Clinical trials: IBD (Inflammatory Bowel Disease)
Ulcerative Colitis (UC), Crohn Disease (CD)
Effect of Isoflavone and Vitamin D Supplementation on Serum Vitamin D Levels, Body Composition, Inflammatory Markers, and Quality of Life in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by recurrent intestinal inflammation, impaired nutritional status, and reduced quality of life.
- Trial name
- NCT07656233
- Testing
- Standard medical treatment, Tempeh Isoflavone, Vitamin D (Cholecalciferol )
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Parasite IBS IBD
Role of Parasitic Infection in Inflammatory Bowel Disease and Irritable Bowel Syndrome
Role of parasitic infection in Inflammatory bowel disease and Irritable bowel The burden of the parasitic disease is in-direct relation with the health and nutritional status of the host, inducing not only parasite-specific…
- Trial name
- NCT04760600
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Colo-rectal Cancer, Crohn Disease
Anastomotic Leakage and Value Of Indocyanine Green in Decreasing Leakage Rates
Anastomotic leakage (AL) is one of the major complications after gastrointestinal surgery. Compromised tissue perfusion at the anastomosis site increases the risk of AL.
- Conditions
- Colo-rectal Cancer, Crohn Disease, Resectable Colorectal Carcinoma
- Trial name
- AVOID (NCT04712032)
- Testing
- ICG-guided bowel perfusion assessment
- Where
- Netherlands
- Volunteers
- 978 people
- Sponsor
- Leiden University Medical Center
Ulcerative Colitis
Study for the Treatment of Ulcerative Colitis With Adacolumn (Companion to US Study 512-04-205)
The purpose of the study is to demonstrate the safety and effectiveness of the Adacolumn Apheresis System to treat the signs and symptoms of ulcerative colitis.
- Trial name
- NCT00219414
- Testing
- Adacolumn Apheresis System
- Volunteers
- 42 people
- Sponsor
- Otsuka Frankfurt Research Institute GmbH
Irritable Bowel Syndrome, Ulcerative Colitis
Efficacy of Gralise® for Chronic Pelvic Pain
This study is done to investigate the pain relieving effects of the study drug Gralise (a novel long acting gabapentinoid) for people who experience chronic pelvic pain.
- Conditions
- Irritable Bowel Syndrome, Ulcerative Colitis, Interstitial Cystitis, Prostatitis
- Trial name
- NCT01678911
- Testing
- Gralise
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Shirley Ryan AbilityLab
Ulcerative Colitis
TUDCA as a Therapy for Ulcerative Colitis (UC)
This is a Phase I open label study examining the efficacy and safety of TUDCA (tauroursodeoxycholic acid) in ulcerative colitis treatment.
- Trial name
- TUDCA (NCT04114292)
- Testing
- Tauroursoursodeoxycholic acid, brand name Tudcabil
- Where
- 3 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Inflammatory Bowel Diseases
JUMP Inflammatory Bowel Disease Study
Children and adolescents with inflammatory bowel disease are at increased risk of poor bone and muscle health through a variety of factors, including underlying disease processes, nutritional deficits, and reduced physical…
- Trial name
- JUMP IBD (NCT04067934)
- Testing
- Jumping Exercise programme
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- NHS Greater Glasgow and Clyde
Systemic Lupus Erythematosus, Arthritic Psoriasis
A Study to Evaluate BMS-986165 Tablet Formulation Relative to BMS-986165 Capsule Formulation and the Effect of a High-Fat/ High-Calorie Meal and Increased Gastric pH on the BMS-986165 Tablet Formulation
The purpose of this study is to evaluate BMS-986165 tablet formulation versus BMS-986165 capsule formulation. This study will also evaluate the effect of a high-fat/ high-calorie meal and increased gastric pH on the BMS-986165…
- Conditions
- Systemic Lupus Erythematosus, Arthritic Psoriasis, Psoriasis, Inflammatory Bowel Diseases
- Trial name
- NCT03254784
- Testing
- BMS-986165 Capsule, BMS-986165 Tablet
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Inflammatory Bowel Diseases, Crohn Disease
Immunogenicity of Herpes Zoster Subunit Vaccine in Inflammatory Bowel Disease Patients Treated With Vedolizumab
Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract affecting 1.6-3.1 million people in the United States.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Herpes Zoster
- Trial name
- NCT03798691
- Testing
- Shingrix
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Wisconsin, Madison
Thiopurine-induced Leukopenia
Pre-genotype NUDT 15 R139C on Reducing Thiopurine-induced Leucopenia in Inflammatory Bowel Disease
NUDT15 R139C was comfirmed to be associated with thiopurine-induced leukopenia inflammatory bowel disease (IBD) cohort.The present study aim to explor the following questions:can optimizing thiopurine dose by NUDT15 genotype…
- Trial name
- NCT02929706
- Testing
- Pre-genotype NUDT15 and optimize azathioprine dosage
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn Disease
Surgically Resected Crohn's Disease Patients: Prognostic Factors for Re-operation and New Score Building
The project will consist of a multicentre, prospective, observational study with a total duration of 24 months. Clinical, endoscopic and ultrasound data will be collected in a dedicated database (on IG-IBD Register), which will…
- Trial name
- POCD2017 (NCT03150238)
- Testing
- observation of prognostic factors for relapse
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Istituto Clinico Humanitas
Inflammatory Bowel Diseases
Identifying Saliva Markers in Inflammatory Bowel Disease
Under normal conditions intestinal mucosa presents a baseline "physiological inflammation" caused by a controlled immune response that eliminates offending dietary and microbial antigens.
- Trial name
- NCT01590043
- Testing
- Salivary samples
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Hadassah Medical Organization
Ulcerative Colitis
Efficacy, Safety and Immunogenicity of the Proposed Biosimilar Vedolizumab PB016 in Comparison With Entyvio®
This is a multi-center, randomized, parallel arm, double-blind study with approximately 750 participants with moderately to severely active Colitis Ulcerosa randomized to receive either PB016 or Entyvio®
- Trial name
- UCESIVE (NCT05771155)
- Testing
- Intravenous (IV) infusions
- Where
- Georgia
- Volunteers
- 750 people
- Sponsor
- Polpharma Biologics S.A.
Inflammatory Bowel Disease
Study of the Role of Soluble Inhibitor of Interleukin 22, Interleukin 22 Binding Protein (IL-22BP), in Chronic Inflammatory Bowel Disease
IL-22 is an IL-10 family cytokine that plays major actions to increase intestinal epithelial barrier function and regeneration during experimental colitis.
- Trial name
- IL-22BP MICI (NCT02847052)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Nantes University Hospital
Crohn's Disease
Phase 2 Study of the Safety and Efficacy of LDP-02 in Mildly to Moderately Active Crohn's Patients
The objectives of this study were to assess the safety and tolerability of LDP-02 in patients with active Crohn's disease who were not receiving corticosteroids or immunosuppressives, to assess the ability of LDP-02 to reduce…
- Trial name
- NCT00655135
- Testing
- LDP-02
- Volunteers
- 185 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Ulcerative Colitis
Safety and Efficacy of Two Different Doses of Asacol in the Treatment of Moderately Active Ulcerative Colitis
This study is a prospective clinical study to evaluate the safety and efficacy of two different doses of Asacol for the treatment of moderately active ulcerative colitis.
- Trial name
- NCT00073021
- Testing
- Asacol 800 mg (mesalamine), Asacol 400 mg (mesalamine)
- Where
- 57 sites in United States, Canada and 1 more
- Volunteers
- 386 people
- Sponsor
- Warner Chilcott
Crohn's Disease, Ulcerative Colitis
The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation
Fifty patients will get probiotics (109 bacteria [L. acidophilus, B. bifidum, S. thermophilus, L. rhamnosus, L. casei] in 2 capsules) and half will get placebo (2 capsules that look the same like the probiotic capsules and will…
- Trial name
- NCT01078935
- Testing
- probiotics
- Volunteers
- 100 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Crohn Disease (CD)
Impact of Advanced Crohn's Disease Therapies on Sleep Quality
The goal of this observational study is to measure changes in sleep quality before and after starting treatment with advance therapy in adult with Crohn disease.
- Trial name
- NCT07649408
- Testing
- Wearable activity and sleep tracker
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Shmuel Kivity, MD
Crohn Disease
Microflora and Metabolomics of Crohn's Disease Patients
The purpose of this study is to explore the microflora characteristics of different ecological loci and multiple metabolic pathways in Crohn's disease patients with different disease course states.
- Trial name
- NCT04965584
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Ulcerative Colitis
GI-270384 Study In Patients With Mild To Moderate Ulcerative Colitis
The aim of this double blind, placebo controlled, study is to evaluate activity consistent with efficacy provided by 14 days administration of GI270384X, and to provide preliminary pharmacokinetics and safety/tolerability of 14…
- Trial name
- NCT00457171
- Testing
- GI-270384
- Volunteers
- 16 people
- Sponsor
- GlaxoSmithKline
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