Clinical trials: IBD-Inflammatory Bowel Disease
Crohn Disease (CD), Intensification
Optimal Care With Guselkumab in Crohn's Disease / OPTIM Study A Prospective Open Label Interventional, Multicenter Study
Crohn's disease (CD) is a chronic and destructive inflammatory disease of the gastrointestinal tract characterized by phases of relapse and remission.
- Trial name
- OPTIM (NCT07616687)
- Testing
- Guselkumab
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Ulcerative Colitis
Optimal Fecal Microbiota Transplant Dosing for Mild to Moderate Ulcerative Colitis
This is a prospective unblinded, randomized trial for the use of Fecal Microbiota Transplantation (FMT) for the treatment of Ulcerative Colitis (UC), in combination with or without antibiotic pretreatment.
- Trial name
- NCT03006809
- Testing
- Fecal Microbiota Transplantation (FMT), OpenBiome, pretreatment antibiotics
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Najwa Elnachef
Ul
A Single-Center Observational Study on the Impact of Symptom Assessment Timing on the Short-Term Efficacy of 5-ASA Therapy in Patients With Initial-Onset or Relapsed Mild-to-Moderate Active Ulcerative Colitis
This study aims to collect the relevant clinical examination results of patients during the 5-ASA treatment period through opportunistic sampling of patients with mild to moderate active ulcerative colitis (UC).
- Trial name
- NCT06998693
- Testing
- 5-ASA (5-Aminosalicylate), Colon Endoscopy Procedure, Blood Routine Test at 4-week
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Crohn Disease
A Study of Ustekinumab (STELARA) in Chinese Participants With Moderately to Severely Active Crohn's Disease
The purpose of this study is to evaluate the clinical and endoscopic efficacy and safety of ustekinumab in Chinese participants with moderately to severely active Crohn's disease.
- Trial name
- NCT05029921
- Testing
- Ustekinumab
- Where
- 29 sites in China
- Volunteers
- 182 people
- Sponsor
- Janssen Research & Development, LLC
Ulcerative Colitis
Safety, Efficacy, Pharmacokinetic and Pharmacodynamic Study of GLPG0974 in Subjects With Ulcerative Colitis
Approximately 45 patients suffering from mild to moderate ulcerative colitis will be examined for any side effects (safety and tolerability) that may occur when taking GLPG0974 or matching placebo (2:1 ratio) for 28 days.
- Trial name
- NCT01829321
- Testing
- GLPG0974
- Where
- 16 sites in Belgium, Czechia and 2 more
- Volunteers
- 45 people
- Sponsor
- Lakefront Biotherapeutics NV
Inflammatory Bowel Diseases
Heart Rate Variability and Inflammatory Bowel Disease
The goals of this study are to test the effectiveness of a virtually delivered, group-based coping skills treatment program incorporating heart rate variability biofeedback to target autonomic dysfunction in youth diagnosed with…
- Trial name
- NCT06537258
- Testing
- Biofeedback Enhanced Treatment
- Where
- 3 sites in United States
- Volunteers
- 128 people
- Sponsor
- Emory University
ColoRectal Cancer and Inflammatory Bowel Disease
Impact of the Enhanced Recovery After Surgery System for Colorectal Surgery
This is an observational study to look at the impact of the Enhanced Recovery After Surgery system for colorectal surgery (Group 1) in shortening hospital length of stay, reducing postoperative narcotic consumption, lowering…
- Trial name
- NCT02997293
- Testing
- Enhanced Recovery protocol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Ulcerative Colitis (UC)
A National Multicenter Study of Etrasimod for the Treatment of Patients With Active UC
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that causes symptoms such as bloody diarrhea, abdominal pain, and frequent bowel movements. It can significantly affect patients' quality of life.
- Trial name
- E-Heal China (NCT07705126)
- Testing
- Etrasimod
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tang-Du Hospital
Crohn's Disease, Ulcerative Colitis (UC)
A Blood and Tissue Sample Collection Study of Patients Who Have Inflammatory Bowel Disease, Who Have Been Treated With Adalimumab and Who Developed Hepatosplenic T-Cell Lymphoma
To collect and store blood and biopsy samples obtained from CD or UC patients exposed to adalimumab and diagnosed with Hepatosplenic T-cell Lymphoma (HSTCL), for the purpose of identifying potential biomarkers and genetic…
- Conditions
- Crohn's Disease, Ulcerative Colitis (UC), Hepatosplenic T-Cell Lymphoma
- Trial name
- HSTCL (NCT02087878)
- Where
- Italy
- Sponsor
- AbbVie
Ulcerative Colitis, Inflammatory Bowel Disease
A Trial of Rosiglitazone for Ulcerative Colitis
This is a multicenter, randomized, double-blind, placebo-controlled study evaluating rosiglitazone: 4 mg tablets or placebo tablets administered orally twice daily for 12 weeks.
- Trial name
- NCT00065065
- Testing
- Rosiglitazone
- Where
- 13 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- James Lewis
Inflammatory Bowel Diseases
Metformin in Patients With Ulcerative Colitis Treated With Mesalamine
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease characterized by diffused inflammation of the colon and rectum mucosa, however, the exact underlying mechanisms of UC remain poorly understood.UC is strongly…
- Trial name
- NCT05553704
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Ulcerative Colitis
Predicting Clinical Response to Golimumab With Mucosal Barrier Dysfunction
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease (IBD). UC is an ongoing disease of the colon or large intestine. Studies have shown that leakiness of the gut plays a major role in the development of UC.
- Trial name
- NCT02729233
- Testing
- patients receiving biopsies
- Sponsor
- University of Arkansas
Inflammatory Bowel Disease
Study of the Role of Soluble Inhibitor of Interleukin 22, Interleukin 22 Binding Protein (IL-22BP), in Chronic Inflammatory Bowel Disease
IL-22 is an IL-10 family cytokine that plays major actions to increase intestinal epithelial barrier function and regeneration during experimental colitis.
- Trial name
- IL-22BP MICI (NCT02847052)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Nantes University Hospital
Ulcerative Colitis
Fecal Biotherapy for the Induction of Remission in Active Ulcerative Colitis
Ulcerative colitis is a condition that mainly affects young adults where the lining of the bowel is inflamed causing bloody diarrhea.
- Trial name
- NCT01545908
- Testing
- Fecal transplant
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Hamilton Health Sciences Corporation
Colitis, Ulcerative, Crohn's Disease
Effect of a Comprehensive Nutrition Support Product on the Nutritional Status of Adults With Inflammatory Bowel Disease
Individuals with IBD are at risk for nutrient deficiencies. This prospective, non-randomized, open-label study will assess the effect of a nutrition support product on nutritional status in adults with IBD.
- Trial name
- NCT02801240
- Testing
- Nutrition support product
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National University of Natural Medicine
Ulcerative Colitis
LFMT vs Placebo in New Biologic Start for Ulcerative Colitis
To compare the safety and efficacy of concomitant LFMT versus placebo in UC patients who are starting vedolizumab or ustekinumab.
- Trial name
- NCT05327790
- Testing
- Lyophilized fecal microbiota (LFMT)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Irritable Bowel Disease
Plant Exosomes +/- Curcumin to Abrogate Symptoms of Inflammatory Bowel Disease
The trial will test the hypothesis that edible structures within plant cells (ginger) will have clinically important anti-inflammatory effects on the gut lining of patients with inflammable bowel disease.
- Trial name
- NCT04879810
- Testing
- Sigmoidoscopy and biopsy, blood work
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Louisville
Ulcerative Colitis, Crohn's Disease
Study of Oral Upadacitinib to Assess Change in Disease Activity and Adverse Events in Adult Participants With Ulcerative Colitis or Crohn's Disease
Ulcerative colitis (UC) is an idiopathic, chronic, inflammatory disease affecting the colon. Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract.
- Trial name
- NCT06459297
- Where
- 14 sites in South Korea
- Volunteers
- 105 people
- Sponsor
- AbbVie
Crohn's Disease, Perianal Fistulas
The Influence of Hyperbaric Oxygen in Patients With Perianal Crohn's Disease Already Treated With TNF Alpha Blockers Treated With TNF Alpha Blockers
The aim of this study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on patient suffering from residual Crohn's disease related perianal fistulas already treated with TNF alpha blockers
- Trial name
- NCT01828190
- Testing
- Hyperbaric oxygen
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Inflammatory Bowel Diseases
Effectiveness and Safety of COVID-19 Vaccine in Patients With IBD Treated With Immunomodulatory or Biological Drugs (ESCAPE-IBD)
The COVID-19 pandemic has led to initial concerns for patients with Inflammatory Bowel Disease treated with immunosuppressive drugs, as they could be theoretically exposed to a higher risk of SARS-CoV-2 infection and/or severe…
- Trial name
- ESCAPE-IBD (NCT04769258)
- Testing
- Pfizer Comirnaty vaccine
- Volunteers
- 1,380 people
- Sponsor
- Italian Group for the study of Inflammatory Bowel Disease (IG-IBD)
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