Clinical trials: IBD (Inflammatory Bowel Disease)
Crohn Disease
PANenteric Crohn's Capsule Versus Ileo-Colonoscopy and Scan Study
Crohn's disease (CD) is a lifelong condition affecting the small and/or large bowel, causing diarrhoea, abdominal pain and weight loss.
- Trial name
- PAN-ICS (NCT04274010)
- Testing
- PillCamTM Crohn's capsule, Magnetic resonance enterography, Ileo-colonoscopy
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- South Tyneside and Sunderland NHS Foundation Trust
Ulcerative Colitis
A Study With GB004 in Adult Subjects With Active Ulcerative Colitis (UC)
A 2-part study, comprising of a 36-week placebo-controlled period (PCP) and a 24-week open-label extension (OLE) period, to assess the efficacy and safety of 2 dose regimens of GB004 when added to background UC therapy of…
- Trial name
- NCT04556383
- Testing
- GB004
- Where
- 77 sites in United States, Georgia and 7 more
- Volunteers
- 236 people
- Sponsor
- GB004, Inc.
Clostridium Difficile Infection, Ulcerative Colitis
Fecal Microbial Transplantation for C. Difficile and/or Ulcerative Colitis or Indeterminate Colitis
Fecal Microbiota Transplantation will be offered to eligible C. difficile patients (does not require Investigational New Drug designation) and to eligible ulcerative colitis or indeterminate colitis patients as Investigational…
- Conditions
- Clostridium Difficile Infection, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- FMT (NCT03268213)
- Testing
- Fecal Microbial Transplantation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stony Brook University
Colonic Neoplasms, Rectal Neoplasms
NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery
After resection of diseased segments of the large intestine, the continuity of the intestine has to be restored. This can be done by suturing or with so called stapling devices.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases
- Trial name
- NCT01056913
- Testing
- Compression Anastomosis Device, follow-up colonoscopy
- Volunteers
- 62 people
- Sponsor
- St John of God Hospital, Vienna
Ulcerative Colitis (UC), Crohn Disease (CD)
VedAryo® (Vedolizumab) Effectiveness and Safety Evaluation
The aim of this observational study is to evaluate Effectiveness and safety of VedAryo® (Vedolizumab) in male or female participants with clinical diagnosis of Inflammatory Bowel Disease. The main questions are aim to answer: 1.
- Conditions
- Ulcerative Colitis (UC), Crohn Disease (CD), Inflammatory Bowel Disease (IBD)
- Trial name
- NCT07273760
- Testing
- Vedolizumab
- Where
- 12 sites in Iran
- Volunteers
- 150 people
- Sponsor
- AryoGen Pharmed Co.
Crohn's Disease
High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease
The purpose of this 4 week study is to determine whether PASER®, an approved delayed-release oral formulation of 4-aminosalicylic acid, in doses of 4 grams three times daily for 2 weeks followed by 4 grams twice daily for 2…
- Trial name
- NCT00417690
- Testing
- 4-Aminosalicylic acid
- Where
- 5 sites in United States, Israel
- Volunteers
- 54 people
- Sponsor
- Jacobus Pharmaceutical
Ulcerative Colitis
High Definition Versus Chromoendoscopy for Dysplasia Detection in Ulcerative Colitis (UC)
Patients with ulcerative colitis (UC) have an increased risk for colorectal cancer (CRC) compared to the general population. Regular screening by colonoscopy is an internationally recommended cancer prevention strategy.
- Trial name
- NCT02138318
- Testing
- High definition (HD) endoscopy, chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Spondyloarthritis, Crohn's Disease
Effectiveness and Safety of Spondylitis Related to Inflammatory Bowel Disease
Adalimumab is an antibody treatment that targets and neutralizes a molecule produced in the body that is associated with inflammation, tumor necrosis factor (TNF).
- Trial name
- NCT00972218
- Testing
- Adalimumab
- Where
- Canada
- Sponsor
- University of Alberta
Malabsorption Syndromes, Granulomatous Enteritis
Plasma Citrulline Concentration in Tropical Enteropathy
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations.
- Conditions
- Malabsorption Syndromes, Granulomatous Enteritis, Enteritis, HIV Enteropathy
- Trial name
- NCT00816842
- Where
- Zambia
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Crohn Disease
Immune Ablation and Stem Cell Support for Crohn's Disease
The investigators anticipate that this study will also form the basis to clarify further the role of the immune system in Crohn's disease.
- Trial name
- NCT00179842
- Testing
- Stem Cell Transplant
- Where
- United States
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Irritable Bowel Syndrome
Effect of Vitamin D3 Supplementation in Treatment of Irritable Bowel Syndrome
The purpose of this study is to determine whether vitamin D3 supplementation is effective in the treatment of clinical signs, biomarkers of inflammation and oxidative stress due to Irritable Bowel Syndrome (IBS).
- Trial name
- NCT02579902
- Testing
- Vitamin D3 (Cholecalciferol)
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Ulcerative Colitis
A Study To Investigate The Safety And Efficacy Of CP- 690,550 In Patients With Moderate And Severe Ulcerative Colitis.
The hypothesis of the study is that at least one dose of CP 690 550 is superior to placebo (inactive drug) in inducing remission in patients with moderate to severe ulcerative colitis.
- Trial name
- NCT00787202
- Testing
- CP- 690 550
- Where
- 59 sites in Belgium, Brazil and 15 more
- Volunteers
- 195 people
- Sponsor
- Pfizer
Ulcerative Colitis, Telemedicine
The Use of Web-app Constant-Care in Patients With Acute Severe Ulcerative Colitis Treated With Rescue Therapy
The primary aim is to evaluate if introduction of eHealth in its form of the web application Constant-Care (https://ibd.constant-care.com) could reduce the length of hospitalization in patients with acute severe Ulcerative…
- Trial name
- NCT04165265
- Testing
- Constant-Care
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Nordsjaellands Hospital
Ulcerative Colitis
Infliximab Accelerated Induction in Moderate to Severe Pediatric UC
Objectives: To examine the effect of accelerated infliximab induction in children with moderate to severe UC. Design: A multi-center, prospective, randomized, open label study. Setting: Pediatric gastroenterology centers.
- Trial name
- INDUCE (NCT03209232)
- Testing
- Infliximab
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Schneider Children's Medical Center, Israel
Ulcerative Colitis
ABTECT - Maintenance
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active…
- Trial name
- NCT05535946
- Testing
- ABX464
- Where
- 413 sites in United States, Argentina and 32 more
- Volunteers
- 1,116 people
- Sponsor
- Abivax S.A.
Inflammatory Bowel Disease
Early Biomarkers in Circulating α 4β7 + T Cells to Predict Response to Vedolizumab in Inflamatory Bowel Disease Patients.
Background: Infiltration of GI by T lymphocytes is a pathogenic mechanism both in ulcerative colitis (UC) and in Crohn's disease (CD).
- Trial name
- NCT02712866
- Testing
- Vedolizumab
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Parc de Salut Mar
Inflammatory Bowel Disease, Crohn's Disease
IDeaL Pilot Study - Infliximab Dose to Level: Pilot Study
Crohn's disease (CD) is a lifelong condition of inflammation in the bowel. CD can affect any part of the gastrointestinal tract from mouth to anus.
- Trial name
- IDeaL (NCT02847884)
- Testing
- Infliximab
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- University of Alberta
Crohn's Disease, Ulcerative Colitis
Study of Anti-glycan Antibodies Stability in Saint-Etienne IBD Cohort
Prognostic factors in Inflammatory Bowel Diseases (IBD) are currently mainly based on clinical factors (disease extension, perianal involvement, need for surgery, use of immunomodulators…).
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- NCT02502552
- Testing
- blood specimen
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Inflammatory Bowel Diseases, Crohn Disease
Study of Dietary Composition in Crohn's Disease
Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome.
- Trial name
- CD (NCT04431700)
- Testing
- Anti-inflammatory diet, Regular diet
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, Los Angeles
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
ALPCO Calprotectin ELISA - Measurement of Calprotectin Levels in Human Stool
The ALPCO Calprotectin ELISA is an in vitro diagnostic test intended to quantitatively measure concentrations of fecal calprotectin in human stool samples. Calprotectin is a protein biomarker of mucosal inflammation.
- Trial name
- NCT03082287
- Testing
- Fecal Calprotectin Level
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
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