Clinical trials: IBD-Inflammatory Bowel Disease
Ulcerative Colitis
Colon Capsule Endoscopy Versus Standard Colonoscopy in Ulcerative Colitis
The dimension of diagnostic procedures and therapy of chronic inflammatory bowel diseases largely depends on the degree of mucosal inflammation.
- Trial name
- NCT00837304
- Testing
- PillCam Colon Capsule, Standard Colonoscopy
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- University Hospital Muenster
Inflammatory Bowel Diseases, Crohn Disease
Intestinal Ultrasound Guided Management in Inflammatory Bowel Disease
This randomized controlled trial evaluates whether adding point-of-care intestinal ultrasound (IUS) to standard of care changes clinical management in patients with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Colitis, Ulcerative
- Trial name
- NCT07775352
- Testing
- Intestinal ultrasound (IUS), Standard of care
- Where
- Thailand
- Volunteers
- 137 people
- Sponsor
- Mahidol University
Inflammatory Bowel Diseases, Crohn Disease
Manitoba Inflammatory Bowel Disease Cohort Study
The Manitoba Inflammatory Bowel Disease (IBD) Cohort Study participants were drawn from a population-based research registry. The cohort consisted of 388 adult enrollees with recent IBD onset who completed the baseline survey and…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT03262649
- Volunteers
- 388 people
- Sponsor
- University of Manitoba
Inflammatory Bowel Diseases
VeDOlizumab PERsistence in IBD Patients After Switching From Intravenous to Subcutaneous Administration : a Real-life Multicenter Study (DOPER)
Descriptive : A 12-months multicenter, observational, prospective cohort study. Population : IBD patients under stable clinical and biological remission will be proposed to switch from the IV vedolizumab to the SC vedolizumab as…
- Trial name
- DOPER (NCT05158517)
- Testing
- Subcutaneous vedolizumab
- Where
- France
- Volunteers
- 349 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn Disease
The Intensive Post Exclusive Enteral Nutrition Study
Crohn's disease (CD) is a chronic inflammatory condition with phases where the disease is active and other, where there are no symptoms.
- Trial name
- iPENS (NCT04225689)
- Testing
- CD-TREAT diet
- Where
- 5 sites in United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Inflammatory Bowel Disease
Iron Isomaltoside 1000 (Monofer®) Administered by a High Dosing Regimen in Subjects With Inflammatory Bowel Disease
The study is a prospective, non-controlled, open-label multi-centre pilot safety study of iron isomaltoside 1000 (Monofer®) administered to subjects with anaemia and Inflammatory Bowel Disease (IBD).
- Trial name
- IBD-02 (NCT01599702)
- Testing
- Iron Isomaltoside 1000
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Pharmacosmos A/S
Ulcerative Colitis
Tolerability and Efficacy of Sodium Picosulfate/Magnesium Citrate Versus PEG/Ascorbic Acid in Ulcerative Colitis Patients
Ulcerative colitis is a chronic condition that results in the inflammation of the colon and rectum. Patients suspected to have ulcerative colitis are diagnosed via colonoscopy.
- Trial name
- NCT03581149
- Testing
- Sodium Picosulfate/Magnesium Citrate Laxative, 2L polyethylene glycol/ascorbic acid
- Where
- Lebanon
- Volunteers
- 68 people
- Sponsor
- American University of Beirut Medical Center
Crohn's Disease
Ustekinumab Real World Evidence Study
The purpose of this study is to capture the real-world experience of CD patients treated with ustekinumab as part of their clinical care in a variety of care settings from large teaching/research centres to smaller district…
- Trial name
- UndieS (NCT07748338)
- Testing
- Ustekinumab
- Where
- 22 sites in United Kingdom
- Volunteers
- 601 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Crohn's Disease
Autologous Hematopoietic Stem Cell Transplantation for Crohn's Disease Treatment
The purpose of this study is to evaluate the safety and potential clinical benefit of lymphoablation followed by autologous HSCT rescue in therapy refractory Crohn's disease
- Trial name
- HSCT (NCT01932658)
- Testing
- Hematopoietic stem cell transplantation
- Where
- United States
- Sponsor
- University of California, Los Angeles
Crohn Disease
Individual Treatment of Ustekinumab in Perianal Fistulizing Crohn's Disease
This study intends to further explore the actual efficacy of ustekinumab in the individualized treatment of anal fistula Crohn's disease.
- Trial name
- NCT06739278
- Where
- China
- Volunteers
- 119 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Inflammatory Bowel Diseases (IBD), Crohn Disease
Longitudinal Registry of Difficult-to-Treat Inflammatory Bowel Disease
Difficult-to-treat inflammatory bowel disease (DTT-IBD) represents a heterogeneous group of patients with treatment-refractory, structurally complicated, postoperative, perianal, pouch-related, or psychosocially complex disease.
- Conditions
- Inflammatory Bowel Diseases (IBD), Crohn Disease, Colitis, Ulcerative
- Trial name
- DTT-IBD (NCT07877649)
- Testing
- Routine IBD Management and Advanced-Therapy Exposure
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Crohn's Disease
Wireless Capsule Endoscopy in Small-Bowel Crohn's Disease
The purpose of this study is to determine the best role for capsule endoscopy in diagnosing Crohn's disease.
- Trial name
- NCT00178438
- Testing
- Capsule Endoscopy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Rochester
Crohn's Disease
SECURE, the Cimzia ® Crohn's Disease Post-Marketing Registry
The purpose of this study is to monitor safety outcomes of patients who have taken Cimzia® as compared to a non- Cimzia® control population.
- Trial name
- SECURE (NCT00844285)
- Testing
- Cimzia
- Where
- 197 sites in United States
- Volunteers
- 3,072 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Postoperative Disease Recurrence, Crohns Disease
Extensive Mesenteric Excision (EME) Versus Local Mesenteric Excision (LME) for Crohn's Disease
Crohn's patients receiving ileocolonic resection are randomized into extensive mesenteric resection group and local mesenteric resection group.
- Trial name
- NCT02542904
- Testing
- mesenteric excision
- Where
- China
- Volunteers
- 119 people
- Sponsor
- Jinling Hospital, China
Ulcerative Colitis
European Safety Registry in Ulcerative Colitis (P04808)
This is a prospective, safety surveillance registry in participants with moderate-to-severe active ulcerative colitis (UC).
- Trial name
- OPUS (NCT00705484)
- Testing
- infliximab, Standard Therapy
- Volunteers
- 2,239 people
- Sponsor
- Merck Sharp & Dohme LLC
Inflammatory Bowel Disease
Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab
Infliximab (IFX) is highly effective in inducing and maintaining remission in patients with inflammatory bowel disease (IBD). However, a large proportion of patients will eventually lose response to IFX.
- Trial name
- PRECISION (NCT02453776)
- Testing
- PRECISION dosing Infliximab
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Fecal Calprotectin Collection Protocol
The primary objective is to obtain stool samples from subjects diagnosed with , and displaying signs and/or symptoms of IBD and/or IBS will be evaluated in this study.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Ulcerative Colitis, Crohn Disease
- Trial name
- CALFE (NCT03143517)
- Testing
- Stool collection
- Where
- 13 sites in United States
- Volunteers
- 240 people
- Sponsor
- DiaSorin Inc.
Crohn's Disease
Evaluation of Digestive Damage and Associated Predictive Factors in Crohn's Disease 5 to 10 Years After Diagnosis
The primary objective is to evaluate digestive damage in CD 5 to 10 years after diagnosis in the GETAID centers included in the RAPID study. Secondary objective is to identify predictive factors of the evolution digestive damage.
- Trial name
- DESTIN (NCT02549976)
- Testing
- Abdominal MRI, Upper endoscopy, Colonoscopy
- Where
- 9 sites in France
- Volunteers
- 54 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn's Disease
Real-World Study of IL-23 Inhibitors in Active Crohn's Disease
The goal of this observational study is to learn about the effectiveness and safety of IL-23 inhibitors in adults with active Crohn's disease in real-world clinical practice.
- Trial name
- NCT07545317
- Testing
- IL-23 inhibitor, TNF inhibitors
- Where
- China
- Volunteers
- 665 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
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