Clinical trials: IBD-Inflammatory Bowel Disease
Inflammatory Bowel Diseases, Colitis, Ulcerative
Study of Relationship Between Vedolizumab Therapeutic Drug Monitoring, Biomarkers of Inflammation and Clinical Outcomes
The purpose of this study is to determine if a relationship exists between Week 6 vedolizumab therapeutic drug monitoring (TDM) and Week 30 Faecal calprotectin (FCP).
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- VEDO TDM RWE (NCT04567628)
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 7,873 people
- Sponsor
- Takeda
Healthy Nutrition
Dietary Impact on Intestinal Sulfate Metabolism
This is a 5-week crossover pilot study of 15 highly motivated healthy volunteers who will consume two 7-day intervention diets: 1) a diet low in sulfur-containing amino acids (Low-S diet), emphasizing plant-based foods and fat…
- Trial name
- NCT05333900
- Testing
- Plant-Based Diet then animal-based diet, Animal-based diet then plant-based diet
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Crohn's Disease
Bologna IBD Markers
Individuate possible predictive factors of anti-TNFalfa-induced deep remission in Crohn's disease.
- Trial name
- NCT02580864
- Where
- Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Inflammatory Bowel Diseases
IBD Disease Course of Infliximab-naïve IBD Patients Treated With Subcutaneous Infliximab CT-P13 Remsima®
CURRENT STATE OF KNOWLEDGE IN VIEW OF THE RESEARCH About the condition under investigation Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic diseases characterized by relapsing and…
- Trial name
- PRIME (NCT05722353)
- Testing
- Biocollection
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
IBD (Inflammatory Bowel Disease)
Sequencing in Inflammatory Bowel Diseases (IBD) Therapy: "the Latium Net".
Patients with IBD, both UC and CD, who fulfil the inclusion and exclusion criteria will be included consecutively: Retrospective cohort Patients treated with IBD from January 2015 to June 2024 will be included.
- Trial name
- STRIKE (NCT06603337)
- Where
- Italy
- Volunteers
- 2,700 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colitis, Ulcerative
Effect of GSK1399686 in Patients With Mild to Moderately Active Ulcerative Colitis
This study is the first-time-in-patient trial of GSK1399686, a novel locally-acting anti-inflammatory compound, aimed at obtaining initial information on the tolerability, safety, pharmacokinetics (including concentrations in…
- Trial name
- NCT01036022
- Testing
- GSK1399686
- Where
- 26 sites in Belgium, Canada and 3 more
- Volunteers
- 120 people
- Sponsor
- GlaxoSmithKline
Colitis, Ulcerative
A Phase 2a, Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Trial of IBD98-M
IBD98-M-2002 is a phase 2a , Randomized, Double blind, Placebo-controlled of IBD98-M Delayed Release capsules in subjects with Mild to Moderately Ulcerative Colitis to investigate the clinical efficacy of IBD98-M delayed release…
- Trial name
- NCT02493712
- Testing
- High dose, Low dose
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Holy Stone Healthcare Co., Ltd
Crohn's Disease
Intermittent Caloric Restriction in Patients With Mild to Moderate Crohn's Disease
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal (GI) tract. CD is a common inflammatory bowel disease (IBD), frequent (150,000 patients in France and 1.5 million in Europe), disabling and incurable.
- Trial name
- TONIC (NCT05683730)
- Testing
- Intermittent caloric restriction
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Central Hospital, Nancy, France
Crohn's Disease
Diet for Induction and Maintenance of Remission and Re-biosis in Crohn's Disease
The modified-Exclusive Enteral Nutrition (mEEN) is an open label randomized controlled trial in mild to severe Crohn's Disease patients.
- Trial name
- DIETOMICS-CD (NCT02843100)
- Testing
- Modified Exclusive Enteral Nutrition, Crohn's Disease Exclusion Diet, Partial Enteral Nutrition
- Where
- 7 sites in Canada, Ireland and 2 more
- Volunteers
- 63 people
- Sponsor
- Prof. Arie Levine
Colitis, Ulcerative
Correlation of Soluble Suppression of Tumorigenicity 2 (ST2) With Golimumab (MK-8259) Response in Participants With Ulcerative Colitis (UC) (MK-8529-022).
The purpose of this study is to evaluate serum soluble human ST2 protein, the receptor for Interleukin-33 (IL-33) and a member of the proinflammatory Interleukin-1 (IL-1) receptor superfamily, as a surrogate biological marker…
- Trial name
- EVOLUTION (NCT02318667)
- Testing
- Golimumab
- Volunteers
- 38 people
- Sponsor
- Merck Sharp & Dohme LLC
Inflammatory Bowel Disease, Fatty Liver
Fatty Liver in Inflammatory Bowel Disease (IBD) Patients
Fatty liver is known to be one of the most frequent liver pathologies in IBD patients (35-40%). Despite this fact, there are only few publications that evaluated the prevalence of fatty liver in IBD patients.
- Trial name
- NCT00855907
- Testing
- clinical evaluation
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Ulcerative Colitis (UC)
Effectiveness and Safety of Mirikizumab in Patients With Moderate-to-severe Ulcerative Colitis: a Real-life Retrospective Multicenter Study
This is a real-life, multicenter, retrospective observational study with the aim to evaluate effectiveness and safety of Mirikizumab in a real life setting from the baseline up to manteinance at 12, 24 and 52 weeks.
- Trial name
- MIRI REAL (NCT07695636)
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Diseases, Iron-deficiency
Predicting Response to Iron Supplementation in Patients With Active Inflammatory Bowel Disease
Iron deficiency anemia is the most common systemic manifestation of Inflammatory Bowel Diseases (IBD)-Crohn's disease and ulcerative colitis.
- Conditions
- Inflammatory Bowel Diseases, Iron-deficiency, Iron Deficiency Anemia
- Trial name
- PRIme (NCT05456932)
- Testing
- Intravenous iron, Ferric maltol, Ferrous fumarate
- Where
- 5 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Leiden University Medical Center
Ulcerative Colitis
Efficacy, Safety and Tolerability of Propionyl-L-Carnitine Hydrochloride in Patients With Mild Ulcerative Colitis
The aim of the trial is to test safety, tolerability and efficacy of Propionyl-L-carnitine modified release tablets 1g/die in reducing the symptoms of the disease with respect to the proportion of patients with disease remission…
- Trial name
- NCT01538251
- Testing
- Propionyl-L-Carnitine
- Where
- 58 sites in Belgium, Czechia and 6 more
- Volunteers
- 147 people
- Sponsor
- sigma-tau i.f.r. S.p.A.
Inflammatory Bowel Disease, Colitis, Ulcerative
LMT503 First-in-human SAD, MAD, and FE Study
This is a double-blind, randomized, placebo-controlled study, consisting of a single ascending dose (SAD) part with integrated food effect (FE) arm, and a multiple ascending dose (MAD) part to assess the safety, tolerability, and…
- Conditions
- Inflammatory Bowel Disease, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT05659953
- Testing
- LMT503
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lmito Therapeutics Inc.
Rectal Cancer, Ulcerative Colitis
Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses
The primary purpose of this prospective, randomized multicenter center study is to evaluate and compare the outcomes of colorectal, coloanal and ileoanal anastomoses reinforced with a bioabsorbable staple line reinforcement…
- Conditions
- Rectal Cancer, Ulcerative Colitis, Familial Adenomatous Polyposis, Diverticulitis
- Trial name
- NCT00663819
- Testing
- GORE SEAMGUARD® Bioabsorbable Staple Line Reinforcement, Staple line without reinforcement
- Where
- 16 sites in United States
- Volunteers
- 258 people
- Sponsor
- W.L.Gore & Associates
Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA)
German Spondyloarthritis Inception Cohort
The German Spondyloarthritis Inception cohort (GESPIC) was started 2000 as a prospective, longitudinal, multicentre, nationwide study in Germany on patients with early SpA including ankylosing spondylitis (AS, also known as…
- Conditions
- Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA), Axial Psoriatic Arthritis (axPsA), Acute Anterior Uveitis (AAU)
- Trial name
- GESPIC (NCT01277419)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Inflammatory Bowel Diseases
Regulation of Mucosal Healing in Inflammatory Bowel Disease
The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid…
- Trial name
- NCT04504136
- Testing
- Serial Biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Terrence A Barrett
PRD (Paediatric Rheumatological Disease), IBD (Inflammatory Bowel Disease)
HPV Vaccination in Special Risk Groups: 5 Year Follow-up
In 2007-2009 the investigators conducted a study to determine the immunogenicity response to HPV vaccine in special risk patients known to be at increased risk of abnormal cervical cytology.
- Trial name
- NCT01896986
- Where
- Australia
- Volunteers
- 37 people
- Sponsor
- Murdoch Childrens Research Institute
Ulcerative Colitis
Study of Freeze-dried Black Raspberry in Maintenance of Ulcerative Colitis
This research study is about adding Black Raspberry powder to the treatment regimen of patients with ulcerative colitis who are currently in remission and doing well.
- Trial name
- BRB (NCT02267694)
- Testing
- Freeze-dried black raspberry powder
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- UConn Health
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.