Uterosacral Ligament Suspension at the Time of Hysterectomy for Prevention of Vaginal Vault Prolapse
Is routine uterosacral ligament suspension an appropriate clinical adjunct at the time of hysterectomy? The answers to these questions will facilitate the treatment of many American women.
- Trial name
- NCT01364025
- Testing
- uterosacral ligament suspension colpopexy bilateral
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Kaiser Permanente
Total Laparoscopic Hysterectomy
Laparoscopic Versus Transvaginal Closure of the Vaginal Vault After Total Laparoscopic Hysterectomy
The goal of this clinical trial is to compare the laparoscopic and transvaginal closure techniques of the vaginal vault in patients who perform TLH, regarding the risk of vaginal vault hematoma and other complications as vaginal…
- Trial name
- NCT06867614
- Testing
- Total laparoscopic hysterectomy
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Ain Shams University
Hysterectomy
Vaginal Preparation Prior to Hysterectomy
This is a randomized controlled trial to determine the influence of chlorhexidine gluconate surgical/topical antiseptic solutions on the bacterial environment of the vagina during hysterectomy and compare that to the effect of…
- Trial name
- NCT03412734
- Testing
- Chlorhexidine, Iodine
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- TriHealth Inc.
Pelvic Organ Prolapse
Difference in Pain, Quality of Life Following Vaginal Hysterectomy With Vaginal Reconstruction Versus Robotic Colpopexy?
The purpose of this study is to to determine if there is a difference in patient related outcomes of pain and quality of life following vaginal hysterectomy with vaginal prolapse repair compared to robotic-assisted repair.
- Trial name
- NCT02049996
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Uterine Myomas, Adenomyosis
Single-port Access Laparoscopic-assisted Vaginal Hysterectomy
Minimally invasive surgery has become the standard treatment for many gynecologic disease processes. In the last decade, numerous studies have demonstrated that laparoscopic approaches to various gynecologic oncology…
- Trial name
- NCT01048931
- Testing
- single-port LAVH
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Postoperative Analgesia, Postoperative Pain Management
Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia
In this study the participants aim to Compare The Effect of Intravenous Combination Dexmedetomidine _ Ketamine versus Dexmedetomidine on Post-Operative Analgesia In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia regarding…
- Trial name
- NCT07330375
- Testing
- Dexmedetomidine, Ketamine, Saline (0.9% NaCl)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Postoperative Pain
Bupivacaine for Postoperative Pain After Laparoscopic Hysterectomy
This prospective, randomized, single-blind controlled study aims to evaluate the effect of bupivacaine injection at trocar entry sites and the vaginal cuff on postoperative pain in patients undergoing total laparoscopic…
- Trial name
- bupivacaine (NCT07435909)
- Testing
- Bupivacaine %0.5 (hyperbaric)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Serkan Kumbasar
Blood Loss During Vaginal Hysterectomy
Comparison of the Effects of Cervical Vasopressin Versus no Premedication on Blood Loss During Vaginal Hysterectomy: A Randomized, Placebo Controlled Trial
Vasoconstrictive agents are increasingly being used in order to decrease blood loss during vaginal hysterectomy. The first reported study of the use of a vasoconstrictive agent for this purpose was on the use of epinephrine…
- Trial name
- NCT00799292
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ascher-Walsh, Charles, M.D.
Hysterectomy, Surgery
Vaginal Cuff Closure by Modification of the Bakay Technique in Total Laparoscopic Hysterectomy
Modified Bakay technique offers a novel colpotomy and cuff closure technique for total laparoscopic hysterectomy (TLH), and consists of placing a single continuous running purse-string suture facilitating the cuff closure before…
- Conditions
- Hysterectomy, Surgery, Laparoscopy
- Trial name
- NCT05080114
- Testing
- Modified Bakay technique (MT), Standard technique (ST)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Hysterectomy
Barriers for the Uptake of LaparoScopic Hysterectomy
Hysterectomy (surgical removal of the uterus) is the most common major gynaecological operation in women in developed countries.
- Trial name
- LIgHT (NCT02167672)
- Where
- Australia
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Queensland Centre for Gynaecological Cancer