Clinical trials: IBD (Inflammatory Bowel Disease)
Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD)
Unravelling Intestinal Fibrosis in Ulcerative Colitis
The main objectives are: (i) to identify candidate fibrotic cellular pathways in UC patients treated with a JAK inhibitor filgotinib), and (ii) to detect and monitor in vivo fibrosis in UC patients using FAPi-PET/CT imaging
- Conditions
- Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD), Fibroblast Activation Protein Inhibitor
- Trial name
- INTERACT (NCT06604273)
- Testing
- Fibroblast Activation Protein Inhibitor
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Crohn Disease
Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease
The purpose of this study is to determine the effect of a novel gut microbiota-targeted therapeutic regimen (bowel lavage and antibiotics with or without an antifungal) in the management of active Crohn's Disease (CD) or…
- Trial name
- Holiday (NCT03476317)
- Testing
- Vancomycin, Neomycin, Ciprofloxacin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Crohn Disease
Real World Evidence Study With Restrictive Diet and Otral Nutritional Supplementation on Pediatric Patients With Active Chron Disease
This prospective study aims to provide real-world evidence of the effectiveness of the NEP + CDED diet in paediatric patients with Crohn's disease under conditions of routine clinical practice.
- Trial name
- REVIDEC (NCT07211789)
- Where
- 15 sites in Spain
- Volunteers
- 58 people
- Sponsor
- Outcomes'10
Ulcerative Colitis
Nitazoxanide in Patients With Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory bowel Disease (IBD) that primarily affects the rectum and colon. The severity and persistence of mucosal inflammation are associated with morbidity and mortality.
- Trial name
- NCT06993974
- Testing
- Mesalamine, Nitazoxanide
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Alexandria University
Ulcerative Colitis
Diet Treatment of Patients With Ulcerative Colitis in Remission
The study examines the effect of a low FODMAP diet in patients with UC in remission but still having GI symptoms (IBS in IBD). 15 patients will be on watchful waiting. 15 patients will be on low FODMAP diet.
- Trial name
- NCT02469220
- Testing
- Low FODMAP, Standardized FODMAP
- Where
- Denmark
- Volunteers
- 19 people
- Sponsor
- Regionshospital Nordjylland
Crohns Disease
Impaired Insulin-like Growth Factor-1 (IGF-1) Generation Causes Protein Catabolism and Poor Growth in Children With Crohn Disease
The investigators will prospectively recruit 26 children with moderate - severe active Crohn disease (PCDAI >30). Results will be compared to 26 patients in sustained remission (PCDAI <10 and physician global assessment of…
- Trial name
- NCT00946361
- Testing
- Examinations
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Nationwide Children's Hospital
Crohn's Disease
Comparison of Standard and Low Dose CT Enterography for Crohn's Disease
The investigators will be assessing the efficacy of a Model Based Iterative Reconstruction algorithm (MBIR) as a noise reduction tool in computed tomographic (CT) examinations for Crohn's Disease.
- Trial name
- NCT01736046
- Testing
- CT Enterography
- Where
- Canada
- Volunteers
- 163 people
- Sponsor
- University of British Columbia
Ulcerative Colitis
Phase 2 Dose-finding IMU-838 for Ulcerative Colitis
This is a phase 2, multicenter, randomized, double-blind, placebo-controlled, dose-finding study to evaluate the efficacy and safety of IMU-838 for induction and maintenance therapy with an option for open-label treatment…
- Trial name
- CALDOSE-1 (NCT03341962)
- Testing
- IMU-838
- Where
- 131 sites in United States, Albania and 17 more
- Volunteers
- 263 people
- Sponsor
- Immunic AG
Ulcerative Colitis
Trial on Profermin and Fresubin in Ulcerative Colitis
This study aim to investigate the effect of Profermin versus Fresubin in the dietetic treatment of active ulcerative colitis.
- Trial name
- CUPE2 (NCT01193894)
- Testing
- Profermin, Fresubin
- Where
- Denmark
- Volunteers
- 73 people
- Sponsor
- Nordisk Rebalance A/S
Inflammatory Bowel Diseases, Colitis, Ulcerative
Investigation of the Correlation Between Polyamine Levels and Their Key Enzymatic Activities in Association With Inflammatory Bowel Disease Progression
Inflammatory Bowel Disease (IBD), encompassing Ulcerative Colitis (UC) and Crohn's Disease (CD), significantly impairs patients' quality of life.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease, Polyamines
- Trial name
- NCT06995170
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Xijing Hospital
Colitis, Ulcerative
A Study to Investigate the Efficacy and Safety of GSK1605786 for Treatment of Patients With Active Ulcerative Colitis
GSK1605786 is an oral antagonist specific for the chemokine receptor CCR9 in development for treatment of small bowel and colonic Crohn's disease (CD).
- Trial name
- NCT01658605
- Testing
- GSK1605786
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Sponsor
- GlaxoSmithKline
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Crohn's Disease
VSL#3 Treatment in Children With Crohn's Disease
Crohn's disease (CD) in childhood is a chronic relapsing and remitting condition that has a significant impact on growth and development. The disease is characterized by an increased and unregulated immune response.
- Trial name
- NCT00367705
- Testing
- VSL#3®
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Crohn's Disease
Relationship Between Prophylactic Drainage and Postoperative Complications (PPOI) in Crohn's Patients After Surgery
For patients with Crohn's diseases，whether prophylactic abdominal drainage is necessary need further exploration. the present study is focusing on the necessity of prophylactic abdominal drainage in CD patients after surgery.
- Trial name
- RBPD (NCT03815851)
- Testing
- prophylactic drainage, no prophylactic drainage
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jinling Hospital, China
Crohn's Disease
Understanding the Relationship Between Infliximab Levels to Clinical Response of Remicade in Crohn's Disease
The purpose of this study is to improve the investigators understanding of the relationship between Crohn's disease and blood levels of the drug infliximab (Remicade).
- Trial name
- NCT01438151
- Testing
- Remicade
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Shradha Agarwal
Ulcerative Colitis
Gastrointestinal Motility in Severe Ulcerative Colitis Obtained by Motilis-3D-transit
The purpose of this study is to describe gastrointestinal (GI) motility in patients suffering from severe Ulcerative Colitis (UC) and to compare these results with similar results obtained in remission.
- Trial name
- NCT01745029
- Testing
- Motilis-3D-transit
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Crohn Disease
Observational Investigation of the CDED in a Real World IBD Clinic
A prospective observational study, which will follow a cohort of adult CD patients who are prescribed the Crohn disease exclusion diet (CDED) during their routine clinical dietary therapy.
- Trial name
- NCT05554445
- Where
- 2 sites in Israel
- Volunteers
- 1,000 people
- Sponsor
- Eli Sprecher, MD
Inflammatory Bowel Diseases
Development of a Questionnaire Based on Patients' Messages on an Internet Forum for Flare Detection in IBD
Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD) are chronic disabling conditions characterized by flares followed by periods of remission.
- Trial name
- FLARE_IBD (NCT04180345)
- Testing
- Psychometric validation of the questionnaire
- Volunteers
- 260 people
- Sponsor
- Central Hospital, Nancy, France
Colorectal Cancer, Gastric Cancer
Samples Procurement for Colorectal Cancer, Gastric Cancer, and Non-malignant Disease
The purposes of this study are to collect and store samples including blood, normal and tumor tissue from patients with colorectal cancer or gastric cancer, to collect and store samples including blood and/or normal…
- Conditions
- Colorectal Cancer, Gastric Cancer, Inflammatory Bowel Diseases, Gastric Ulcer
- Trial name
- NCT03972956
- Testing
- No intervention will be given to patients.
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Renmin Hospital of Wuhan University
Ulcerative Colitis
ABTECT-1 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -1
This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinical remission in subjects with moderately to severely active ulcerative colitis…
- Trial name
- NCT05507203
- Testing
- ABX464
- Where
- 264 sites in United States, Argentina and 22 more
- Volunteers
- 639 people
- Sponsor
- Abivax S.A.
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