Clinical trials: IBD-Inflammatory Bowel Disease
Inflammatory Bowel Disease, Ulcerative Colitis
Web-based Monitoring in Children and Adolescents With Inflammatory Bowel Disease
The investigators hypothesize that E-health - web based monitoring of disease and treatment - in young patients with chronic inflammatory disease (IBD) can improve the disease course and quality of life.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Crohn´s Disease
- Trial name
- NCT01860651
- Testing
- Web-monitoring
- Where
- Denmark
- Volunteers
- 103 people
- Sponsor
- Hvidovre University Hospital
Crohn's Disease
Single and Repeat Dose Pharmacokinetic Study of GSK1605786 in Healthy Chinese Subjects
This is an open-label, parallel group, single and repeat dose pharmacokinetic (PK) study in healthy male and female subjects. This study will confirm the PK and safety profile in Chinese subjects.
- Trial name
- NCT01827631
- Testing
- GSK1605786 capsule
- Where
- China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Colonic Neoplasms, Diverticulosis, Colonic
Biodegradable Stenting Anastomoses Versus Double-layer Hand Sutures for Reconstruction in Intestinal Anastomosis
Intestinal anastomosis plays an important role in various general surgeries, but the complications such as anastomotic leakage,stenosis and hemorrhage cannot been avoided.
- Conditions
- Colonic Neoplasms, Diverticulosis, Colonic, Crohn Disease
- Trial name
- NCT02752360
- Testing
- Biodegradable Stenting Anastomoses, Double-layer Hand Sutures
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Beijing Friendship Hospital
Inflammatory Bowel Disease, Crohn's Disease
Endoscopy and Endomicroscopy for Assessment of Mucosal Healing in Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease (IBD) encompasses two major forms of chronic intestinal disorders, Crohn's disease and ulcerative colitis (UC).
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT01524120
- Testing
- Endoscopy (EPK-i, Pentax, Tokyo, Japan), Endomicroscopy (iCLE, Pentax, Tokyo, Japan)
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Ulcerative Colitis
Prospective Multicenter Trial to Determine the Efficacy and Outcome of the UCRI Biomarker Panel and Algorithm to Detect Mucosal Healing in Moderate to Severe Ulcerative Colitis Patients.
The purpose of this research study is to determine the efficacy and outcome of the UCRI (an in-vitro diagnostics device in the form of a blood test and an algorithm) as a tool to detect mucosal healing (level of inflammation in…
- Trial name
- NCT04897282
- Testing
- UCRI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Glycominds, LLC
Colorectal Anastomosis, Endometrial
Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal Diversion
There are many indications for performing a fecal diversion stoma. In both scheduled and emergency situations, and whatever the context (indication or type of fecal diversion stoma), stomal complications can occur early (10-60%)…
- Conditions
- Colorectal Anastomosis, Endometrial, Anastomotic Leak Rectum, Ulcerative Colitis (Disorder)
- Trial name
- RESTODIG (NCT06881303)
- Testing
- preoperative stoma identification and education
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Proctitis, Proctosigmoiditis
The Safety and Tolerability of Budesonide Foam in Participants With Active Ulcerative Proctitis or Proctosigmoiditis
The purpose of this study is to evaluate safety and tolerability of cyclically-dosed rectal budesonide foam in participants with active ulcerative proctitis (UP) or ulcerative proctosigmoiditis (UPS).
- Trial name
- NCT01349673
- Testing
- Budesonide Foam
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Bausch Health Americas, Inc.
Inflammatory Bowel Disease (IBD), CD - Crohn's Disease
Prophylactic Dexamethasone Before Infliximab in Moderate-to-Severe IBD
This comparative observational cohort clinical study aims to investigate the necessity of premedication for allergy prevention prior to infliximab injection, and is designed to evaluate whether non-routine administration of…
- Conditions
- Inflammatory Bowel Disease (IBD), CD - Crohn's Disease, UC - Ulcerative Colitis
- Trial name
- PA (NCT07385131)
- Testing
- Dexamethasone (IV)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ulcerative Colitis (UC)
Study to Evaluate the Efficacy and Safety of Ponesimod (VSP-128) in Patients With Moderately to Severely Active Ulcerative Colitis
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of Ponesimod (VSP-128) in patients with moderately to severely active ulcerative colitis
- Trial name
- NCT07686081
- Testing
- Ponesimod
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Vanda Pharmaceuticals
Irritable Bowel Syndrome (IBS), Functional Dyspepsia
Interactive Effects of Early-Life Stress, Diet, and Metabolism on Gastrointestinal Dysfunction With Neuropsychiatric Symptoms
The goal of this observational case-control study is to learn how stressful experiences, dietary habits, and blood nutrient levels are associated with gastrointestinal symptoms and symptoms of depression and anxiety in adults…
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Inflammatory Bowel Disease (IBD), Gastroparesis
- Trial name
- NCT07852819
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Colitis Ulcerosa, Colitis Ulcerative
Magnesium in Gastrointestinal Disease
Individuals with gastrointestinal diseases - such as Crohn's disease, ulcerative colitis, ileostomy, or bile acid diarrhoea - are at increased risk of magnesium deficiency.
- Conditions
- Colitis Ulcerosa, Colitis Ulcerative, Crohns Disease, Morbus Crohn
- Trial name
- MAGIC (NCT07338565)
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Colon Cancer, Colon Polyp
German Colon Capsule Registry
Aim of the registry is to evaluate all colon capsule endoscopies performed in Germany. This is to investigate safety, quality assurance and quality control of colon capsule endoscopy.
- Conditions
- Colon Cancer, Colon Polyp, Diarrhea, Inflammatory Bowel System
- Trial name
- DEKOR (NCT02182466)
- Testing
- Colon capsule endoscopy
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Inflammatory Bowel Diseases
First Time in Human Study of Intravenous Interleukin-18 Antibody
GSK1070806 is a humanised monoclonal antibody that blocks a protein present in the body called Interleukin-18. The main purpose of this study is to test GSK1070806 in healthy and obese male subjects with normal immune systems to…
- Trial name
- A18110040 (NCT01035645)
- Testing
- GSK1070806
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Crohn´s Disease
Trichuris Suis Ova (TSO) Suspension Versus Placebo in Active Crohn's Disease
This study will run in centers in Germany, Denmark, Austria, Czech Republic, and Switzerland, only. This proof-of-concept study aims to evaluate the efficacy of three doses of oral TSO suspension vs.
- Trial name
- TRUST-2 (NCT01279577)
- Testing
- Low dose TSO, Medium dose TSO, High dose TSO
- Where
- Germany
- Volunteers
- 254 people
- Sponsor
- Dr. Falk Pharma GmbH
Crohn Disease, Fistula
Anal Crohn Fistula Surgery
The purpose of this study is to demonstrate, in patients treated with adalimumab, the efficacy of proctological surgery in anoperineal fistula healing after the removal of seton drain.
- Conditions
- Crohn Disease, Fistula, Anoperineal Fistula, Anal Fistula
- Trial name
- FACC (NCT01388257)
- Testing
- All types of surgery procedures, Simple seton drain removal
- Where
- 15 sites in France
- Volunteers
- 180 people
- Sponsor
- French Society of Coloproctology
Ulcerative Colitis
Clinical Study of Cord Blood Mononuclear Cells on Treatment of Hormone-resistant or Hormone-dependent Ulcerative Colitis
This study conducted a systematic clinical observation of the clinical efficacy of UCB-MNCs in the treatment of hormone-resistant or hormone-dependent ulcerative colitis, in order to observe its clinical safety and efficacy.
- Trial name
- NCT04882683
- Testing
- Prednisone, Azathioprine, Adalimumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shandong Qilu Stem Cells Engineering Co., Ltd.
Crohn Disease, Colitis, Ulcerative
Immune Modulation From Trichuris Trichiura
Mucosal immunology during helminth infection
- Conditions
- Crohn Disease, Colitis, Ulcerative, Intestinal Helminthiasis
- Trial name
- NCT02399683
- Testing
- Trichuris trichiura eggs
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ulcerative Colitis (UC), Healthy Volunteer
Phase 1 Study Evaluating PALI-2108 in Healthy Volunteers and Ulcerative Colitis Patients.
PALI-2108 is a new oral medication designed to treat ulcerative colitis (UC) by targeting the intestines. It works as a phosphodiesterase-4 (PDE4) inhibitor prodrug, meaning it becomes active only after being processed by…
- Trial name
- NCT06663605
- Testing
- PALI-2108
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Palisade Bio
IBD, Ulcerative Colitis
Ibd CAncer and seRious Infections in France (I-CARE 2)
This is a French prospective longitudinal observational multicentre cohort study. Primary objective : to assess prospectively the presence and the extent of safety concerns (cancer, serious infections, arterial and venous…
- Conditions
- IBD, Ulcerative Colitis, Crohn Disease
- Trial name
- I-CARE 2 (NCT06089590)
- Testing
- Non-interventional
- Where
- 2 sites in France
- Volunteers
- 6,000 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn Disease
Evaluation of a New Oral Contrast Agent for MR Enterography in the Assessment of Crohn Disease in the Small Bowel
The purpose of this study is to assess the exam quality and accuracy of MR using a new oral contrast agent for the evaluation of Crohn Disease in the small bowel.
- Trial name
- NCT00587210
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
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